YOR289W_p

Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR289W / YOR289W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.60|P-value:4.24E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.07|P-value:3.99E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-2.93|P-value:6.71E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.76|P-value:1.03E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.40|P-value:1.01E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.15|P-value:2.90E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.53|P-value:6.40E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.64|P-value:3.49E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.50|P-value:7.53E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:3.15|P-value:3.28E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.57|P-value:4.93E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.50|P-value:6.53E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:4.26|P-value:1.91E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:3.19|P-value:2.71E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.90|P-value:8.48E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.82|P-value:8.53E-8 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.68|P-value:1.91E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.15|P-value:2.85E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.16|P-value:2.75E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-2.84|P-value:9.43E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.10|P-value:3.91E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.35|P-value:1.29E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.92|P-value:6.95E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.86|P-value:9.65E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.65|P-value:3.31E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.48|P-value:8.08E-5 ID:SGTC_2102|Compound:5377816|FD-Score:3.29|P-value:1.82E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.25|P-value:2.06E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.97|P-value:5.95E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.89|P-value:7.89E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.71|P-value:2.83E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.10|P-value:3.96E-4 ID:SGTC_2585|Compound:alliin|FD-Score:2.86|P-value:9.64E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-2.91|P-value:7.47E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.30|P-value:1.55E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.95|P-value:8.13E-6 ID:SGTC_2794|Compound:7785382|FD-Score:5.24|P-value:6.45E-9 ID:SGTC_2795|Compound:7780010|FD-Score:3.91|P-value:1.14E-5 ID:SGTC_2799|Compound:7812892|FD-Score:5.64|P-value:4.66E-10 ID:SGTC_2849|Compound:9019321|FD-Score:-3.31|P-value:1.52E-4 ID:SGTC_3012|Compound:9080433|FD-Score:2.94|P-value:7.24E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.23|P-value:2.05E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.03|P-value:5.38E-6 ID:SGTC_3155|Compound:9099265|FD-Score:-4.24|P-value:1.86E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.11|P-value:3.71E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.69|P-value:2.74E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.60|P-value:4.22E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.60|P-value:4.24E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.07|P-value:3.99E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-2.93|P-value:6.71E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.76|P-value:1.03E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.40|P-value:1.01E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.15|P-value:2.90E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.53|P-value:6.40E-5 ID:SGTC_264|Compound:promethazine|FD-Score:-3.64|P-value:3.49E-5 ID:SGTC_276|Compound:colchicine|FD-Score:3.50|P-value:7.53E-5 ID:SGTC_292|Compound:k038-0015|FD-Score:3.15|P-value:3.28E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.57|P-value:4.93E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.50|P-value:6.53E-5 ID:SGTC_686|Compound:1319-0111|FD-Score:4.26|P-value:1.91E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:3.19|P-value:2.71E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:2.90|P-value:8.48E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.82|P-value:8.53E-8 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.68|P-value:1.91E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.15|P-value:2.85E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.16|P-value:2.75E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:-2.84|P-value:9.43E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:3.10|P-value:3.91E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.35|P-value:1.29E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.92|P-value:6.95E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.86|P-value:9.65E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-3.65|P-value:3.31E-5 ID:SGTC_2054|Compound:5233173|FD-Score:3.48|P-value:8.08E-5 ID:SGTC_2102|Compound:5377816|FD-Score:3.29|P-value:1.82E-4 ID:SGTC_2340|Compound:7987427|FD-Score:4.25|P-value:2.06E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.97|P-value:5.95E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-2.89|P-value:7.89E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.71|P-value:2.83E-5 ID:SGTC_2483|Compound:5729050|FD-Score:3.10|P-value:3.96E-4 ID:SGTC_2585|Compound:alliin|FD-Score:2.86|P-value:9.64E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:-2.91|P-value:7.47E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.30|P-value:1.55E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.95|P-value:8.13E-6 ID:SGTC_2794|Compound:7785382|FD-Score:5.24|P-value:6.45E-9 ID:SGTC_2795|Compound:7780010|FD-Score:3.91|P-value:1.14E-5 ID:SGTC_2799|Compound:7812892|FD-Score:5.64|P-value:4.66E-10 ID:SGTC_2849|Compound:9019321|FD-Score:-3.31|P-value:1.52E-4 ID:SGTC_3012|Compound:9080433|FD-Score:2.94|P-value:7.24E-4 ID:SGTC_3138|Compound:9097216|FD-Score:-3.23|P-value:2.05E-4 ID:SGTC_3140|Compound:9094243|FD-Score:-4.03|P-value:5.38E-6 ID:SGTC_3155|Compound:9099265|FD-Score:-4.24|P-value:1.86E-6 ID:SGTC_3203|Compound:9113543|FD-Score:3.11|P-value:3.71E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-3.69|P-value:2.74E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.60|P-value:4.22E-5

Top fitness defect scores for YOR289W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2799 7812892 5.64 81.8 µM 4.66E-10 superoxide 11 8.56E-9
2 SGTC_2794 7785382 5.24 27.3 µM 6.45E-9 7 7.99E-8
3 SGTC_1120 ficusin 4.82 1.8 µM 8.53E-8 10 7.20E-7
4 SGTC_1125 tnp00248 4.68 1.3 µM 1.91E-7 15 1.43E-6
5 SGTC_686 1319-0111 4.26 510.0 µM 1.91E-6 60S ribosome export 24 1.02E-5
6 SGTC_2340 7987427 4.25 183.4 µM 2.06E-6 24 1.09E-5
7 SGTC_2795 7780010 3.91 54.5 µM 1.14E-5 30 4.69E-5
8 SGTC_2454 5-benzylidenerhodanine 3.71 10.4 µM 2.83E-5 TRP & mitochondrial translation 47 1.02E-4
9 SGTC_193 1273-0060 3.53 1.6 µM 6.40E-5 ergosterol biosynthesis 16 2.05E-4
10 SGTC_276 colchicine 3.50 750.0 µM 7.53E-5 28 2.35E-4
11 SGTC_2054 5233173 3.48 129.0 µM 8.08E-5 mitochondrial response to ROS 75 2.50E-4
12 SGTC_2102 5377816 3.29 72.8 µM 1.82E-4 43 5.02E-4
13 SGTC_808 0711-0032 3.19 135.0 µM 2.71E-4 39 7.06E-4
14 SGTC_292 k038-0015 3.15 474.0 µM 3.28E-4 21 8.30E-4
15 SGTC_3203 9113543 3.11 49.5 µM 3.71E-4 76 9.22E-4
16 SGTC_1348 1493-0373 3.10 93.8 µM 3.91E-4 44 9.64E-4
17 SGTC_2483 5729050 3.10 27.2 µM 3.96E-4 60 9.76E-4
18 SGTC_3012 9080433 2.94 71.4 µM 7.24E-4 48 0.00164
19 SGTC_875 0709-0210 2.90 25.7 µM 8.48E-4 fatty acid desaturase (OLE1) 78 0.00188
20 SGTC_2585 alliin 2.86 100.0 µM 9.64E-4 96 0.00210

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 2.65E-30 YLL063C AYT1 hom Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
0.160 1.67E-20 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.157 8.37E-20 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.132 1.93E-14 YJR153W PGU1 hom Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
0.132 2.03E-14 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.127 1.80E-13 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.123 8.48E-13 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.123 1.10E-12 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.122 1.46E-12 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.121 2.31E-12 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
0.120 2.80E-12 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.119 4.39E-12 YLR356W ATG33 hom Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes
0.118 7.83E-12 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.118 8.11E-12 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.116 1.93E-11 YDR109C_p YDR109C_p hom Putative kinase