YOR298W / MUM3

Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR298W / MUM3

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.38|P-value:3.51E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.52|P-value:1.73E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-4.32|P-value:5.86E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.96|P-value:3.13E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.36|P-value:3.73E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.27|P-value:5.26E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.05|P-value:9.62E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.51|P-value:2.14E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.23|P-value:5.96E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.27|P-value:5.14E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.14|P-value:6.96E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.37|P-value:3.62E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.14|P-value:8.12E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.93|P-value:3.25E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.41|P-value:3.14E-4 ID:SGTC_1737|Compound:st035557|FD-Score:8.11|P-value:1.70E-16 ID:SGTC_1750|Compound:st081859|FD-Score:-3.21|P-value:5.46E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:2.05E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.04|P-value:2.04E-7 ID:SGTC_2268|Compound:7933382|FD-Score:3.87|P-value:5.17E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.09|P-value:9.65E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.95|P-value:3.63E-5 ID:SGTC_2325|Compound:6158266|FD-Score:-3.79|P-value:6.04E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-3.70|P-value:8.72E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-4.01|P-value:2.32E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.20|P-value:1.23E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.07|P-value:9.03E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.80|P-value:5.70E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.58|P-value:1.65E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.09|P-value:8.50E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.19|P-value:5.94E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.34|P-value:4.11E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.41|P-value:3.12E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.15|P-value:7.98E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-4.10|P-value:1.58E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.19|P-value:7.00E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.27|P-value:8.97E-6 ID:SGTC_3234|Compound:9132280|FD-Score:-3.48|P-value:2.05E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.65|P-value:1.07E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.38|P-value:3.51E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-3.52|P-value:1.73E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-4.32|P-value:5.86E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:4.96|P-value:3.13E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.36|P-value:3.73E-4 ID:SGTC_692|Compound:k241-0027|FD-Score:3.27|P-value:5.26E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.05|P-value:9.62E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.51|P-value:2.14E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.23|P-value:5.96E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.27|P-value:5.14E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.14|P-value:6.96E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.37|P-value:3.62E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.14|P-value:8.12E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.93|P-value:3.25E-5 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.66|P-value:1.20E-4 ID:SGTC_1516|Compound:st013856|FD-Score:3.41|P-value:3.14E-4 ID:SGTC_1737|Compound:st035557|FD-Score:8.11|P-value:1.70E-16 ID:SGTC_1750|Compound:st081859|FD-Score:-3.21|P-value:5.46E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.52|P-value:2.05E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.04|P-value:2.04E-7 ID:SGTC_2268|Compound:7933382|FD-Score:3.87|P-value:5.17E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.09|P-value:9.65E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.95|P-value:3.63E-5 ID:SGTC_2325|Compound:6158266|FD-Score:-3.79|P-value:6.04E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-3.70|P-value:8.72E-5 ID:SGTC_2513|Compound:baicalein|FD-Score:-4.01|P-value:2.32E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.20|P-value:1.23E-5 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.07|P-value:9.03E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.80|P-value:5.70E-5 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.58|P-value:1.65E-4 ID:SGTC_2714|Compound:st079313|FD-Score:-3.09|P-value:8.50E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.19|P-value:5.94E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.34|P-value:4.11E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.41|P-value:3.12E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.15|P-value:7.98E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-4.10|P-value:1.58E-5 ID:SGTC_3149|Compound:9097855|FD-Score:3.19|P-value:7.00E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.27|P-value:8.97E-6 ID:SGTC_3234|Compound:9132280|FD-Score:-3.48|P-value:2.05E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.65|P-value:1.07E-4

Top fitness defect scores for YOR298W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1737 st035557 8.11 69.7 µM 1.70E-16 1 2.63E-16
2 SGTC_1936 st074407 5.04 74.3 µM 2.04E-7 DNA damage response 11 2.32E-7
3 SGTC_436 n,n-dimethylsphingosine 4.96 3.3 µM 3.13E-7 11 3.54E-7
4 SGTC_3180 9109287 4.27 49.5 µM 8.97E-6 4 9.69E-6
5 SGTC_2519 cryptotanshinone 4.20 88.0 µM 1.23E-5 heme biosynthesis & mitochondrial translocase 9 1.32E-5
6 SGTC_2320 7373003 3.95 200.0 µM 3.63E-5 27 3.86E-5
7 SGTC_2268 7933382 3.87 153.8 µM 5.17E-5 40 5.47E-5
8 SGTC_1274 0865-0114 3.66 173.0 µM 1.20E-4 34 1.26E-4
9 SGTC_2660 2',4'-dihydroxychalcone 3.58 17.1 µM 1.65E-4 27 1.72E-4
10 SGTC_1916 st067606 3.52 49.2 µM 2.05E-4 57 2.13E-4
11 SGTC_722 3534-0461 3.51 190.0 µM 2.14E-4 PDR1 51 2.22E-4
12 SGTC_2969 9091408 3.41 28.7 µM 3.12E-4 50 3.23E-4
13 SGTC_1516 st013856 3.41 110.0 µM 3.14E-4 24 3.25E-4
14 SGTC_65 0798-0905 3.38 35.0 µM 3.51E-4 calcium & mitochondrial duress 123 3.63E-4
15 SGTC_1119 parthenolide 3.37 318.5 nM 3.62E-4 TSC3-RPN4 69 3.74E-4
16 SGTC_453 enantio-paf c16 3.36 10.0 µM 3.73E-4 201 3.86E-4
17 SGTC_2883 9059145 3.34 45.5 µM 4.11E-4 22 4.24E-4
18 SGTC_795 0685-0265 3.27 78.0 µM 5.14E-4 excess fatty acid 54 5.28E-4
19 SGTC_692 k241-0027 3.27 77.8 µM 5.26E-4 25 5.41E-4
20 SGTC_743 1275-0778 3.23 158.0 µM 5.96E-4 excess fatty acid 70 6.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.96E-13 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.117 1.09E-11 YPR062W FCY1 hom Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
0.105 1.07E-9 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.093 7.09E-8 YMR085W_p YMR085W_p hom Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.092 8.66E-8 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.091 1.22E-7 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.090 1.91E-7 YFR055W_p IRC7_p hom Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner
0.089 2.09E-7 YBR270C_p BIT2_p hom Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication
0.087 4.05E-7 YIR002C MPH1 hom 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases
0.086 6.63E-7 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 8.15E-7 YOR138C RUP1 hom Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress
0.081 2.61E-6 YPL067C_p YPL067C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
0.077 7.62E-6 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.076 9.17E-6 YLR101C_d YLR101C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W
0.076 1.01E-5 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable