YOR292C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR292C / YOR292C

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-3.34|P-value:2.22E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:3.10|P-value:4.30E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.07|P-value:4.82E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.51|P-value:8.30E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.24|P-value:3.31E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.46|P-value:1.33E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:4.04|P-value:7.38E-6 ID:SGTC_627|Compound:1391-0720|FD-Score:2.94|P-value:7.85E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:2.93|P-value:8.07E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-4.25|P-value:3.65E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.97|P-value:8.97E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.17|P-value:3.26E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.32|P-value:1.83E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.91|P-value:8.73E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.88|P-value:9.84E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.10|P-value:5.63E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.71|P-value:4.68E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.30|P-value:2.00E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.11|P-value:4.21E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.25|P-value:2.43E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.97|P-value:7.12E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-3.57|P-value:8.40E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.86|P-value:1.02E-7 ID:SGTC_1908|Compound:st060353|FD-Score:3.79|P-value:2.42E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-3.16|P-value:4.52E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.61|P-value:5.34E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-3.39|P-value:1.82E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.61|P-value:7.05E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.14|P-value:4.89E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.04|P-value:5.50E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.71|P-value:4.64E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.90|P-value:1.44E-5 ID:SGTC_2439|Compound:5492030|FD-Score:2.88|P-value:9.82E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-4.28|P-value:3.19E-6 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.99|P-value:6.58E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.95|P-value:7.73E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.63|P-value:6.93E-13 ID:SGTC_2585|Compound:alliin|FD-Score:3.20|P-value:2.98E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.07|P-value:6.36E-6 ID:SGTC_2707|Compound:st078556|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.38|P-value:1.45E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.34|P-value:2.22E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:3.10|P-value:4.30E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.07|P-value:4.82E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:3.00|P-value:6.25E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.51|P-value:8.30E-5 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.24|P-value:3.31E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.46|P-value:1.33E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:4.04|P-value:7.38E-6 ID:SGTC_627|Compound:1391-0720|FD-Score:2.94|P-value:7.85E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:2.93|P-value:8.07E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:-4.25|P-value:3.65E-6 ID:SGTC_666|Compound:0272-0154|FD-Score:-2.97|P-value:8.97E-4 ID:SGTC_718|Compound:1130-0073|FD-Score:3.17|P-value:3.26E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.32|P-value:1.83E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.91|P-value:8.73E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.88|P-value:9.84E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.10|P-value:5.63E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.71|P-value:4.68E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.30|P-value:2.00E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.11|P-value:4.21E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.25|P-value:2.43E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:3.46|P-value:1.01E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:2.97|P-value:7.12E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-3.57|P-value:8.40E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.86|P-value:1.02E-7 ID:SGTC_1908|Compound:st060353|FD-Score:3.79|P-value:2.42E-5 ID:SGTC_1911|Compound:st060208|FD-Score:-3.16|P-value:4.52E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.61|P-value:5.34E-5 ID:SGTC_2023|Compound:5144124|FD-Score:-3.39|P-value:1.82E-4 ID:SGTC_2242|Compound:6630449|FD-Score:-3.61|P-value:7.05E-5 ID:SGTC_2264|Compound:7948757|FD-Score:-3.14|P-value:4.89E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.04|P-value:5.50E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.71|P-value:4.64E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.90|P-value:1.44E-5 ID:SGTC_2439|Compound:5492030|FD-Score:2.88|P-value:9.82E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-4.28|P-value:3.19E-6 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.99|P-value:6.58E-4 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:2.95|P-value:7.73E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.63|P-value:6.93E-13 ID:SGTC_2585|Compound:alliin|FD-Score:3.20|P-value:2.98E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.07|P-value:6.36E-6 ID:SGTC_2707|Compound:st078556|FD-Score:3.39|P-value:1.39E-4 ID:SGTC_2716|Compound:st080858|FD-Score:3.38|P-value:1.45E-4

Top fitness defect scores for YOR292C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2583 asiatic acid 6.63 100.0 µM 6.93E-13 6 1.65E-11
2 SGTC_1789 tunicamycin 4.86 25.0 nM 1.02E-7 unfolded protein response 28 6.01E-7
3 SGTC_1080 nisoldipine 4.32 24.4 µM 1.83E-6 TSC3-RPN4 18 7.73E-6
4 SGTC_2586 curcumin 4.07 80.0 µM 6.36E-6 iron homeostasis 46 2.32E-5
5 SGTC_418 lividomycin a 4.04 100.0 µM 7.38E-6 10 2.64E-5
6 SGTC_2426 5582046 3.90 32.2 µM 1.44E-5 32 4.77E-5
7 SGTC_1908 st060353 3.79 56.5 µM 2.42E-5 RPP1 & pyrimidine depletion 42 7.56E-5
8 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.61 70.1 µM 5.34E-5 40 1.52E-4
9 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.51 4.6 µM 8.30E-5 heat shock/prefoldin 54 2.24E-4
10 SGTC_1499 4480-0877 3.46 67.3 µM 1.01E-4 14 2.66E-4
11 SGTC_2707 st078556 3.39 66.6 µM 1.39E-4 23 3.53E-4
12 SGTC_2716 st080858 3.38 38.6 µM 1.45E-4 60S ribosome export 32 3.67E-4
13 SGTC_1296 1068-0102 3.30 11.9 µM 2.00E-4 18 4.89E-4
14 SGTC_1360 1598-0022 3.25 39.8 µM 2.43E-4 ERG2 63 5.80E-4
15 SGTC_2585 alliin 3.20 100.0 µM 2.98E-4 59 6.95E-4
16 SGTC_718 1130-0073 3.17 349.0 µM 3.26E-4 48 7.52E-4
17 SGTC_1315 1237-0019 3.11 3.7 µM 4.21E-4 35 9.42E-4
18 SGTC_80 0159-0065 3.10 512.2 µM 4.30E-4 16 9.61E-4
19 SGTC_113 0099-0221 3.07 2.5 µM 4.82E-4 68 0.00106
20 SGTC_2336 9001819 3.04 198.7 µM 5.50E-4 heme biosynthesis & mitochondrial translocase 102 0.00119

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 6.54E-13 YDR488C PAC11 hom Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
0.123 7.73E-13 YGR209C TRX2 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.122 1.25E-12 YJL084C ALY2 hom Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication
0.117 8.96E-12 YBR248C HIS7 hom Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor
0.111 9.96E-11 YKL183W LOT5 hom Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress
0.111 1.07E-10 YAL017W PSK1 hom PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication
0.111 1.34E-10 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.105 9.37E-10 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.105 1.40E-9 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.104 1.42E-9 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.101 4.43E-9 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.100 6.09E-9 YOR040W GLO4 hom Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.099 7.85E-9 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.097 1.74E-8 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.095 3.27E-8 YIL130W ASG1 hom Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance