YOR322C / LDB19

Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR322C / LDB19

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.52|P-value:9.72E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:4.82|P-value:1.03E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.71|P-value:5.37E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.71|P-value:1.40E-9 ID:SGTC_62|Compound:0180-0423|FD-Score:3.97|P-value:2.32E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.87|P-value:2.35E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.53|P-value:7.02E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.56|P-value:8.64E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.60|P-value:2.46E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.93|P-value:4.53E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:6.14|P-value:2.71E-8 ID:SGTC_253|Compound:dyclonine|FD-Score:7.69|P-value:4.56E-12 ID:SGTC_283|Compound:0987-0079|FD-Score:6.88|P-value:5.46E-10 ID:SGTC_305|Compound:1682-2595|FD-Score:5.19|P-value:2.21E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.50|P-value:7.76E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.43|P-value:9.44E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:4.30|P-value:7.50E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:6.29|P-value:1.29E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:3.54|P-value:9.26E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.85|P-value:3.50E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.76|P-value:4.69E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.61|P-value:7.35E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.73|P-value:5.10E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.56|P-value:8.58E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:6.40|P-value:7.26E-9 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.19|P-value:2.25E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.94|P-value:6.34E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-5.47|P-value:4.29E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:-4.43|P-value:3.20E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-9.02|P-value:2.89E-16 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.20|P-value:7.38E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.55|P-value:6.64E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.63|P-value:7.00E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.72|P-value:5.34E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.49|P-value:8.05E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.58|P-value:8.20E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.64|P-value:6.86E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:4.79|P-value:1.15E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.52|P-value:9.79E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.76|P-value:3.39E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.95|P-value:1.80E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.26|P-value:8.48E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.74|P-value:4.88E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.90|P-value:2.21E-26 ID:SGTC_2136|Compound:5328288|FD-Score:4.53|P-value:3.19E-5 ID:SGTC_2186|Compound:6124449|FD-Score:3.94|P-value:2.59E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.28|P-value:8.05E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.62|P-value:5.38E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.07|P-value:1.67E-4 ID:SGTC_2262|Compound:9014885|FD-Score:5.80|P-value:1.41E-7 ID:SGTC_2291|Compound:7917025|FD-Score:3.64|P-value:6.73E-4 ID:SGTC_2307|Compound:7538926|FD-Score:6.99|P-value:2.92E-10 ID:SGTC_2322|Compound:7413319|FD-Score:3.90|P-value:2.91E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.29|P-value:7.81E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.60|P-value:7.58E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.83|P-value:1.01E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-4.24|P-value:6.39E-5 ID:SGTC_2466|Compound:5983409|FD-Score:5.95|P-value:6.84E-8 ID:SGTC_2526|Compound:patulin|FD-Score:4.34|P-value:6.39E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:7.42|P-value:2.40E-11 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.64|P-value:4.99E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:7.36|P-value:3.52E-11 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.63|P-value:2.21E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.96|P-value:2.44E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.48|P-value:8.15E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.48|P-value:8.22E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:4.57|P-value:2.72E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.08|P-value:3.68E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.05|P-value:2.09E-10 ID:SGTC_2701|Compound:st077767|FD-Score:3.72|P-value:5.29E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.42|P-value:4.74E-5 ID:SGTC_3080|Compound:9117754|FD-Score:-3.87|P-value:2.32E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.40|P-value:9.08E-7 ID:SGTC_3293|Compound:9120939|FD-Score:4.59|P-value:2.53E-5 ID:SGTC_3331|Compound:9141060|FD-Score:3.77|P-value:4.53E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.52|P-value:9.72E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:4.82|P-value:1.03E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:3.71|P-value:5.37E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.71|P-value:1.40E-9 ID:SGTC_62|Compound:0180-0423|FD-Score:3.97|P-value:2.32E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.87|P-value:2.35E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:-3.53|P-value:7.02E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.56|P-value:8.64E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:4.60|P-value:2.46E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.93|P-value:4.53E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:6.14|P-value:2.71E-8 ID:SGTC_253|Compound:dyclonine|FD-Score:7.69|P-value:4.56E-12 ID:SGTC_283|Compound:0987-0079|FD-Score:6.88|P-value:5.46E-10 ID:SGTC_305|Compound:1682-2595|FD-Score:5.19|P-value:2.21E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.50|P-value:7.76E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.43|P-value:9.44E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:4.30|P-value:7.50E-5 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:6.29|P-value:1.29E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:3.54|P-value:9.26E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.85|P-value:3.50E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.76|P-value:4.69E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.61|P-value:7.35E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.73|P-value:5.10E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.56|P-value:8.58E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:6.40|P-value:7.26E-9 ID:SGTC_1021|Compound:4476-0760|FD-Score:5.19|P-value:2.25E-6 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.94|P-value:6.34E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-5.47|P-value:4.29E-7 ID:SGTC_1035|Compound:k081-0041|FD-Score:-4.43|P-value:3.20E-5 ID:SGTC_1038|Compound:k292-0204|FD-Score:-9.02|P-value:2.89E-16 ID:SGTC_1043|Compound:0916-0009|FD-Score:-4.20|P-value:7.38E-5 ID:SGTC_1053|Compound:3366-3204|FD-Score:-3.55|P-value:6.64E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:3.63|P-value:7.00E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:3.72|P-value:5.34E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.49|P-value:8.05E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.58|P-value:8.20E-4 ID:SGTC_1694|Compound:st024011|FD-Score:3.64|P-value:6.86E-4 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:4.79|P-value:1.15E-5 ID:SGTC_1707|Compound:st032323|FD-Score:3.52|P-value:9.79E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.76|P-value:3.39E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.95|P-value:1.80E-4 ID:SGTC_1766|Compound:st045414|FD-Score:4.26|P-value:8.48E-5 ID:SGTC_1786|Compound:berberine|FD-Score:3.74|P-value:4.88E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:11.90|P-value:2.21E-26 ID:SGTC_2136|Compound:5328288|FD-Score:4.53|P-value:3.19E-5 ID:SGTC_2186|Compound:6124449|FD-Score:3.94|P-value:2.59E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.28|P-value:8.05E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.62|P-value:5.38E-4 ID:SGTC_2257|Compound:7960413|FD-Score:4.07|P-value:1.67E-4 ID:SGTC_2262|Compound:9014885|FD-Score:5.80|P-value:1.41E-7 ID:SGTC_2291|Compound:7917025|FD-Score:3.64|P-value:6.73E-4 ID:SGTC_2307|Compound:7538926|FD-Score:6.99|P-value:2.92E-10 ID:SGTC_2322|Compound:7413319|FD-Score:3.90|P-value:2.91E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.29|P-value:7.81E-5 ID:SGTC_2358|Compound:9037157|FD-Score:3.60|P-value:7.58E-4 ID:SGTC_2456|Compound:5770359|FD-Score:4.83|P-value:1.01E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-4.24|P-value:6.39E-5 ID:SGTC_2466|Compound:5983409|FD-Score:5.95|P-value:6.84E-8 ID:SGTC_2526|Compound:patulin|FD-Score:4.34|P-value:6.39E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:7.42|P-value:2.40E-11 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.64|P-value:4.99E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:7.36|P-value:3.52E-11 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.63|P-value:2.21E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.96|P-value:2.44E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.48|P-value:8.15E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-3.48|P-value:8.22E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:4.57|P-value:2.72E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.08|P-value:3.68E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.05|P-value:2.09E-10 ID:SGTC_2701|Compound:st077767|FD-Score:3.72|P-value:5.29E-4 ID:SGTC_2982|Compound:9019404|FD-Score:4.42|P-value:4.74E-5 ID:SGTC_3080|Compound:9117754|FD-Score:-3.87|P-value:2.32E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.40|P-value:9.08E-7 ID:SGTC_3293|Compound:9120939|FD-Score:4.59|P-value:2.53E-5 ID:SGTC_3331|Compound:9141060|FD-Score:3.77|P-value:4.53E-4

Top fitness defect scores for YOR322C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 11.90 4.0 nM 2.21E-26 24 6.84E-33
2 SGTC_253 dyclonine 7.69 31.2 µM 4.56E-12 amide catabolism 7 7.22E-15
3 SGTC_2532 xanthone 7.42 78.9 µM 2.40E-11 4 5.83E-14
4 SGTC_2564 betulinic acid 7.36 100.0 µM 3.52E-11 3 9.45E-14
5 SGTC_2679 rapamycin 7.05 1.0 nM 2.09E-10 57 8.88E-13
6 SGTC_2307 7538926 6.99 6.3 µM 2.92E-10 6 1.36E-12
7 SGTC_283 0987-0079 6.88 11.7 µM 5.46E-10 3 2.98E-12
8 SGTC_58 0957-0393 6.71 9.0 µM 1.40E-9 cell wall 174 9.80E-12
9 SGTC_1012 4112-3522 6.40 18.0 µM 7.26E-9 2 7.75E-11
10 SGTC_388 3',4'-dichloroisocoumarin 6.29 16.7 µM 1.29E-8 3 1.60E-10
11 SGTC_182 3448-4371 6.14 550.5 µM 2.71E-8 6 4.06E-10
12 SGTC_2651 1327-0036 6.08 5.0 µM 3.68E-8 71 5.97E-10
13 SGTC_2466 5983409 5.95 37.1 µM 6.84E-8 2 1.30E-9
14 SGTC_2262 9014885 5.80 67.5 µM 1.41E-7 1 3.23E-9
15 SGTC_3210 9128157 5.40 49.5 µM 9.08E-7 20 3.37E-8
16 SGTC_305 1682-2595 5.19 20.8 µM 2.21E-6 RNA processing & uracil transport 8 1.03E-7
17 SGTC_1021 4476-0760 5.19 85.3 µM 2.25E-6 8 1.05E-7
18 SGTC_1028 k015-0029 4.94 4.8 µM 6.34E-6 6 3.87E-7
19 SGTC_2456 5770359 4.83 74.5 µM 1.01E-5 7 6.99E-7
20 SGTC_29 0299-0004 4.82 13.0 µM 1.03E-5 19 7.09E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.237 5.67E-44 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.213 1.03E-35 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.211 5.09E-35 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.198 6.58E-31 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.196 2.73E-30 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.188 5.48E-28 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.172 1.16E-23 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.169 8.55E-23 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.168 1.55E-22 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.167 2.68E-22 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.165 8.14E-22 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.159 1.87E-20 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.155 1.36E-19 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.155 1.61E-19 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.154 3.01E-19 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae