Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR284W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.169 | 6.04E-23 | YCR105W | ADH7 | hom | NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance |
0.150 | 2.12E-18 | YMR173W | DDR48 | hom | DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress |
0.145 | 3.71E-17 | YKL205W | LOS1 | hom | Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm |
0.138 | 9.09E-16 | YPL210C | SRP72 | het | Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane |
0.133 | 9.92E-15 | YFL041W | FET5 | hom | Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport |
0.125 | 4.12E-13 | YBL063W | KIP1 | hom | Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions |
0.124 | 6.86E-13 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
0.115 | 2.20E-11 | YMR147W_p | YMR147W_p | hom | Putative protein of unknown function |
0.111 | 1.34E-10 | YER064C | VHR2 | hom | Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
0.110 | 1.82E-10 | YDL012C | YDL012C | hom | Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication |
0.108 | 3.82E-10 | YBL066C | SEF1 | hom | Putative transcription factor, has homolog in Kluyveromyces lactis |
0.107 | 6.00E-10 | YBL086C_p | YBL086C_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
0.105 | 9.35E-10 | YGR127W_p | YGR127W_p | hom | Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response |
0.105 | 9.82E-10 | YNL176C_p | TDA7_p | hom | Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele |
0.105 | 1.14E-9 | YDL078C | MDH3 | hom | Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle |