YOR288C / MPD1

Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR288C / MPD1

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:3.34|P-value:1.26E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.52|P-value:5.19E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.11|P-value:3.25E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.24|P-value:1.93E-4 ID:SGTC_484|Compound:loperamide|FD-Score:3.09|P-value:3.58E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.51|P-value:5.78E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:-2.82|P-value:9.31E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.52|P-value:5.73E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.69|P-value:2.57E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:5.68|P-value:2.21E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:-5.26|P-value:3.49E-9 ID:SGTC_1103|Compound:duloxetine|FD-Score:2.91|P-value:7.17E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:2.87|P-value:8.40E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.06|P-value:3.64E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.17|P-value:2.51E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:2.92|P-value:6.85E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.62|P-value:3.55E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-3.81|P-value:1.32E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.54|P-value:4.73E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.74|P-value:1.01E-7 ID:SGTC_2045|Compound:5106652|FD-Score:3.36|P-value:1.16E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.39|P-value:1.00E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.17|P-value:2.38E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.14|P-value:2.69E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-3.28|P-value:1.47E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.04|P-value:4.23E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.23|P-value:1.84E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.65|P-value:3.12E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.35|P-value:1.17E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.68|P-value:2.65E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.08|P-value:1.18E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.18|P-value:2.44E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.20|P-value:2.29E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.50|P-value:6.30E-5 ID:SGTC_3008|Compound:9078912|FD-Score:-3.03|P-value:4.08E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.40|P-value:9.62E-5 ID:SGTC_3297|Compound:9117502|FD-Score:3.42|P-value:8.87E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:3.34|P-value:1.26E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:-3.52|P-value:5.19E-5 ID:SGTC_459|Compound:nigericin|FD-Score:3.11|P-value:3.25E-4 ID:SGTC_462|Compound:ag-879|FD-Score:3.24|P-value:1.93E-4 ID:SGTC_484|Compound:loperamide|FD-Score:3.09|P-value:3.58E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.51|P-value:5.78E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:-2.82|P-value:9.31E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.52|P-value:5.73E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.69|P-value:2.57E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:5.68|P-value:2.21E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:-5.26|P-value:3.49E-9 ID:SGTC_1103|Compound:duloxetine|FD-Score:2.91|P-value:7.17E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:2.87|P-value:8.40E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.06|P-value:3.64E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.17|P-value:2.51E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:2.92|P-value:6.85E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.62|P-value:3.55E-5 ID:SGTC_1910|Compound:st062352|FD-Score:-3.81|P-value:1.32E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.54|P-value:4.73E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.74|P-value:1.01E-7 ID:SGTC_2045|Compound:5106652|FD-Score:3.36|P-value:1.16E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.39|P-value:1.00E-4 ID:SGTC_2105|Compound:5350118|FD-Score:-3.17|P-value:2.38E-4 ID:SGTC_2112|Compound:5488546|FD-Score:-3.14|P-value:2.69E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-3.28|P-value:1.47E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.04|P-value:4.23E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-3.23|P-value:1.84E-4 ID:SGTC_2525|Compound:harmine|FD-Score:3.65|P-value:3.12E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.35|P-value:1.17E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.68|P-value:2.65E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:5.08|P-value:1.18E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.18|P-value:2.44E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.20|P-value:2.29E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.50|P-value:6.30E-5 ID:SGTC_3008|Compound:9078912|FD-Score:-3.03|P-value:4.08E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.40|P-value:9.62E-5 ID:SGTC_3297|Compound:9117502|FD-Score:3.42|P-value:8.87E-5

Top fitness defect scores for YOR288C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_924 2046-0044 5.68 21.3 µM 2.21E-10 3 6.70E-9
2 SGTC_2639 lactacystin 5.08 53.0 µM 1.18E-8 12 1.84E-7
3 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.74 70.1 µM 1.01E-7 8 1.09E-6
4 SGTC_656 4090-1979 3.69 187.0 µM 2.57E-5 25 1.12E-4
5 SGTC_2576 guaiol 3.68 23.1 µM 2.65E-5 30 1.15E-4
6 SGTC_2525 harmine 3.65 47.9 µM 3.12E-5 ergosterol biosynthesis 12 1.32E-4
7 SGTC_1908 st060353 3.62 56.5 µM 3.55E-5 RPP1 & pyrimidine depletion 52 1.47E-4
8 SGTC_638 3970-0837 3.52 4.1 µM 5.73E-5 55 2.18E-4
9 SGTC_485 niflumic acid 3.51 177.0 µM 5.78E-5 18 2.20E-4
10 SGTC_2935 9038016 3.50 30.0 µM 6.30E-5 28 2.37E-4
11 SGTC_3297 9117502 3.42 71.4 µM 8.87E-5 18 3.15E-4
12 SGTC_3061 glucosamine 3.40 200.0 µM 9.62E-5 20 3.37E-4
13 SGTC_2050 5263056 3.39 171.0 µM 1.00E-4 fatty acid desaturase (OLE1) 75 3.49E-4
14 SGTC_2045 5106652 3.36 78.0 µM 1.16E-4 32 3.94E-4
15 SGTC_2570 licareol 3.35 100.0 µM 1.17E-4 53 3.98E-4
16 SGTC_76 0433-0009 3.34 400.3 µM 1.26E-4 25 4.22E-4
17 SGTC_462 ag-879 3.24 158.0 µM 1.93E-4 58 6.05E-4
18 SGTC_2807 7945238 3.20 52.0 µM 2.29E-4 68 6.98E-4
19 SGTC_2767 sibutramine 3.18 71.5 µM 2.44E-4 46 7.35E-4
20 SGTC_1567 st069303 3.17 68.4 µM 2.51E-4 mitochondrial processes 49 7.54E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.146 1.77E-17 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study
0.118 7.76E-12 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.113 5.51E-11 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.104 1.71E-9 YDR156W RPA14 hom RNA polymerase I subunit A14
0.101 4.76E-9 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 9.26E-9 YBR185C MBA1 hom Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane
0.097 1.84E-8 YFR016C YFR016C hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
0.096 2.69E-8 YDR488C PAC11 hom Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
0.094 4.21E-8 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.094 5.11E-8 YBR181C RPS6B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
0.092 8.57E-8 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.092 1.05E-7 YLR185W RPL37A hom Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication
0.091 1.38E-7 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.091 1.44E-7 YER150W SPI1 hom GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
0.090 1.88E-7 YDL121C_p YDL121C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein