HIPHOP chemogenomics database

YOR292C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR292C / YOR292C

Click on Significant Values for Screen Details

Top fitness defect scores for YOR292C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2583	asiatic acid	6.63	100.0 µM	6.93E-13		6	1.65E-11
2	SGTC_1789	tunicamycin	4.86	25.0 nM	1.02E-7	unfolded protein response	28	6.01E-7
3	SGTC_1080	nisoldipine	4.32	24.4 µM	1.83E-6	TSC3-RPN4	18	7.73E-6
4	SGTC_2586	curcumin	4.07	80.0 µM	6.36E-6	iron homeostasis	46	2.32E-5
5	SGTC_418	lividomycin a	4.04	100.0 µM	7.38E-6		10	2.64E-5
6	SGTC_2426	5582046	3.90	32.2 µM	1.44E-5		32	4.77E-5
7	SGTC_1908	st060353	3.79	56.5 µM	2.42E-5	RPP1 & pyrimidine depletion	42	7.56E-5
8	SGTC_1918	oxolan-2-ylmethyl 3-bromobenzoate	3.61	70.1 µM	5.34E-5		40	1.52E-4
9	SGTC_242	5hr heat shock (37°C) + 5-fluorouracil	3.51	4.6 µM	8.30E-5	heat shock/prefoldin	54	2.24E-4
10	SGTC_1499	4480-0877	3.46	67.3 µM	1.01E-4		14	2.66E-4
11	SGTC_2707	st078556	3.39	66.6 µM	1.39E-4		23	3.53E-4
12	SGTC_2716	st080858	3.38	38.6 µM	1.45E-4	60S ribosome export	32	3.67E-4
13	SGTC_1296	1068-0102	3.30	11.9 µM	2.00E-4		18	4.89E-4
14	SGTC_1360	1598-0022	3.25	39.8 µM	2.43E-4	ERG2	63	5.80E-4
15	SGTC_2585	alliin	3.20	100.0 µM	2.98E-4		59	6.95E-4
16	SGTC_718	1130-0073	3.17	349.0 µM	3.26E-4		48	7.52E-4
17	SGTC_1315	1237-0019	3.11	3.7 µM	4.21E-4		35	9.42E-4
18	SGTC_80	0159-0065	3.10	512.2 µM	4.30E-4		16	9.61E-4
19	SGTC_113	0099-0221	3.07	2.5 µM	4.82E-4		68	0.00106
20	SGTC_2336	9001819	3.04	198.7 µM	5.50E-4	heme biosynthesis & mitochondrial translocase	102	0.00119

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.124	6.54E-13	YDR488C	PAC11	hom	Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
0.123	7.73E-13	YGR209C	TRX2	hom	Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.122	1.25E-12	YJL084C	ALY2	hom	Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication
0.117	8.96E-12	YBR248C	HIS7	hom	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
0.111	9.96E-11	YKL183W	LOT5	hom	Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.111	1.07E-10	YAL017W	PSK1	hom	PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.111	1.34E-10	YGR082W	TOM20	het	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.105	9.37E-10	YJR106W	ECM27	hom	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.105	1.40E-9	YDR112W_d	IRC2_d	hom	Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.104	1.42E-9	YDL154W	MSH5	hom	Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.101	4.43E-9	YBR276C	PPS1	hom	Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.100	6.09E-9	YOR040W	GLO4	hom	Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.099	7.85E-9	YDR107C	TMN2	hom	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.097	1.74E-8	YBR243C	ALG7	het	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.095	3.27E-8	YIL130W	ASG1	hom	Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance