YOR323C / PRO2

Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR323C / PRO2

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:-4.73|P-value:4.73E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.73|P-value:3.20E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.27|P-value:1.16E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.92|P-value:2.75E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:7.24|P-value:3.89E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:10.40|P-value:6.67E-13 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:7.92|P-value:3.08E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:15.30|P-value:6.01E-26 ID:SGTC_134|Compound:0269-0018|FD-Score:6.75|P-value:2.05E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:5.37|P-value:1.28E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.85|P-value:3.33E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.37|P-value:1.28E-4 ID:SGTC_263|Compound:alizarin|FD-Score:6.76|P-value:2.01E-6 ID:SGTC_269|Compound:exalamide|FD-Score:4.94|P-value:3.91E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:7.51|P-value:1.45E-7 ID:SGTC_327|Compound:1273-0057|FD-Score:5.08|P-value:2.77E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.64|P-value:8.12E-4 ID:SGTC_397|Compound:arbidol|FD-Score:4.86|P-value:4.79E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:5.66|P-value:5.89E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:8.84|P-value:7.52E-10 ID:SGTC_467|Compound:ro 31-8220|FD-Score:9.09|P-value:2.53E-10 ID:SGTC_468|Compound:gf-109203x|FD-Score:7.96|P-value:2.69E-8 ID:SGTC_500|Compound:h-89|FD-Score:4.91|P-value:4.22E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.98|P-value:9.40E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:19.90|P-value:1.19E-42 ID:SGTC_661|Compound:1304-0007|FD-Score:5.05|P-value:3.01E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:5.12|P-value:2.50E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.57|P-value:7.48E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:4.66|P-value:7.83E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.50|P-value:9.02E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:12.30|P-value:2.17E-17 ID:SGTC_772|Compound:k072-0172|FD-Score:11.30|P-value:5.52E-15 ID:SGTC_801|Compound:0866-0028|FD-Score:6.33|P-value:8.02E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:4.93|P-value:3.98E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:5.29|P-value:1.62E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.04|P-value:1.95E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:7.94|P-value:2.89E-8 ID:SGTC_877|Compound:0771-0151|FD-Score:5.21|P-value:1.97E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:7.18|P-value:4.78E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.95|P-value:2.73E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.75|P-value:6.27E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.63|P-value:6.28E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:5.19|P-value:2.05E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.04|P-value:3.06E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.24|P-value:3.86E-7 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.79|P-value:3.96E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:12.10|P-value:4.85E-17 ID:SGTC_1018|Compound:4259-0013|FD-Score:8.49|P-value:3.29E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.65|P-value:7.89E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.99|P-value:9.33E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:9.43|P-value:5.44E-11 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.10|P-value:1.85E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:7.95|P-value:2.76E-8 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.45|P-value:1.05E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:14.60|P-value:4.86E-24 ID:SGTC_1389|Compound:3405-0187|FD-Score:7.81|P-value:4.70E-8 ID:SGTC_1422|Compound:4031-0024|FD-Score:8.40|P-value:4.73E-9 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.38|P-value:1.26E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:5.34|P-value:1.39E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:6.28|P-value:9.36E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.73|P-value:6.59E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.69|P-value:7.31E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-4.65|P-value:5.76E-4 ID:SGTC_1612|Compound:st002233|FD-Score:7.93|P-value:3.04E-8 ID:SGTC_1627|Compound:st003713|FD-Score:8.30|P-value:7.03E-9 ID:SGTC_1635|Compound:st007035|FD-Score:10.70|P-value:1.09E-13 ID:SGTC_1637|Compound:st007924|FD-Score:10.90|P-value:4.18E-14 ID:SGTC_1656|Compound:st012921|FD-Score:6.68|P-value:2.60E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-6.60|P-value:2.15E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-7.19|P-value:2.82E-7 ID:SGTC_1781|Compound:st038725|FD-Score:-4.76|P-value:4.40E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.19|P-value:2.10E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.65|P-value:5.73E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.09|P-value:2.67E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.56|P-value:9.81E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:5.74|P-value:4.66E-5 ID:SGTC_1884|Compound:5633444|FD-Score:16.30|P-value:1.78E-29 ID:SGTC_1911|Compound:st060208|FD-Score:4.78|P-value:5.83E-4 ID:SGTC_1919|Compound:st067113|FD-Score:5.12|P-value:2.50E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.66|P-value:7.68E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.64|P-value:5.89E-4 ID:SGTC_1962|Compound:st076595|FD-Score:5.05|P-value:2.96E-4 ID:SGTC_1973|Compound:st070275|FD-Score:9.51|P-value:3.80E-11 ID:SGTC_2034|Compound:5197015|FD-Score:7.91|P-value:3.28E-8 ID:SGTC_2043|Compound:5101342|FD-Score:4.89|P-value:4.43E-4 ID:SGTC_2046|Compound:4110841|FD-Score:13.10|P-value:1.38E-19 ID:SGTC_2049|Compound:5262831|FD-Score:6.24|P-value:1.07E-5 ID:SGTC_2055|Compound:5235184|FD-Score:8.63|P-value:1.78E-9 ID:SGTC_2066|Compound:5222451|FD-Score:6.28|P-value:9.15E-6 ID:SGTC_2068|Compound:5226020|FD-Score:6.91|P-value:1.22E-6 ID:SGTC_2083|Compound:5306046|FD-Score:4.82|P-value:5.24E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.83|P-value:3.65E-4 ID:SGTC_2144|Compound:5628481|FD-Score:4.86|P-value:4.82E-4 ID:SGTC_2167|Compound:5876490|FD-Score:7.09|P-value:6.47E-7 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:10.70|P-value:1.32E-13 ID:SGTC_2183|Compound:6420625|FD-Score:10.90|P-value:3.49E-14 ID:SGTC_2225|Compound:6654152|FD-Score:6.79|P-value:1.78E-6 ID:SGTC_2246|Compound:7293507|FD-Score:7.81|P-value:4.71E-8 ID:SGTC_2269|Compound:7935389|FD-Score:7.58|P-value:1.13E-7 ID:SGTC_2307|Compound:7538926|FD-Score:9.18|P-value:1.69E-10 ID:SGTC_2332|Compound:7982454|FD-Score:14.50|P-value:1.27E-23 ID:SGTC_2340|Compound:7987427|FD-Score:6.16|P-value:1.35E-5 ID:SGTC_2344|Compound:7990960|FD-Score:9.05|P-value:3.04E-10 ID:SGTC_2358|Compound:9037157|FD-Score:4.58|P-value:9.37E-4 ID:SGTC_2374|Compound:9071832|FD-Score:7.44|P-value:1.85E-7 ID:SGTC_2377|Compound:9073351|FD-Score:5.04|P-value:3.05E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.86|P-value:4.75E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:20.40|P-value:8.18E-45 ID:SGTC_2436|Compound:5633522|FD-Score:6.12|P-value:1.52E-5 ID:SGTC_2466|Compound:5983409|FD-Score:5.61|P-value:6.66E-5 ID:SGTC_2479|Compound:5617353|FD-Score:5.23|P-value:1.87E-4 ID:SGTC_2485|Compound:5633444|FD-Score:14.70|P-value:4.38E-24 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:18.50|P-value:2.52E-37 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:8.93|P-value:5.07E-10 ID:SGTC_2586|Compound:curcumin|FD-Score:6.40|P-value:6.35E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:9.97|P-value:4.45E-12 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.51|P-value:4.44E-6 ID:SGTC_2699|Compound:st077704|FD-Score:4.64|P-value:8.17E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:6.36|P-value:7.34E-6 ID:SGTC_2845|Compound:9003024|FD-Score:5.38|P-value:1.26E-4 ID:SGTC_2902|Compound:5787006|FD-Score:5.11|P-value:2.57E-4 ID:SGTC_2913|Compound:7966556|FD-Score:4.64|P-value:8.13E-4 ID:SGTC_2925|Compound:9010536|FD-Score:13.00|P-value:2.57E-19 ID:SGTC_2930|Compound:9013230|FD-Score:9.14|P-value:2.00E-10 ID:SGTC_2941|Compound:9056145|FD-Score:7.94|P-value:2.87E-8 ID:SGTC_2958|Compound:9077254|FD-Score:5.77|P-value:4.29E-5 ID:SGTC_2991|Compound:9074669|FD-Score:11.10|P-value:1.76E-14 ID:SGTC_3082|Compound:9117008|FD-Score:6.20|P-value:1.20E-5 ID:SGTC_3105|Compound:9121040|FD-Score:7.73|P-value:6.38E-8 ID:SGTC_3110|Compound:9122132|FD-Score:9.82|P-value:8.84E-12 ID:SGTC_3142|Compound:9086498|FD-Score:5.71|P-value:5.11E-5 ID:SGTC_3143|Compound:9086658|FD-Score:6.87|P-value:1.40E-6 ID:SGTC_3149|Compound:9097855|FD-Score:10.00|P-value:3.75E-12 ID:SGTC_3161|Compound:9100388|FD-Score:4.64|P-value:8.21E-4 ID:SGTC_3175|Compound:9106517|FD-Score:9.35|P-value:8.06E-11 ID:SGTC_3185|Compound:9108267|FD-Score:5.56|P-value:7.62E-5 ID:SGTC_3199|Compound:9111318|FD-Score:7.66|P-value:8.43E-8 ID:SGTC_3203|Compound:9113543|FD-Score:-5.86|P-value:2.17E-5 ID:SGTC_3204|Compound:9114183|FD-Score:5.84|P-value:3.50E-5 ID:SGTC_3211|Compound:9128781|FD-Score:13.40|P-value:1.73E-20 ID:SGTC_3237|Compound:9133362|FD-Score:5.23|P-value:1.87E-4 ID:SGTC_3263|Compound:9137018|FD-Score:5.16|P-value:2.23E-4 ID:SGTC_3286|Compound:9117135|FD-Score:6.03|P-value:1.97E-5 ID:SGTC_3305|Compound:9127027|FD-Score:7.40|P-value:2.17E-7 ID:SGTC_3349|Compound:9149703|FD-Score:4.76|P-value:6.08E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-4.73|P-value:4.73E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-5.73|P-value:3.20E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-5.27|P-value:1.16E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:5.92|P-value:2.75E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:7.24|P-value:3.89E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:10.40|P-value:6.67E-13 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:7.92|P-value:3.08E-8 ID:SGTC_123|Compound:0083-0120|FD-Score:15.30|P-value:6.01E-26 ID:SGTC_134|Compound:0269-0018|FD-Score:6.75|P-value:2.05E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:5.37|P-value:1.28E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.85|P-value:3.33E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.37|P-value:1.28E-4 ID:SGTC_263|Compound:alizarin|FD-Score:6.76|P-value:2.01E-6 ID:SGTC_269|Compound:exalamide|FD-Score:4.94|P-value:3.91E-4 ID:SGTC_273|Compound:hydroxyurea|FD-Score:7.51|P-value:1.45E-7 ID:SGTC_327|Compound:1273-0057|FD-Score:5.08|P-value:2.77E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:4.64|P-value:8.12E-4 ID:SGTC_397|Compound:arbidol|FD-Score:4.86|P-value:4.79E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:5.66|P-value:5.89E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:8.84|P-value:7.52E-10 ID:SGTC_467|Compound:ro 31-8220|FD-Score:9.09|P-value:2.53E-10 ID:SGTC_468|Compound:gf-109203x|FD-Score:7.96|P-value:2.69E-8 ID:SGTC_500|Compound:h-89|FD-Score:4.91|P-value:4.22E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.98|P-value:9.40E-7 ID:SGTC_660|Compound:4031-1742|FD-Score:19.90|P-value:1.19E-42 ID:SGTC_661|Compound:1304-0007|FD-Score:5.05|P-value:3.01E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:5.12|P-value:2.50E-4 ID:SGTC_695|Compound:3505-6186|FD-Score:5.57|P-value:7.48E-5 ID:SGTC_728|Compound:3030-5151|FD-Score:4.66|P-value:7.83E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.50|P-value:9.02E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:12.30|P-value:2.17E-17 ID:SGTC_772|Compound:k072-0172|FD-Score:11.30|P-value:5.52E-15 ID:SGTC_801|Compound:0866-0028|FD-Score:6.33|P-value:8.02E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:4.93|P-value:3.98E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:5.29|P-value:1.62E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.04|P-value:1.95E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:7.94|P-value:2.89E-8 ID:SGTC_877|Compound:0771-0151|FD-Score:5.21|P-value:1.97E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:7.18|P-value:4.78E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:-4.95|P-value:2.73E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:4.75|P-value:6.27E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.63|P-value:6.28E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:5.19|P-value:2.05E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.04|P-value:3.06E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:7.24|P-value:3.86E-7 ID:SGTC_1010|Compound:4112-3296|FD-Score:5.79|P-value:3.96E-5 ID:SGTC_1011|Compound:4112-3381|FD-Score:12.10|P-value:4.85E-17 ID:SGTC_1018|Compound:4259-0013|FD-Score:8.49|P-value:3.29E-9 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.65|P-value:7.89E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:6.99|P-value:9.33E-7 ID:SGTC_1057|Compound:3448-5381|FD-Score:9.43|P-value:5.44E-11 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.10|P-value:1.85E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:7.95|P-value:2.76E-8 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.45|P-value:1.05E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:14.60|P-value:4.86E-24 ID:SGTC_1389|Compound:3405-0187|FD-Score:7.81|P-value:4.70E-8 ID:SGTC_1422|Compound:4031-0024|FD-Score:8.40|P-value:4.73E-9 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.38|P-value:1.26E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:5.34|P-value:1.39E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:6.28|P-value:9.36E-6 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.73|P-value:6.59E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.69|P-value:7.31E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-4.65|P-value:5.76E-4 ID:SGTC_1612|Compound:st002233|FD-Score:7.93|P-value:3.04E-8 ID:SGTC_1627|Compound:st003713|FD-Score:8.30|P-value:7.03E-9 ID:SGTC_1635|Compound:st007035|FD-Score:10.70|P-value:1.09E-13 ID:SGTC_1637|Compound:st007924|FD-Score:10.90|P-value:4.18E-14 ID:SGTC_1656|Compound:st012921|FD-Score:6.68|P-value:2.60E-6 ID:SGTC_1727|Compound:st034309|FD-Score:-6.60|P-value:2.15E-6 ID:SGTC_1732|Compound:st034308|FD-Score:-7.19|P-value:2.82E-7 ID:SGTC_1781|Compound:st038725|FD-Score:-4.76|P-value:4.40E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.19|P-value:2.10E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.65|P-value:5.73E-4 ID:SGTC_1847|Compound:st056231|FD-Score:5.09|P-value:2.67E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.56|P-value:9.81E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:5.74|P-value:4.66E-5 ID:SGTC_1884|Compound:5633444|FD-Score:16.30|P-value:1.78E-29 ID:SGTC_1911|Compound:st060208|FD-Score:4.78|P-value:5.83E-4 ID:SGTC_1919|Compound:st067113|FD-Score:5.12|P-value:2.50E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.66|P-value:7.68E-4 ID:SGTC_1950|Compound:st077106|FD-Score:-4.64|P-value:5.89E-4 ID:SGTC_1962|Compound:st076595|FD-Score:5.05|P-value:2.96E-4 ID:SGTC_1973|Compound:st070275|FD-Score:9.51|P-value:3.80E-11 ID:SGTC_2034|Compound:5197015|FD-Score:7.91|P-value:3.28E-8 ID:SGTC_2043|Compound:5101342|FD-Score:4.89|P-value:4.43E-4 ID:SGTC_2046|Compound:4110841|FD-Score:13.10|P-value:1.38E-19 ID:SGTC_2049|Compound:5262831|FD-Score:6.24|P-value:1.07E-5 ID:SGTC_2055|Compound:5235184|FD-Score:8.63|P-value:1.78E-9 ID:SGTC_2066|Compound:5222451|FD-Score:6.28|P-value:9.15E-6 ID:SGTC_2068|Compound:5226020|FD-Score:6.91|P-value:1.22E-6 ID:SGTC_2083|Compound:5306046|FD-Score:4.82|P-value:5.24E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.83|P-value:3.65E-4 ID:SGTC_2144|Compound:5628481|FD-Score:4.86|P-value:4.82E-4 ID:SGTC_2167|Compound:5876490|FD-Score:7.09|P-value:6.47E-7 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:10.70|P-value:1.32E-13 ID:SGTC_2183|Compound:6420625|FD-Score:10.90|P-value:3.49E-14 ID:SGTC_2225|Compound:6654152|FD-Score:6.79|P-value:1.78E-6 ID:SGTC_2246|Compound:7293507|FD-Score:7.81|P-value:4.71E-8 ID:SGTC_2269|Compound:7935389|FD-Score:7.58|P-value:1.13E-7 ID:SGTC_2307|Compound:7538926|FD-Score:9.18|P-value:1.69E-10 ID:SGTC_2332|Compound:7982454|FD-Score:14.50|P-value:1.27E-23 ID:SGTC_2340|Compound:7987427|FD-Score:6.16|P-value:1.35E-5 ID:SGTC_2344|Compound:7990960|FD-Score:9.05|P-value:3.04E-10 ID:SGTC_2358|Compound:9037157|FD-Score:4.58|P-value:9.37E-4 ID:SGTC_2374|Compound:9071832|FD-Score:7.44|P-value:1.85E-7 ID:SGTC_2377|Compound:9073351|FD-Score:5.04|P-value:3.05E-4 ID:SGTC_2398|Compound:5228213|FD-Score:4.86|P-value:4.75E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:20.40|P-value:8.18E-45 ID:SGTC_2436|Compound:5633522|FD-Score:6.12|P-value:1.52E-5 ID:SGTC_2466|Compound:5983409|FD-Score:5.61|P-value:6.66E-5 ID:SGTC_2479|Compound:5617353|FD-Score:5.23|P-value:1.87E-4 ID:SGTC_2485|Compound:5633444|FD-Score:14.70|P-value:4.38E-24 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:18.50|P-value:2.52E-37 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:8.93|P-value:5.07E-10 ID:SGTC_2586|Compound:curcumin|FD-Score:6.40|P-value:6.35E-6 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:9.97|P-value:4.45E-12 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:6.51|P-value:4.44E-6 ID:SGTC_2699|Compound:st077704|FD-Score:4.64|P-value:8.17E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:6.36|P-value:7.34E-6 ID:SGTC_2845|Compound:9003024|FD-Score:5.38|P-value:1.26E-4 ID:SGTC_2902|Compound:5787006|FD-Score:5.11|P-value:2.57E-4 ID:SGTC_2913|Compound:7966556|FD-Score:4.64|P-value:8.13E-4 ID:SGTC_2925|Compound:9010536|FD-Score:13.00|P-value:2.57E-19 ID:SGTC_2930|Compound:9013230|FD-Score:9.14|P-value:2.00E-10 ID:SGTC_2941|Compound:9056145|FD-Score:7.94|P-value:2.87E-8 ID:SGTC_2958|Compound:9077254|FD-Score:5.77|P-value:4.29E-5 ID:SGTC_2991|Compound:9074669|FD-Score:11.10|P-value:1.76E-14 ID:SGTC_3082|Compound:9117008|FD-Score:6.20|P-value:1.20E-5 ID:SGTC_3105|Compound:9121040|FD-Score:7.73|P-value:6.38E-8 ID:SGTC_3110|Compound:9122132|FD-Score:9.82|P-value:8.84E-12 ID:SGTC_3142|Compound:9086498|FD-Score:5.71|P-value:5.11E-5 ID:SGTC_3143|Compound:9086658|FD-Score:6.87|P-value:1.40E-6 ID:SGTC_3149|Compound:9097855|FD-Score:10.00|P-value:3.75E-12 ID:SGTC_3161|Compound:9100388|FD-Score:4.64|P-value:8.21E-4 ID:SGTC_3175|Compound:9106517|FD-Score:9.35|P-value:8.06E-11 ID:SGTC_3185|Compound:9108267|FD-Score:5.56|P-value:7.62E-5 ID:SGTC_3199|Compound:9111318|FD-Score:7.66|P-value:8.43E-8 ID:SGTC_3203|Compound:9113543|FD-Score:-5.86|P-value:2.17E-5 ID:SGTC_3204|Compound:9114183|FD-Score:5.84|P-value:3.50E-5 ID:SGTC_3211|Compound:9128781|FD-Score:13.40|P-value:1.73E-20 ID:SGTC_3237|Compound:9133362|FD-Score:5.23|P-value:1.87E-4 ID:SGTC_3263|Compound:9137018|FD-Score:5.16|P-value:2.23E-4 ID:SGTC_3286|Compound:9117135|FD-Score:6.03|P-value:1.97E-5 ID:SGTC_3305|Compound:9127027|FD-Score:7.40|P-value:2.17E-7 ID:SGTC_3349|Compound:9149703|FD-Score:4.76|P-value:6.08E-4

Top fitness defect scores for YOR323C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2405 ticlatone 20.40 3.5 µM 8.18E-45 2 1.42E-92
2 SGTC_660 4031-1742 19.90 102.0 µM 1.19E-42 redox potentiating 1 5.14E-88
3 SGTC_2501 sodium tetradecyl sulfate 18.50 13.4 µM 2.52E-37 1 8.35E-77
4 SGTC_1884 5633444 16.30 25.0 µM 1.78E-29 redox potentiating 4 2.80E-60
5 SGTC_123 0083-0120 15.30 66.7 µM 6.01E-26 5 7.49E-53
6 SGTC_2485 5633444 14.70 17.8 µM 4.38E-24 redox potentiating 1 6.23E-49
7 SGTC_1371 2421-0008 14.60 32.7 µM 4.86E-24 mitochondrial processes 1 7.72E-49
8 SGTC_2332 7982454 14.50 138.9 µM 1.27E-23 1 5.84E-48
9 SGTC_3211 9128781 13.40 49.5 µM 1.73E-20 2 2.27E-41
10 SGTC_2046 4110841 13.10 106.0 µM 1.38E-19 iron homeostasis 1 1.80E-39
11 SGTC_2925 9010536 13.00 32.5 µM 2.57E-19 azole & statin 2 6.64E-39
12 SGTC_771 0250-0039 12.30 27.3 µM 2.17E-17 1 7.41E-35
13 SGTC_1011 4112-3381 12.10 17.4 µM 4.85E-17 3 4.04E-34
14 SGTC_772 k072-0172 11.30 35.3 µM 5.52E-15 1 8.41E-30
15 SGTC_2991 9074669 11.10 71.4 µM 1.76E-14 azole & statin 4 9.57E-29
16 SGTC_2183 6420625 10.90 130.5 µM 3.49E-14 mitochondrial processes 2 4.05E-28
17 SGTC_1637 st007924 10.90 17.4 µM 4.18E-14 1 5.89E-28
18 SGTC_1635 st007035 10.70 42.4 µM 1.09E-13 69 4.44E-27
19 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 10.70 49.5 µM 1.32E-13 1 6.57E-27
20 SGTC_100 0086-0128 10.40 49.6 µM 6.67E-13 copper-dependent oxidative stress 6 1.98E-25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 6.76E-22 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.142 1.60E-16 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.128 1.48E-13 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.127 1.54E-13 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.121 1.98E-12 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.118 6.56E-12 YJL088W ARG3 hom Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine
0.117 1.16E-11 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.117 1.15E-11 YBR192W RIM2 het Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
0.117 1.19E-11 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.113 6.19E-11 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.109 2.89E-10 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.108 3.30E-10 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.108 3.79E-10 YOL058W ARG1 hom Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
0.108 4.06E-10 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.104 1.75E-9 YDR126W SWF1 hom Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion