YOR304C-A_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR304C-A / YOR304C-A

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:4.25|P-value:3.46E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:3.46|P-value:6.03E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.53|P-value:4.81E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.07|P-value:7.22E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.55|P-value:4.40E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.15|P-value:1.24E-14 ID:SGTC_67|Compound:0335-0847|FD-Score:5.25|P-value:4.42E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:6.54|P-value:4.88E-10 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.14|P-value:5.56E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.71|P-value:2.60E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.89|P-value:1.34E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.69|P-value:2.77E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:5.39|P-value:2.28E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:7.01|P-value:2.70E-11 ID:SGTC_819|Compound:1013-0258|FD-Score:3.61|P-value:3.59E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.55|P-value:4.52E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:6.10|P-value:5.94E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:4.27|P-value:3.24E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.47|P-value:5.77E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.37|P-value:2.17E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-5.41|P-value:2.17E-7 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.04|P-value:1.21E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:-4.59|P-value:9.19E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.93|P-value:1.17E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:5.30|P-value:3.61E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.21|P-value:4.30E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.32|P-value:2.66E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.92|P-value:1.28E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.61|P-value:3.61E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.55|P-value:4.52E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-4.12|P-value:5.96E-5 ID:SGTC_1855|Compound:st056195|FD-Score:4.52|P-value:1.16E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-3.86|P-value:1.56E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.75|P-value:4.35E-6 ID:SGTC_2286|Compound:7945697|FD-Score:4.50|P-value:1.28E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-5.07|P-value:1.08E-6 ID:SGTC_2467|Compound:5474540|FD-Score:-4.42|P-value:1.87E-5 ID:SGTC_2482|Compound:5981709|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.82|P-value:3.30E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.30|P-value:9.99E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.75|P-value:2.22E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.14|P-value:5.31E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.80|P-value:1.96E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.55|P-value:4.61E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.27|P-value:3.26E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.70|P-value:2.65E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.44|P-value:6.37E-4 ID:SGTC_3284|Compound:9108171|FD-Score:4.20|P-value:4.25E-5 ID:SGTC_3297|Compound:9117502|FD-Score:5.93|P-value:1.49E-8 ID:SGTC_3307|Compound:9126885|FD-Score:-4.10|P-value:6.51E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:4.25|P-value:3.46E-5 ID:SGTC_14|Compound:0354-0009|FD-Score:3.46|P-value:6.03E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.53|P-value:4.81E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.07|P-value:7.22E-5 ID:SGTC_56|Compound:0957-0365|FD-Score:3.55|P-value:4.40E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.15|P-value:1.24E-14 ID:SGTC_67|Compound:0335-0847|FD-Score:5.25|P-value:4.42E-7 ID:SGTC_266|Compound:formosanin C|FD-Score:6.54|P-value:4.88E-10 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-4.14|P-value:5.56E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:3.71|P-value:2.60E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.89|P-value:1.34E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.69|P-value:2.77E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:5.39|P-value:2.28E-7 ID:SGTC_794|Compound:k038-0031|FD-Score:7.01|P-value:2.70E-11 ID:SGTC_819|Compound:1013-0258|FD-Score:3.61|P-value:3.59E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.55|P-value:4.52E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:6.10|P-value:5.94E-9 ID:SGTC_852|Compound:0418-0143|FD-Score:4.27|P-value:3.24E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:3.47|P-value:5.77E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.37|P-value:2.17E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:-5.41|P-value:2.17E-7 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.04|P-value:1.21E-6 ID:SGTC_1019|Compound:4262-0212|FD-Score:-4.59|P-value:9.19E-6 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.59|P-value:3.95E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.93|P-value:1.17E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:5.30|P-value:3.61E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-4.21|P-value:4.30E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.32|P-value:2.66E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-3.92|P-value:1.28E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.61|P-value:3.61E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.55|P-value:4.52E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-4.12|P-value:5.96E-5 ID:SGTC_1855|Compound:st056195|FD-Score:4.52|P-value:1.16E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-3.86|P-value:1.56E-4 ID:SGTC_2046|Compound:4110841|FD-Score:4.75|P-value:4.35E-6 ID:SGTC_2286|Compound:7945697|FD-Score:4.50|P-value:1.28E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:-5.07|P-value:1.08E-6 ID:SGTC_2467|Compound:5474540|FD-Score:-4.42|P-value:1.87E-5 ID:SGTC_2482|Compound:5981709|FD-Score:3.84|P-value:1.64E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.82|P-value:3.30E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.30|P-value:9.99E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.75|P-value:2.22E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.14|P-value:5.31E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.80|P-value:1.96E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.55|P-value:4.61E-4 ID:SGTC_3080|Compound:9117754|FD-Score:4.27|P-value:3.26E-5 ID:SGTC_3131|Compound:9127911|FD-Score:3.70|P-value:2.65E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.44|P-value:6.37E-4 ID:SGTC_3284|Compound:9108171|FD-Score:4.20|P-value:4.25E-5 ID:SGTC_3297|Compound:9117502|FD-Score:5.93|P-value:1.49E-8 ID:SGTC_3307|Compound:9126885|FD-Score:-4.10|P-value:6.51E-5

Top fitness defect scores for YOR304C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 8.15 9.0 µM 1.24E-14 cell wall 117 1.80E-16
2 SGTC_794 k038-0031 7.01 316.0 µM 2.70E-11 ubiquinone biosynthesis & proteasome 42 1.17E-12
3 SGTC_266 formosanin C 6.54 406.0 nM 4.88E-10 sphingolipid biosynthesis & PDR1 20 3.17E-11
4 SGTC_823 0417-1665 6.10 178.0 µM 5.94E-9 17 5.47E-10
5 SGTC_3297 9117502 5.93 71.4 µM 1.49E-8 4 1.56E-9
6 SGTC_635 k038-0028 5.39 24.7 µM 2.28E-7 ubiquinone biosynthesis & proteasome 23 3.49E-8
7 SGTC_1508 1080-0625 5.30 72.9 µM 3.61E-7 3 5.90E-8
8 SGTC_67 0335-0847 5.25 266.0 µM 4.42E-7 ubiquinone biosynthesis & proteasome 82 7.41E-8
9 SGTC_1017 4239-0030 5.04 168.0 µM 1.21E-6 8 2.34E-7
10 SGTC_2582 agaric acid 4.82 100.0 µM 3.30E-6 redox potentiating 232 7.31E-7
11 SGTC_2046 4110841 4.75 106.0 µM 4.35E-6 iron homeostasis 14 1.00E-6
12 SGTC_1855 st056195 4.52 39.6 µM 1.16E-5 60S ribosome export 9 3.06E-6
13 SGTC_2286 7945697 4.50 125.0 µM 1.28E-5 38 3.41E-6
14 SGTC_967 1306-0166 4.37 352.0 µM 2.17E-5 18 6.24E-6
15 SGTC_1587 estradiol valerate 4.32 56.1 µM 2.66E-5 6 7.86E-6
16 SGTC_852 0418-0143 4.27 439.0 µM 3.24E-5 calcium & mitochondrial duress 55 9.82E-6
17 SGTC_3080 9117754 4.27 49.5 µM 3.26E-5 13 9.90E-6
18 SGTC_8 0354-0001 4.25 70.0 µM 3.46E-5 66 1.06E-5
19 SGTC_3284 9108171 4.20 64.9 µM 4.25E-5 22 1.34E-5
20 SGTC_2858 9025781 4.14 9.0 µM 5.31E-5 sphingolipid biosynthesis & PDR1 93 1.72E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 3.02E-41 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.213 7.87E-36 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.206 2.24E-33 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.201 6.65E-32 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.189 3.15E-28 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.176 8.15E-25 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.169 9.49E-23 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.167 2.41E-22 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.166 3.07E-22 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.165 9.02E-22 YNL257C SIP3 hom Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication
0.163 2.35E-21 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.162 3.63E-21 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.162 3.98E-21 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.162 4.50E-21 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.159 2.21E-20 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation