YOR319W / HSH49

U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR319W / HSH49

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:5.76|P-value:2.63E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-4.62|P-value:3.68E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.51|P-value:8.30E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.55|P-value:5.06E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.79|P-value:4.07E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:7.26|P-value:1.58E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:6.07|P-value:1.00E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-5.18|P-value:8.09E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-4.31|P-value:8.11E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.75|P-value:4.52E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.38|P-value:3.70E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.17|P-value:1.49E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.82|P-value:3.81E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.50|P-value:8.47E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.44|P-value:9.83E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.07|P-value:1.02E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.43|P-value:3.82E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.75|P-value:4.57E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.66|P-value:5.65E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:8.08|P-value:6.05E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.94|P-value:2.77E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.31|P-value:2.28E-6 ID:SGTC_500|Compound:h-89|FD-Score:4.55|P-value:7.49E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.80|P-value:2.38E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:9.05|P-value:8.16E-11 ID:SGTC_632|Compound:0781-2353|FD-Score:6.43|P-value:3.16E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:4.85|P-value:3.49E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:4.54|P-value:7.73E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:5.07|P-value:1.96E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.72|P-value:4.93E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:6.86|P-value:6.86E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.51|P-value:8.31E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:5.54|P-value:5.17E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-5.06|P-value:1.14E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:7.92|P-value:1.16E-8 ID:SGTC_875|Compound:0709-0210|FD-Score:4.89|P-value:3.13E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:8.01|P-value:8.23E-9 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.23|P-value:6.92E-5 ID:SGTC_917|Compound:harmaline|FD-Score:6.86|P-value:6.92E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.76|P-value:4.39E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.49|P-value:2.56E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.80|P-value:4.01E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.65|P-value:3.69E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:8.92|P-value:1.48E-10 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.88|P-value:1.86E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.27|P-value:1.56E-7 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.02|P-value:2.22E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.49|P-value:8.65E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.88|P-value:3.26E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:5.96|P-value:1.43E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.26|P-value:9.02E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.87|P-value:3.27E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.78|P-value:2.50E-5 ID:SGTC_1638|Compound:st008370|FD-Score:5.98|P-value:1.34E-5 ID:SGTC_1649|Compound:st011737|FD-Score:-4.65|P-value:3.44E-4 ID:SGTC_1731|Compound:st035964|FD-Score:6.69|P-value:1.26E-6 ID:SGTC_1750|Compound:st081859|FD-Score:6.85|P-value:7.30E-7 ID:SGTC_1769|Compound:st044406|FD-Score:5.15|P-value:1.55E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.24|P-value:5.84E-6 ID:SGTC_1959|Compound:st077091|FD-Score:5.92|P-value:1.63E-5 ID:SGTC_1962|Compound:st076595|FD-Score:5.07|P-value:1.94E-4 ID:SGTC_1999|Compound:st074831|FD-Score:5.98|P-value:1.33E-5 ID:SGTC_2006|Compound:4011487|FD-Score:8.01|P-value:7.98E-9 ID:SGTC_2050|Compound:5263056|FD-Score:5.79|P-value:2.41E-5 ID:SGTC_2060|Compound:5238662|FD-Score:5.80|P-value:2.36E-5 ID:SGTC_2086|Compound:5274770|FD-Score:5.77|P-value:2.56E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.48|P-value:8.88E-4 ID:SGTC_2147|Compound:5545932|FD-Score:6.69|P-value:1.26E-6 ID:SGTC_2148|Compound:5546263|FD-Score:4.72|P-value:4.88E-4 ID:SGTC_2155|Compound:5570423|FD-Score:7.84|P-value:1.60E-8 ID:SGTC_2185|Compound:6113692|FD-Score:5.09|P-value:1.83E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.57|P-value:4.73E-5 ID:SGTC_2271|Compound:7849410|FD-Score:4.74|P-value:4.62E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.53|P-value:7.77E-4 ID:SGTC_2307|Compound:7538926|FD-Score:8.28|P-value:2.55E-9 ID:SGTC_2323|Compound:6148992|FD-Score:6.31|P-value:4.67E-6 ID:SGTC_2332|Compound:7982454|FD-Score:4.77|P-value:4.34E-4 ID:SGTC_2398|Compound:5228213|FD-Score:7.24|P-value:1.74E-7 ID:SGTC_2440|Compound:5628896|FD-Score:7.60|P-value:4.20E-8 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.15|P-value:1.57E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:6.48|P-value:2.58E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.91|P-value:2.95E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.49|P-value:8.57E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:6.87|P-value:6.67E-7 ID:SGTC_2671|Compound:danthron|FD-Score:6.39|P-value:3.55E-6 ID:SGTC_2694|Compound:st077685|FD-Score:5.08|P-value:1.90E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:6.91|P-value:5.87E-7 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.04|P-value:1.66E-7 ID:SGTC_2743|Compound:auranofin|FD-Score:6.99|P-value:4.32E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.87|P-value:6.79E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.68|P-value:1.79E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.37|P-value:6.96E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.27|P-value:1.13E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.20|P-value:1.36E-4 ID:SGTC_2829|Compound:7992743|FD-Score:5.66|P-value:3.57E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.90|P-value:3.04E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-7.15|P-value:1.09E-7 ID:SGTC_2913|Compound:7966556|FD-Score:-5.44|P-value:3.71E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-5.31|P-value:5.56E-5 ID:SGTC_2935|Compound:9038016|FD-Score:4.53|P-value:7.88E-4 ID:SGTC_2938|Compound:9059746|FD-Score:6.55|P-value:2.09E-6 ID:SGTC_2948|Compound:9070189|FD-Score:4.81|P-value:3.85E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.45|P-value:9.42E-4 ID:SGTC_3000|Compound:9075062|FD-Score:7.53|P-value:5.71E-8 ID:SGTC_3032|Compound:9089427|FD-Score:-5.41|P-value:4.10E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-4.97|P-value:1.43E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.64|P-value:5.95E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.95|P-value:1.47E-5 ID:SGTC_3294|Compound:9122953|FD-Score:4.45|P-value:9.45E-4 ID:SGTC_3308|Compound:9128332|FD-Score:8.10|P-value:5.54E-9 ID:SGTC_56|Compound:0957-0365|FD-Score:5.76|P-value:2.63E-5 ID:SGTC_57|Compound:miconazole|FD-Score:-4.62|P-value:3.68E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:4.51|P-value:8.30E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:5.55|P-value:5.06E-5 ID:SGTC_123|Compound:0083-0120|FD-Score:4.79|P-value:4.07E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:7.26|P-value:1.58E-7 ID:SGTC_149|Compound:3970-0822|FD-Score:6.07|P-value:1.00E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-5.18|P-value:8.09E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:-4.31|P-value:8.11E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.75|P-value:4.52E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.38|P-value:3.70E-6 ID:SGTC_237|Compound:nikkomycin|FD-Score:5.17|P-value:1.49E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.82|P-value:3.81E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:4.50|P-value:8.47E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.44|P-value:9.83E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:6.07|P-value:1.02E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.43|P-value:3.82E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.75|P-value:4.57E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:4.66|P-value:5.65E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:8.08|P-value:6.05E-9 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.94|P-value:2.77E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.31|P-value:2.28E-6 ID:SGTC_500|Compound:h-89|FD-Score:4.55|P-value:7.49E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.80|P-value:2.38E-5 ID:SGTC_590|Compound:k048-0076|FD-Score:9.05|P-value:8.16E-11 ID:SGTC_632|Compound:0781-2353|FD-Score:6.43|P-value:3.16E-6 ID:SGTC_669|Compound:0108-0021|FD-Score:4.85|P-value:3.49E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:4.54|P-value:7.73E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:5.07|P-value:1.96E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.72|P-value:4.93E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:6.86|P-value:6.86E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.51|P-value:8.31E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:5.54|P-value:5.17E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-5.06|P-value:1.14E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:7.92|P-value:1.16E-8 ID:SGTC_875|Compound:0709-0210|FD-Score:4.89|P-value:3.13E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:8.01|P-value:8.23E-9 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.23|P-value:6.92E-5 ID:SGTC_917|Compound:harmaline|FD-Score:6.86|P-value:6.92E-7 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.76|P-value:4.39E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.49|P-value:2.56E-6 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.80|P-value:4.01E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.65|P-value:3.69E-5 ID:SGTC_1097|Compound:itavastatin|FD-Score:8.92|P-value:1.48E-10 ID:SGTC_1113|Compound:artemisinin|FD-Score:-4.88|P-value:1.86E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.27|P-value:1.56E-7 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.02|P-value:2.22E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.49|P-value:8.65E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:4.88|P-value:3.26E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:5.96|P-value:1.43E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.26|P-value:9.02E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.87|P-value:3.27E-4 ID:SGTC_1623|Compound:st003709|FD-Score:5.78|P-value:2.50E-5 ID:SGTC_1638|Compound:st008370|FD-Score:5.98|P-value:1.34E-5 ID:SGTC_1649|Compound:st011737|FD-Score:-4.65|P-value:3.44E-4 ID:SGTC_1731|Compound:st035964|FD-Score:6.69|P-value:1.26E-6 ID:SGTC_1750|Compound:st081859|FD-Score:6.85|P-value:7.30E-7 ID:SGTC_1769|Compound:st044406|FD-Score:5.15|P-value:1.55E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.24|P-value:5.84E-6 ID:SGTC_1959|Compound:st077091|FD-Score:5.92|P-value:1.63E-5 ID:SGTC_1962|Compound:st076595|FD-Score:5.07|P-value:1.94E-4 ID:SGTC_1999|Compound:st074831|FD-Score:5.98|P-value:1.33E-5 ID:SGTC_2006|Compound:4011487|FD-Score:8.01|P-value:7.98E-9 ID:SGTC_2050|Compound:5263056|FD-Score:5.79|P-value:2.41E-5 ID:SGTC_2060|Compound:5238662|FD-Score:5.80|P-value:2.36E-5 ID:SGTC_2086|Compound:5274770|FD-Score:5.77|P-value:2.56E-5 ID:SGTC_2121|Compound:5257820|FD-Score:4.48|P-value:8.88E-4 ID:SGTC_2147|Compound:5545932|FD-Score:6.69|P-value:1.26E-6 ID:SGTC_2148|Compound:5546263|FD-Score:4.72|P-value:4.88E-4 ID:SGTC_2155|Compound:5570423|FD-Score:7.84|P-value:1.60E-8 ID:SGTC_2185|Compound:6113692|FD-Score:5.09|P-value:1.83E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.57|P-value:4.73E-5 ID:SGTC_2271|Compound:7849410|FD-Score:4.74|P-value:4.62E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.53|P-value:7.77E-4 ID:SGTC_2307|Compound:7538926|FD-Score:8.28|P-value:2.55E-9 ID:SGTC_2323|Compound:6148992|FD-Score:6.31|P-value:4.67E-6 ID:SGTC_2332|Compound:7982454|FD-Score:4.77|P-value:4.34E-4 ID:SGTC_2398|Compound:5228213|FD-Score:7.24|P-value:1.74E-7 ID:SGTC_2440|Compound:5628896|FD-Score:7.60|P-value:4.20E-8 ID:SGTC_2489|Compound:cantharidin|FD-Score:5.15|P-value:1.57E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:6.48|P-value:2.58E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.91|P-value:2.95E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.49|P-value:8.57E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:6.87|P-value:6.67E-7 ID:SGTC_2671|Compound:danthron|FD-Score:6.39|P-value:3.55E-6 ID:SGTC_2694|Compound:st077685|FD-Score:5.08|P-value:1.90E-4 ID:SGTC_2718|Compound:lomofungin|FD-Score:6.91|P-value:5.87E-7 ID:SGTC_2739|Compound:tacrine|FD-Score:-7.04|P-value:1.66E-7 ID:SGTC_2743|Compound:auranofin|FD-Score:6.99|P-value:4.32E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.87|P-value:6.79E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.68|P-value:1.79E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.37|P-value:6.96E-4 ID:SGTC_2781|Compound:5567276|FD-Score:5.27|P-value:1.13E-4 ID:SGTC_2784|Compound:7567673|FD-Score:5.20|P-value:1.36E-4 ID:SGTC_2829|Compound:7992743|FD-Score:5.66|P-value:3.57E-5 ID:SGTC_2887|Compound:9044784|FD-Score:4.90|P-value:3.04E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-7.15|P-value:1.09E-7 ID:SGTC_2913|Compound:7966556|FD-Score:-5.44|P-value:3.71E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-5.31|P-value:5.56E-5 ID:SGTC_2935|Compound:9038016|FD-Score:4.53|P-value:7.88E-4 ID:SGTC_2938|Compound:9059746|FD-Score:6.55|P-value:2.09E-6 ID:SGTC_2948|Compound:9070189|FD-Score:4.81|P-value:3.85E-4 ID:SGTC_2971|Compound:9092186|FD-Score:4.45|P-value:9.42E-4 ID:SGTC_3000|Compound:9075062|FD-Score:7.53|P-value:5.71E-8 ID:SGTC_3032|Compound:9089427|FD-Score:-5.41|P-value:4.10E-5 ID:SGTC_3072|Compound:9116419|FD-Score:-4.97|P-value:1.43E-4 ID:SGTC_3110|Compound:9122132|FD-Score:4.64|P-value:5.95E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.95|P-value:1.47E-5 ID:SGTC_3294|Compound:9122953|FD-Score:4.45|P-value:9.45E-4 ID:SGTC_3308|Compound:9128332|FD-Score:8.10|P-value:5.54E-9

Top fitness defect scores for YOR319W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_590 k048-0076 9.05 22.4 µM 8.16E-11 RSC & ERG11 1 7.00E-20 2.06
2 SGTC_1097 itavastatin 8.92 7.2 µM 1.48E-10 azole & statin 1 2.24E-19 2.27
3 SGTC_2307 7538926 8.28 6.3 µM 2.55E-9 3 5.94E-17 0.74
4 SGTC_3308 9128332 8.10 17.6 µM 5.54E-9 plasma membrane duress 2 2.71E-16 2.32
5 SGTC_430 0958-0115 8.08 16.4 µM 6.05E-9 1 3.23E-16 1.61
6 SGTC_2006 4011487 8.01 200.0 µM 7.98E-9 endomembrane recycling 6 5.54E-16 0.78
7 SGTC_887 0885-0007 8.01 9.6 µM 8.23E-9 endomembrane recycling 4 5.89E-16 1.39
8 SGTC_830 4076-0286 7.92 57.8 µM 1.16E-8 translation 1 1.14E-15 3.12
9 SGTC_2155 5570423 7.84 76.0 µM 1.60E-8 ergosterol biosynthesis 1 2.17E-15 2.61
10 SGTC_2440 5628896 7.60 157.8 µM 4.20E-8 1 1.43E-14 1.98
11 SGTC_3000 9075062 7.53 71.4 µM 5.71E-8 1 2.60E-14 2.14
12 SGTC_1239 0337-0584 7.27 35.4 µM 1.56E-7 unfolded protein response 9 1.85E-13 0.15
13 SGTC_145 3737-0113 7.26 38.4 µM 1.58E-7 DNA intercalators 7 1.91E-13 0.06
14 SGTC_2398 5228213 7.24 48.8 µM 1.74E-7 iron homeostasis 4 2.30E-13 0.91
15 SGTC_2743 auranofin 6.99 4.3 µM 4.32E-7 RPP1 & pyrimidine depletion 5 1.36E-12 0.45
16 SGTC_2718 lomofungin 6.91 53.0 µM 5.87E-7 mitochondrial processes 1 2.47E-12 1.07
17 SGTC_2648 atorvastatin 6.87 78.7 µM 6.67E-7 azole & statin 3 3.18E-12 0.27
18 SGTC_2753 fluvastatin 6.87 17.1 µM 6.79E-7 azole & statin 3 3.29E-12 1.24
19 SGTC_783 0848-0141 6.86 92.7 µM 6.86E-7 RSC & ERG11 4 3.36E-12 0.46
20 SGTC_917 harmaline 6.86 728.1 nM 6.92E-7 ergosterol biosynthesis 2 3.41E-12 1.83

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.375 1.29E-112 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.295 2.08E-68 YOR157C PUP1 het Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
0.203 1.04E-32 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.192 2.57E-29 YOR340C RPA43 het RNA polymerase I subunit A43
0.178 3.25E-25 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.171 2.11E-23 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.168 1.58E-22 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.159 2.63E-20 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.156 1.16E-19 YLR268W SEC22 hom R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
0.154 3.27E-19 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.152 7.58E-19 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.152 1.14E-18 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.151 1.85E-18 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.147 1.13E-17 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.142 1.59E-16 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor