YOR318C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR318C / YOR318C

Click on Significant Values for Screen Details ID:SGTC_258|Compound:haloperidol|FD-Score:3.92|P-value:2.09E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:3.62|P-value:7.70E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:3.11|P-value:5.76E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.25|P-value:3.40E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.16|P-value:4.83E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.23|P-value:3.78E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:6.75|P-value:8.20E-13 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.93|P-value:1.76E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:4.80|P-value:2.65E-7 ID:SGTC_828|Compound:2074-0507|FD-Score:4.43|P-value:1.86E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:9.70|P-value:1.59E-24 ID:SGTC_830|Compound:4076-0286|FD-Score:3.16|P-value:4.92E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.19|P-value:6.02E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:-5.16|P-value:2.93E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.13|P-value:5.46E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.84|P-value:3.00E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.06|P-value:1.14E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.80|P-value:2.57E-7 ID:SGTC_1152|Compound:3909-8331|FD-Score:-2.97|P-value:8.77E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.12|P-value:5.74E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.44|P-value:1.67E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.08|P-value:6.55E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.48|P-value:1.42E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-2.99|P-value:8.32E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.10|P-value:6.04E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.31|P-value:2.70E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.07|P-value:6.68E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-4.75|P-value:2.95E-7 ID:SGTC_1682|Compound:st012968|FD-Score:-3.63|P-value:6.65E-5 ID:SGTC_1691|Compound:st019933|FD-Score:2.98|P-value:9.27E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.82|P-value:2.97E-5 ID:SGTC_1728|Compound:st035614|FD-Score:4.14|P-value:7.54E-6 ID:SGTC_1746|Compound:st038117|FD-Score:3.19|P-value:4.29E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.57|P-value:8.50E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.39|P-value:2.19E-6 ID:SGTC_1892|Compound:st058411|FD-Score:-3.10|P-value:5.48E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.20|P-value:3.75E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.99|P-value:9.17E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.31|P-value:2.50E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.34|P-value:2.17E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.81|P-value:3.53E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.80|P-value:3.18E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.00|P-value:8.86E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.04|P-value:7.50E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.93|P-value:2.04E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.62|P-value:5.94E-7 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.70|P-value:5.49E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.42|P-value:1.78E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.66|P-value:6.00E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.29|P-value:2.72E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:2.98|P-value:9.39E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.82|P-value:3.32E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.04|P-value:7.62E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.89|P-value:2.46E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.88|P-value:2.56E-5 ID:SGTC_2905|Compound:7799065|FD-Score:3.86|P-value:2.77E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.99|P-value:8.94E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.83|P-value:3.10E-5 ID:SGTC_3102|Compound:9121669|FD-Score:3.15|P-value:4.97E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.79|P-value:3.74E-5 ID:SGTC_3215|Compound:9129942|FD-Score:4.38|P-value:2.36E-6 ID:SGTC_3293|Compound:9120939|FD-Score:3.41|P-value:1.85E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.92|P-value:2.09E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:3.62|P-value:7.70E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:3.11|P-value:5.76E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.25|P-value:3.40E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.16|P-value:4.83E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.23|P-value:3.78E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:6.75|P-value:8.20E-13 ID:SGTC_821|Compound:1114-0266|FD-Score:-3.93|P-value:1.76E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:4.80|P-value:2.65E-7 ID:SGTC_828|Compound:2074-0507|FD-Score:4.43|P-value:1.86E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:9.70|P-value:1.59E-24 ID:SGTC_830|Compound:4076-0286|FD-Score:3.16|P-value:4.92E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.19|P-value:6.02E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:-5.16|P-value:2.93E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.13|P-value:5.46E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.84|P-value:3.00E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:4.06|P-value:1.14E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.80|P-value:2.57E-7 ID:SGTC_1152|Compound:3909-8331|FD-Score:-2.97|P-value:8.77E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.12|P-value:5.74E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.44|P-value:1.67E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.08|P-value:6.55E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.48|P-value:1.42E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-2.99|P-value:8.32E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.10|P-value:6.04E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.31|P-value:2.70E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.07|P-value:6.68E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-4.75|P-value:2.95E-7 ID:SGTC_1682|Compound:st012968|FD-Score:-3.63|P-value:6.65E-5 ID:SGTC_1691|Compound:st019933|FD-Score:2.98|P-value:9.27E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-3.82|P-value:2.97E-5 ID:SGTC_1728|Compound:st035614|FD-Score:4.14|P-value:7.54E-6 ID:SGTC_1746|Compound:st038117|FD-Score:3.19|P-value:4.29E-4 ID:SGTC_1862|Compound:st057513|FD-Score:-3.57|P-value:8.50E-5 ID:SGTC_1886|Compound:st057356|FD-Score:4.39|P-value:2.19E-6 ID:SGTC_1892|Compound:st058411|FD-Score:-3.10|P-value:5.48E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.20|P-value:3.75E-4 ID:SGTC_2035|Compound:5154463|FD-Score:2.99|P-value:9.17E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.31|P-value:2.50E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-3.34|P-value:2.17E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.81|P-value:3.53E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.80|P-value:3.18E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.00|P-value:8.86E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.04|P-value:7.50E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.93|P-value:2.04E-5 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.62|P-value:5.94E-7 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.70|P-value:5.49E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.42|P-value:1.78E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.66|P-value:6.00E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-3.29|P-value:2.72E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:2.98|P-value:9.39E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.82|P-value:3.32E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.04|P-value:7.62E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.89|P-value:2.46E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.88|P-value:2.56E-5 ID:SGTC_2905|Compound:7799065|FD-Score:3.86|P-value:2.77E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.99|P-value:8.94E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.83|P-value:3.10E-5 ID:SGTC_3102|Compound:9121669|FD-Score:3.15|P-value:4.97E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.79|P-value:3.74E-5 ID:SGTC_3215|Compound:9129942|FD-Score:4.38|P-value:2.36E-6 ID:SGTC_3293|Compound:9120939|FD-Score:3.41|P-value:1.85E-4

Top fitness defect scores for YOR318C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_829 1635-0120 9.70 117.0 µM 1.59E-24 DNA damage response 6 1.50E-22
2 SGTC_817 1391-0715 6.75 46.0 µM 8.20E-13 1 7.36E-12
3 SGTC_1118 chelidonine 4.80 707.5 nM 2.57E-7 9 7.80E-7
4 SGTC_825 1988-2224 4.80 89.6 µM 2.65E-7 cell wall signaling 23 8.00E-7
5 SGTC_828 2074-0507 4.43 139.0 µM 1.86E-6 RPP1 & pyrimidine depletion 16 4.78E-6
6 SGTC_1886 st057356 4.39 49.9 µM 2.19E-6 60S ribosome export 9 5.55E-6
7 SGTC_3215 9129942 4.38 49.5 µM 2.36E-6 6 5.94E-6
8 SGTC_972 1319-0219 4.19 195.0 µM 6.02E-6 20 1.40E-5
9 SGTC_1728 st035614 4.14 33.8 µM 7.54E-6 38 1.72E-5
10 SGTC_1099 5-nonyloxytryptamine 4.06 2.9 µM 1.14E-5 15 2.51E-5
11 SGTC_2447 5741742 3.93 33.8 µM 2.04E-5 19 4.29E-5
12 SGTC_258 haloperidol 3.92 50.8 µM 2.09E-5 fatty acid desaturase (OLE1) 31 4.39E-5
13 SGTC_2827 7993847 3.89 71.4 µM 2.46E-5 28 5.09E-5
14 SGTC_2871 9038510 3.88 13.0 µM 2.56E-5 19 5.28E-5
15 SGTC_2905 7799065 3.86 20.1 µM 2.77E-5 14 5.67E-5
16 SGTC_1098 clofazimine 3.84 15.1 µM 3.00E-5 heme biosynthesis & mitochondrial translocase 25 6.11E-5
17 SGTC_3098 9119039 3.83 49.5 µM 3.10E-5 Golgi 37 6.29E-5
18 SGTC_2789 5281112 3.82 71.4 µM 3.32E-5 43 6.69E-5
19 SGTC_2055 5235184 3.81 200.0 µM 3.53E-5 ERG2 40 7.09E-5
20 SGTC_3153 9100258 3.79 49.5 µM 3.74E-5 24 7.48E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.152 7.50E-19 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.119 5.24E-12 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.118 6.17E-12 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.104 1.35E-9 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.103 2.17E-9 YKR003W OSH6 hom Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion
0.094 4.23E-8 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.089 2.76E-7 YOL006C TOP1 hom Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
0.088 3.58E-7 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.087 4.88E-7 YKL111C_d YKL111C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1
0.086 5.32E-7 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.086 6.45E-7 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.085 9.10E-7 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 9.34E-7 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.084 1.03E-6 YOR384W FRE5 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.084 1.05E-6 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G