YOR328W / PDR10

ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR328W / PDR10

Click on Significant Values for Screen Details ID:SGTC_341|Compound:1486-1430|FD-Score:-4.30|P-value:3.18E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.29|P-value:2.77E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.06|P-value:6.46E-4 ID:SGTC_442|Compound:cape|FD-Score:3.28|P-value:2.86E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.21|P-value:3.75E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.84|P-value:2.79E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:4.12|P-value:7.68E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.50|P-value:1.20E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.05|P-value:6.91E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:5.33|P-value:1.11E-8 ID:SGTC_916|Compound:4466-0038|FD-Score:3.07|P-value:6.40E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.32|P-value:2.45E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.02|P-value:6.71E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.01|P-value:8.03E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.14|P-value:6.83E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.05|P-value:6.87E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.68|P-value:5.62E-5 ID:SGTC_1862|Compound:st057513|FD-Score:-3.75|P-value:4.13E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.70|P-value:5.22E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.96|P-value:1.63E-5 ID:SGTC_2080|Compound:5212524|FD-Score:3.70|P-value:5.21E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.53|P-value:1.05E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.40|P-value:1.80E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.15|P-value:4.69E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.30|P-value:2.64E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.25|P-value:3.29E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.00|P-value:8.06E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.73|P-value:4.52E-5 ID:SGTC_2671|Compound:danthron|FD-Score:3.91|P-value:1.99E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.28|P-value:2.83E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.16|P-value:4.49E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.87|P-value:2.45E-5 ID:SGTC_2967|Compound:9089538|FD-Score:4.98|P-value:8.64E-8 ID:SGTC_3089|Compound:9117425|FD-Score:-3.03|P-value:7.39E-4 ID:SGTC_3107|Compound:9121808|FD-Score:4.45|P-value:1.53E-6 ID:SGTC_3141|Compound:9094609|FD-Score:2.95|P-value:9.79E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.03|P-value:7.33E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-4.30|P-value:3.18E-6 ID:SGTC_366|Compound:0181-0206|FD-Score:-3.29|P-value:2.77E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.06|P-value:6.46E-4 ID:SGTC_442|Compound:cape|FD-Score:3.28|P-value:2.86E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.21|P-value:3.75E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.84|P-value:2.79E-5 ID:SGTC_581|Compound:0958-0271|FD-Score:4.12|P-value:7.68E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:3.50|P-value:1.20E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.05|P-value:6.91E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:5.33|P-value:1.11E-8 ID:SGTC_916|Compound:4466-0038|FD-Score:3.07|P-value:6.40E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.32|P-value:2.45E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:5.02|P-value:6.71E-8 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.43|P-value:1.60E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.01|P-value:8.03E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.14|P-value:6.83E-6 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.05|P-value:6.87E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.68|P-value:5.62E-5 ID:SGTC_1862|Compound:st057513|FD-Score:-3.75|P-value:4.13E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.70|P-value:5.22E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.96|P-value:1.63E-5 ID:SGTC_2080|Compound:5212524|FD-Score:3.70|P-value:5.21E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.53|P-value:1.05E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.40|P-value:1.80E-4 ID:SGTC_2143|Compound:5623677|FD-Score:3.15|P-value:4.69E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.30|P-value:2.64E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.25|P-value:3.29E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.00|P-value:8.06E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.73|P-value:4.52E-5 ID:SGTC_2671|Compound:danthron|FD-Score:3.91|P-value:1.99E-5 ID:SGTC_2705|Compound:st078069|FD-Score:3.28|P-value:2.83E-4 ID:SGTC_2788|Compound:5282734|FD-Score:-3.16|P-value:4.49E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.87|P-value:2.45E-5 ID:SGTC_2967|Compound:9089538|FD-Score:4.98|P-value:8.64E-8 ID:SGTC_3089|Compound:9117425|FD-Score:-3.03|P-value:7.39E-4 ID:SGTC_3107|Compound:9121808|FD-Score:4.45|P-value:1.53E-6 ID:SGTC_3141|Compound:9094609|FD-Score:2.95|P-value:9.79E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.03|P-value:7.33E-4

Top fitness defect scores for YOR328W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_786 4544-0069 5.33 423.0 µM 1.11E-8 10 4.94E-8
2 SGTC_1131 3454-3128 5.02 32.3 µM 6.71E-8 14 2.55E-7
3 SGTC_2967 9089538 4.98 49.9 µM 8.64E-8 12 3.21E-7
4 SGTC_3107 9121808 4.45 49.5 µM 1.53E-6 3 4.38E-6
5 SGTC_1234 0326-0494 4.14 15.5 µM 6.83E-6 11 1.71E-5
6 SGTC_581 0958-0271 4.12 211.0 µM 7.68E-6 46 1.91E-5
7 SGTC_2061 5245884 3.96 81.0 µM 1.63E-5 tubulin folding & SWR complex 23 3.79E-5
8 SGTC_2671 danthron 3.91 100.0 µM 1.99E-5 DNA damage response 43 4.54E-5
9 SGTC_2799 7812892 3.87 81.8 µM 2.45E-5 superoxide 30 5.48E-5
10 SGTC_2614 arthonioic acid 3.73 13.4 µM 4.52E-5 26 9.58E-5
11 SGTC_2080 5212524 3.70 12.4 µM 5.21E-5 copper-dependent oxidative stress 17 1.09E-4
12 SGTC_1951 sophoraflavanone G 3.70 9.2 µM 5.22E-5 RNA processing & uracil transport 34 1.09E-4
13 SGTC_1430 4049-0248 3.68 69.1 µM 5.62E-5 26 1.17E-4
14 SGTC_2116 5511452 3.53 16.9 µM 1.05E-4 23 2.06E-4
15 SGTC_725 1497-0963 3.50 19.0 µM 1.20E-4 copper-dependent oxidative stress 32 2.34E-4
16 SGTC_1133 3473-0247 3.43 50.0 µM 1.60E-4 RSC complex & mRNA processing 74 3.03E-4
17 SGTC_2138 5575593 3.40 77.7 µM 1.80E-4 24 3.38E-4
18 SGTC_1073 triclabendazole 3.32 3.1 µM 2.45E-4 59 4.48E-4
19 SGTC_2705 st078069 3.28 42.8 µM 2.83E-4 26 5.10E-4
20 SGTC_442 cape 3.28 100.0 µM 2.86E-4 29 5.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 5.48E-26 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.102 3.16E-9 YJR119C JHD2 hom JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation
0.100 7.38E-9 YPL156C PRM4 hom Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
0.099 1.08E-8 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.096 2.93E-8 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.083 1.50E-6 YOL118C_d YOL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.87E-6 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.080 3.88E-6 YER149C PEA2 hom Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
0.079 4.88E-6 YPR007C REC8 hom Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p
0.078 5.63E-6 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.078 6.58E-6 YFR054C_d YFR054C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 7.21E-6 YHR037W PUT2 hom Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
0.076 9.34E-6 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.076 9.79E-6 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.076 1.19E-5 YCL069W VBA3 hom Permease of basic amino acids in the vacuolar membrane