YOR307C / SLY41

Protein involved in ER-to-Golgi transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR307C / SLY41

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:3.34|P-value:5.04E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.58|P-value:2.09E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.76|P-value:8.04E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.58|P-value:2.10E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.01|P-value:3.74E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.64|P-value:1.68E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.57|P-value:1.65E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.60|P-value:1.91E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.39|P-value:3.23E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.58|P-value:2.08E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.79|P-value:9.30E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.36|P-value:3.68E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.26|P-value:9.74E-8 ID:SGTC_1622|Compound:st003707|FD-Score:-3.21|P-value:6.07E-4 ID:SGTC_1794|Compound:st048918|FD-Score:4.97|P-value:4.48E-7 ID:SGTC_1799|Compound:st045822|FD-Score:-3.22|P-value:5.97E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.84|P-value:5.73E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.71|P-value:1.24E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.17|P-value:6.97E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.14|P-value:7.84E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.52|P-value:4.06E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.76|P-value:1.05E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.58|P-value:2.11E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-5.47|P-value:2.07E-8 ID:SGTC_2341|Compound:7987486|FD-Score:4.23|P-value:1.47E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.25|P-value:6.92E-4 ID:SGTC_2469|Compound:5655019|FD-Score:4.83|P-value:8.89E-7 ID:SGTC_2691|Compound:st077356|FD-Score:-3.31|P-value:4.30E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.76|P-value:1.03E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:7.84|P-value:3.88E-15 ID:SGTC_2801|Compound:7907800|FD-Score:3.81|P-value:8.60E-5 ID:SGTC_2983|Compound:9022671|FD-Score:3.66|P-value:1.55E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.56|P-value:2.27E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.77|P-value:1.20E-6 ID:SGTC_3123|Compound:9126162|FD-Score:-5.47|P-value:2.13E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-4.02|P-value:2.74E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.22|P-value:7.62E-4 ID:SGTC_3228|Compound:9131799|FD-Score:-3.12|P-value:8.48E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-3.53|P-value:1.90E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.34|P-value:5.04E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.58|P-value:2.09E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:-3.76|P-value:8.04E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:3.58|P-value:2.10E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:4.01|P-value:3.74E-5 ID:SGTC_738|Compound:1315-0003|FD-Score:3.64|P-value:1.68E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:-3.57|P-value:1.65E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.60|P-value:1.91E-4 ID:SGTC_918|Compound:glabranin|FD-Score:-3.39|P-value:3.23E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.58|P-value:2.08E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.79|P-value:9.30E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.36|P-value:3.68E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:3.75|P-value:1.08E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.26|P-value:9.74E-8 ID:SGTC_1622|Compound:st003707|FD-Score:-3.21|P-value:6.07E-4 ID:SGTC_1794|Compound:st048918|FD-Score:4.97|P-value:4.48E-7 ID:SGTC_1799|Compound:st045822|FD-Score:-3.22|P-value:5.97E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:-3.84|P-value:5.73E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.71|P-value:1.24E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.17|P-value:6.97E-4 ID:SGTC_2080|Compound:5212524|FD-Score:-3.14|P-value:7.84E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:4.52|P-value:4.06E-6 ID:SGTC_2255|Compound:7941087|FD-Score:3.76|P-value:1.05E-4 ID:SGTC_2258|Compound:7960471|FD-Score:3.58|P-value:2.11E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-5.47|P-value:2.07E-8 ID:SGTC_2341|Compound:7987486|FD-Score:4.23|P-value:1.47E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.25|P-value:6.92E-4 ID:SGTC_2469|Compound:5655019|FD-Score:4.83|P-value:8.89E-7 ID:SGTC_2691|Compound:st077356|FD-Score:-3.31|P-value:4.30E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.76|P-value:1.03E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:7.84|P-value:3.88E-15 ID:SGTC_2801|Compound:7907800|FD-Score:3.81|P-value:8.60E-5 ID:SGTC_2983|Compound:9022671|FD-Score:3.66|P-value:1.55E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.56|P-value:2.27E-4 ID:SGTC_2996|Compound:9066192|FD-Score:4.77|P-value:1.20E-6 ID:SGTC_3123|Compound:9126162|FD-Score:-5.47|P-value:2.13E-8 ID:SGTC_3134|Compound:9127454|FD-Score:-4.02|P-value:2.74E-5 ID:SGTC_3217|Compound:9129673|FD-Score:3.22|P-value:7.62E-4 ID:SGTC_3228|Compound:9131799|FD-Score:-3.12|P-value:8.48E-4 ID:SGTC_3255|Compound:9139072|FD-Score:-3.53|P-value:1.90E-4

Top fitness defect scores for YOR307C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2768 sulfasalazine 7.84 50.2 µM 3.88E-15 1 2.25E-15
2 SGTC_1514 1189-1591 5.26 158.0 µM 9.74E-8 16 7.12E-8
3 SGTC_1794 st048918 4.97 76.9 µM 4.48E-7 5 3.36E-7
4 SGTC_2469 5655019 4.83 90.8 µM 8.89E-7 11 6.72E-7
5 SGTC_2996 9066192 4.77 71.4 µM 1.20E-6 11 9.08E-7
6 SGTC_2252 omeprazole 4.52 400.0 µM 4.06E-6 4 3.15E-6
7 SGTC_2341 7987486 4.23 176.7 µM 1.47E-5 15 1.16E-5
8 SGTC_366 0181-0206 4.01 4.3 µM 3.74E-5 Golgi 39 3.00E-5
9 SGTC_2801 7907800 3.81 81.8 µM 8.60E-5 31 7.00E-5
10 SGTC_1008 4106-0037 3.79 6.0 µM 9.30E-5 PDR1 23 7.57E-5
11 SGTC_2703 st077852 3.76 53.4 µM 1.03E-4 30 8.42E-5
12 SGTC_2255 7941087 3.76 197.4 µM 1.05E-4 35 8.56E-5
13 SGTC_1491 4138-0063 3.75 26.5 µM 1.08E-4 14 8.84E-5
14 SGTC_2056 5235370 3.71 200.0 µM 1.24E-4 51 1.02E-4
15 SGTC_2983 9022671 3.66 13.0 µM 1.55E-4 60S ribosome export 19 1.27E-4
16 SGTC_738 1315-0003 3.64 72.4 µM 1.68E-4 35 1.38E-4
17 SGTC_824 1304-0008 3.60 100.0 µM 1.91E-4 DNA damage response 49 1.58E-4
18 SGTC_972 1319-0219 3.58 195.0 µM 2.08E-4 46 1.71E-4
19 SGTC_89 0302-0250 3.58 142.1 µM 2.09E-4 33 1.73E-4
20 SGTC_184 1494-0393 3.58 24.7 µM 2.10E-4 79 1.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.01E-8 YJL217W REE1 hom Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle
0.093 6.20E-8 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.089 2.25E-7 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.088 3.05E-7 YDL219W DTD1 hom D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
0.088 3.37E-7 YMR085W_p YMR085W_p hom Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.085 9.44E-7 YLR326W_p YLR326W_p hom Putative protein of unknown function, predicted to be palmitoylated
0.082 1.86E-6 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.077 8.20E-6 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.076 1.11E-5 YCR023C YCR023C hom Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.075 1.25E-5 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.074 1.94E-5 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.072 3.06E-5 YDR279W RNH202 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome
0.072 3.10E-5 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.071 3.90E-5 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.070 4.51E-5 YGL007C-A_p YGL007C-A_p hom Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding