YOR316C-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR316C-A / YOR316C-A

Click on Significant Values for Screen Details ID:SGTC_139|Compound:0099-0334|FD-Score:-5.83|P-value:2.07E-10 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.92|P-value:1.36E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:2.86|P-value:9.48E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.64|P-value:2.56E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.34|P-value:1.72E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:5.29|P-value:4.97E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:3.03|P-value:4.96E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:4.44|P-value:7.46E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:4.02|P-value:6.51E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:2.95|P-value:6.63E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.15|P-value:3.46E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:2.92|P-value:7.60E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:2.97|P-value:6.27E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.91|P-value:5.15E-8 ID:SGTC_1115|Compound:galangin|FD-Score:3.12|P-value:3.57E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-2.98|P-value:7.38E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.36|P-value:1.64E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.92|P-value:9.01E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.35|P-value:1.74E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.37|P-value:3.07E-9 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.50|P-value:5.50E-7 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.94|P-value:6.99E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.94|P-value:1.24E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.53|P-value:8.10E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:2.91|P-value:7.83E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.15|P-value:3.14E-4 ID:SGTC_2073|Compound:5212005|FD-Score:5.10|P-value:1.64E-8 ID:SGTC_2167|Compound:5876490|FD-Score:3.32|P-value:1.57E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-2.98|P-value:7.44E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.08|P-value:4.17E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.41|P-value:1.32E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.41|P-value:1.32E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.72|P-value:2.73E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.28|P-value:1.88E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.31|P-value:2.00E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.26|P-value:1.94E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.16|P-value:2.97E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.98|P-value:1.03E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.73|P-value:1.51E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.92|P-value:1.34E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.25|P-value:2.11E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.40|P-value:1.13E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.07|P-value:4.27E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:-5.83|P-value:2.07E-10 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.92|P-value:1.36E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:2.86|P-value:9.48E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.64|P-value:2.56E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.34|P-value:1.72E-6 ID:SGTC_566|Compound:0958-0068|FD-Score:5.29|P-value:4.97E-9 ID:SGTC_568|Compound:1193-0097|FD-Score:3.03|P-value:4.96E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:4.44|P-value:7.46E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:4.02|P-value:6.51E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:2.95|P-value:6.63E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.15|P-value:3.46E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:2.92|P-value:7.60E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:2.97|P-value:6.27E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.91|P-value:5.15E-8 ID:SGTC_1115|Compound:galangin|FD-Score:3.12|P-value:3.57E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:-2.98|P-value:7.38E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:-3.36|P-value:1.64E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:-2.92|P-value:9.01E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:-3.35|P-value:1.74E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.37|P-value:3.07E-9 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.50|P-value:5.50E-7 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.94|P-value:6.99E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.94|P-value:1.24E-5 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.53|P-value:8.10E-5 ID:SGTC_1624|Compound:st003710|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1635|Compound:st007035|FD-Score:2.91|P-value:7.83E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.15|P-value:3.14E-4 ID:SGTC_2073|Compound:5212005|FD-Score:5.10|P-value:1.64E-8 ID:SGTC_2167|Compound:5876490|FD-Score:3.32|P-value:1.57E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-2.98|P-value:7.44E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.08|P-value:4.17E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.41|P-value:1.32E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.41|P-value:1.32E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.72|P-value:2.73E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.28|P-value:1.88E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.31|P-value:2.00E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.26|P-value:1.94E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.16|P-value:2.97E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:-3.98|P-value:1.03E-5 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.73|P-value:1.51E-7 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.92|P-value:1.34E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.25|P-value:2.11E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.40|P-value:1.13E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.07|P-value:4.27E-4

Top fitness defect scores for YOR316C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1255 0566-0045 5.37 221.0 µM 3.07E-9 excess fatty acid 8 3.93E-8
2 SGTC_566 0958-0068 5.29 16.5 µM 4.97E-9 RSC & ERG11 7 5.95E-8
3 SGTC_2073 5212005 5.10 126.0 µM 1.64E-8 2 1.66E-7
4 SGTC_945 3381-0768 4.91 11.3 µM 5.15E-8 endomembrane recycling 15 4.47E-7
5 SGTC_2770 toltrazuril 4.73 17.5 µM 1.51E-7 9 1.13E-6
6 SGTC_236 1509-0011 4.64 5.3 µM 2.56E-7 349 1.78E-6
7 SGTC_1256 0570-0116 4.50 285.0 µM 5.50E-7 8 3.44E-6
8 SGTC_623 k072-0108 4.44 16.9 µM 7.46E-7 heme biosynthesis & mitochondrial translocase 7 4.47E-6
9 SGTC_2759 disulfiram 4.26 3.4 µM 1.94E-6 19 1.02E-5
10 SGTC_773 4358-1457 4.15 44.6 µM 3.46E-6 39 1.68E-5
11 SGTC_634 1611-4317 4.02 11.2 µM 6.51E-6 ERG2 14 2.89E-5
12 SGTC_2520 obtusaquinone 3.72 4.7 µM 2.73E-5 25 9.98E-5
13 SGTC_2808 7946468 3.40 45.5 µM 1.13E-4 48 3.40E-4
14 SGTC_2167 5876490 3.32 200.0 µM 1.57E-4 58 4.51E-4
15 SGTC_2574 2',4'-dihydroxychalcone 3.28 14.6 µM 1.88E-4 40 5.27E-4
16 SGTC_2807 7945238 3.25 52.0 µM 2.11E-4 64 5.82E-4
17 SGTC_1624 st003710 3.18 6.2 µM 2.78E-4 calcium & mitochondrial duress 77 7.39E-4
18 SGTC_2763 lisinopril 3.16 49.3 µM 2.97E-4 28 7.82E-4
19 SGTC_1940 st075990 3.15 51.1 µM 3.14E-4 60S ribosome export 55 8.21E-4
20 SGTC_1115 galangin 3.12 695.7 nM 3.57E-4 RPP1 & pyrimidine depletion 46 9.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.172 1.47E-23 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.152 6.74E-19 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.145 2.63E-17 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.145 4.07E-17 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.143 9.28E-17 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.143 1.06E-16 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.142 1.11E-16 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.137 1.39E-15 YPL277C_p YPL277C_p hom Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels
0.137 1.66E-15 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.135 4.77E-15 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.134 8.01E-15 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.131 2.70E-14 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.131 2.88E-14 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.130 4.13E-14 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.129 7.92E-14 YOL027C MDM38 hom Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome