YOR285W / RDL1

Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR285W / RDL1

Click on Significant Values for Screen Details ID:SGTC_164|Compound:4100-3994|FD-Score:3.01|P-value:9.32E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-4.07|P-value:1.78E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:2.99|P-value:9.79E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:6.88|P-value:7.40E-13 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.40|P-value:2.80E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.14|P-value:5.89E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.18|P-value:5.01E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.89|P-value:2.97E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:4.46|P-value:2.13E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:4.91|P-value:2.09E-7 ID:SGTC_843|Compound:0310-0051|FD-Score:3.17|P-value:5.22E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.70|P-value:6.75E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.18|P-value:5.07E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.07|P-value:9.40E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.15|P-value:1.25E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:8.12|P-value:3.52E-17 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.31|P-value:3.95E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.26|P-value:3.84E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.76|P-value:5.27E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.82|P-value:5.29E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.44|P-value:2.44E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.33|P-value:2.90E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.18|P-value:6.27E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.99|P-value:2.57E-5 ID:SGTC_1744|Compound:st037937|FD-Score:3.84|P-value:3.76E-5 ID:SGTC_1998|Compound:st075797|FD-Score:4.28|P-value:5.19E-6 ID:SGTC_2084|Compound:5306078|FD-Score:4.12|P-value:1.07E-5 ID:SGTC_2105|Compound:5350118|FD-Score:4.16|P-value:8.97E-6 ID:SGTC_2107|Compound:5363541|FD-Score:5.14|P-value:6.05E-8 ID:SGTC_2124|Compound:5246320|FD-Score:3.62|P-value:9.20E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.02|P-value:9.07E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.14|P-value:7.37E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.00|P-value:1.83E-5 ID:SGTC_2372|Compound:9071633|FD-Score:3.06|P-value:7.64E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.17|P-value:5.27E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.41|P-value:2.71E-4 ID:SGTC_2381|Compound:9035592|FD-Score:5.49|P-value:7.94E-9 ID:SGTC_2389|Compound:9091542|FD-Score:3.09|P-value:6.94E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.14|P-value:7.31E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.45|P-value:1.81E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.74|P-value:7.30E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.89|P-value:3.00E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.18|P-value:5.01E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.27|P-value:5.22E-6 ID:SGTC_2797|Compound:7859098|FD-Score:3.03|P-value:8.75E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.06|P-value:7.79E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.13|P-value:7.53E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.22|P-value:6.80E-6 ID:SGTC_3213|Compound:9129884|FD-Score:3.66|P-value:7.98E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.09|P-value:8.59E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.60|P-value:1.02E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.01|P-value:9.32E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-4.07|P-value:1.78E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:2.99|P-value:9.79E-4 ID:SGTC_249|Compound:wiskostatin|FD-Score:6.88|P-value:7.40E-13 ID:SGTC_380|Compound:3970-0968|FD-Score:-3.40|P-value:2.80E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.14|P-value:5.89E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:3.18|P-value:5.01E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:3.89|P-value:2.97E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:4.46|P-value:2.13E-6 ID:SGTC_788|Compound:1182-0090|FD-Score:4.91|P-value:2.09E-7 ID:SGTC_843|Compound:0310-0051|FD-Score:3.17|P-value:5.22E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.70|P-value:6.75E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.18|P-value:5.07E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-3.07|P-value:9.40E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.15|P-value:1.25E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:8.12|P-value:3.52E-17 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.31|P-value:3.95E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.26|P-value:3.84E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.76|P-value:5.27E-5 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.82|P-value:5.29E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.44|P-value:2.44E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.33|P-value:2.90E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:-3.18|P-value:6.27E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.99|P-value:2.57E-5 ID:SGTC_1744|Compound:st037937|FD-Score:3.84|P-value:3.76E-5 ID:SGTC_1998|Compound:st075797|FD-Score:4.28|P-value:5.19E-6 ID:SGTC_2084|Compound:5306078|FD-Score:4.12|P-value:1.07E-5 ID:SGTC_2105|Compound:5350118|FD-Score:4.16|P-value:8.97E-6 ID:SGTC_2107|Compound:5363541|FD-Score:5.14|P-value:6.05E-8 ID:SGTC_2124|Compound:5246320|FD-Score:3.62|P-value:9.20E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.02|P-value:9.07E-4 ID:SGTC_2181|Compound:6316240|FD-Score:-3.14|P-value:7.37E-4 ID:SGTC_2321|Compound:7390090|FD-Score:4.00|P-value:1.83E-5 ID:SGTC_2372|Compound:9071633|FD-Score:3.06|P-value:7.64E-4 ID:SGTC_2374|Compound:9071832|FD-Score:3.17|P-value:5.27E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-3.41|P-value:2.71E-4 ID:SGTC_2381|Compound:9035592|FD-Score:5.49|P-value:7.94E-9 ID:SGTC_2389|Compound:9091542|FD-Score:3.09|P-value:6.94E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.14|P-value:7.31E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.45|P-value:1.81E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.74|P-value:7.30E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.89|P-value:3.00E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:3.18|P-value:5.01E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.27|P-value:5.22E-6 ID:SGTC_2797|Compound:7859098|FD-Score:3.03|P-value:8.75E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.06|P-value:7.79E-4 ID:SGTC_2842|Compound:9000675|FD-Score:-3.13|P-value:7.53E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.22|P-value:6.80E-6 ID:SGTC_3213|Compound:9129884|FD-Score:3.66|P-value:7.98E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.09|P-value:8.59E-4 ID:SGTC_3345|Compound:9148410|FD-Score:3.60|P-value:1.02E-4

Top fitness defect scores for YOR285W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1132 3456-3614 8.12 2.5 µM 3.52E-17 tubulin folding & SWR complex 4 2.32E-16
2 SGTC_249 wiskostatin 6.88 11.2 µM 7.40E-13 1 2.99E-12
3 SGTC_2381 9035592 5.49 200.0 µM 7.94E-9 3 2.02E-8
4 SGTC_2107 5363541 5.14 170.2 µM 6.05E-8 1 1.39E-7
5 SGTC_788 1182-0090 4.91 188.0 µM 2.09E-7 endomembrane recycling 53 4.52E-7
6 SGTC_695 3505-6186 4.46 243.0 µM 2.13E-6 18 4.10E-6
7 SGTC_1998 st075797 4.28 76.8 µM 5.19E-6 mitochondrial response to ROS 11 9.54E-6
8 SGTC_2752 diclazuril 4.27 33.1 µM 5.22E-6 101 9.59E-6
9 SGTC_3027 9089541 4.22 49.5 µM 6.80E-6 fatty acid desaturase (OLE1) 17 1.23E-5
10 SGTC_2105 5350118 4.16 200.0 µM 8.97E-6 22 1.60E-5
11 SGTC_2084 5306078 4.12 60.6 µM 1.07E-5 17 1.89E-5
12 SGTC_2321 7390090 4.00 138.8 µM 1.83E-5 25 3.15E-5
13 SGTC_623 k072-0108 3.89 16.9 µM 2.97E-5 heme biosynthesis & mitochondrial translocase 22 5.01E-5
14 SGTC_2553 4-methylesculetin 3.89 85.1 µM 3.00E-5 25 5.04E-5
15 SGTC_1744 st037937 3.84 38.9 µM 3.76E-5 32 6.25E-5
16 SGTC_1228 0124-0032 3.76 52.5 µM 5.27E-5 21 8.62E-5
17 SGTC_960 1222-0186 3.70 7.7 µM 6.75E-5 39 1.09E-4
18 SGTC_3213 9129884 3.66 49.5 µM 7.98E-5 25 1.28E-4
19 SGTC_2124 5246320 3.62 200.0 µM 9.20E-5 heme biosynthesis & mitochondrial translocase 26 1.46E-4
20 SGTC_3345 9148410 3.60 3.6 µM 1.02E-4 12 1.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.22E-17 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.110 1.76E-10 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.104 1.46E-9 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.100 7.04E-9 YLR300W EXG1 hom Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
0.098 1.32E-8 YFR052W RPN12 het Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
0.098 1.38E-8 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.091 1.10E-7 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.091 1.21E-7 YKL185W ASH1 hom Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
0.089 2.40E-7 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.088 3.18E-7 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.088 3.30E-7 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.087 4.15E-7 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.086 5.58E-7 YLR339C_d YLR339C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
0.086 6.87E-7 YFL040W_p YFL040W_p hom Putative transporter, member of the sugar porter family; YFL040W is not an essential gene
0.084 1.15E-6 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication