YOR284W / HUA2

Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR284W / HUA2

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:3.31|P-value:3.28E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide (4-NQO)|FD-Score:3.01|P-value:9.77E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.29|P-value:2.57E-8 ID:SGTC_442|Compound:cape|FD-Score:-3.17|P-value:5.22E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.43|P-value:2.52E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.15|P-value:5.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.39|P-value:2.23E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.15|P-value:9.68E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.34|P-value:2.93E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.35|P-value:2.81E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.36|P-value:2.49E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.65|P-value:7.77E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.29|P-value:3.51E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.32|P-value:4.25E-6 ID:SGTC_1783|Compound:st039459|FD-Score:3.20|P-value:5.03E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.73|P-value:5.73E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.07|P-value:1.24E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.47|P-value:1.75E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.46|P-value:1.82E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.55|P-value:1.27E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.16|P-value:9.31E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.47|P-value:1.76E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.27|P-value:3.51E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.68|P-value:7.58E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.90|P-value:2.73E-5 ID:SGTC_2792|Compound:7535235|FD-Score:3.59|P-value:1.07E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.37|P-value:1.59E-8 ID:SGTC_2827|Compound:7993847|FD-Score:4.51|P-value:1.67E-6 ID:SGTC_2880|Compound:9042983|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.91|P-value:2.78E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.21|P-value:4.51E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.22|P-value:6.78E-6 ID:SGTC_3057|Compound:9095946|FD-Score:4.61|P-value:1.02E-6 ID:SGTC_3083|Compound:9117465|FD-Score:-3.15|P-value:5.48E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.01|P-value:9.82E-4 ID:SGTC_3290|Compound:9121031|FD-Score:4.57|P-value:1.24E-6 ID:SGTC_3323|Compound:9138564|FD-Score:3.87|P-value:3.34E-5 ID:SGTC_101|Compound:0490-5701|FD-Score:3.31|P-value:3.28E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide (4-NQO)|FD-Score:3.01|P-value:9.77E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:5.29|P-value:2.57E-8 ID:SGTC_442|Compound:cape|FD-Score:-3.17|P-value:5.22E-4 ID:SGTC_444|Compound:curcumin|FD-Score:4.43|P-value:2.52E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:3.15|P-value:5.88E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.39|P-value:2.23E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.15|P-value:9.68E-6 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.34|P-value:2.93E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.35|P-value:2.81E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.36|P-value:2.49E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.65|P-value:7.77E-5 ID:SGTC_1764|Compound:st044502|FD-Score:3.29|P-value:3.51E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.32|P-value:4.25E-6 ID:SGTC_1783|Compound:st039459|FD-Score:3.20|P-value:5.03E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.73|P-value:5.73E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.07|P-value:1.24E-5 ID:SGTC_2030|Compound:5175110|FD-Score:3.47|P-value:1.75E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.46|P-value:1.82E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.55|P-value:1.27E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:4.16|P-value:9.31E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.47|P-value:1.76E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.27|P-value:3.51E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.68|P-value:7.58E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.90|P-value:2.73E-5 ID:SGTC_2792|Compound:7535235|FD-Score:3.59|P-value:1.07E-4 ID:SGTC_2816|Compound:7982706|FD-Score:5.37|P-value:1.59E-8 ID:SGTC_2827|Compound:7993847|FD-Score:4.51|P-value:1.67E-6 ID:SGTC_2880|Compound:9042983|FD-Score:3.31|P-value:3.33E-4 ID:SGTC_2904|Compound:7225135|FD-Score:3.91|P-value:2.78E-5 ID:SGTC_2972|Compound:9093619|FD-Score:-3.21|P-value:4.51E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.22|P-value:6.78E-6 ID:SGTC_3057|Compound:9095946|FD-Score:4.61|P-value:1.02E-6 ID:SGTC_3083|Compound:9117465|FD-Score:-3.15|P-value:5.48E-4 ID:SGTC_3161|Compound:9100388|FD-Score:3.01|P-value:9.82E-4 ID:SGTC_3290|Compound:9121031|FD-Score:4.57|P-value:1.24E-6 ID:SGTC_3323|Compound:9138564|FD-Score:3.87|P-value:3.34E-5

Top fitness defect scores for YOR284W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2816 7982706 5.37 58.4 µM 1.59E-8 azole & statin 22 3.98E-8
2 SGTC_341 1486-1430 5.29 230.0 µM 2.57E-8 7 6.26E-8
3 SGTC_3057 9095946 4.61 49.5 µM 1.02E-6 Golgi 7 2.01E-6
4 SGTC_3290 9121031 4.57 71.4 µM 1.24E-6 4 2.41E-6
5 SGTC_2827 7993847 4.51 71.4 µM 1.67E-6 13 3.20E-6
6 SGTC_444 curcumin 4.43 90.4 µM 2.52E-6 iron homeostasis 18 4.72E-6
7 SGTC_1779 st039427 4.32 55.0 µM 4.25E-6 16 7.72E-6
8 SGTC_2975 9084847 4.22 53.7 µM 6.78E-6 18 1.20E-5
9 SGTC_2563 tomatine 4.16 8.5 µM 9.31E-6 39 1.61E-5
10 SGTC_1258 0671-0043 4.15 57.1 µM 9.68E-6 22 1.68E-5
11 SGTC_2904 7225135 3.91 42.0 µM 2.78E-5 6 4.53E-5
12 SGTC_3323 9138564 3.87 53.9 µM 3.34E-5 22 5.39E-5
13 SGTC_2759 disulfiram 3.68 3.4 µM 7.58E-5 46 1.17E-4
14 SGTC_2792 7535235 3.59 81.8 µM 1.07E-4 fatty acid desaturase (OLE1) 46 1.62E-4
15 SGTC_2425 5628681 3.55 7.8 µM 1.27E-4 40 1.90E-4
16 SGTC_2030 5175110 3.47 200.0 µM 1.75E-4 Golgi 40 2.58E-4
17 SGTC_2640 pentamidine 3.47 10.4 µM 1.76E-4 mitochondrial processes 48 2.58E-4
18 SGTC_2381 9035592 3.46 200.0 µM 1.82E-4 34 2.67E-4
19 SGTC_1393 3470-5649 3.35 58.2 µM 2.81E-4 60S ribosome export 26 4.02E-4
20 SGTC_1262 0737-0114 3.34 49.6 µM 2.93E-4 48 4.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 6.04E-23 YCR105W ADH7 hom NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
0.150 2.12E-18 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.145 3.71E-17 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.138 9.09E-16 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.133 9.92E-15 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.125 4.12E-13 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
0.124 6.86E-13 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.115 2.20E-11 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.111 1.34E-10 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.110 1.82E-10 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.108 3.82E-10 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.107 6.00E-10 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.105 9.35E-10 YGR127W_p YGR127W_p hom Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response
0.105 9.82E-10 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.105 1.14E-9 YDL078C MDH3 hom Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle