YOR305W / RRG7

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR305W / RRG7

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:6.16|P-value:4.00E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:7.60|P-value:2.04E-14 ID:SGTC_116|Compound:0155-0182|FD-Score:6.84|P-value:4.70E-12 ID:SGTC_118|Compound:0083-0097|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.25|P-value:8.04E-8 ID:SGTC_127|Compound:0180-0333|FD-Score:4.41|P-value:5.01E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:16.90|P-value:2.75E-63 ID:SGTC_141|Compound:0443-0274|FD-Score:4.80|P-value:7.78E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:3.89|P-value:4.79E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.22|P-value:9.24E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.89|P-value:5.17E-7 ID:SGTC_159|Compound:3970-0959|FD-Score:3.63|P-value:1.33E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:7.69|P-value:1.03E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:10.20|P-value:1.82E-24 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.58|P-value:1.61E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.59|P-value:2.55E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.30|P-value:7.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.64|P-value:1.71E-6 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.45|P-value:4.20E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.67|P-value:1.16E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.91|P-value:7.45E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.14|P-value:7.78E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.29|P-value:7.29E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.12|P-value:8.33E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:7.81|P-value:3.97E-15 ID:SGTC_644|Compound:1498-1197|FD-Score:3.18|P-value:6.91E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.66|P-value:1.97E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.21|P-value:9.70E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.50|P-value:2.14E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.45|P-value:2.69E-8 ID:SGTC_854|Compound:0422-0053|FD-Score:3.97|P-value:3.40E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.21|P-value:6.25E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:6.52|P-value:4.17E-11 ID:SGTC_1020|Compound:4335-0961|FD-Score:5.19|P-value:1.09E-7 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.09|P-value:9.11E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.90|P-value:4.78E-7 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.16|P-value:7.25E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.45|P-value:2.66E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.36|P-value:3.62E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.35|P-value:5.98E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.17|P-value:1.49E-5 ID:SGTC_1521|Compound:st012942|FD-Score:4.54|P-value:2.78E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.13|P-value:8.00E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.62|P-value:1.90E-6 ID:SGTC_1618|Compound:st003135|FD-Score:4.02|P-value:2.82E-5 ID:SGTC_1635|Compound:st007035|FD-Score:6.39|P-value:9.67E-11 ID:SGTC_1721|Compound:st082152|FD-Score:3.75|P-value:8.43E-5 ID:SGTC_1768|Compound:st044301|FD-Score:3.10|P-value:8.82E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.58|P-value:6.37E-14 ID:SGTC_1845|Compound:st056753|FD-Score:4.28|P-value:8.90E-6 ID:SGTC_1849|Compound:st056239|FD-Score:3.26|P-value:5.10E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.31|P-value:7.78E-6 ID:SGTC_2063|Compound:5246145|FD-Score:4.21|P-value:1.26E-5 ID:SGTC_2191|Compound:5911152|FD-Score:3.23|P-value:5.74E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.48|P-value:3.70E-6 ID:SGTC_2314|Compound:7727897|FD-Score:-5.74|P-value:1.13E-8 ID:SGTC_2329|Compound:6138490|FD-Score:3.91|P-value:4.46E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.42|P-value:4.86E-6 ID:SGTC_2473|Compound:5854593|FD-Score:3.13|P-value:8.16E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-5.51|P-value:3.90E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.24|P-value:8.63E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.31|P-value:7.03E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-4.31|P-value:1.42E-5 ID:SGTC_2875|Compound:9039966|FD-Score:-5.01|P-value:5.39E-7 ID:SGTC_2877|Compound:9040724|FD-Score:-4.57|P-value:4.43E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-5.36|P-value:8.98E-8 ID:SGTC_2900|Compound:5328528|FD-Score:3.07|P-value:9.87E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.48|P-value:2.36E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.04|P-value:4.46E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.08|P-value:9.64E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:6.16|P-value:4.00E-10 ID:SGTC_70|Compound:0141-0289|FD-Score:7.60|P-value:2.04E-14 ID:SGTC_116|Compound:0155-0182|FD-Score:6.84|P-value:4.70E-12 ID:SGTC_118|Compound:0083-0097|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:5.25|P-value:8.04E-8 ID:SGTC_127|Compound:0180-0333|FD-Score:4.41|P-value:5.01E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:16.90|P-value:2.75E-63 ID:SGTC_141|Compound:0443-0274|FD-Score:4.80|P-value:7.78E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:3.89|P-value:4.79E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.22|P-value:9.24E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.89|P-value:5.17E-7 ID:SGTC_159|Compound:3970-0959|FD-Score:3.63|P-value:1.33E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:7.69|P-value:1.03E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:10.20|P-value:1.82E-24 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.58|P-value:1.61E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.59|P-value:2.55E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.30|P-value:7.28E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.64|P-value:1.71E-6 ID:SGTC_328|Compound:k915-0120|FD-Score:-3.45|P-value:4.20E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.67|P-value:1.16E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.91|P-value:7.45E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:3.14|P-value:7.78E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.29|P-value:7.29E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.12|P-value:8.33E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:7.81|P-value:3.97E-15 ID:SGTC_644|Compound:1498-1197|FD-Score:3.18|P-value:6.91E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:-3.66|P-value:1.97E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.21|P-value:9.70E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.50|P-value:2.14E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.45|P-value:2.69E-8 ID:SGTC_854|Compound:0422-0053|FD-Score:3.97|P-value:3.40E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.21|P-value:6.25E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:6.52|P-value:4.17E-11 ID:SGTC_1020|Compound:4335-0961|FD-Score:5.19|P-value:1.09E-7 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.09|P-value:9.11E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.90|P-value:4.78E-7 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.24|P-value:5.57E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.16|P-value:7.25E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.45|P-value:2.66E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.36|P-value:3.62E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:-3.35|P-value:5.98E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:4.17|P-value:1.49E-5 ID:SGTC_1521|Compound:st012942|FD-Score:4.54|P-value:2.78E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.13|P-value:8.00E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.62|P-value:1.90E-6 ID:SGTC_1618|Compound:st003135|FD-Score:4.02|P-value:2.82E-5 ID:SGTC_1635|Compound:st007035|FD-Score:6.39|P-value:9.67E-11 ID:SGTC_1721|Compound:st082152|FD-Score:3.75|P-value:8.43E-5 ID:SGTC_1768|Compound:st044301|FD-Score:3.10|P-value:8.82E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.58|P-value:6.37E-14 ID:SGTC_1845|Compound:st056753|FD-Score:4.28|P-value:8.90E-6 ID:SGTC_1849|Compound:st056239|FD-Score:3.26|P-value:5.10E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.31|P-value:7.78E-6 ID:SGTC_2063|Compound:5246145|FD-Score:4.21|P-value:1.26E-5 ID:SGTC_2191|Compound:5911152|FD-Score:3.23|P-value:5.74E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.48|P-value:3.70E-6 ID:SGTC_2314|Compound:7727897|FD-Score:-5.74|P-value:1.13E-8 ID:SGTC_2329|Compound:6138490|FD-Score:3.91|P-value:4.46E-5 ID:SGTC_2336|Compound:9001819|FD-Score:4.42|P-value:4.86E-6 ID:SGTC_2473|Compound:5854593|FD-Score:3.13|P-value:8.16E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-5.51|P-value:3.90E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.24|P-value:8.63E-4 ID:SGTC_2850|Compound:9015429|FD-Score:-3.31|P-value:7.03E-4 ID:SGTC_2865|Compound:9030313|FD-Score:-4.31|P-value:1.42E-5 ID:SGTC_2875|Compound:9039966|FD-Score:-5.01|P-value:5.39E-7 ID:SGTC_2877|Compound:9040724|FD-Score:-4.57|P-value:4.43E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-5.36|P-value:8.98E-8 ID:SGTC_2900|Compound:5328528|FD-Score:3.07|P-value:9.87E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.48|P-value:2.36E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-4.04|P-value:4.46E-5 ID:SGTC_3164|Compound:9100705|FD-Score:3.08|P-value:9.64E-4

Top fitness defect scores for YOR305W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_134 0269-0018 16.90 6.9 µM 2.75E-63 13 1.58E-64
2 SGTC_236 1509-0011 10.20 5.3 µM 1.82E-24 192 8.32E-25
3 SGTC_625 k213-0058 7.81 121.0 µM 3.97E-15 translation 13 2.84E-15
4 SGTC_168 3970-0862 7.69 530.5 µM 1.03E-14 21 7.53E-15
5 SGTC_70 0141-0289 7.60 43.3 µM 2.04E-14 mitochondrial stress 44 1.51E-14
6 SGTC_116 0155-0182 6.84 31.8 µM 4.70E-12 mitochondrial response to ROS 16 3.83E-12
7 SGTC_1017 4239-0030 6.52 168.0 µM 4.17E-11 3 3.54E-11
8 SGTC_1635 st007035 6.39 42.4 µM 9.67E-11 131 8.33E-11
9 SGTC_66 0109-0187 6.16 42.4 µM 4.00E-10 11 3.53E-10
10 SGTC_800 3448-7362 5.45 155.0 µM 2.69E-8 translation 68 2.55E-8
11 SGTC_119 0121-0043 5.25 24.8 µM 8.04E-8 mitochondrial stress 48 7.74E-8
12 SGTC_1020 4335-0961 5.19 93.3 µM 1.09E-7 2 1.05E-7
13 SGTC_1024 4507-0395 4.90 26.0 µM 4.78E-7 TSC3-RPN4 12 4.73E-7
14 SGTC_157 1348-1695 4.89 65.8 µM 5.17E-7 iron homeostasis 36 5.11E-7
15 SGTC_141 0443-0274 4.80 32.3 µM 7.78E-7 mitochondrial response to ROS 25 7.74E-7
16 SGTC_310 1273-0058 4.64 1.1 µM 1.71E-6 mitochondrial stress 200 1.72E-6
17 SGTC_1604 st002052 4.62 72.4 µM 1.90E-6 TSC3-RPN4 17 1.92E-6
18 SGTC_1521 st012942 4.54 49.4 µM 2.78E-6 21 2.82E-6
19 SGTC_2307 7538926 4.48 6.3 µM 3.70E-6 24 3.77E-6
20 SGTC_2336 9001819 4.42 198.7 µM 4.86E-6 heme biosynthesis & mitochondrial translocase 36 4.96E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.488 4.40E-200 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.466 2.38E-180 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.441 4.70E-160 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.438 2.18E-157 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.414 3.26E-139 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.406 1.64E-133 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.402 2.38E-130 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.396 3.74E-126 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.391 2.73E-123 YHL004W MRP4 hom Mitochondrial ribosomal protein of the small subunit
0.391 8.19E-123 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.387 1.79E-120 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.386 3.68E-119 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.385 5.46E-119 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.382 3.06E-117 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.382 4.31E-117 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii