YOR341W / RPA190

RNA polymerase I largest subunit A190

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR341W / RPA190

Click on Significant Values for Screen Details ID:SGTC_171|Compound:k064-0041|FD-Score:-3.32|P-value:3.41E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.04|P-value:9.07E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.12|P-value:1.17E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:3.15|P-value:6.12E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.02|P-value:9.53E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.54|P-value:1.37E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.28|P-value:3.72E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.19|P-value:5.21E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.22|P-value:4.68E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.11|P-value:7.02E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.24|P-value:4.49E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.08|P-value:7.65E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.40|P-value:3.14E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:3.19|P-value:5.25E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.27|P-value:5.80E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.16|P-value:5.81E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.35|P-value:2.92E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:5.27|P-value:3.16E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.34|P-value:3.11E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.06|P-value:8.34E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.04|P-value:8.82E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.26|P-value:4.00E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.07|P-value:8.10E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.32|P-value:3.29E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.03|P-value:9.30E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.61|P-value:1.05E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.01|P-value:1.88E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.06|P-value:8.20E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.07|P-value:8.04E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.31|P-value:3.30E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.29|P-value:3.59E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.26|P-value:4.26E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.53|P-value:1.66E-6 ID:SGTC_2887|Compound:9044784|FD-Score:-4.08|P-value:1.44E-5 ID:SGTC_2892|Compound:9047358|FD-Score:-3.34|P-value:3.05E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.11|P-value:7.01E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.26|P-value:4.07E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.27|P-value:4.02E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.15|P-value:6.03E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.05|P-value:8.65E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.11|P-value:7.04E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.10|P-value:7.16E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.32|P-value:3.41E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.04|P-value:9.07E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:4.12|P-value:1.17E-5 ID:SGTC_295|Compound:k015-0027|FD-Score:3.15|P-value:6.12E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:3.02|P-value:9.53E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.54|P-value:1.37E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.28|P-value:3.72E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:3.19|P-value:5.21E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.22|P-value:4.68E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:3.11|P-value:7.02E-4 ID:SGTC_772|Compound:k072-0172|FD-Score:-3.24|P-value:4.49E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.08|P-value:7.65E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:4.40|P-value:3.14E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:3.19|P-value:5.25E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.27|P-value:5.80E-6 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.16|P-value:5.81E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.35|P-value:2.92E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:5.27|P-value:3.16E-8 ID:SGTC_1364|Compound:1653-0028|FD-Score:-3.34|P-value:3.11E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.06|P-value:8.34E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.59|P-value:1.15E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:3.04|P-value:8.82E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.26|P-value:4.00E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.07|P-value:8.10E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.32|P-value:3.29E-4 ID:SGTC_1845|Compound:st056753|FD-Score:3.03|P-value:9.30E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.61|P-value:1.05E-4 ID:SGTC_2156|Compound:5649887|FD-Score:4.01|P-value:1.88E-5 ID:SGTC_2185|Compound:6113692|FD-Score:3.06|P-value:8.20E-4 ID:SGTC_2212|Compound:7123476|FD-Score:3.07|P-value:8.04E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.31|P-value:3.30E-4 ID:SGTC_2365|Compound:9042475|FD-Score:3.29|P-value:3.59E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.26|P-value:4.26E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.53|P-value:1.66E-6 ID:SGTC_2887|Compound:9044784|FD-Score:-4.08|P-value:1.44E-5 ID:SGTC_2892|Compound:9047358|FD-Score:-3.34|P-value:3.05E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.11|P-value:7.01E-4 ID:SGTC_3157|Compound:9099274|FD-Score:3.26|P-value:4.07E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.27|P-value:4.02E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.15|P-value:6.03E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.05|P-value:8.65E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.11|P-value:7.04E-4 ID:SGTC_3323|Compound:9138564|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.10|P-value:7.16E-4

Top fitness defect scores for YOR341W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1051 3253-3903 5.27 78.0 µM 3.16E-8 1 6.88E-8 1.02
2 SGTC_2849 9019321 4.53 13.0 µM 1.66E-6 5 2.97E-6 0.19
3 SGTC_803 4488-1585 4.40 147.0 µM 3.14E-6 1 5.46E-6 0.37
4 SGTC_919 tnp00227 4.27 403.6 nM 5.80E-6 RNA pol III & RNase P/MRP 11 9.79E-6 0.93
5 SGTC_274 sirtinol 4.12 40.1 µM 1.17E-5 16 1.90E-5 0.34
6 SGTC_2156 5649887 4.01 115.0 µM 1.88E-5 RPP1 & pyrimidine depletion 17 3.00E-5 0.26
7 SGTC_1892 st058411 3.61 7.4 µM 1.05E-4 7 1.55E-4 0.04
8 SGTC_1534 6-azauridine 3.59 81.6 µM 1.15E-4 RNA pol III & RNase P/MRP 8 1.68E-4 0.05
9 SGTC_451 chloral hydrate 3.54 100.0 µM 1.37E-4 25 1.99E-4 0.02
10 SGTC_3323 9138564 3.48 53.9 µM 1.73E-4 8 2.47E-4 0.17
11 SGTC_1029 k015-0030 3.35 64.7 µM 2.92E-4 10 4.08E-4 0.06
12 SGTC_1771 st048882 3.32 4.2 µM 3.29E-4 RPP1 & pyrimidine depletion 15 4.56E-4 0.09
13 SGTC_2238 6671620 3.31 73.2 µM 3.30E-4 8 4.58E-4 0.14
14 SGTC_2365 9042475 3.29 200.0 µM 3.59E-4 11 4.96E-4 0.15
15 SGTC_475 α-linolenic acid 3.28 10.0 µM 3.72E-4 excess fatty acid 10 5.13E-4 0.07
16 SGTC_1712 st032288 3.26 53.4 µM 4.00E-4 calcium & mitochondrial duress 50 5.50E-4 0.05
17 SGTC_3157 9099274 3.26 49.5 µM 4.07E-4 10 5.59E-4 0.15
18 SGTC_579 4491-1009 3.22 110.0 µM 4.68E-4 60S ribosome export 17 6.39E-4 0.08
19 SGTC_560 2332-1943 3.19 155.0 µM 5.21E-4 9 7.08E-4 0.02
20 SGTC_912 3474-0017 3.19 2.2 µM 5.25E-4 11 7.12E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.62E-12 YKL052C ASK1 het Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress
0.114 3.91E-11 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.106 6.59E-10 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.105 1.13E-9 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.099 9.99E-9 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.094 5.27E-8 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.093 7.75E-8 YMR093W UTP15 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.091 1.49E-7 YDR398W UTP5 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.086 5.97E-7 YER142C MAG1 hom 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress
0.082 2.00E-6 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.081 2.35E-6 YGR148C RPL24B hom Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication
0.081 2.85E-6 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.079 4.35E-6 YOR143C THI80 het Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
0.079 4.79E-6 YLR266C PDR8 hom Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication
0.078 6.16E-6 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication