YOR340C / RPA43

RNA polymerase I subunit A43

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR340C / RPA43

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:4.79|P-value:5.29E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-4.72|P-value:5.48E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-6.82|P-value:1.26E-6 ID:SGTC_57|Compound:miconazole|FD-Score:-7.32|P-value:2.22E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:5.71|P-value:4.67E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:6.21|P-value:1.07E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.70|P-value:4.90E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:5.56|P-value:7.17E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-5.83|P-value:2.87E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.77|P-value:5.56E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:8.42|P-value:4.05E-9 ID:SGTC_816|Compound:0325-0417|FD-Score:-8.08|P-value:1.27E-8 ID:SGTC_817|Compound:1391-0715|FD-Score:-8.20|P-value:7.82E-9 ID:SGTC_818|Compound:4072-2707|FD-Score:-7.92|P-value:2.40E-8 ID:SGTC_958|Compound:1222-0007|FD-Score:-5.43|P-value:8.88E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-8.54|P-value:1.94E-9 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-5.69|P-value:4.31E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:-5.32|P-value:1.18E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-4.57|P-value:7.93E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:5.10|P-value:2.45E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:6.82|P-value:1.54E-6 ID:SGTC_1558|Compound:st069300|FD-Score:7.54|P-value:1.23E-7 ID:SGTC_1588|Compound:farnesol|FD-Score:7.25|P-value:3.45E-7 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.16|P-value:4.73E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-7.11|P-value:4.79E-7 ID:SGTC_1618|Compound:st003135|FD-Score:4.57|P-value:8.91E-4 ID:SGTC_1623|Compound:st003709|FD-Score:6.64|P-value:2.80E-6 ID:SGTC_1624|Compound:st003710|FD-Score:6.06|P-value:1.69E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-5.11|P-value:2.08E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.12|P-value:2.03E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-8.28|P-value:5.84E-9 ID:SGTC_1791|Compound:st048313|FD-Score:6.10|P-value:1.52E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.53|P-value:3.94E-6 ID:SGTC_2135|Compound:5326629|FD-Score:7.61|P-value:9.57E-8 ID:SGTC_2173|Compound:5763948|FD-Score:5.75|P-value:4.26E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.58|P-value:8.89E-4 ID:SGTC_2189|Compound:6047310|FD-Score:4.69|P-value:6.80E-4 ID:SGTC_2332|Compound:7982454|FD-Score:5.68|P-value:5.10E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-4.62|P-value:6.99E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.87|P-value:2.94E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-5.61|P-value:5.35E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-6.07|P-value:1.41E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.52|P-value:8.86E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-5.73|P-value:3.85E-5 ID:SGTC_2950|Compound:9072895|FD-Score:6.26|P-value:9.38E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-5.04|P-value:2.48E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.65|P-value:6.54E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.89|P-value:4.16E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.26|P-value:1.61E-4 ID:SGTC_3127|Compound:9126946|FD-Score:5.69|P-value:5.03E-5 ID:SGTC_3155|Compound:9099265|FD-Score:4.83|P-value:4.90E-4 ID:SGTC_3203|Compound:9113543|FD-Score:5.04|P-value:2.90E-4 ID:SGTC_3212|Compound:9128307|FD-Score:11.30|P-value:4.09E-15 ID:SGTC_3282|Compound:9108498|FD-Score:4.87|P-value:4.38E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-6.01|P-value:1.67E-5 ID:SGTC_3321|Compound:9137793|FD-Score:5.79|P-value:3.79E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.83|P-value:4.88E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.79|P-value:5.29E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:-4.72|P-value:5.48E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-6.82|P-value:1.26E-6 ID:SGTC_57|Compound:miconazole|FD-Score:-7.32|P-value:2.22E-7 ID:SGTC_132|Compound:0417-1715|FD-Score:5.71|P-value:4.67E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:6.21|P-value:1.07E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:5.70|P-value:4.90E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:5.56|P-value:7.17E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-5.83|P-value:2.87E-5 ID:SGTC_545|Compound:4218-0007|FD-Score:4.77|P-value:5.56E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:8.42|P-value:4.05E-9 ID:SGTC_816|Compound:0325-0417|FD-Score:-8.08|P-value:1.27E-8 ID:SGTC_817|Compound:1391-0715|FD-Score:-8.20|P-value:7.82E-9 ID:SGTC_818|Compound:4072-2707|FD-Score:-7.92|P-value:2.40E-8 ID:SGTC_958|Compound:1222-0007|FD-Score:-5.43|P-value:8.88E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:-8.54|P-value:1.94E-9 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-5.69|P-value:4.31E-5 ID:SGTC_1266|Compound:0828-0227|FD-Score:-5.32|P-value:1.18E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-4.57|P-value:7.93E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:5.10|P-value:2.45E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:6.82|P-value:1.54E-6 ID:SGTC_1558|Compound:st069300|FD-Score:7.54|P-value:1.23E-7 ID:SGTC_1588|Compound:farnesol|FD-Score:7.25|P-value:3.45E-7 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.16|P-value:4.73E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-7.11|P-value:4.79E-7 ID:SGTC_1618|Compound:st003135|FD-Score:4.57|P-value:8.91E-4 ID:SGTC_1623|Compound:st003709|FD-Score:6.64|P-value:2.80E-6 ID:SGTC_1624|Compound:st003710|FD-Score:6.06|P-value:1.69E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-5.11|P-value:2.08E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.12|P-value:2.03E-4 ID:SGTC_1775|Compound:st081588|FD-Score:-8.28|P-value:5.84E-9 ID:SGTC_1791|Compound:st048313|FD-Score:6.10|P-value:1.52E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.53|P-value:3.94E-6 ID:SGTC_2135|Compound:5326629|FD-Score:7.61|P-value:9.57E-8 ID:SGTC_2173|Compound:5763948|FD-Score:5.75|P-value:4.26E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.58|P-value:8.89E-4 ID:SGTC_2189|Compound:6047310|FD-Score:4.69|P-value:6.80E-4 ID:SGTC_2332|Compound:7982454|FD-Score:5.68|P-value:5.10E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-4.62|P-value:6.99E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.87|P-value:2.94E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-5.61|P-value:5.35E-5 ID:SGTC_2585|Compound:alliin|FD-Score:-6.07|P-value:1.41E-5 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-4.52|P-value:8.86E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-5.73|P-value:3.85E-5 ID:SGTC_2950|Compound:9072895|FD-Score:6.26|P-value:9.38E-6 ID:SGTC_2968|Compound:9090663|FD-Score:-5.04|P-value:2.48E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-4.65|P-value:6.54E-4 ID:SGTC_3081|Compound:9117243|FD-Score:4.89|P-value:4.16E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.26|P-value:1.61E-4 ID:SGTC_3127|Compound:9126946|FD-Score:5.69|P-value:5.03E-5 ID:SGTC_3155|Compound:9099265|FD-Score:4.83|P-value:4.90E-4 ID:SGTC_3203|Compound:9113543|FD-Score:5.04|P-value:2.90E-4 ID:SGTC_3212|Compound:9128307|FD-Score:11.30|P-value:4.09E-15 ID:SGTC_3282|Compound:9108498|FD-Score:4.87|P-value:4.38E-4 ID:SGTC_3292|Compound:9120825|FD-Score:-6.01|P-value:1.67E-5 ID:SGTC_3321|Compound:9137793|FD-Score:5.79|P-value:3.79E-5 ID:SGTC_3335|Compound:9143315|FD-Score:4.83|P-value:4.88E-4

Top fitness defect scores for YOR340C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3212 9128307 11.30 49.5 µM 4.09E-15 1 4.69E-30 5.24
2 SGTC_566 0958-0068 8.42 16.5 µM 4.05E-9 RSC & ERG11 2 1.87E-17 0.53
3 SGTC_2135 5326629 7.61 150.4 µM 9.57E-8 RPP1 & pyrimidine depletion 2 1.40E-14 2.40
4 SGTC_1558 st069300 7.54 45.6 µM 1.23E-7 1 2.35E-14 3.65
5 SGTC_1588 farnesol 7.25 29.9 µM 3.45E-7 1 2.03E-13 2.21
6 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 7.16 54.9 µM 4.73E-7 redox potentiating 1 3.94E-13 1.06
7 SGTC_1539 benzyladenosine 6.82 56.0 µM 1.54E-6 1 4.58E-12 1.12
8 SGTC_1623 st003709 6.64 20.3 µM 2.80E-6 calcium & mitochondrial duress 2 1.60E-11 1.03
9 SGTC_1873 rapamycin 6.53 2.0 nM 3.94E-6 8 3.25E-11 0.15
10 SGTC_2950 9072895 6.26 21.5 µM 9.38E-6 2 1.98E-10 0.50
11 SGTC_176 1486-1328 6.21 72.8 µM 1.07E-5 2 2.62E-10 0.92
12 SGTC_1791 st048313 6.10 56.1 µM 1.52E-5 2 5.35E-10 1.40
13 SGTC_1624 st003710 6.06 6.2 µM 1.69E-5 calcium & mitochondrial duress 1 6.69E-10 1.26
14 SGTC_2502 avocadyne acetate 5.87 18.6 µM 2.94E-5 1 2.12E-9 0.86
15 SGTC_3321 9137793 5.79 26.8 µM 3.79E-5 cell wall 9 3.57E-9 0.40
16 SGTC_2173 5763948 5.75 167.0 µM 4.26E-5 tubulin folding & SWR complex 1 4.55E-9 1.21
17 SGTC_132 0417-1715 5.71 25.8 µM 4.67E-5 RPP1 & pyrimidine depletion 3 5.49E-9 0.05
18 SGTC_221 trifluoperazine 5.70 10.3 µM 4.90E-5 NEO1-PIK1 18 6.08E-9 0.08
19 SGTC_3127 9126946 5.69 49.5 µM 5.03E-5 ERG2 2 6.42E-9 0.25
20 SGTC_2332 7982454 5.68 138.9 µM 5.10E-5 2 6.61E-9 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.65E-32 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.192 2.57E-29 YOR319W HSH49 het U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
0.167 1.85E-22 YOR157C PUP1 het Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
0.135 3.94E-15 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.134 5.49E-15 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.117 1.31E-11 YOR224C RPB8 het RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
0.110 1.46E-10 YIL026C IRR1 het Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
0.106 7.07E-10 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.105 1.06E-9 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.103 1.85E-9 YOL127W RPL25 het Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
0.103 2.16E-9 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.102 3.01E-9 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.102 3.19E-9 YNR017W TIM23 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
0.101 5.13E-9 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.098 1.58E-8 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly