YOR294W / RRS1

Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR294W / RRS1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.38|P-value:8.68E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:3.38|P-value:4.61E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:5.20|P-value:1.72E-7 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.36|P-value:4.69E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.58|P-value:2.10E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.21|P-value:7.83E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.39|P-value:4.43E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:7.24|P-value:5.98E-13 ID:SGTC_358|Compound:0075-0058|FD-Score:3.43|P-value:3.93E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.24|P-value:7.42E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.82|P-value:8.87E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.16|P-value:9.64E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.27|P-value:6.78E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.80|P-value:1.25E-6 ID:SGTC_469|Compound:w7|FD-Score:5.10|P-value:2.89E-7 ID:SGTC_470|Compound:aa-861|FD-Score:7.54|P-value:7.00E-14 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:8.47|P-value:4.57E-17 ID:SGTC_512|Compound:prima-1|FD-Score:3.60|P-value:2.06E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.41|P-value:3.89E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.58|P-value:2.28E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.25|P-value:1.55E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:6.10|P-value:1.09E-9 ID:SGTC_700|Compound:3453-2283|FD-Score:3.37|P-value:4.72E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:5.25|P-value:1.29E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:3.25|P-value:7.33E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.90|P-value:6.54E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:3.80|P-value:9.82E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:4.00|P-value:4.44E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:3.60|P-value:2.07E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.48|P-value:3.28E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.50|P-value:3.05E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-4.67|P-value:2.13E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:8.04|P-value:1.46E-15 ID:SGTC_1015|Compound:4130-4525|FD-Score:12.30|P-value:6.10E-34 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.20|P-value:1.94E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.96|P-value:5.67E-7 ID:SGTC_1024|Compound:4507-0395|FD-Score:-4.29|P-value:1.20E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:-4.93|P-value:6.22E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.53|P-value:2.70E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.59|P-value:2.14E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.35|P-value:5.08E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.49|P-value:2.95E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.28|P-value:6.47E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.94|P-value:5.50E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:5.00|P-value:4.73E-7 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.72|P-value:1.33E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:5.20|P-value:1.73E-7 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.91|P-value:7.20E-7 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.53|P-value:4.37E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.34|P-value:5.25E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.24|P-value:7.38E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.57|P-value:2.31E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.67|P-value:1.61E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.51|P-value:2.85E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.60|P-value:2.07E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.02|P-value:4.13E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.62|P-value:1.92E-4 ID:SGTC_2308|Compound:7584454|FD-Score:4.73|P-value:1.75E-6 ID:SGTC_2468|Compound:5987765|FD-Score:-3.21|P-value:7.91E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.41|P-value:4.18E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.79|P-value:1.33E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.31|P-value:5.98E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.24|P-value:7.21E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.52|P-value:4.55E-6 ID:SGTC_2798|Compound:7813637|FD-Score:3.38|P-value:4.68E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.11|P-value:2.78E-5 ID:SGTC_3040|Compound:9091894|FD-Score:5.01|P-value:4.35E-7 ID:SGTC_3043|Compound:9092303|FD-Score:5.10|P-value:2.87E-7 ID:SGTC_3144|Compound:9087057|FD-Score:-3.24|P-value:7.04E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.27|P-value:6.78E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.38|P-value:8.68E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:3.38|P-value:4.61E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:5.20|P-value:1.72E-7 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.36|P-value:4.69E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.58|P-value:2.10E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.21|P-value:7.83E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.39|P-value:4.43E-4 ID:SGTC_330|Compound:1488-0319|FD-Score:7.24|P-value:5.98E-13 ID:SGTC_358|Compound:0075-0058|FD-Score:3.43|P-value:3.93E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.24|P-value:7.42E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.82|P-value:8.87E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.16|P-value:9.64E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.27|P-value:6.78E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.80|P-value:1.25E-6 ID:SGTC_469|Compound:w7|FD-Score:5.10|P-value:2.89E-7 ID:SGTC_470|Compound:aa-861|FD-Score:7.54|P-value:7.00E-14 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:8.47|P-value:4.57E-17 ID:SGTC_512|Compound:prima-1|FD-Score:3.60|P-value:2.06E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.41|P-value:3.89E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.58|P-value:2.28E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:4.25|P-value:1.55E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:6.10|P-value:1.09E-9 ID:SGTC_700|Compound:3453-2283|FD-Score:3.37|P-value:4.72E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:5.25|P-value:1.29E-7 ID:SGTC_789|Compound:1309-1135|FD-Score:3.25|P-value:7.33E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.90|P-value:6.54E-5 ID:SGTC_907|Compound:3448-6986|FD-Score:3.80|P-value:9.82E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:4.00|P-value:4.44E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:3.60|P-value:2.07E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.48|P-value:3.28E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.50|P-value:3.05E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-4.67|P-value:2.13E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:8.04|P-value:1.46E-15 ID:SGTC_1015|Compound:4130-4525|FD-Score:12.30|P-value:6.10E-34 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.20|P-value:1.94E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.96|P-value:5.67E-7 ID:SGTC_1024|Compound:4507-0395|FD-Score:-4.29|P-value:1.20E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:-4.93|P-value:6.22E-7 ID:SGTC_1047|Compound:2043-3044|FD-Score:3.53|P-value:2.70E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.59|P-value:2.14E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.35|P-value:5.08E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.49|P-value:2.95E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.58|P-value:2.23E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.28|P-value:6.47E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.94|P-value:5.50E-5 ID:SGTC_1290|Compound:0986-0249|FD-Score:5.00|P-value:4.73E-7 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.72|P-value:1.33E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:5.20|P-value:1.73E-7 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.91|P-value:7.20E-7 ID:SGTC_1460|Compound:k062-0059|FD-Score:4.53|P-value:4.37E-6 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.34|P-value:5.25E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.24|P-value:7.38E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:3.57|P-value:2.31E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.67|P-value:1.61E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.61|P-value:1.98E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.51|P-value:2.85E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.60|P-value:2.07E-4 ID:SGTC_2059|Compound:5238311|FD-Score:4.02|P-value:4.13E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.62|P-value:1.92E-4 ID:SGTC_2308|Compound:7584454|FD-Score:4.73|P-value:1.75E-6 ID:SGTC_2468|Compound:5987765|FD-Score:-3.21|P-value:7.91E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.41|P-value:4.18E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.79|P-value:1.33E-6 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.31|P-value:5.98E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-3.24|P-value:7.21E-4 ID:SGTC_2797|Compound:7859098|FD-Score:4.52|P-value:4.55E-6 ID:SGTC_2798|Compound:7813637|FD-Score:3.38|P-value:4.68E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.11|P-value:2.78E-5 ID:SGTC_3040|Compound:9091894|FD-Score:5.01|P-value:4.35E-7 ID:SGTC_3043|Compound:9092303|FD-Score:5.10|P-value:2.87E-7 ID:SGTC_3144|Compound:9087057|FD-Score:-3.24|P-value:7.04E-4 ID:SGTC_3283|Compound:9109332|FD-Score:3.27|P-value:6.78E-4

Top fitness defect scores for YOR294W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1015 4130-4525 12.30 82.0 µM 6.10E-34 60S ribosome export 1 3.91E-35 5.46
2 SGTC_471 1-acyl-paf 8.47 4.0 µM 4.57E-17 DNA intercalators 3 1.21E-17 1.17
3 SGTC_1010 4112-3296 8.04 15.2 µM 1.46E-15 1 4.37E-16 2.13
4 SGTC_470 aa-861 7.54 153.0 µM 7.00E-14 sphingolipid biosynthesis & PDR1 2 2.42E-14 1.47
5 SGTC_330 1488-0319 7.24 80.1 µM 5.98E-13 RPP1 & pyrimidine depletion 1 2.23E-13 1.15
6 SGTC_679 0422-0091 6.10 41.4 µM 1.09E-9 Golgi 3 5.36E-10 1.11
7 SGTC_765 1319-0117 5.25 244.0 µM 1.29E-7 60S ribosome export 4 7.51E-8 0.24
8 SGTC_72 0744-0168 5.20 198.4 µM 1.72E-7 RPP1 & pyrimidine depletion 4 1.02E-7 0.61
9 SGTC_1415 3966-0071 5.20 78.1 µM 1.73E-7 DNA intercalators 2 1.02E-7 0.46
10 SGTC_3043 9092303 5.10 49.5 µM 2.87E-7 3 1.73E-7 0.99
11 SGTC_469 w7 5.10 172.0 µM 2.89E-7 ERG2 2 1.74E-7 1.12
12 SGTC_3040 9091894 5.01 49.5 µM 4.35E-7 DNA intercalators 7 2.66E-7 0.34
13 SGTC_1290 0986-0249 5.00 10.2 µM 4.73E-7 DNA intercalators 4 2.90E-7 0.31
14 SGTC_1019 4262-0212 4.96 3.4 µM 5.67E-7 ergosterol depletion effects on membrane 7 3.50E-7 0.15
15 SGTC_1459 k035-0031 4.91 35.7 µM 7.20E-7 DNA intercalators 6 4.48E-7 0.43
16 SGTC_468 gf-109203x 4.80 121.0 µM 1.25E-6 amide catabolism 2 7.96E-7 1.33
17 SGTC_2603 homopterocarpin 4.79 100.0 µM 1.33E-6 3 8.48E-7 0.43
18 SGTC_2308 7584454 4.73 197.6 µM 1.75E-6 6 1.12E-6 0.39
19 SGTC_1460 k062-0059 4.53 9.2 µM 4.37E-6 Golgi 2 2.90E-6 4.79E-4
20 SGTC_2797 7859098 4.52 81.8 µM 4.55E-6 5 3.02E-6 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.346 4.43E-95 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.326 9.57E-84 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.315 6.70E-78 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.298 7.17E-70 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.295 3.64E-68 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.286 2.84E-64 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.242 1.02E-45 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.213 1.44E-35 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.212 3.24E-35 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.210 7.21E-35 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.206 1.60E-33 YKL139W CTK1 hom Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
0.186 1.44E-27 YGL023C PIB2 hom Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27
0.178 2.93E-25 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.167 1.90E-22 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.154 2.36E-19 YLR083C EMP70 hom Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments