YOR287C / RRP36

Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR287C / RRP36

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.72|P-value:1.09E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:4.18|P-value:8.79E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:-2.90|P-value:4.69E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.20|P-value:1.33E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:2.98|P-value:3.32E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.11|P-value:1.95E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.86|P-value:5.17E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.62|P-value:6.44E-8 ID:SGTC_425|Compound:3825-7017|FD-Score:5.38|P-value:4.02E-10 ID:SGTC_428|Compound:3448-4153|FD-Score:-2.88|P-value:5.10E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.40|P-value:5.02E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:2.80|P-value:6.82E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.68|P-value:1.33E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-2.72|P-value:9.68E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.05|P-value:2.44E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:2.74|P-value:8.50E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.97|P-value:3.51E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-2.83|P-value:6.23E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:2.74|P-value:8.52E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.36|P-value:6.01E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.59|P-value:8.44E-11 ID:SGTC_1081|Compound:sertraline|FD-Score:3.12|P-value:1.84E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.50|P-value:3.22E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:2.96|P-value:3.53E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.15|P-value:1.62E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.21|P-value:1.24E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.31|P-value:7.63E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.39|P-value:5.37E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.53|P-value:2.76E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.83|P-value:6.14E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.35|P-value:3.40E-7 ID:SGTC_1984|Compound:st072354|FD-Score:3.04|P-value:2.55E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-2.85|P-value:5.69E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-2.78|P-value:7.56E-4 ID:SGTC_2093|Compound:5331342|FD-Score:2.88|P-value:4.92E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.07|P-value:1.62E-6 ID:SGTC_2107|Compound:5363541|FD-Score:2.72|P-value:9.34E-4 ID:SGTC_2210|Compound:7115885|FD-Score:-2.88|P-value:5.06E-4 ID:SGTC_2367|Compound:9070478|FD-Score:2.77|P-value:7.60E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.27|P-value:9.38E-5 ID:SGTC_2414|Compound:st077232|FD-Score:-3.16|P-value:1.57E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-3.00|P-value:3.13E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.01|P-value:2.91E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.42|P-value:4.74E-5 ID:SGTC_2445|Compound:5742597|FD-Score:-3.88|P-value:4.77E-6 ID:SGTC_2452|Compound:5863136|FD-Score:-2.80|P-value:6.95E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:5.51|P-value:1.53E-10 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.07|P-value:2.22E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.15|P-value:1.58E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-2.79|P-value:7.37E-4 ID:SGTC_2793|Compound:7325131|FD-Score:2.76|P-value:7.93E-4 ID:SGTC_2870|Compound:9038528|FD-Score:2.80|P-value:6.94E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.57|P-value:2.25E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.23|P-value:6.67E-7 ID:SGTC_2974|Compound:9094440|FD-Score:2.86|P-value:5.45E-4 ID:SGTC_3284|Compound:9108171|FD-Score:2.78|P-value:7.50E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-4.11|P-value:1.37E-6 ID:SGTC_3301|Compound:9125354|FD-Score:-2.90|P-value:4.68E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.00|P-value:3.11E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.62|P-value:6.61E-8 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.72|P-value:1.09E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:4.18|P-value:8.79E-7 ID:SGTC_148|Compound:3253-0744|FD-Score:-2.90|P-value:4.69E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.20|P-value:1.33E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:2.98|P-value:3.32E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.11|P-value:1.95E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.86|P-value:5.17E-6 ID:SGTC_421|Compound:streptovitacin|FD-Score:4.62|P-value:6.44E-8 ID:SGTC_425|Compound:3825-7017|FD-Score:5.38|P-value:4.02E-10 ID:SGTC_428|Compound:3448-4153|FD-Score:-2.88|P-value:5.10E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.40|P-value:5.02E-5 ID:SGTC_504|Compound:lovastatin|FD-Score:2.80|P-value:6.82E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.68|P-value:1.33E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-2.72|P-value:9.68E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.05|P-value:2.44E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:2.74|P-value:8.50E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.97|P-value:3.51E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-2.83|P-value:6.23E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:2.74|P-value:8.52E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.36|P-value:6.01E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.59|P-value:8.44E-11 ID:SGTC_1081|Compound:sertraline|FD-Score:3.12|P-value:1.84E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.50|P-value:3.22E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:2.96|P-value:3.53E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.15|P-value:1.62E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.21|P-value:1.24E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.31|P-value:7.63E-5 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.39|P-value:5.37E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.53|P-value:2.76E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-2.83|P-value:6.14E-4 ID:SGTC_1924|Compound:st058459|FD-Score:4.35|P-value:3.40E-7 ID:SGTC_1984|Compound:st072354|FD-Score:3.04|P-value:2.55E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-2.85|P-value:5.69E-4 ID:SGTC_2083|Compound:5306046|FD-Score:-2.78|P-value:7.56E-4 ID:SGTC_2093|Compound:5331342|FD-Score:2.88|P-value:4.92E-4 ID:SGTC_2102|Compound:5377816|FD-Score:4.07|P-value:1.62E-6 ID:SGTC_2107|Compound:5363541|FD-Score:2.72|P-value:9.34E-4 ID:SGTC_2210|Compound:7115885|FD-Score:-2.88|P-value:5.06E-4 ID:SGTC_2367|Compound:9070478|FD-Score:2.77|P-value:7.60E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.27|P-value:9.38E-5 ID:SGTC_2414|Compound:st077232|FD-Score:-3.16|P-value:1.57E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-3.00|P-value:3.13E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.01|P-value:2.91E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-3.42|P-value:4.74E-5 ID:SGTC_2445|Compound:5742597|FD-Score:-3.88|P-value:4.77E-6 ID:SGTC_2452|Compound:5863136|FD-Score:-2.80|P-value:6.95E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:5.51|P-value:1.53E-10 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.07|P-value:2.22E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.15|P-value:1.58E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-2.79|P-value:7.37E-4 ID:SGTC_2793|Compound:7325131|FD-Score:2.76|P-value:7.93E-4 ID:SGTC_2870|Compound:9038528|FD-Score:2.80|P-value:6.94E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.57|P-value:2.25E-5 ID:SGTC_2973|Compound:9094665|FD-Score:4.23|P-value:6.67E-7 ID:SGTC_2974|Compound:9094440|FD-Score:2.86|P-value:5.45E-4 ID:SGTC_3284|Compound:9108171|FD-Score:2.78|P-value:7.50E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-4.11|P-value:1.37E-6 ID:SGTC_3301|Compound:9125354|FD-Score:-2.90|P-value:4.68E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.00|P-value:3.11E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.62|P-value:6.61E-8

Top fitness defect scores for YOR287C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_915 methyl methanesulfonate (MMS) 5.59 110.0 mM 8.44E-11 DNA damage response 4 1.14E-8 0.32
2 SGTC_2605 digitonin 5.51 300.0 nM 1.53E-10 3 1.80E-8 1.74
3 SGTC_425 3825-7017 5.38 13.1 µM 4.02E-10 4 3.80E-8 0.02
4 SGTC_421 streptovitacin 4.62 30.0 mM 6.44E-8 1 1.92E-6 0.73
5 SGTC_3307 9126885 4.62 69.3 µM 6.61E-8 5 1.96E-6 0.17
6 SGTC_1924 st058459 4.35 75.1 µM 3.40E-7 2 6.94E-6 0.01
7 SGTC_2973 9094665 4.23 18.0 µM 6.67E-7 NEO1 16 1.17E-5 0.17
8 SGTC_75 0159-0059 4.18 199.0 µM 8.79E-7 fatty acid desaturase (OLE1) 8 1.45E-5 0.17
9 SGTC_2102 5377816 4.07 72.8 µM 1.62E-6 5 2.32E-5 0.34
10 SGTC_362 0310-0100 3.86 9.0 µM 5.17E-6 RPP1 & pyrimidine depletion 9 5.72E-5 0.08
11 SGTC_517 1365-0151 3.68 113.0 µM 1.33E-5 5 1.19E-4 0.05
12 SGTC_2967 9089538 3.57 49.9 µM 2.25E-5 19 1.79E-4 0.00
13 SGTC_1448 4255-0083 3.53 152.0 µM 2.76E-5 ERG2 8 2.10E-4 0.04
14 SGTC_430 0958-0115 3.40 16.4 µM 5.02E-5 18 3.34E-4 0.04
15 SGTC_884 0851-0618 3.36 334.0 µM 6.01E-5 9 3.84E-4 0.07
16 SGTC_1291 0993-0025 3.31 5.8 µM 7.63E-5 3 4.62E-4 0.14
17 SGTC_2399 5884133 3.27 200.0 µM 9.38E-5 cell wall signaling 25 5.43E-4 0.02
18 SGTC_2616 abietic acid 3.15 100.0 µM 1.58E-4 9 8.15E-4 0.01
19 SGTC_1269 0831-0796 3.15 3.0 µM 1.62E-4 60S ribosome export 14 8.29E-4 0.09
20 SGTC_1081 sertraline 3.12 6.0 µM 1.84E-4 60S ribosome export 12 9.16E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 7.20E-21 YLR092W SUL2 hom High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.159 2.39E-20 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.145 2.61E-17 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.140 3.43E-16 YBR167C POP7 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.119 5.23E-12 YLR127C APC2 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
0.109 2.62E-10 YMR149W SWP1 het Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
0.108 3.80E-10 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.105 1.11E-9 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.102 2.97E-9 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.100 5.99E-9 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.093 7.00E-8 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.093 7.34E-8 YKL142W MRP8 hom Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
0.093 7.37E-8 YHR158C KEL1 hom Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
0.087 4.68E-7 YLR373C VID22 hom Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles
0.086 6.04E-7 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene