YOR325W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR325W / YOR325W

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:7.35|P-value:1.30E-13 ID:SGTC_13|Compound:0199-0087|FD-Score:5.40|P-value:3.75E-8 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.29|P-value:5.02E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.17|P-value:8.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.53|P-value:3.32E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:5.22|P-value:1.03E-7 ID:SGTC_99|Compound:0109-0120|FD-Score:-4.05|P-value:2.61E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.98|P-value:3.71E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.30|P-value:4.89E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.33|P-value:4.37E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.63|P-value:1.54E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.84|P-value:6.59E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:4.99|P-value:3.40E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:3.61|P-value:1.68E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.18|P-value:7.92E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.15|P-value:1.46E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.42|P-value:3.15E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.48|P-value:2.59E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.17|P-value:8.17E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:4.03|P-value:3.08E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:3.29|P-value:5.32E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:5.17|P-value:1.34E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.48|P-value:2.66E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.19|P-value:7.47E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.58|P-value:1.86E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.17|P-value:1.69E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.09|P-value:2.32E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.57|P-value:2.77E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:5.63|P-value:1.06E-8 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.17|P-value:8.20E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.42|P-value:3.31E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.23|P-value:1.28E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.49|P-value:2.59E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.58|P-value:1.84E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.66|P-value:1.37E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.14|P-value:9.02E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.24|P-value:6.41E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.14|P-value:9.08E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.20|P-value:7.38E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-4.64|P-value:1.80E-6 ID:SGTC_2452|Compound:5863136|FD-Score:4.04|P-value:2.92E-5 ID:SGTC_2463|Compound:5473429|FD-Score:4.83|P-value:7.85E-7 ID:SGTC_2473|Compound:5854593|FD-Score:6.46|P-value:6.33E-11 ID:SGTC_2475|Compound:5812728|FD-Score:4.13|P-value:2.02E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.15|P-value:8.58E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.42|P-value:5.56E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.57|P-value:1.46E-8 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.52|P-value:2.31E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.39|P-value:6.38E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-3.17|P-value:7.75E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.83|P-value:7.84E-7 ID:SGTC_2924|Compound:9010168|FD-Score:3.26|P-value:5.88E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-5.70|P-value:6.58E-9 ID:SGTC_2939|Compound:9044578|FD-Score:4.78|P-value:9.91E-7 ID:SGTC_3020|Compound:9089140|FD-Score:-3.32|P-value:4.55E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.62|P-value:1.60E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.16|P-value:8.11E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-4.55|P-value:2.81E-6 ID:SGTC_3295|Compound:9122362|FD-Score:3.90|P-value:5.18E-5 ID:SGTC_3319|Compound:9138450|FD-Score:3.70|P-value:1.15E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:7.35|P-value:1.30E-13 ID:SGTC_13|Compound:0199-0087|FD-Score:5.40|P-value:3.75E-8 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.29|P-value:5.02E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.17|P-value:8.12E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.53|P-value:3.32E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:5.22|P-value:1.03E-7 ID:SGTC_99|Compound:0109-0120|FD-Score:-4.05|P-value:2.61E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:3.98|P-value:3.71E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.30|P-value:4.89E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.33|P-value:4.37E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.63|P-value:1.54E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.84|P-value:6.59E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:4.99|P-value:3.40E-7 ID:SGTC_356|Compound:1634-0012|FD-Score:3.61|P-value:1.68E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:3.18|P-value:7.92E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.15|P-value:1.46E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.42|P-value:3.15E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.48|P-value:2.59E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.17|P-value:8.17E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:4.03|P-value:3.08E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:3.29|P-value:5.32E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:5.17|P-value:1.34E-7 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.48|P-value:2.66E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.19|P-value:7.47E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.58|P-value:1.86E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:4.17|P-value:1.69E-5 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.09|P-value:2.32E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:4.57|P-value:2.77E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:5.63|P-value:1.06E-8 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.17|P-value:8.20E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.42|P-value:3.31E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.23|P-value:1.28E-5 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.49|P-value:2.59E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.58|P-value:1.84E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.66|P-value:1.37E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.14|P-value:9.02E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.24|P-value:6.41E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.14|P-value:9.08E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.20|P-value:7.38E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-4.64|P-value:1.80E-6 ID:SGTC_2452|Compound:5863136|FD-Score:4.04|P-value:2.92E-5 ID:SGTC_2463|Compound:5473429|FD-Score:4.83|P-value:7.85E-7 ID:SGTC_2473|Compound:5854593|FD-Score:6.46|P-value:6.33E-11 ID:SGTC_2475|Compound:5812728|FD-Score:4.13|P-value:2.02E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.15|P-value:8.58E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.42|P-value:5.56E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:5.57|P-value:1.46E-8 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.52|P-value:2.31E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:4.39|P-value:6.38E-6 ID:SGTC_2781|Compound:5567276|FD-Score:-3.17|P-value:7.75E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.83|P-value:7.84E-7 ID:SGTC_2924|Compound:9010168|FD-Score:3.26|P-value:5.88E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-5.70|P-value:6.58E-9 ID:SGTC_2939|Compound:9044578|FD-Score:4.78|P-value:9.91E-7 ID:SGTC_3020|Compound:9089140|FD-Score:-3.32|P-value:4.55E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.62|P-value:1.60E-4 ID:SGTC_3209|Compound:9113616|FD-Score:-3.16|P-value:8.11E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-4.55|P-value:2.81E-6 ID:SGTC_3295|Compound:9122362|FD-Score:3.90|P-value:5.18E-5 ID:SGTC_3319|Compound:9138450|FD-Score:3.70|P-value:1.15E-4

Top fitness defect scores for YOR325W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_8 0354-0001 7.35 70.0 µM 1.30E-13 15 1.03E-13
2 SGTC_2473 5854593 6.46 8.9 µM 6.33E-11 1 5.23E-11
3 SGTC_1423 4048-0112 5.63 5.6 µM 1.06E-8 9 9.11E-9
4 SGTC_2604 4'-hydroxychalcone 5.57 11.3 µM 1.46E-8 9 1.26E-8
5 SGTC_13 0199-0087 5.40 65.0 µM 3.75E-8 ERG2 5 3.26E-8
6 SGTC_98 0074-0023 5.22 107.7 µM 1.03E-7 Golgi 18 9.06E-8
7 SGTC_993 3909-8757 5.17 62.7 µM 1.34E-7 6 1.17E-7
8 SGTC_453 enantio-paf c16 5.15 10.0 µM 1.46E-7 82 1.28E-7
9 SGTC_350 k064-0020 4.99 19.8 µM 3.40E-7 heme requiring 13 3.00E-7
10 SGTC_2923 7992654 4.83 58.1 µM 7.84E-7 Golgi 11 6.97E-7
11 SGTC_2463 5473429 4.83 200.0 µM 7.85E-7 ERG2 6 6.98E-7
12 SGTC_2939 9044578 4.78 71.4 µM 9.91E-7 24 8.84E-7
13 SGTC_1379 2144-0755 4.57 36.5 µM 2.77E-6 13 2.49E-6
14 SGTC_95 0471-0001 4.53 561.1 µM 3.32E-6 15 2.99E-6
15 SGTC_2567 aureobasidin a 4.42 60.0 nM 5.56E-6 74 5.03E-6
16 SGTC_2777 climbazole 4.39 1.5 µM 6.38E-6 iron homeostasis 35 5.77E-6
17 SGTC_1492 4158-0558 4.23 28.5 µM 1.28E-5 60S ribosome export 10 1.17E-5
18 SGTC_1258 0671-0043 4.17 57.1 µM 1.69E-5 21 1.55E-5
19 SGTC_2475 5812728 4.13 15.0 µM 2.02E-5 mitochondrial processes 18 1.84E-5
20 SGTC_1367 1812-0510 4.09 76.9 µM 2.32E-5 18 2.12E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.59E-19 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.129 7.06E-14 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.128 1.02E-13 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.115 2.80E-11 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.103 2.26E-9 YKL014C URB1 het Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
0.100 6.46E-9 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.096 2.60E-8 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.093 6.67E-8 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.093 6.84E-8 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 6.94E-8 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.089 2.52E-7 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.088 3.04E-7 YBR224W_d YBR224W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1
0.083 1.35E-6 YDR024W_d FYV1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin
0.083 1.63E-6 YBR194W AIM4 hom Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress
0.083 1.70E-6 YOR185C GSP2 hom GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress