YOR327C / SNC2

Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR327C / SNC2

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:8.35|P-value:2.32E-14 ID:SGTC_18|Compound:0111-0177|FD-Score:14.60|P-value:1.15E-39 ID:SGTC_22|Compound:0964-0034|FD-Score:4.17|P-value:7.14E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.04|P-value:2.21E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:3.63|P-value:4.56E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.59|P-value:2.01E-7 ID:SGTC_202|Compound:3594-0513|FD-Score:5.54|P-value:2.47E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.46|P-value:7.92E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.47|P-value:7.58E-4 ID:SGTC_389|Compound:tpck|FD-Score:9.44|P-value:7.68E-18 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.48|P-value:3.23E-7 ID:SGTC_574|Compound:1315-0397|FD-Score:3.71|P-value:3.49E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:4.20|P-value:6.59E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:3.38|P-value:9.83E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:9.19|P-value:5.13E-17 ID:SGTC_738|Compound:1315-0003|FD-Score:3.87|P-value:2.07E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.82|P-value:5.81E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:4.75|P-value:7.85E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:5.66|P-value:1.38E-7 ID:SGTC_860|Compound:0443-0016|FD-Score:4.46|P-value:2.47E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.91|P-value:1.82E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.06|P-value:1.09E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:6.10|P-value:1.57E-8 ID:SGTC_985|Compound:1493-0307|FD-Score:11.00|P-value:1.47E-23 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.23|P-value:5.86E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.87|P-value:2.06E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.44|P-value:2.67E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.53|P-value:9.54E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.41|P-value:9.05E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.66|P-value:4.19E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.63|P-value:4.56E-4 ID:SGTC_1652|Compound:st011932|FD-Score:7.59|P-value:3.40E-12 ID:SGTC_1783|Compound:st039459|FD-Score:6.21|P-value:9.05E-9 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.53|P-value:1.90E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-5.38|P-value:9.90E-7 ID:SGTC_2077|Compound:5212015|FD-Score:4.11|P-value:8.90E-5 ID:SGTC_2241|Compound:6772625|FD-Score:4.54|P-value:1.78E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.93|P-value:1.68E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.19|P-value:1.12E-4 ID:SGTC_2378|Compound:9074213|FD-Score:5.16|P-value:1.40E-6 ID:SGTC_2412|Compound:st077135|FD-Score:3.59|P-value:5.28E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.65|P-value:4.32E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.75|P-value:3.11E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.74|P-value:4.94E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.12|P-value:1.40E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.18|P-value:7.09E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.68|P-value:3.91E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.02|P-value:2.53E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:7.39|P-value:1.18E-11 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.42|P-value:2.97E-9 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.86|P-value:2.15E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.98|P-value:2.31E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.62|P-value:7.25E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.79|P-value:4.24E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.13|P-value:8.46E-5 ID:SGTC_3122|Compound:9126309|FD-Score:4.53|P-value:1.85E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.67|P-value:4.05E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.73|P-value:8.54E-6 ID:SGTC_3350|Compound:9150499|FD-Score:4.18|P-value:6.95E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.51|P-value:6.70E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:8.35|P-value:2.32E-14 ID:SGTC_18|Compound:0111-0177|FD-Score:14.60|P-value:1.15E-39 ID:SGTC_22|Compound:0964-0034|FD-Score:4.17|P-value:7.14E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:6.04|P-value:2.21E-8 ID:SGTC_70|Compound:0141-0289|FD-Score:3.63|P-value:4.56E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:5.59|P-value:2.01E-7 ID:SGTC_202|Compound:3594-0513|FD-Score:5.54|P-value:2.47E-7 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.46|P-value:7.92E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.47|P-value:7.58E-4 ID:SGTC_389|Compound:tpck|FD-Score:9.44|P-value:7.68E-18 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.48|P-value:3.23E-7 ID:SGTC_574|Compound:1315-0397|FD-Score:3.71|P-value:3.49E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:4.20|P-value:6.59E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:3.38|P-value:9.83E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:9.19|P-value:5.13E-17 ID:SGTC_738|Compound:1315-0003|FD-Score:3.87|P-value:2.07E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.82|P-value:5.81E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:4.75|P-value:7.85E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:5.66|P-value:1.38E-7 ID:SGTC_860|Compound:0443-0016|FD-Score:4.46|P-value:2.47E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.91|P-value:1.82E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.06|P-value:1.09E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:6.10|P-value:1.57E-8 ID:SGTC_985|Compound:1493-0307|FD-Score:11.00|P-value:1.47E-23 ID:SGTC_1162|Compound:k048-0130|FD-Score:4.23|P-value:5.86E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.87|P-value:2.06E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.44|P-value:2.67E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.53|P-value:9.54E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.41|P-value:9.05E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.66|P-value:4.19E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.63|P-value:4.56E-4 ID:SGTC_1652|Compound:st011932|FD-Score:7.59|P-value:3.40E-12 ID:SGTC_1783|Compound:st039459|FD-Score:6.21|P-value:9.05E-9 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.53|P-value:1.90E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-5.38|P-value:9.90E-7 ID:SGTC_2077|Compound:5212015|FD-Score:4.11|P-value:8.90E-5 ID:SGTC_2241|Compound:6772625|FD-Score:4.54|P-value:1.78E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.93|P-value:1.68E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.19|P-value:1.12E-4 ID:SGTC_2378|Compound:9074213|FD-Score:5.16|P-value:1.40E-6 ID:SGTC_2412|Compound:st077135|FD-Score:3.59|P-value:5.28E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.65|P-value:4.32E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.75|P-value:3.11E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:-3.74|P-value:4.94E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.12|P-value:1.40E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:4.18|P-value:7.09E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.68|P-value:3.91E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:5.02|P-value:2.53E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:7.39|P-value:1.18E-11 ID:SGTC_2752|Compound:diclazuril|FD-Score:6.42|P-value:2.97E-9 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.86|P-value:2.15E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.98|P-value:2.31E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.62|P-value:7.25E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.79|P-value:4.24E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.13|P-value:8.46E-5 ID:SGTC_3122|Compound:9126309|FD-Score:4.53|P-value:1.85E-5 ID:SGTC_3140|Compound:9094243|FD-Score:3.67|P-value:4.05E-4 ID:SGTC_3277|Compound:9138724|FD-Score:4.73|P-value:8.54E-6 ID:SGTC_3350|Compound:9150499|FD-Score:4.18|P-value:6.95E-5 ID:SGTC_3356|Compound:9151811|FD-Score:3.51|P-value:6.70E-4

Top fitness defect scores for YOR327C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_18 0111-0177 14.60 500.0 nM 1.15E-39 2 1.93E-48
2 SGTC_985 1493-0307 11.00 8.7 µM 1.47E-23 TSC3-RPN4 2 1.61E-28
3 SGTC_389 tpck 9.44 16.7 µM 7.68E-18 5 1.82E-21
4 SGTC_673 1082-0474 9.19 110.0 µM 5.13E-17 RSC complex & mRNA processing 10 1.89E-20
5 SGTC_7 0192-1582 8.35 4.2 µM 2.32E-14 12 3.54E-17
6 SGTC_1652 st011932 7.59 78.0 µM 3.40E-12 RSC complex & mRNA processing 2 1.63E-14
7 SGTC_2743 auranofin 7.39 4.3 µM 1.18E-11 RPP1 & pyrimidine depletion 6 7.56E-14
8 SGTC_2752 diclazuril 6.42 33.1 µM 2.97E-9 52 6.68E-11
9 SGTC_1783 st039459 6.21 87.5 µM 9.05E-9 Golgi 4 2.62E-10
10 SGTC_975 1335-0046 6.10 28.5 µM 1.57E-8 RPP1 & pyrimidine depletion 6 5.15E-10
11 SGTC_58 0957-0393 6.04 9.0 µM 2.21E-8 cell wall 215 7.82E-10
12 SGTC_854 0422-0053 5.66 192.0 µM 1.38E-7 PDR1 2 7.37E-9
13 SGTC_138 0850-0259 5.59 40.9 µM 2.01E-7 cell wall 119 1.16E-8
14 SGTC_202 3594-0513 5.54 34.8 µM 2.47E-7 PDR1 4 1.50E-8
15 SGTC_391 gliotoxin 5.48 8.3 µM 3.23E-7 32 2.08E-8
16 SGTC_2378 9074213 5.16 121.4 µM 1.40E-6 RSC complex & mRNA processing 2 1.25E-7
17 SGTC_2737 bleomycin 5.02 30.5 nM 2.53E-6 Golgi 53 2.57E-7
18 SGTC_770 0389-1121 4.82 67.2 µM 5.81E-6 RPP1 & pyrimidine depletion 13 7.07E-7
19 SGTC_839 0122-0028 4.75 230.0 µM 7.85E-6 RSC complex & mRNA processing 17 1.02E-6
20 SGTC_3277 9138724 4.73 49.5 µM 8.54E-6 Golgi 13 1.13E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.227 2.45E-40 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.186 1.49E-27 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.184 4.29E-27 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.175 1.54E-24 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.175 1.77E-24 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.169 7.57E-23 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.165 7.33E-22 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.163 2.33E-21 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.155 1.29E-19 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.154 3.23E-19 YML128C MSC1 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
0.150 1.94E-18 YNL271C BNI1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
0.149 3.22E-18 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.148 6.58E-18 YGL005C COG7 hom Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.142 1.20E-16 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.135 3.70E-15 YAL001C TFC3 het Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding