YOR330C / MIP1

Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR330C / MIP1

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:7.37|P-value:9.41E-17 ID:SGTC_108|Compound:0509-0257|FD-Score:2.86|P-value:6.83E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.77|P-value:1.26E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.67|P-value:1.21E-10 ID:SGTC_134|Compound:0269-0018|FD-Score:8.34|P-value:6.09E-21 ID:SGTC_168|Compound:3970-0862|FD-Score:4.22|P-value:1.20E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:3.29|P-value:1.16E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:2.82|P-value:8.00E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:39.60|P-value:0 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.97|P-value:4.34E-29 ID:SGTC_279|Compound:1273-0055|FD-Score:3.54|P-value:3.63E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:4.41|P-value:4.10E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.72|P-value:1.76E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:8.82|P-value:3.37E-23 ID:SGTC_386|Compound:1509-0011|FD-Score:17.50|P-value:3.94E-85 ID:SGTC_435|Compound:c-PAF|FD-Score:3.61|P-value:2.70E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:2.95|P-value:4.71E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.09|P-value:2.70E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.43|P-value:7.07E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:2.97|P-value:4.42E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.75|P-value:6.33E-11 ID:SGTC_1188|Compound:1403-0014|FD-Score:8.94|P-value:9.02E-24 ID:SGTC_1218|Compound:1348-1416|FD-Score:-4.15|P-value:2.00E-6 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.27|P-value:1.42E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.31|P-value:1.17E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.45|P-value:3.25E-7 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.16|P-value:2.28E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-9.38|P-value:8.29E-26 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.19|P-value:2.84E-12 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.82|P-value:7.98E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.40|P-value:2.02E-37 ID:SGTC_1658|Compound:st012944|FD-Score:-2.91|P-value:6.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.49|P-value:5.39E-5 ID:SGTC_1722|Compound:st034304|FD-Score:4.50|P-value:2.39E-7 ID:SGTC_1742|Compound:st038235|FD-Score:2.78|P-value:9.29E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.16|P-value:4.85E-9 ID:SGTC_1796|Compound:st049173|FD-Score:2.88|P-value:6.38E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.32|P-value:1.01E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.31|P-value:1.03E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.79|P-value:1.14E-5 ID:SGTC_1946|Compound:st076057|FD-Score:2.78|P-value:9.36E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.01|P-value:4.22E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.01|P-value:4.16E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-3.65|P-value:2.54E-5 ID:SGTC_2098|Compound:5376439|FD-Score:-3.39|P-value:8.19E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.17|P-value:1.97E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.84|P-value:7.26E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.04|P-value:3.63E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.37|P-value:9.08E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.71|P-value:8.78E-11 ID:SGTC_2278|Compound:7948257|FD-Score:3.10|P-value:2.60E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.82|P-value:9.39E-6 ID:SGTC_2389|Compound:9091542|FD-Score:-3.17|P-value:2.18E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.45|P-value:5.64E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.85|P-value:7.83E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.55|P-value:3.53E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.71|P-value:6.97E-8 ID:SGTC_2646|Compound:retinol|FD-Score:2.76|P-value:9.77E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-2.98|P-value:4.73E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.91|P-value:7.05E-6 ID:SGTC_2932|Compound:9016711|FD-Score:3.35|P-value:8.70E-5 ID:SGTC_2935|Compound:9038016|FD-Score:2.84|P-value:7.33E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:7.37|P-value:9.41E-17 ID:SGTC_108|Compound:0509-0257|FD-Score:2.86|P-value:6.83E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.77|P-value:1.26E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:5.67|P-value:1.21E-10 ID:SGTC_134|Compound:0269-0018|FD-Score:8.34|P-value:6.09E-21 ID:SGTC_168|Compound:3970-0862|FD-Score:4.22|P-value:1.20E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:3.29|P-value:1.16E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:2.82|P-value:8.00E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:39.60|P-value:0 ID:SGTC_275|Compound:trichlorophene|FD-Score:9.97|P-value:4.34E-29 ID:SGTC_279|Compound:1273-0055|FD-Score:3.54|P-value:3.63E-5 ID:SGTC_283|Compound:0987-0079|FD-Score:4.41|P-value:4.10E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.72|P-value:1.76E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:8.82|P-value:3.37E-23 ID:SGTC_386|Compound:1509-0011|FD-Score:17.50|P-value:3.94E-85 ID:SGTC_435|Compound:c-PAF|FD-Score:3.61|P-value:2.70E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:2.95|P-value:4.71E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:3.09|P-value:2.70E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.43|P-value:7.07E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:2.97|P-value:4.42E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.75|P-value:6.33E-11 ID:SGTC_1188|Compound:1403-0014|FD-Score:8.94|P-value:9.02E-24 ID:SGTC_1218|Compound:1348-1416|FD-Score:-4.15|P-value:2.00E-6 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.27|P-value:1.42E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.31|P-value:1.17E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:4.45|P-value:3.25E-7 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.16|P-value:2.28E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-9.38|P-value:8.29E-26 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.19|P-value:2.84E-12 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.82|P-value:7.98E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.40|P-value:2.02E-37 ID:SGTC_1658|Compound:st012944|FD-Score:-2.91|P-value:6.23E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.49|P-value:5.39E-5 ID:SGTC_1722|Compound:st034304|FD-Score:4.50|P-value:2.39E-7 ID:SGTC_1742|Compound:st038235|FD-Score:2.78|P-value:9.29E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.16|P-value:4.85E-9 ID:SGTC_1796|Compound:st049173|FD-Score:2.88|P-value:6.38E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.32|P-value:1.01E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.31|P-value:1.03E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.79|P-value:1.14E-5 ID:SGTC_1946|Compound:st076057|FD-Score:2.78|P-value:9.36E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.01|P-value:4.22E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.01|P-value:4.16E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-3.65|P-value:2.54E-5 ID:SGTC_2098|Compound:5376439|FD-Score:-3.39|P-value:8.19E-5 ID:SGTC_2107|Compound:5363541|FD-Score:3.17|P-value:1.97E-4 ID:SGTC_2126|Compound:5251174|FD-Score:2.84|P-value:7.26E-4 ID:SGTC_2136|Compound:5328288|FD-Score:-3.04|P-value:3.63E-4 ID:SGTC_2145|Compound:5634607|FD-Score:-3.37|P-value:9.08E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.71|P-value:8.78E-11 ID:SGTC_2278|Compound:7948257|FD-Score:3.10|P-value:2.60E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.82|P-value:9.39E-6 ID:SGTC_2389|Compound:9091542|FD-Score:-3.17|P-value:2.18E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.45|P-value:5.64E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.85|P-value:7.83E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.55|P-value:3.53E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.71|P-value:6.97E-8 ID:SGTC_2646|Compound:retinol|FD-Score:2.76|P-value:9.77E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-2.98|P-value:4.73E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.91|P-value:7.05E-6 ID:SGTC_2932|Compound:9016711|FD-Score:3.35|P-value:8.70E-5 ID:SGTC_2935|Compound:9038016|FD-Score:2.84|P-value:7.33E-4

Top fitness defect scores for YOR330C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 39.60 5.3 µM 0 1 0
2 SGTC_386 1509-0011 17.50 3.1 µM 3.94E-85 14 8.43E-69
3 SGTC_1635 st007035 11.40 42.4 µM 2.02E-37 65 2.01E-30
4 SGTC_275 trichlorophene 9.97 5.7 µM 4.34E-29 mitochondrial stress 46 1.02E-23
5 SGTC_1188 1403-0014 8.94 4.6 µM 9.02E-24 mitochondrial stress 3 1.94E-19
6 SGTC_365 0121-0052 8.82 13.6 µM 3.37E-23 mitochondrial response to ROS 5 5.61E-19
7 SGTC_134 0269-0018 8.34 6.9 µM 6.09E-21 58 3.68E-17
8 SGTC_70 0141-0289 7.37 43.3 µM 9.41E-17 mitochondrial stress 48 8.70E-14
9 SGTC_908 3448-7491 5.75 47.7 µM 6.33E-11 mitochondrial stress 55 4.35E-9
10 SGTC_2250 alverine citrate 5.71 130.0 µM 8.78E-11 60 5.66E-9
11 SGTC_119 0121-0043 5.67 24.8 µM 1.21E-10 mitochondrial stress 30 7.35E-9
12 SGTC_2582 agaric acid 4.71 100.0 µM 6.97E-8 redox potentiating 242 1.24E-6
13 SGTC_1722 st034304 4.50 3.6 µM 2.39E-7 mitochondrial processes 15 3.35E-6
14 SGTC_1418 3966-3099 4.45 2.4 µM 3.25E-7 13 4.31E-6
15 SGTC_283 0987-0079 4.41 11.7 µM 4.10E-7 15 5.20E-6
16 SGTC_168 3970-0862 4.22 530.5 µM 1.20E-6 104 1.24E-5
17 SGTC_2375 9072683 3.82 200.0 µM 9.39E-6 mitochondrial processes 22 6.56E-5
18 SGTC_1938 st074717 3.79 56.4 µM 1.14E-5 14 7.67E-5
19 SGTC_116 0155-0182 3.77 31.8 µM 1.26E-5 mitochondrial response to ROS 92 8.32E-5
20 SGTC_435 c-PAF 3.61 6.7 µM 2.70E-5 60 1.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.774 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.748 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.735 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.733 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.730 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.709 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.702 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.700 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.695 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.683 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.675 0 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.674 0 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.673 0 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.668 0 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.663 0 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme