YOR313C / SPS4

Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR313C / SPS4

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:3.46|P-value:2.18E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.14|P-value:7.04E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.38|P-value:2.56E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.49|P-value:1.90E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.45|P-value:2.23E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.77|P-value:5.90E-7 ID:SGTC_196|Compound:k015-0023|FD-Score:3.38|P-value:2.87E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.20|P-value:5.62E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:5.59|P-value:5.89E-9 ID:SGTC_656|Compound:4090-1979|FD-Score:4.72|P-value:7.58E-7 ID:SGTC_795|Compound:0685-0265|FD-Score:7.99|P-value:1.76E-16 ID:SGTC_796|Compound:1234-0020|FD-Score:-4.02|P-value:1.76E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:6.85|P-value:1.41E-12 ID:SGTC_822|Compound:1487-0950|FD-Score:-5.42|P-value:1.29E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:-7.34|P-value:2.49E-14 ID:SGTC_833|Compound:3852-0053|FD-Score:3.68|P-value:8.94E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.69|P-value:8.69E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.95|P-value:2.31E-7 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.02|P-value:9.33E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-3.16|P-value:5.75E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.77|P-value:5.32E-5 ID:SGTC_1842|Compound:st055362|FD-Score:-3.01|P-value:9.69E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.07|P-value:7.95E-4 ID:SGTC_1968|Compound:st069590|FD-Score:5.82|P-value:1.50E-9 ID:SGTC_1999|Compound:st074831|FD-Score:3.53|P-value:1.66E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-7.28|P-value:4.09E-14 ID:SGTC_2019|Compound:4016004|FD-Score:-4.37|P-value:3.59E-6 ID:SGTC_2037|Compound:5169046|FD-Score:-3.02|P-value:9.27E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.84|P-value:3.98E-5 ID:SGTC_2189|Compound:6047310|FD-Score:3.08|P-value:8.62E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.51|P-value:1.53E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.04|P-value:9.92E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.01|P-value:9.65E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.27|P-value:3.84E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.26|P-value:4.54E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.62|P-value:1.17E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.30|P-value:3.44E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.71|P-value:6.73E-5 ID:SGTC_2551|Compound:apiole|FD-Score:3.81|P-value:5.27E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.95|P-value:2.86E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.71|P-value:7.92E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.71|P-value:6.94E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.63|P-value:1.20E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.88|P-value:2.62E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.17|P-value:6.74E-8 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.23|P-value:4.46E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.10|P-value:7.10E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.54|P-value:1.58E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.00|P-value:1.72E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-3.32|P-value:3.14E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.70|P-value:8.16E-5 ID:SGTC_3013|Compound:9080133|FD-Score:4.48|P-value:2.48E-6 ID:SGTC_3213|Compound:9129884|FD-Score:3.20|P-value:5.63E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-4.31|P-value:4.65E-6 ID:SGTC_20|Compound:0481-0013|FD-Score:3.46|P-value:2.18E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.14|P-value:7.04E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.38|P-value:2.56E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:3.49|P-value:1.90E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.45|P-value:2.23E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.77|P-value:5.90E-7 ID:SGTC_196|Compound:k015-0023|FD-Score:3.38|P-value:2.87E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.20|P-value:5.62E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:5.59|P-value:5.89E-9 ID:SGTC_656|Compound:4090-1979|FD-Score:4.72|P-value:7.58E-7 ID:SGTC_795|Compound:0685-0265|FD-Score:7.99|P-value:1.76E-16 ID:SGTC_796|Compound:1234-0020|FD-Score:-4.02|P-value:1.76E-5 ID:SGTC_814|Compound:3342-0569|FD-Score:6.85|P-value:1.41E-12 ID:SGTC_822|Compound:1487-0950|FD-Score:-5.42|P-value:1.29E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:-7.34|P-value:2.49E-14 ID:SGTC_833|Compound:3852-0053|FD-Score:3.68|P-value:8.94E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.69|P-value:8.69E-5 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.95|P-value:2.31E-7 ID:SGTC_1358|Compound:1509-0022|FD-Score:-3.02|P-value:9.33E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.47|P-value:2.06E-4 ID:SGTC_1749|Compound:st037932|FD-Score:-3.16|P-value:5.75E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.77|P-value:5.32E-5 ID:SGTC_1842|Compound:st055362|FD-Score:-3.01|P-value:9.69E-4 ID:SGTC_1954|Compound:st077032|FD-Score:-3.07|P-value:7.95E-4 ID:SGTC_1968|Compound:st069590|FD-Score:5.82|P-value:1.50E-9 ID:SGTC_1999|Compound:st074831|FD-Score:3.53|P-value:1.66E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-7.28|P-value:4.09E-14 ID:SGTC_2019|Compound:4016004|FD-Score:-4.37|P-value:3.59E-6 ID:SGTC_2037|Compound:5169046|FD-Score:-3.02|P-value:9.27E-4 ID:SGTC_2044|Compound:5102272|FD-Score:-3.84|P-value:3.98E-5 ID:SGTC_2189|Compound:6047310|FD-Score:3.08|P-value:8.62E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.51|P-value:1.53E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.04|P-value:9.92E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.01|P-value:9.65E-4 ID:SGTC_2354|Compound:9060492|FD-Score:-3.27|P-value:3.84E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:3.26|P-value:4.54E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:3.62|P-value:1.17E-4 ID:SGTC_2547|Compound:epiafzelechin trimethyl ether|FD-Score:-3.30|P-value:3.44E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:-3.71|P-value:6.73E-5 ID:SGTC_2551|Compound:apiole|FD-Score:3.81|P-value:5.27E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.95|P-value:2.86E-5 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.71|P-value:7.92E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.71|P-value:6.94E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.63|P-value:1.20E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.88|P-value:2.62E-7 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.17|P-value:6.74E-8 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.23|P-value:4.46E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.10|P-value:7.10E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.54|P-value:1.58E-4 ID:SGTC_2824|Compound:7998404|FD-Score:5.00|P-value:1.72E-7 ID:SGTC_2874|Compound:9043904|FD-Score:-3.32|P-value:3.14E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.70|P-value:8.16E-5 ID:SGTC_3013|Compound:9080133|FD-Score:4.48|P-value:2.48E-6 ID:SGTC_3213|Compound:9129884|FD-Score:3.20|P-value:5.63E-4 ID:SGTC_3238|Compound:9133470|FD-Score:-4.31|P-value:4.65E-6

Top fitness defect scores for YOR313C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_795 0685-0265 7.99 78.0 µM 1.76E-16 excess fatty acid 3 6.82E-16
2 SGTC_814 3342-0569 6.85 96.0 µM 1.41E-12 2 3.76E-12
3 SGTC_1968 st069590 5.82 43.6 µM 1.50E-9 2 3.01E-9
4 SGTC_600 1495-0418 5.59 41.6 µM 5.89E-9 RPP1 & pyrimidine depletion 3 1.12E-8
5 SGTC_2566 crystal violet carbinol 5.17 226.0 nM 6.74E-8 17 1.16E-7
6 SGTC_2824 7998404 5.00 52.0 µM 1.72E-7 14 2.84E-7
7 SGTC_1352 1496-0991 4.95 99.0 µM 2.31E-7 tubulin folding & SWR complex 13 3.79E-7
8 SGTC_180 1486-1293 4.77 102.8 µM 5.90E-7 25 9.31E-7
9 SGTC_656 4090-1979 4.72 187.0 µM 7.58E-7 7 1.18E-6
10 SGTC_2562 3',7'-dimethoxyflavone 4.63 64.9 µM 1.20E-6 14 1.84E-6
11 SGTC_3013 9080133 4.48 71.4 µM 2.48E-6 10 3.69E-6
12 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.95 66.7 µM 2.86E-5 25 3.88E-5
13 SGTC_2551 apiole 3.81 73.9 µM 5.27E-5 9 6.98E-5
14 SGTC_2560 caryophyllene 3.71 100.0 µM 7.92E-5 23 1.03E-4
15 SGTC_3011 9081274 3.70 71.4 µM 8.16E-5 23 1.06E-4
16 SGTC_1145 3546-0597 3.69 10.2 µM 8.69E-5 mitochondrial processes 23 1.13E-4
17 SGTC_833 3852-0053 3.68 558.0 µM 8.94E-5 19 1.16E-4
18 SGTC_2529 gangaleoidin 3.62 93.6 µM 1.17E-4 26 1.50E-4
19 SGTC_2004 4023728 3.58 41.9 µM 1.34E-4 37 1.71E-4
20 SGTC_2788 5282734 3.54 71.4 µM 1.58E-4 66 2.01E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.92E-12 YLR146C SPE4 hom Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
0.105 9.05E-10 YNL245C CWC25 het Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p
0.096 2.36E-8 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.088 2.97E-7 YLL053C_p YLL053C_p hom Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
0.088 3.04E-7 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.080 3.43E-6 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.080 3.90E-6 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.077 8.01E-6 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.077 8.06E-6 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.076 9.18E-6 YJR141W_p YJR141W_p het Essential protein of unknown function
0.074 1.64E-5 YAL056W GPB2 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication
0.074 1.79E-5 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.073 2.28E-5 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.072 2.64E-5 YGL057C GEP7 hom Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.071 3.44E-5 YPL108W_p YPL108W_p hom Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS