YOR290C / SNF2

Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR290C / SNF2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.57|P-value:8.96E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:4.71|P-value:3.24E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.69|P-value:3.44E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:4.33|P-value:8.76E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:5.23|P-value:7.61E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.82|P-value:2.41E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-5.44|P-value:2.71E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-7.42|P-value:2.04E-8 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-5.24|P-value:5.03E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:8.36|P-value:5.67E-10 ID:SGTC_517|Compound:1365-0151|FD-Score:7.57|P-value:1.81E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:5.14|P-value:9.86E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:4.52|P-value:5.39E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.39|P-value:7.42E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:7.88|P-value:4.92E-9 ID:SGTC_649|Compound:1123-0311|FD-Score:-5.46|P-value:2.56E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.81|P-value:1.78E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:8.87|P-value:5.33E-11 ID:SGTC_777|Compound:1315-0167|FD-Score:4.80|P-value:2.56E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.80|P-value:2.57E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:5.87|P-value:1.02E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.22|P-value:8.47E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.07|P-value:8.30E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:5.18|P-value:8.63E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:5.47|P-value:3.68E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:6.14|P-value:4.13E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.19|P-value:9.24E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:5.36|P-value:5.05E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.51|P-value:5.55E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.52|P-value:5.33E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.47|P-value:6.07E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:12.70|P-value:8.59E-21 ID:SGTC_1388|Compound:3346-4487|FD-Score:5.44|P-value:4.01E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:6.28|P-value:2.57E-6 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.04|P-value:5.72E-6 ID:SGTC_1531|Compound:st059297|FD-Score:5.40|P-value:4.54E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-4.57|P-value:3.46E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.73|P-value:3.06E-4 ID:SGTC_1656|Compound:st012921|FD-Score:9.76|P-value:5.73E-13 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.67|P-value:1.34E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.32|P-value:8.84E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.73|P-value:1.59E-5 ID:SGTC_1982|Compound:st072467|FD-Score:4.71|P-value:3.28E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.17|P-value:9.52E-4 ID:SGTC_2276|Compound:7947513|FD-Score:5.15|P-value:9.48E-5 ID:SGTC_2281|Compound:7943571|FD-Score:-4.40|P-value:5.29E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.78|P-value:2.68E-4 ID:SGTC_2288|Compound:7946289|FD-Score:10.70|P-value:3.82E-15 ID:SGTC_2291|Compound:7917025|FD-Score:-5.69|P-value:1.25E-5 ID:SGTC_2358|Compound:9037157|FD-Score:7.80|P-value:6.93E-9 ID:SGTC_2366|Compound:9070441|FD-Score:4.56|P-value:4.81E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.29|P-value:9.59E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.36|P-value:8.05E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.59|P-value:2.48E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.54|P-value:2.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.82|P-value:1.22E-5 ID:SGTC_2701|Compound:st077767|FD-Score:5.63|P-value:2.23E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:12.60|P-value:2.31E-20 ID:SGTC_2828|Compound:7998861|FD-Score:5.75|P-value:1.52E-5 ID:SGTC_2862|Compound:9027634|FD-Score:8.24|P-value:1.00E-9 ID:SGTC_2912|Compound:7964298|FD-Score:4.39|P-value:7.49E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.65|P-value:3.79E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-4.17|P-value:9.64E-4 ID:SGTC_2995|Compound:9067767|FD-Score:4.75|P-value:2.94E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.28|P-value:7.33E-4 ID:SGTC_3038|Compound:9091290|FD-Score:5.22|P-value:7.67E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-4.95|P-value:1.18E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.55|P-value:3.64E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.31|P-value:9.19E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.85|P-value:2.25E-4 ID:SGTC_3303|Compound:9125618|FD-Score:7.11|P-value:1.20E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:6.57|P-value:8.96E-7 ID:SGTC_59|Compound:0330-0160|FD-Score:4.71|P-value:3.24E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:4.69|P-value:3.44E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:4.33|P-value:8.76E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:5.23|P-value:7.61E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.82|P-value:2.41E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-5.44|P-value:2.71E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-7.42|P-value:2.04E-8 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:-5.24|P-value:5.03E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:8.36|P-value:5.67E-10 ID:SGTC_517|Compound:1365-0151|FD-Score:7.57|P-value:1.81E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:5.14|P-value:9.86E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:4.52|P-value:5.39E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:4.39|P-value:7.42E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:7.88|P-value:4.92E-9 ID:SGTC_649|Compound:1123-0311|FD-Score:-5.46|P-value:2.56E-5 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.81|P-value:1.78E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:8.87|P-value:5.33E-11 ID:SGTC_777|Compound:1315-0167|FD-Score:4.80|P-value:2.56E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:4.80|P-value:2.57E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:5.87|P-value:1.02E-5 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.22|P-value:8.47E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.07|P-value:8.30E-5 ID:SGTC_955|Compound:1216-0110|FD-Score:5.18|P-value:8.63E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:5.47|P-value:3.68E-5 ID:SGTC_1049|Compound:3226-0134|FD-Score:6.14|P-value:4.13E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.19|P-value:9.24E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:5.36|P-value:5.05E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.51|P-value:5.55E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.52|P-value:5.33E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:4.47|P-value:6.07E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:12.70|P-value:8.59E-21 ID:SGTC_1388|Compound:3346-4487|FD-Score:5.44|P-value:4.01E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:6.28|P-value:2.57E-6 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.04|P-value:5.72E-6 ID:SGTC_1531|Compound:st059297|FD-Score:5.40|P-value:4.54E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-4.57|P-value:3.46E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.73|P-value:3.06E-4 ID:SGTC_1656|Compound:st012921|FD-Score:9.76|P-value:5.73E-13 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.67|P-value:1.34E-5 ID:SGTC_1750|Compound:st081859|FD-Score:4.32|P-value:8.84E-4 ID:SGTC_1909|Compound:st060837|FD-Score:5.73|P-value:1.59E-5 ID:SGTC_1982|Compound:st072467|FD-Score:4.71|P-value:3.28E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-4.17|P-value:9.52E-4 ID:SGTC_2276|Compound:7947513|FD-Score:5.15|P-value:9.48E-5 ID:SGTC_2281|Compound:7943571|FD-Score:-4.40|P-value:5.29E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.78|P-value:2.68E-4 ID:SGTC_2288|Compound:7946289|FD-Score:10.70|P-value:3.82E-15 ID:SGTC_2291|Compound:7917025|FD-Score:-5.69|P-value:1.25E-5 ID:SGTC_2358|Compound:9037157|FD-Score:7.80|P-value:6.93E-9 ID:SGTC_2366|Compound:9070441|FD-Score:4.56|P-value:4.81E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.29|P-value:9.59E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.36|P-value:8.05E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.59|P-value:2.48E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:5.54|P-value:2.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.82|P-value:1.22E-5 ID:SGTC_2701|Compound:st077767|FD-Score:5.63|P-value:2.23E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:12.60|P-value:2.31E-20 ID:SGTC_2828|Compound:7998861|FD-Score:5.75|P-value:1.52E-5 ID:SGTC_2862|Compound:9027634|FD-Score:8.24|P-value:1.00E-9 ID:SGTC_2912|Compound:7964298|FD-Score:4.39|P-value:7.49E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.65|P-value:3.79E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-4.17|P-value:9.64E-4 ID:SGTC_2995|Compound:9067767|FD-Score:4.75|P-value:2.94E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-4.28|P-value:7.33E-4 ID:SGTC_3038|Compound:9091290|FD-Score:5.22|P-value:7.67E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-4.95|P-value:1.18E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.55|P-value:3.64E-4 ID:SGTC_3212|Compound:9128307|FD-Score:4.31|P-value:9.19E-4 ID:SGTC_3231|Compound:9132313|FD-Score:4.85|P-value:2.25E-4 ID:SGTC_3303|Compound:9125618|FD-Score:7.11|P-value:1.20E-7

Top fitness defect scores for YOR290C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1373 2887-0003 12.70 58.5 µM 8.59E-21 Golgi 1 2.48E-37
2 SGTC_2741 miltefosine 12.60 3.0 µM 2.31E-20 4 1.56E-36
3 SGTC_2288 7946289 10.70 167.3 µM 3.82E-15 1 7.71E-27
4 SGTC_1656 st012921 9.76 11.0 µM 5.73E-13 10 8.45E-23
5 SGTC_710 3448-4187 8.87 58.0 µM 5.33E-11 fatty acid desaturase (OLE1) 6 3.77E-19
6 SGTC_513 4245-1575 8.36 41.7 µM 5.67E-10 unfolded protein response 25 3.01E-17
7 SGTC_2862 9027634 8.24 71.4 µM 1.00E-9 ERG2 3 8.66E-17
8 SGTC_642 0335-0876 7.88 158.0 µM 4.92E-9 ubiquinone biosynthesis & proteasome 9 1.64E-15
9 SGTC_2358 9037157 7.80 4.0 µM 6.93E-9 3 3.10E-15
10 SGTC_517 1365-0151 7.57 113.0 µM 1.81E-8 4 1.83E-14
11 SGTC_3303 9125618 7.11 40.6 µM 1.20E-7 6 5.99E-13
12 SGTC_58 0957-0393 6.57 9.0 µM 8.96E-7 cell wall 181 2.46E-11
13 SGTC_1389 3405-0187 6.28 19.0 µM 2.57E-6 2 1.71E-10
14 SGTC_1049 3226-0134 6.14 66.0 µM 4.13E-6 4 4.12E-10
15 SGTC_1425 4048-4433 6.04 7.3 µM 5.72E-6 copper-dependent oxidative stress 9 7.49E-10
16 SGTC_883 0850-0245 5.87 24.6 µM 1.02E-5 cell wall 8 2.16E-9
17 SGTC_2582 agaric acid 5.82 100.0 µM 1.22E-5 redox potentiating 166 3.01E-9
18 SGTC_2828 7998861 5.75 71.4 µM 1.52E-5 3 4.52E-9
19 SGTC_1909 st060837 5.73 51.5 µM 1.59E-5 20 4.89E-9
20 SGTC_2701 st077767 5.63 14.7 µM 2.23E-5 17 9.10E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.157 5.69E-20 YMR216C SKY1 hom SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
0.137 1.62E-15 YPL254W HFI1 hom Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
0.135 3.56E-15 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.132 1.56E-14 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.132 1.49E-14 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.130 3.40E-14 YPR060C ARO7 hom Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
0.128 1.18E-13 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.124 5.46E-13 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.123 7.51E-13 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.119 5.86E-12 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.117 1.16E-11 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.117 1.15E-11 YDR226W ADK1 hom Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress
0.110 1.86E-10 YJR059W PTK2 hom Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
0.109 2.06E-10 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.107 5.59E-10 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism