YOR326W / MYO2

Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR326W / MYO2

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:-3.53|P-value:3.53E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.61|P-value:1.85E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.09|P-value:2.62E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.92|P-value:3.77E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:-5.79|P-value:3.34E-11 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.00|P-value:2.98E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:2.86|P-value:5.24E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.16|P-value:1.52E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.45|P-value:5.26E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:2.77|P-value:7.49E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.10|P-value:2.44E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:2.97|P-value:3.37E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.91|P-value:4.05E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-2.78|P-value:8.96E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:2.75|P-value:8.29E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.58|P-value:1.21E-7 ID:SGTC_709|Compound:3807-1509|FD-Score:-4.23|P-value:9.28E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:3.00|P-value:2.95E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:2.91|P-value:4.29E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.64|P-value:1.63E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:3.47|P-value:3.58E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-2.98|P-value:4.14E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.09|P-value:2.12E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.67|P-value:1.81E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.67|P-value:1.39E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.84|P-value:2.40E-8 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.45|P-value:5.26E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.94|P-value:3.36E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.79|P-value:8.80E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-2.93|P-value:4.99E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.78|P-value:7.90E-6 ID:SGTC_1433|Compound:4060-0023|FD-Score:2.88|P-value:4.86E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.78|P-value:2.56E-8 ID:SGTC_1727|Compound:st034309|FD-Score:5.99|P-value:4.44E-12 ID:SGTC_1780|Compound:st038448|FD-Score:2.82|P-value:6.09E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.41|P-value:4.92E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.06|P-value:2.28E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.46|P-value:3.91E-5 ID:SGTC_1902|Compound:st060212|FD-Score:2.72|P-value:9.25E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.18|P-value:1.75E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.88|P-value:6.17E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.54|P-value:1.11E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.96|P-value:3.10E-6 ID:SGTC_2132|Compound:5317594|FD-Score:-3.99|P-value:3.58E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.62|P-value:1.73E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.54|P-value:3.45E-5 ID:SGTC_2368|Compound:9071271|FD-Score:-3.20|P-value:1.60E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-8.59|P-value:1.37E-22 ID:SGTC_2438|Compound:5259590|FD-Score:3.11|P-value:1.86E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-2.99|P-value:3.94E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-2.90|P-value:5.64E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.48|P-value:3.54E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.97|P-value:3.32E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-4.73|P-value:4.84E-8 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.15|P-value:1.45E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.29|P-value:8.26E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.42|P-value:6.16E-5 ID:SGTC_2849|Compound:9019321|FD-Score:-2.93|P-value:5.05E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.63|P-value:1.67E-5 ID:SGTC_3338|Compound:9144300|FD-Score:2.70|P-value:9.75E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.53|P-value:3.53E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:3.61|P-value:1.85E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.09|P-value:2.62E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.92|P-value:3.77E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:-5.79|P-value:3.34E-11 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.00|P-value:2.98E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:2.86|P-value:5.24E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.16|P-value:1.52E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.45|P-value:5.26E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:2.77|P-value:7.49E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.10|P-value:2.44E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:2.97|P-value:3.37E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.91|P-value:4.05E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:-2.78|P-value:8.96E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:2.75|P-value:8.29E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:-4.58|P-value:1.21E-7 ID:SGTC_709|Compound:3807-1509|FD-Score:-4.23|P-value:9.28E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:3.00|P-value:2.95E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:2.91|P-value:4.29E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:3.64|P-value:1.63E-5 ID:SGTC_826|Compound:1683-5028|FD-Score:3.47|P-value:3.58E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:-2.98|P-value:4.14E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.09|P-value:2.12E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:-3.67|P-value:1.81E-5 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.67|P-value:1.39E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-4.84|P-value:2.40E-8 ID:SGTC_1187|Compound:1391-0724|FD-Score:-3.45|P-value:5.26E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.94|P-value:3.36E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.79|P-value:8.80E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-2.93|P-value:4.99E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:3.78|P-value:7.90E-6 ID:SGTC_1433|Compound:4060-0023|FD-Score:2.88|P-value:4.86E-4 ID:SGTC_1509|Compound:1326-1131|FD-Score:4.78|P-value:2.56E-8 ID:SGTC_1727|Compound:st034309|FD-Score:5.99|P-value:4.44E-12 ID:SGTC_1780|Compound:st038448|FD-Score:2.82|P-value:6.09E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.41|P-value:4.92E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.06|P-value:2.28E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.46|P-value:3.91E-5 ID:SGTC_1902|Compound:st060212|FD-Score:2.72|P-value:9.25E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.18|P-value:1.75E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-2.88|P-value:6.17E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.54|P-value:1.11E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.96|P-value:3.10E-6 ID:SGTC_2132|Compound:5317594|FD-Score:-3.99|P-value:3.58E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.62|P-value:1.73E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.54|P-value:3.45E-5 ID:SGTC_2368|Compound:9071271|FD-Score:-3.20|P-value:1.60E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-8.59|P-value:1.37E-22 ID:SGTC_2438|Compound:5259590|FD-Score:3.11|P-value:1.86E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-2.99|P-value:3.94E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-2.90|P-value:5.64E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.48|P-value:3.54E-5 ID:SGTC_2625|Compound:euphol|FD-Score:2.97|P-value:3.32E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-4.73|P-value:4.84E-8 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.15|P-value:1.45E-6 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.29|P-value:8.26E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.42|P-value:6.16E-5 ID:SGTC_2849|Compound:9019321|FD-Score:-2.93|P-value:5.05E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.63|P-value:1.67E-5 ID:SGTC_3338|Compound:9144300|FD-Score:2.70|P-value:9.75E-4

Top fitness defect scores for YOR326W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1727 st034309 5.99 9.9 µM 4.44E-12 2 1.05E-9 0.45
2 SGTC_1509 1326-1131 4.78 80.0 µM 2.56E-8 2 8.94E-7 0.91
3 SGTC_2065 5221596 4.54 34.3 µM 1.11E-7 3 2.80E-6 0.06
4 SGTC_2129 girgensonine 3.96 121.0 µM 3.10E-6 heme biosynthesis & mitochondrial translocase 24 3.77E-5 0.04
5 SGTC_1247 0448-0043 3.94 5.8 µM 3.36E-6 ERG2 10 4.02E-5 0.02
6 SGTC_135 0933-0004 3.92 26.4 µM 3.77E-6 60S ribosome export 6 4.40E-5 0.12
7 SGTC_571 k831-0106 3.91 44.2 µM 4.05E-6 4 4.65E-5 0.04
8 SGTC_1429 4049-0205 3.78 9.5 µM 7.90E-6 2 7.85E-5 0.59
9 SGTC_1086 cerivastatin 3.67 2.2 µM 1.39E-5 azole & statin 4 1.22E-4 0.06
10 SGTC_821 1114-0266 3.64 29.2 µM 1.63E-5 5 1.39E-4 0.23
11 SGTC_3002 9075603 3.63 71.4 µM 1.67E-5 8 1.41E-4 0.04
12 SGTC_2290 7904846 3.62 200.0 µM 1.73E-5 20 1.45E-4 0.11
13 SGTC_42 0133-0086 3.61 60.6 µM 1.85E-5 14 1.53E-4 0.12
14 SGTC_2619 obliquin 3.48 87.9 µM 3.54E-5 cell wall 36 2.54E-4 0.04
15 SGTC_826 1683-5028 3.47 118.0 µM 3.58E-5 5 2.56E-4 0.17
16 SGTC_1851 st056236 3.46 18.9 µM 3.91E-5 9 2.74E-4 0.01
17 SGTC_1798 st045719 3.41 61.0 µM 4.92E-5 9 3.28E-4 0.12
18 SGTC_2772 vinpocetine 3.29 57.1 µM 8.26E-5 13 4.93E-4 0.15
19 SGTC_319 1348-1596 3.16 45.5 µM 1.52E-4 RSC & ERG11 11 7.96E-4 0.07
20 SGTC_2438 5259590 3.11 200.0 µM 1.86E-4 10 9.32E-4 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.61E-12 YNL131W TOM22 het Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
0.109 2.17E-10 YGL219C MDM34 hom Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth
0.104 1.49E-9 YDL243C AAD4 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.091 1.32E-7 YKL049C CSE4 het Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions
0.088 3.53E-7 YGR054W YGR054W hom Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A
0.086 5.58E-7 YBR114W RAD16 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.080 3.53E-6 YDR147W EKI1 hom Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication
0.078 6.54E-6 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.076 1.04E-5 YPR052C NHP6A hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.074 1.56E-5 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.074 1.59E-5 YDR261C EXG2 hom Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.073 2.20E-5 YKL023W_p YKL023W_p hom Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.073 2.29E-5 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.072 2.94E-5 YDL097C RPN6 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
0.070 5.20E-5 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation