YOR321W / PMT3

Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR321W / PMT3

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.04|P-value:1.65E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.63|P-value:1.15E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.28|P-value:4.42E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.37|P-value:4.48E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:5.03|P-value:1.23E-7 ID:SGTC_353|Compound:1988-1175|FD-Score:3.08|P-value:7.66E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.08|P-value:9.00E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.26|P-value:4.68E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.07|P-value:7.98E-4 ID:SGTC_490|Compound:phenamil|FD-Score:4.00|P-value:1.95E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.28|P-value:3.70E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.21|P-value:4.72E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.07|P-value:7.93E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-4.15|P-value:1.24E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.85|P-value:4.70E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.26|P-value:4.79E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.24|P-value:6.60E-6 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.72|P-value:6.68E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:6.68|P-value:3.86E-12 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:5.27|P-value:3.19E-8 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.28|P-value:4.39E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.39|P-value:2.45E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-3.14|P-value:7.20E-4 ID:SGTC_1697|Compound:st025554|FD-Score:4.07|P-value:1.45E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.27|P-value:4.60E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.07|P-value:1.42E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.21|P-value:4.74E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.67|P-value:8.02E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.79|P-value:4.94E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.21|P-value:4.80E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.41|P-value:2.27E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.19|P-value:5.19E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.46|P-value:1.90E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.75|P-value:5.51E-7 ID:SGTC_2359|Compound:9039622|FD-Score:4.85|P-value:3.20E-7 ID:SGTC_2362|Compound:9071156|FD-Score:7.67|P-value:1.93E-15 ID:SGTC_2366|Compound:9070441|FD-Score:5.12|P-value:7.52E-8 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.17|P-value:5.48E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.06|P-value:1.87E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.12|P-value:6.73E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.13|P-value:7.55E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.17|P-value:5.53E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.05|P-value:9.78E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-5.46|P-value:1.37E-8 ID:SGTC_2919|Compound:7978188|FD-Score:3.38|P-value:2.54E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.35|P-value:3.43E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.04|P-value:1.65E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.63|P-value:1.15E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.28|P-value:4.42E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.37|P-value:4.48E-6 ID:SGTC_170|Compound:4197-0004|FD-Score:5.03|P-value:1.23E-7 ID:SGTC_353|Compound:1988-1175|FD-Score:3.08|P-value:7.66E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.08|P-value:9.00E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.26|P-value:4.68E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.07|P-value:7.98E-4 ID:SGTC_490|Compound:phenamil|FD-Score:4.00|P-value:1.95E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:3.28|P-value:3.70E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.21|P-value:4.72E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.07|P-value:7.93E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:-4.15|P-value:1.24E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.85|P-value:4.70E-5 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.26|P-value:4.79E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:4.24|P-value:6.60E-6 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.72|P-value:6.68E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:6.68|P-value:3.86E-12 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.11|P-value:6.94E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:5.27|P-value:3.19E-8 ID:SGTC_1473|Compound:k844-0725|FD-Score:-3.28|P-value:4.39E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.39|P-value:2.45E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-3.14|P-value:7.20E-4 ID:SGTC_1697|Compound:st025554|FD-Score:4.07|P-value:1.45E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.27|P-value:4.60E-4 ID:SGTC_1737|Compound:st035557|FD-Score:4.07|P-value:1.42E-5 ID:SGTC_1815|Compound:st051655|FD-Score:3.21|P-value:4.74E-4 ID:SGTC_1886|Compound:st057356|FD-Score:3.67|P-value:8.02E-5 ID:SGTC_1889|Compound:st059080|FD-Score:3.79|P-value:4.94E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.21|P-value:4.80E-4 ID:SGTC_2094|Compound:5332512|FD-Score:3.41|P-value:2.27E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.19|P-value:5.19E-4 ID:SGTC_2270|Compound:7924575|FD-Score:3.46|P-value:1.90E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.75|P-value:5.51E-7 ID:SGTC_2359|Compound:9039622|FD-Score:4.85|P-value:3.20E-7 ID:SGTC_2362|Compound:9071156|FD-Score:7.67|P-value:1.93E-15 ID:SGTC_2366|Compound:9070441|FD-Score:5.12|P-value:7.52E-8 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.17|P-value:5.48E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.06|P-value:1.87E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.12|P-value:6.73E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.13|P-value:7.55E-4 ID:SGTC_2709|Compound:st078560|FD-Score:3.17|P-value:5.53E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-3.05|P-value:9.78E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-5.46|P-value:1.37E-8 ID:SGTC_2919|Compound:7978188|FD-Score:3.38|P-value:2.54E-4 ID:SGTC_3332|Compound:9141069|FD-Score:-3.35|P-value:3.43E-4

Top fitness defect scores for YOR321W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2362 9071156 7.67 126.0 µM 1.93E-15 1 8.53E-15
2 SGTC_1211 1056-0033 6.68 32.3 µM 3.86E-12 1 1.22E-11
3 SGTC_1466 k213-0079 5.27 57.5 µM 3.19E-8 4 6.79E-8
4 SGTC_2366 9070441 5.12 60.6 µM 7.52E-8 9 1.54E-7
5 SGTC_170 4197-0004 5.03 226.0 µM 1.23E-7 7 2.46E-7
6 SGTC_2359 9039622 4.85 200.0 µM 3.20E-7 endomembrane recycling 8 6.15E-7
7 SGTC_2336 9001819 4.75 198.7 µM 5.51E-7 heme biosynthesis & mitochondrial translocase 26 1.03E-6
8 SGTC_1197 1601-0112 4.24 267.0 µM 6.60E-6 13 1.11E-5
9 SGTC_1737 st035557 4.07 69.7 µM 1.42E-5 15 2.31E-5
10 SGTC_1697 st025554 4.07 27.7 µM 1.45E-5 22 2.35E-5
11 SGTC_58 0957-0393 4.04 9.0 µM 1.65E-5 cell wall 368 2.66E-5
12 SGTC_490 phenamil 4.00 164.0 µM 1.95E-5 heme requiring 9 3.11E-5
13 SGTC_1889 st059080 3.79 5.2 µM 4.94E-5 22 7.56E-5
14 SGTC_1208 2323-2347 3.72 50.3 µM 6.68E-5 10 1.01E-4
15 SGTC_1886 st057356 3.67 49.9 µM 8.02E-5 60S ribosome export 24 1.20E-4
16 SGTC_2270 7924575 3.46 90.9 µM 1.90E-4 RPP1 & pyrimidine depletion 28 2.74E-4
17 SGTC_2094 5332512 3.41 191.7 µM 2.27E-4 45 3.24E-4
18 SGTC_1632 st005650 3.39 90.0 µM 2.45E-4 48 3.49E-4
19 SGTC_2919 7978188 3.38 46.4 µM 2.54E-4 45 3.62E-4
20 SGTC_491 tetrandrine 3.28 80.3 µM 3.70E-4 24 5.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.94E-16 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.116 1.71E-11 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.109 2.36E-10 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.107 4.78E-10 YER024W YAT2 hom Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
0.105 9.47E-10 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.105 1.28E-9 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.104 1.71E-9 YJL178C ATG27 hom Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site
0.102 2.99E-9 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.099 1.03E-8 YFL027C GYP8 hom GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
0.098 1.12E-8 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.093 7.91E-8 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.091 1.18E-7 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.091 1.42E-7 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.089 2.59E-7 YNL299W TRF5 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.088 3.32E-7 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly