YOR315W / SFG1

Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR315W / SFG1

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:3.46|P-value:1.70E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.72|P-value:5.87E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.20|P-value:4.56E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.41|P-value:2.12E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-4.10|P-value:1.10E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.57|P-value:1.08E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.43|P-value:1.90E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:4.35|P-value:3.29E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.01|P-value:9.09E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.58|P-value:1.04E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:-3.39|P-value:2.24E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.18|P-value:4.90E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.03|P-value:8.57E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:4.19|P-value:7.24E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:6.51|P-value:8.11E-12 ID:SGTC_928|Compound:2764-0428|FD-Score:3.88|P-value:2.95E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:3.10|P-value:6.59E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-6.64|P-value:2.94E-12 ID:SGTC_947|Compound:3447-0010|FD-Score:3.68|P-value:7.11E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:4.53|P-value:1.39E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.55|P-value:1.16E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.42|P-value:2.00E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.61|P-value:9.49E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.61|P-value:9.34E-5 ID:SGTC_1752|Compound:st044819|FD-Score:3.27|P-value:3.55E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.29|P-value:3.20E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.22|P-value:4.31E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-4.12|P-value:9.66E-6 ID:SGTC_2329|Compound:6138490|FD-Score:-3.45|P-value:1.78E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.16|P-value:5.41E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.97|P-value:1.94E-5 ID:SGTC_2556|Compound:citropten|FD-Score:3.67|P-value:7.18E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.11|P-value:6.48E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.09|P-value:6.88E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.54|P-value:1.20E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.13|P-value:5.94E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.46|P-value:1.70E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.72|P-value:5.87E-5 ID:SGTC_170|Compound:4197-0004|FD-Score:3.20|P-value:4.56E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.41|P-value:2.12E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:-4.10|P-value:1.10E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.57|P-value:1.08E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.43|P-value:1.90E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:4.35|P-value:3.29E-6 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.01|P-value:9.09E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:3.58|P-value:1.04E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:-3.39|P-value:2.24E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:-3.18|P-value:4.90E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-3.03|P-value:8.57E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:4.19|P-value:7.24E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:6.51|P-value:8.11E-12 ID:SGTC_928|Compound:2764-0428|FD-Score:3.88|P-value:2.95E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:3.10|P-value:6.59E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:-6.64|P-value:2.94E-12 ID:SGTC_947|Compound:3447-0010|FD-Score:3.68|P-value:7.11E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:4.53|P-value:1.39E-6 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.55|P-value:1.16E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.42|P-value:2.00E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.61|P-value:9.49E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.61|P-value:9.34E-5 ID:SGTC_1752|Compound:st044819|FD-Score:3.27|P-value:3.55E-4 ID:SGTC_1970|Compound:st070122|FD-Score:-3.29|P-value:3.20E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.22|P-value:4.31E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-4.12|P-value:9.66E-6 ID:SGTC_2329|Compound:6138490|FD-Score:-3.45|P-value:1.78E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.16|P-value:5.41E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.97|P-value:1.94E-5 ID:SGTC_2556|Compound:citropten|FD-Score:3.67|P-value:7.18E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.11|P-value:6.48E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.09|P-value:6.88E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.54|P-value:1.20E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.13|P-value:5.94E-4

Top fitness defect scores for YOR315W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_927 2425-1185 6.51 123.0 µM 8.11E-12 4 3.85E-11
2 SGTC_972 1319-0219 4.53 195.0 µM 1.39E-6 12 3.00E-6
3 SGTC_642 0335-0876 4.35 158.0 µM 3.29E-6 ubiquinone biosynthesis & proteasome 32 6.69E-6
4 SGTC_856 0433-0016 4.19 11.3 µM 7.24E-6 12 1.40E-5
5 SGTC_928 2764-0428 3.88 58.7 µM 2.95E-5 cell wall 61 5.22E-5
6 SGTC_145 3737-0113 3.72 38.4 µM 5.87E-5 DNA intercalators 83 9.93E-5
7 SGTC_947 3447-0010 3.68 211.0 µM 7.11E-5 19 1.19E-4
8 SGTC_2556 citropten 3.67 84.6 µM 7.18E-5 30 1.20E-4
9 SGTC_1355 1499-0035 3.61 1.7 µM 9.34E-5 26 1.53E-4
10 SGTC_1049 3226-0134 3.61 66.0 µM 9.49E-5 41 1.56E-4
11 SGTC_758 0868-0029 3.58 16.0 µM 1.04E-4 10 1.69E-4
12 SGTC_481 bay k-8644 3.58 50.0 µM 1.07E-4 29 1.74E-4
13 SGTC_804 1595-0054 3.50 20.9 µM 1.45E-4 sphingolipid biosynthesis & PDR1 56 2.32E-4
14 SGTC_101 0490-5701 3.46 117.5 µM 1.70E-4 29 2.68E-4
15 SGTC_453 enantio-paf c16 3.43 10.0 µM 1.90E-4 190 2.98E-4
16 SGTC_1031 k035-0009 3.42 16.0 µM 2.00E-4 50 3.13E-4
17 SGTC_402 epigallocatechin gallate 3.41 10.0 µM 2.12E-4 55 3.31E-4
18 SGTC_1752 st044819 3.27 83.0 µM 3.55E-4 42 5.36E-4
19 SGTC_2198 6589944 3.22 200.0 µM 4.31E-4 29 6.43E-4
20 SGTC_170 4197-0004 3.20 226.0 µM 4.56E-4 39 6.78E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.10E-15 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
0.112 6.57E-11 YPL260W YPL260W hom Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress
0.095 3.23E-8 YKR064W OAF3 hom Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.095 3.11E-8 YGR024C THG1 het tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
0.091 1.40E-7 YOR337W TEA1 hom Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
0.090 1.72E-7 YOR111W_p YOR111W_p hom Putative protein of unknown function
0.089 2.32E-7 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.70E-7 YOR214C_p YOR214C_p hom Putative protein of unknown function; YOR214C is not an essential gene
0.087 5.06E-7 YER115C SPR6 hom Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation
0.082 1.91E-6 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.079 5.12E-6 YLL004W ORC3 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.078 6.13E-6 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.075 1.22E-5 YGL101W_p YGL101W_p hom Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
0.075 1.29E-5 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.074 1.99E-5 YDL188C PPH22 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication