YOR295W / UAF30

Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR295W / UAF30

Click on Significant Values for Screen Details ID:SGTC_81|Compound:0411-0046|FD-Score:3.26|P-value:4.82E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:5.04|P-value:1.82E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:3.32|P-value:3.98E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.64|P-value:1.17E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.04|P-value:5.70E-10 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.10|P-value:2.34E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:4.63|P-value:1.49E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.32|P-value:4.99E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.64|P-value:1.16E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.16|P-value:1.30E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.45|P-value:3.08E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:5.79|P-value:2.72E-9 ID:SGTC_712|Compound:r015-0009|FD-Score:3.07|P-value:9.52E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.19|P-value:6.20E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.29|P-value:4.32E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.36|P-value:4.30E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.18|P-value:8.08E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.79|P-value:6.38E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.71|P-value:8.79E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:4.15|P-value:1.37E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:6.61|P-value:1.45E-11 ID:SGTC_1015|Compound:4130-4525|FD-Score:5.36|P-value:3.23E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.10|P-value:2.32E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.41|P-value:2.79E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.59|P-value:1.44E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.57|P-value:1.51E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.29|P-value:4.34E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.22|P-value:6.99E-8 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.45|P-value:2.40E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.38|P-value:3.10E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.79|P-value:6.42E-5 ID:SGTC_1644|Compound:st010134|FD-Score:3.59|P-value:1.42E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:5.63|P-value:6.91E-9 ID:SGTC_1781|Compound:st038725|FD-Score:8.43|P-value:1.11E-17 ID:SGTC_1786|Compound:berberine|FD-Score:-3.15|P-value:9.00E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.32|P-value:3.94E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.45|P-value:3.04E-4 ID:SGTC_1930|Compound:st074634|FD-Score:5.23|P-value:6.64E-8 ID:SGTC_1936|Compound:st074407|FD-Score:-3.80|P-value:8.12E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.08|P-value:8.94E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.57|P-value:1.98E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.37|P-value:3.30E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.23|P-value:5.41E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.09|P-value:8.72E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.50|P-value:2.60E-4 ID:SGTC_2374|Compound:9071832|FD-Score:4.29|P-value:7.38E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-4.68|P-value:1.59E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.14|P-value:1.10E-7 ID:SGTC_2544|Compound:sphondin|FD-Score:4.56|P-value:2.14E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.11|P-value:8.09E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.57|P-value:1.48E-8 ID:SGTC_2591|Compound:skatole|FD-Score:3.49|P-value:2.10E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.23|P-value:9.85E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.91|P-value:3.75E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.39|P-value:4.61E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.36|P-value:4.25E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.23|P-value:6.69E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.93|P-value:1.18E-9 ID:SGTC_81|Compound:0411-0046|FD-Score:3.26|P-value:4.82E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:5.04|P-value:1.82E-7 ID:SGTC_87|Compound:0100-0052|FD-Score:3.32|P-value:3.98E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.64|P-value:1.17E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.04|P-value:5.70E-10 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.10|P-value:2.34E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:4.63|P-value:1.49E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.32|P-value:4.99E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.64|P-value:1.16E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.16|P-value:1.30E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.45|P-value:3.08E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:5.79|P-value:2.72E-9 ID:SGTC_712|Compound:r015-0009|FD-Score:3.07|P-value:9.52E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.19|P-value:6.20E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.29|P-value:4.32E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.36|P-value:4.30E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.18|P-value:8.08E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.79|P-value:6.38E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:3.71|P-value:8.79E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:4.15|P-value:1.37E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:6.61|P-value:1.45E-11 ID:SGTC_1015|Compound:4130-4525|FD-Score:5.36|P-value:3.23E-8 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.10|P-value:2.32E-5 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.41|P-value:2.79E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.59|P-value:1.44E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.57|P-value:1.51E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.29|P-value:4.34E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.22|P-value:6.99E-8 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.45|P-value:2.40E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.38|P-value:3.10E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.79|P-value:6.42E-5 ID:SGTC_1644|Compound:st010134|FD-Score:3.59|P-value:1.42E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:5.63|P-value:6.91E-9 ID:SGTC_1781|Compound:st038725|FD-Score:8.43|P-value:1.11E-17 ID:SGTC_1786|Compound:berberine|FD-Score:-3.15|P-value:9.00E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.32|P-value:3.94E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.45|P-value:3.04E-4 ID:SGTC_1930|Compound:st074634|FD-Score:5.23|P-value:6.64E-8 ID:SGTC_1936|Compound:st074407|FD-Score:-3.80|P-value:8.12E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.08|P-value:8.94E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.57|P-value:1.98E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.37|P-value:3.30E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.23|P-value:5.41E-4 ID:SGTC_2307|Compound:7538926|FD-Score:3.09|P-value:8.72E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.50|P-value:2.60E-4 ID:SGTC_2374|Compound:9071832|FD-Score:4.29|P-value:7.38E-6 ID:SGTC_2404|Compound:5161160|FD-Score:-4.68|P-value:1.59E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.14|P-value:1.10E-7 ID:SGTC_2544|Compound:sphondin|FD-Score:4.56|P-value:2.14E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.11|P-value:8.09E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.57|P-value:1.48E-8 ID:SGTC_2591|Compound:skatole|FD-Score:3.49|P-value:2.10E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.23|P-value:9.85E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.91|P-value:3.75E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.39|P-value:4.61E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.36|P-value:4.25E-4 ID:SGTC_3032|Compound:9089427|FD-Score:-3.23|P-value:6.69E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.93|P-value:1.18E-9

Top fitness defect scores for YOR295W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1781 st038725 8.43 66.3 µM 1.11E-17 NEO1 30 1.68E-17
2 SGTC_832 4083-0019 6.61 164.0 µM 1.45E-11 translation 13 1.97E-11
3 SGTC_221 trifluoperazine 6.04 10.3 µM 5.70E-10 NEO1-PIK1 120 7.51E-10
4 SGTC_3037 9091026 5.93 49.5 µM 1.18E-9 NEO1-PIK1 50 1.54E-9
5 SGTC_632 0781-2353 5.79 4.7 µM 2.72E-9 Golgi 10 3.53E-9
6 SGTC_1693 xanthone 5.63 101.9 µM 6.91E-9 DNA damage response 2 8.90E-9
7 SGTC_1015 4130-4525 5.36 82.0 µM 3.23E-8 60S ribosome export 6 4.11E-8
8 SGTC_1930 st074634 5.23 34.3 µM 6.64E-8 RNA pol III & RNase P/MRP 14 8.37E-8
9 SGTC_1178 0988-0033 5.22 191.0 µM 6.99E-8 12 8.81E-8
10 SGTC_2489 cantharidin 5.14 73.4 µM 1.10E-7 cell wall signaling 18 1.38E-7
11 SGTC_84 0443-0269 5.04 128.8 µM 1.82E-7 7 2.27E-7
12 SGTC_2651 1327-0036 4.91 5.0 µM 3.75E-7 113 4.65E-7
13 SGTC_323 4013-0906 4.63 34.3 µM 1.49E-6 ERG2 6 1.83E-6
14 SGTC_2544 sphondin 4.56 68.5 µM 2.14E-6 RNA pol III & RNase P/MRP 14 2.60E-6
15 SGTC_2688 kanamycin b 4.39 96.7 µM 4.61E-6 calcium & mitochondrial duress 311 5.57E-6
16 SGTC_2374 9071832 4.29 200.0 µM 7.38E-6 endomembrane recycling 11 8.87E-6
17 SGTC_2620 irigenin 4.23 100.0 µM 9.85E-6 28 1.18E-5
18 SGTC_449 xestospongin c 4.16 11.2 µM 1.30E-5 NEO1-PIK1 57 1.56E-5
19 SGTC_830 4076-0286 4.15 57.8 µM 1.37E-5 translation 51 1.64E-5
20 SGTC_791 1348-1292 3.79 225.0 µM 6.38E-5 40 7.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 2.94E-57 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.251 1.80E-49 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.209 2.58E-34 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.200 1.22E-31 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.200 2.15E-31 YFL023W BUD27 hom Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP
0.195 3.80E-30 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.179 1.41E-25 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.169 8.67E-23 YDL033C SLM3 hom tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)
0.166 4.01E-22 YOL159C-A YOL159C-A hom Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species
0.162 4.82E-21 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
0.160 1.50E-20 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.156 8.97E-20 YLL036C PRP19 het Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain
0.153 6.31E-19 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.152 7.29E-19 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.151 1.92E-18 YGL100W SEH1 hom Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1