YOR329C / SCD5

Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR329C / SCD5

Click on Significant Values for Screen Details ID:SGTC_135|Compound:0933-0004|FD-Score:2.72|P-value:7.27E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.45|P-value:2.92E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:5.31|P-value:2.58E-10 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-2.83|P-value:4.95E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.95|P-value:2.87E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.19|P-value:1.00E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.15|P-value:1.09E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.23|P-value:7.61E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:2.88|P-value:3.66E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.25|P-value:7.54E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.70|P-value:7.62E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.82|P-value:5.05E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.45|P-value:1.01E-7 ID:SGTC_2054|Compound:5233173|FD-Score:-3.59|P-value:1.39E-5 ID:SGTC_2148|Compound:5546263|FD-Score:2.75|P-value:6.32E-4 ID:SGTC_2337|Compound:9009472|FD-Score:2.64|P-value:9.83E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-2.68|P-value:8.93E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.86|P-value:4.05E-4 ID:SGTC_2808|Compound:7946468|FD-Score:5.31|P-value:2.56E-10 ID:SGTC_2814|Compound:7977482|FD-Score:4.60|P-value:3.69E-8 ID:SGTC_2933|Compound:9026794|FD-Score:6.43|P-value:2.65E-14 ID:SGTC_3090|Compound:9117696|FD-Score:2.78|P-value:5.53E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.04|P-value:1.84E-4 ID:SGTC_3205|Compound:9113483|FD-Score:2.65|P-value:9.38E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.39|P-value:3.64E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:2.72|P-value:7.27E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.45|P-value:2.92E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:5.31|P-value:2.58E-10 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-2.83|P-value:4.95E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.95|P-value:2.87E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.19|P-value:1.00E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.15|P-value:1.09E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.23|P-value:7.61E-5 ID:SGTC_803|Compound:4488-1585|FD-Score:2.88|P-value:3.66E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.25|P-value:7.54E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:2.70|P-value:7.62E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-2.82|P-value:5.05E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.45|P-value:1.01E-7 ID:SGTC_2054|Compound:5233173|FD-Score:-3.59|P-value:1.39E-5 ID:SGTC_2148|Compound:5546263|FD-Score:2.75|P-value:6.32E-4 ID:SGTC_2337|Compound:9009472|FD-Score:2.64|P-value:9.83E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-2.68|P-value:8.93E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.86|P-value:4.05E-4 ID:SGTC_2808|Compound:7946468|FD-Score:5.31|P-value:2.56E-10 ID:SGTC_2814|Compound:7977482|FD-Score:4.60|P-value:3.69E-8 ID:SGTC_2933|Compound:9026794|FD-Score:6.43|P-value:2.65E-14 ID:SGTC_3090|Compound:9117696|FD-Score:2.78|P-value:5.53E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.04|P-value:1.84E-4 ID:SGTC_3205|Compound:9113483|FD-Score:2.65|P-value:9.38E-4 ID:SGTC_3343|Compound:9148379|FD-Score:3.39|P-value:3.64E-5

Top fitness defect scores for YOR329C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2933 9026794 6.43 32.5 µM 2.65E-14 1 6.40E-11 1.06
2 SGTC_2808 7946468 5.31 45.5 µM 2.56E-10 1 5.49E-8 0.67
3 SGTC_359 0081-0058 5.31 15.9 µM 2.58E-10 60S ribosome export 6 5.53E-8 0.34
4 SGTC_2814 7977482 4.60 43.0 µM 3.69E-8 8 2.15E-6 0.09
5 SGTC_3343 9148379 3.39 19.0 µM 3.64E-5 2 3.55E-4 0.31
6 SGTC_766 1391-0721 3.23 126.0 µM 7.61E-5 9 6.14E-4 0.04
7 SGTC_763 3453-1109 3.15 128.0 µM 1.09E-4 12 8.03E-4 0.04
8 SGTC_3127 9126946 3.04 49.5 µM 1.84E-4 ERG2 20 0.00118 0.08
9 SGTC_803 4488-1585 2.88 147.0 µM 3.66E-4 14 0.00198 0.00
10 SGTC_2807 7945238 2.86 52.0 µM 4.05E-4 20 0.00213 0.00
11 SGTC_3090 9117696 2.78 49.5 µM 5.53E-4 14 0.00269 0.11
12 SGTC_2148 5546263 2.75 113.6 µM 6.32E-4 13 0.00298 1.29E-5
13 SGTC_135 0933-0004 2.72 26.4 µM 7.27E-4 60S ribosome export 21 0.00330 0.03
14 SGTC_1083 didemethylchlorpromazine sulfoxide 2.70 707.4 nM 7.62E-4 redox potentiating 44 0.00342 0.03
15 SGTC_3205 9113483 2.65 49.5 µM 9.38E-4 22 0.00400 0.00
16 SGTC_2337 9009472 2.64 200.0 µM 9.83E-4 29 0.00414 0.02
17 SGTC_1570 verbenone 2.59 133.0 µM 0.00122 22 0.00486 0.06
18 SGTC_2555 cholic acid 2.56 100.0 µM 0.00135 12 0.00526 0.02
19 SGTC_564 3555-0129 2.55 330.0 µM 0.00140 16 0.00541 0.02
20 SGTC_1169 aniline yellow 2.50 25.8 µM 0.00167 19 0.00615 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 9.82E-33 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.201 8.52E-32 YGR174W-A_p YGR174W-A_p hom Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis
0.150 2.91E-18 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.134 8.26E-15 YER038C KRE29 het Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.130 3.75E-14 YDR020C_p DAS2_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases
0.128 8.96E-14 YNL035C YNL035C hom Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress
0.125 3.42E-13 YLR042C_p YLR042C_p hom Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
0.124 5.84E-13 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.122 1.51E-12 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.118 6.91E-12 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.114 3.64E-11 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.114 3.85E-11 YOR060C SLD7 het Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
0.114 4.31E-11 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.112 9.27E-11 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.111 1.16E-10 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication