YOR337W / TEA1

Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR337W / TEA1

Click on Significant Values for Screen Details ID:SGTC_245|Compound:methotrexate|FD-Score:4.36|P-value:9.32E-6 ID:SGTC_489|Compound:paxilline|FD-Score:3.17|P-value:8.82E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.69|P-value:1.42E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.44|P-value:3.49E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-4.21|P-value:2.40E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.26|P-value:8.60E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.21|P-value:1.60E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:3.51|P-value:2.77E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.53|P-value:2.59E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.51|P-value:2.75E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.51|P-value:4.76E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.41|P-value:4.00E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.32|P-value:7.07E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.37|P-value:8.91E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:4.78|P-value:1.37E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.09|P-value:2.97E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.79|P-value:7.14E-9 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.74|P-value:1.17E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.94|P-value:5.34E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.23|P-value:1.66E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.63|P-value:2.36E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.38|P-value:4.45E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.84|P-value:7.92E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.46|P-value:3.33E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-4.01|P-value:5.49E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.36|P-value:6.17E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.51|P-value:2.78E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.69|P-value:1.40E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.38|P-value:6.52E-8 ID:SGTC_2054|Compound:5233173|FD-Score:4.98|P-value:5.27E-7 ID:SGTC_2159|Compound:5658611|FD-Score:-3.22|P-value:9.92E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.69|P-value:1.89E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.53|P-value:2.59E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.04|P-value:3.58E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.63|P-value:1.78E-4 ID:SGTC_2871|Compound:9038510|FD-Score:4.04|P-value:3.59E-5 ID:SGTC_2876|Compound:9059903|FD-Score:-3.35|P-value:6.33E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.50|P-value:2.89E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.74|P-value:1.19E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.21|P-value:7.70E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.44|P-value:3.60E-4 ID:SGTC_245|Compound:methotrexate|FD-Score:4.36|P-value:9.32E-6 ID:SGTC_489|Compound:paxilline|FD-Score:3.17|P-value:8.82E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.69|P-value:1.42E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.44|P-value:3.49E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-4.21|P-value:2.40E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:-3.26|P-value:8.60E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.21|P-value:1.60E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:3.51|P-value:2.77E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.53|P-value:2.59E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.51|P-value:2.75E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.51|P-value:4.76E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.41|P-value:4.00E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.32|P-value:7.07E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.37|P-value:8.91E-6 ID:SGTC_928|Compound:2764-0428|FD-Score:4.78|P-value:1.37E-6 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.09|P-value:2.97E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.79|P-value:7.14E-9 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.74|P-value:1.17E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.94|P-value:5.34E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.23|P-value:1.66E-5 ID:SGTC_1521|Compound:st012942|FD-Score:-3.63|P-value:2.36E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.38|P-value:4.45E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.45|P-value:3.47E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.84|P-value:7.92E-5 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.46|P-value:3.33E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-4.01|P-value:5.49E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.36|P-value:6.17E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.51|P-value:2.78E-4 ID:SGTC_1757|Compound:st041620|FD-Score:3.69|P-value:1.40E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.38|P-value:6.52E-8 ID:SGTC_2054|Compound:5233173|FD-Score:4.98|P-value:5.27E-7 ID:SGTC_2159|Compound:5658611|FD-Score:-3.22|P-value:9.92E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.69|P-value:1.89E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.53|P-value:2.59E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.04|P-value:3.58E-5 ID:SGTC_2782|Compound:7736369|FD-Score:3.63|P-value:1.78E-4 ID:SGTC_2871|Compound:9038510|FD-Score:4.04|P-value:3.59E-5 ID:SGTC_2876|Compound:9059903|FD-Score:-3.35|P-value:6.33E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.50|P-value:2.82E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.50|P-value:2.89E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.74|P-value:1.19E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.21|P-value:7.70E-4 ID:SGTC_3252|Compound:9135871|FD-Score:3.44|P-value:3.60E-4

Top fitness defect scores for YOR337W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1204 4049-0315 5.79 18.3 µM 7.14E-9 2 3.61E-9
2 SGTC_1844 rapamycin 5.38 4.0 nM 6.52E-8 102 3.66E-8
3 SGTC_722 3534-0461 5.21 190.0 µM 1.60E-7 PDR1 16 9.38E-8
4 SGTC_2054 5233173 4.98 129.0 µM 5.27E-7 mitochondrial response to ROS 27 3.26E-7
5 SGTC_928 2764-0428 4.78 58.7 µM 1.37E-6 cell wall 36 8.83E-7
6 SGTC_899 1083-0020 4.51 478.0 µM 4.76E-6 15 3.24E-6
7 SGTC_927 2425-1185 4.37 123.0 µM 8.91E-6 21 6.25E-6
8 SGTC_245 methotrexate 4.36 289.6 µM 9.32E-6 35 6.55E-6
9 SGTC_1510 1123-0200 4.23 71.5 µM 1.66E-5 36 1.19E-5
10 SGTC_1112 tnp00069 4.09 1.2 µM 2.97E-5 19 2.20E-5
11 SGTC_2679 rapamycin 4.04 1.0 nM 3.58E-5 137 2.67E-5
12 SGTC_2871 9038510 4.04 13.0 µM 3.59E-5 13 2.68E-5
13 SGTC_1366 1683-0113 3.94 21.9 µM 5.34E-5 13 4.05E-5
14 SGTC_1557 sumaresinolic acid 3.84 42.3 µM 7.92E-5 21 6.11E-5
15 SGTC_1260 0700-1617 3.74 7.8 µM 1.17E-4 calcium & mitochondrial duress 35 9.21E-5
16 SGTC_3027 9089541 3.74 49.5 µM 1.19E-4 fatty acid desaturase (OLE1) 24 9.34E-5
17 SGTC_1757 st041620 3.69 31.8 µM 1.40E-4 37 1.10E-4
18 SGTC_518 1021-0119 3.69 62.6 µM 1.42E-4 ERG2 58 1.13E-4
19 SGTC_2782 7736369 3.63 71.4 µM 1.78E-4 54 1.42E-4
20 SGTC_2318 6029776 3.53 164.0 µM 2.59E-4 45 2.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.205 3.09E-33 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.172 1.00E-23 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.159 1.60E-20 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.134 5.97E-15 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.134 6.76E-15 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.133 1.37E-14 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.132 2.10E-14 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.119 3.99E-12 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.119 4.54E-12 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.118 9.41E-12 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.117 9.79E-12 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.113 5.42E-11 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.112 1.00E-10 YDR158W HOM2 hom Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.111 1.23E-10 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.108 4.20E-10 YMR312W ELP6 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity