YOR342C

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR342C / YOR342C

Click on Significant Values for Screen Details

Top fitness defect scores for YOR342C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2398 5228213 6.97 48.8 µM 1.35E-11 iron homeostasis 4 1.54E-12
2 SGTC_146 3448-8650 5.22 53.1 µM 3.09E-7 NEO1-PIK1 74 8.99E-8
3 SGTC_2329 6138490 4.35 200.0 µM 1.59E-5 18 6.66E-6
4 SGTC_2583 asiatic acid 4.10 100.0 µM 4.43E-5 34 2.03E-5
5 SGTC_1707 st032323 4.07 6.3 µM 5.05E-5 DNA damage response 53 2.34E-5
6 SGTC_627 1391-0720 4.07 175.0 µM 5.12E-5 12 2.38E-5
7 SGTC_2952 9073731 3.97 13.8 µM 7.61E-5 tubulin folding & SWR complex 44 3.66E-5
8 SGTC_1663 st014140 3.86 55.4 µM 1.13E-4 60S ribosome export 18 5.66E-5
9 SGTC_3349 9149703 3.86 23.0 µM 1.15E-4 14 5.76E-5
10 SGTC_3299 9121982 3.77 43.1 µM 1.58E-4 38 8.11E-5
11 SGTC_1361 1608-0041 3.74 5.6 µM 1.76E-4 RPP1 & pyrimidine depletion 23 9.14E-5
12 SGTC_3052 9092717 3.58 49.5 µM 3.13E-4 44 1.71E-4
13 SGTC_1677 st019204 3.57 53.9 µM 3.30E-4 30 1.81E-4
14 SGTC_58 0957-0393 3.49 9.0 µM 4.36E-4 cell wall 429 2.45E-4
15 SGTC_1500 4488-1866 3.47 171.0 µM 4.62E-4 RPP1 & pyrimidine depletion 35 2.62E-4
16 SGTC_347 4534-1311 3.47 26.2 µM 4.66E-4 RPP1 & pyrimidine depletion 23 2.64E-4
17 SGTC_2705 st078069 3.46 42.8 µM 4.75E-4 15 2.70E-4
18 SGTC_1866 st057638 3.46 64.0 µM 4.79E-4 15 2.72E-4
19 SGTC_14 0354-0009 3.46 295.0 µM 4.83E-4 42 2.74E-4
20 SGTC_2400 5203494 3.43 178.7 µM 5.19E-4 RSC complex & mRNA processing 35 2.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.92E-17 YCL057W PRD1 hom Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress
0.128 9.22E-14 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.119 4.29E-12 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.111 1.28E-10 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.108 3.12E-10 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.108 3.38E-10 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.104 1.57E-9 YOR179C SYC1 hom Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
0.104 1.69E-9 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.099 9.79E-9 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.098 1.44E-8 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.094 5.55E-8 YBR296C PHO89 hom Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification
0.093 6.21E-8 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.093 6.62E-8 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.093 7.52E-8 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.092 8.37E-8 YBR221C PDB1 hom E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria