YOR333C_d

Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR333C / YOR333C

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.39|P-value:1.09E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.62|P-value:3.95E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.06|P-value:4.17E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.75|P-value:2.06E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.63|P-value:3.77E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.28|P-value:1.71E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-2.86|P-value:8.91E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.65|P-value:3.44E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.02|P-value:5.83E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.19|P-value:2.53E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.51|P-value:4.33E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.62|P-value:3.88E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:3.16|P-value:2.81E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.88|P-value:1.14E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.00|P-value:5.23E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.41|P-value:1.67E-9 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.96|P-value:6.00E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.98|P-value:7.21E-6 ID:SGTC_1732|Compound:st034308|FD-Score:3.37|P-value:1.20E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.69|P-value:2.89E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.72|P-value:2.51E-5 ID:SGTC_1936|Compound:st074407|FD-Score:-2.87|P-value:8.47E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.69|P-value:2.90E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.17|P-value:2.75E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.50|P-value:6.54E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-3.63|P-value:3.63E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.77|P-value:1.93E-5 ID:SGTC_2347|Compound:9049783|FD-Score:5.92|P-value:5.23E-11 ID:SGTC_2354|Compound:9060492|FD-Score:3.27|P-value:1.78E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.98|P-value:7.24E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.15|P-value:9.57E-9 ID:SGTC_2818|Compound:7996756|FD-Score:3.05|P-value:4.50E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.82|P-value:1.49E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-4.65|P-value:1.94E-7 ID:SGTC_2867|Compound:9039098|FD-Score:3.65|P-value:3.50E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.96|P-value:7.85E-6 ID:SGTC_2874|Compound:9043904|FD-Score:3.93|P-value:9.18E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-5.12|P-value:1.10E-8 ID:SGTC_49|Compound:0717-0965|FD-Score:3.39|P-value:1.09E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.62|P-value:3.95E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.06|P-value:4.17E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:-3.75|P-value:2.06E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.63|P-value:3.77E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-3.28|P-value:1.71E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:-2.86|P-value:8.91E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.65|P-value:3.44E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.02|P-value:5.83E-6 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.19|P-value:2.53E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:4.51|P-value:4.33E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.62|P-value:3.88E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:3.16|P-value:2.81E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.88|P-value:1.14E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.00|P-value:5.23E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-5.41|P-value:1.67E-9 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.96|P-value:6.00E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.98|P-value:7.21E-6 ID:SGTC_1732|Compound:st034308|FD-Score:3.37|P-value:1.20E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.69|P-value:2.89E-5 ID:SGTC_1927|Compound:st060202|FD-Score:3.72|P-value:2.51E-5 ID:SGTC_1936|Compound:st074407|FD-Score:-2.87|P-value:8.47E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.69|P-value:2.90E-5 ID:SGTC_1991|Compound:st073000|FD-Score:3.17|P-value:2.75E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-3.50|P-value:6.54E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-3.63|P-value:3.63E-5 ID:SGTC_2306|Compound:7482397|FD-Score:3.77|P-value:1.93E-5 ID:SGTC_2347|Compound:9049783|FD-Score:5.92|P-value:5.23E-11 ID:SGTC_2354|Compound:9060492|FD-Score:3.27|P-value:1.78E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.98|P-value:7.24E-6 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.15|P-value:9.57E-9 ID:SGTC_2818|Compound:7996756|FD-Score:3.05|P-value:4.50E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.82|P-value:1.49E-5 ID:SGTC_2838|Compound:9002687|FD-Score:-4.65|P-value:1.94E-7 ID:SGTC_2867|Compound:9039098|FD-Score:3.65|P-value:3.50E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.96|P-value:7.85E-6 ID:SGTC_2874|Compound:9043904|FD-Score:3.93|P-value:9.18E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-5.12|P-value:1.10E-8

Top fitness defect scores for YOR333C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2347 9049783 5.92 174.8 µM 5.23E-11 8 1.59E-9
2 SGTC_2612 dictamnine 5.15 15.5 µM 9.57E-9 RNA pol III & RNase P/MRP 21 1.29E-7
3 SGTC_518 1021-0119 4.51 62.6 µM 4.33E-7 ERG2 22 3.22E-6
4 SGTC_453 enantio-paf c16 4.02 10.0 µM 5.83E-6 139 2.91E-5
5 SGTC_1138 3761-0006 3.98 1.0 µM 7.21E-6 3 3.48E-5
6 SGTC_2605 digitonin 3.98 300.0 nM 7.24E-6 27 3.50E-5
7 SGTC_2871 9038510 3.96 13.0 µM 7.85E-6 15 3.75E-5
8 SGTC_2874 9043904 3.93 71.4 µM 9.18E-6 11 4.28E-5
9 SGTC_2306 7482397 3.77 179.5 µM 1.93E-5 RPP1 & pyrimidine depletion 25 8.02E-5
10 SGTC_1927 st060202 3.72 13.8 µM 2.51E-5 25 1.00E-4
11 SGTC_1733 st037357 3.69 54.9 µM 2.89E-5 60S ribosome export 42 1.13E-4
12 SGTC_1945 st075991 3.69 56.6 µM 2.90E-5 60S ribosome export 28 1.14E-4
13 SGTC_366 0181-0206 3.65 4.3 µM 3.44E-5 Golgi 53 1.31E-4
14 SGTC_2867 9039098 3.65 71.4 µM 3.50E-5 iron homeostasis 48 1.33E-4
15 SGTC_236 1509-0011 3.63 5.3 µM 3.77E-5 403 1.42E-4
16 SGTC_57 miconazole 3.62 162.5 nM 3.95E-5 ergosterol depletion effects on membrane 32 1.47E-4
17 SGTC_49 0717-0965 3.39 32.1 µM 1.09E-4 60S ribosome export 41 3.48E-4
18 SGTC_1732 st034308 3.37 51.8 µM 1.20E-4 46 3.78E-4
19 SGTC_2354 9060492 3.27 162.0 µM 1.78E-4 42 5.29E-4
20 SGTC_511 blebbistatin 3.19 171.0 µM 2.53E-4 DNA intercalators 41 7.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 8.42E-26 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.148 7.69E-18 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.123 1.03E-12 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.122 1.25E-12 YCL031C RRP7 het Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
0.122 1.59E-12 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.117 1.00E-11 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.115 2.40E-11 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.113 4.42E-11 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.110 1.54E-10 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.110 1.99E-10 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.107 4.40E-10 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 5.05E-10 YJR048W CYC1 hom Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication
0.106 7.33E-10 YOR147W MDM32 hom Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
0.105 9.19E-10 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.105 9.43E-10 YGL134W PCL10 hom Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate