YOR299W / BUD7

Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR299W / BUD7

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.40|P-value:2.63E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.76|P-value:6.40E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.77|P-value:6.09E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.92|P-value:3.27E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.29|P-value:3.99E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.07|P-value:1.66E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.76|P-value:6.29E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:3.37|P-value:3.04E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.94|P-value:3.00E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:4.80|P-value:5.09E-7 ID:SGTC_786|Compound:4544-0069|FD-Score:3.16|P-value:6.35E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.13|P-value:7.11E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.25|P-value:4.72E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.82|P-value:1.50E-9 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.44|P-value:2.27E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.52|P-value:2.05E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.14|P-value:6.82E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.04|P-value:9.63E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.92|P-value:3.26E-5 ID:SGTC_1695|Compound:st026914|FD-Score:-3.16|P-value:6.36E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.78|P-value:5.96E-5 ID:SGTC_1708|Compound:st033234|FD-Score:3.05|P-value:9.57E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.11|P-value:7.57E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-6.32|P-value:5.94E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.37|P-value:2.99E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.44|P-value:2.28E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.10|P-value:8.03E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.57|P-value:1.61E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.04|P-value:9.88E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.77|P-value:6.04E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.82|P-value:4.98E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.32|P-value:3.54E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.35|P-value:3.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.69|P-value:8.47E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.15|P-value:1.14E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.84|P-value:4.61E-5 ID:SGTC_3306|Compound:9127676|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.67|P-value:9.36E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:3.40|P-value:2.63E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.76|P-value:6.40E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-3.77|P-value:6.09E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.92|P-value:3.27E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.29|P-value:3.99E-4 ID:SGTC_401|Compound:neomycin|FD-Score:4.07|P-value:1.66E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:4.76|P-value:6.29E-7 ID:SGTC_628|Compound:1636-0253|FD-Score:3.37|P-value:3.04E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:-3.94|P-value:3.00E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:4.80|P-value:5.09E-7 ID:SGTC_786|Compound:4544-0069|FD-Score:3.16|P-value:6.35E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-3.13|P-value:7.11E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.25|P-value:4.72E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.82|P-value:1.50E-9 ID:SGTC_1338|Compound:1486-1223|FD-Score:3.44|P-value:2.27E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.52|P-value:2.05E-6 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.14|P-value:6.82E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.04|P-value:9.63E-4 ID:SGTC_1641|Compound:st009299|FD-Score:3.92|P-value:3.26E-5 ID:SGTC_1695|Compound:st026914|FD-Score:-3.16|P-value:6.36E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.78|P-value:5.96E-5 ID:SGTC_1708|Compound:st033234|FD-Score:3.05|P-value:9.57E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.11|P-value:7.57E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-6.32|P-value:5.94E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.37|P-value:2.99E-4 ID:SGTC_2269|Compound:7935389|FD-Score:3.44|P-value:2.28E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.10|P-value:8.03E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.57|P-value:1.61E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.04|P-value:9.88E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.77|P-value:6.04E-5 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.82|P-value:4.98E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.32|P-value:3.54E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.35|P-value:3.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.69|P-value:8.47E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.15|P-value:1.14E-5 ID:SGTC_3209|Compound:9113616|FD-Score:3.84|P-value:4.61E-5 ID:SGTC_3306|Compound:9127676|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.67|P-value:9.36E-5

Top fitness defect scores for YOR299W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_668 1682-0499 4.80 62.6 µM 5.09E-7 10 8.00E-7
2 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 4.76 8.0 µM 6.29E-7 13 9.80E-7
3 SGTC_1381 2324-0066 4.52 62.1 µM 2.05E-6 21 3.07E-6
4 SGTC_401 neomycin 4.07 50.0 µM 1.66E-5 9 2.30E-5
5 SGTC_1641 st009299 3.92 47.1 µM 3.26E-5 mitochondrial processes 5 4.43E-5
6 SGTC_373 0844-0104 3.92 25.9 µM 3.27E-5 ERAD & cell cycle 48 4.43E-5
7 SGTC_3209 9113616 3.84 49.5 µM 4.61E-5 28 6.18E-5
8 SGTC_1699 st031318 3.78 29.1 µM 5.96E-5 24 7.93E-5
9 SGTC_2693 st077581 3.77 40.7 µM 6.04E-5 43 8.02E-5
10 SGTC_14 0354-0009 3.76 295.0 µM 6.40E-5 32 8.48E-5
11 SGTC_3342 9147791 3.67 14.5 µM 9.36E-5 23 1.23E-4
12 SGTC_3306 9127676 3.47 59.8 µM 2.06E-4 39 2.62E-4
13 SGTC_1338 1486-1223 3.44 76.0 µM 2.27E-4 38 2.88E-4
14 SGTC_2269 7935389 3.44 174.4 µM 2.28E-4 tubulin folding & SWR complex 41 2.89E-4
15 SGTC_8 0354-0001 3.40 70.0 µM 2.63E-4 107 3.32E-4
16 SGTC_628 1636-0253 3.37 16.0 µM 3.04E-4 sphingolipid biosynthesis & PDR1 54 3.82E-4
17 SGTC_2839 9003951 3.35 26.0 µM 3.25E-4 28 4.07E-4
18 SGTC_884 0851-0618 3.25 334.0 µM 4.72E-4 41 5.85E-4
19 SGTC_786 4544-0069 3.16 423.0 µM 6.35E-4 71 7.78E-4
20 SGTC_1482 3346-2049 3.14 8.5 µM 6.82E-4 53 8.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.60E-19 YDL210W UGA4 hom Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
0.144 4.57E-17 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.109 2.70E-10 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.107 4.96E-10 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.096 2.48E-8 YLR052W IES3 hom Subunit of the INO80 chromatin remodeling complex
0.096 2.65E-8 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.094 4.63E-8 YMR162C DNF3 hom Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase
0.088 3.40E-7 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.088 3.76E-7 YKL041W VPS24 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
0.087 3.94E-7 YMR070W MOT3 hom Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion
0.086 6.15E-7 YHR155W YSP1 hom Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.086 6.26E-7 YDL175C AIR2 hom RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication
0.086 6.42E-7 YGL121C GPG1 hom Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing
0.085 7.96E-7 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.083 1.65E-6 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase