YOR344C / TYE7

Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR344C / TYE7

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.42|P-value:2.10E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.08|P-value:7.41E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:5.58|P-value:4.25E-9 ID:SGTC_362|Compound:0310-0100|FD-Score:4.35|P-value:3.56E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:4.82|P-value:3.33E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:6.74|P-value:1.81E-12 ID:SGTC_572|Compound:0960-0087|FD-Score:-4.64|P-value:8.84E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:-5.61|P-value:3.67E-9 ID:SGTC_578|Compound:3460-0051|FD-Score:-4.62|P-value:9.48E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:5.05|P-value:9.52E-8 ID:SGTC_687|Compound:k029-0044|FD-Score:3.00|P-value:9.69E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.51|P-value:1.45E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.36|P-value:2.66E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.11|P-value:6.56E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.01|P-value:9.59E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-4.14|P-value:1.02E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.18|P-value:5.11E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.24|P-value:3.28E-8 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.23|P-value:4.24E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.26|P-value:3.92E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.22|P-value:4.39E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.16|P-value:5.62E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.53|P-value:1.39E-4 ID:SGTC_1748|Compound:st037455|FD-Score:6.88|P-value:6.40E-13 ID:SGTC_2046|Compound:4110841|FD-Score:4.09|P-value:1.24E-5 ID:SGTC_2157|Compound:5649910|FD-Score:4.39|P-value:3.02E-6 ID:SGTC_2167|Compound:5876490|FD-Score:3.54|P-value:1.31E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.14|P-value:5.95E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.20|P-value:4.73E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-4.03|P-value:1.63E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:6.89|P-value:6.09E-13 ID:SGTC_2797|Compound:7859098|FD-Score:3.74|P-value:5.70E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.01|P-value:9.46E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.24|P-value:4.19E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.18|P-value:5.23E-4 ID:SGTC_3010|Compound:9080089|FD-Score:4.29|P-value:4.81E-6 ID:SGTC_3300|Compound:9124615|FD-Score:3.35|P-value:2.72E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.12|P-value:1.06E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.42|P-value:2.10E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.08|P-value:7.41E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:5.58|P-value:4.25E-9 ID:SGTC_362|Compound:0310-0100|FD-Score:4.35|P-value:3.56E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:4.82|P-value:3.33E-7 ID:SGTC_571|Compound:k831-0106|FD-Score:6.74|P-value:1.81E-12 ID:SGTC_572|Compound:0960-0087|FD-Score:-4.64|P-value:8.84E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:-5.61|P-value:3.67E-9 ID:SGTC_578|Compound:3460-0051|FD-Score:-4.62|P-value:9.48E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:-3.14|P-value:6.02E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:5.05|P-value:9.52E-8 ID:SGTC_687|Compound:k029-0044|FD-Score:3.00|P-value:9.69E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.51|P-value:1.45E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.36|P-value:2.66E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.11|P-value:6.56E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.01|P-value:9.59E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-4.14|P-value:1.02E-5 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.18|P-value:5.11E-4 ID:SGTC_1346|Compound:1488-2224|FD-Score:5.24|P-value:3.28E-8 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.23|P-value:4.24E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.26|P-value:3.92E-4 ID:SGTC_1618|Compound:st003135|FD-Score:3.22|P-value:4.39E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.16|P-value:5.62E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.53|P-value:1.39E-4 ID:SGTC_1748|Compound:st037455|FD-Score:6.88|P-value:6.40E-13 ID:SGTC_2046|Compound:4110841|FD-Score:4.09|P-value:1.24E-5 ID:SGTC_2157|Compound:5649910|FD-Score:4.39|P-value:3.02E-6 ID:SGTC_2167|Compound:5876490|FD-Score:3.54|P-value:1.31E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.14|P-value:5.95E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.20|P-value:4.73E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-4.03|P-value:1.63E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:6.89|P-value:6.09E-13 ID:SGTC_2797|Compound:7859098|FD-Score:3.74|P-value:5.70E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.01|P-value:9.46E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.24|P-value:4.19E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.18|P-value:5.23E-4 ID:SGTC_3010|Compound:9080089|FD-Score:4.29|P-value:4.81E-6 ID:SGTC_3300|Compound:9124615|FD-Score:3.35|P-value:2.72E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.12|P-value:1.06E-5

Top fitness defect scores for YOR344C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2639 lactacystin 6.89 53.0 µM 6.09E-13 3 2.82E-12
2 SGTC_1748 st037455 6.88 53.6 µM 6.40E-13 3 2.95E-12
3 SGTC_571 k831-0106 6.74 44.2 µM 1.81E-12 3 7.86E-12
4 SGTC_161 4065-0411 5.58 162.2 µM 4.25E-9 33 1.18E-8
5 SGTC_1346 1488-2224 5.24 62.4 µM 3.28E-8 9 8.09E-8
6 SGTC_684 1140-0066 5.05 328.0 µM 9.52E-8 Golgi 6 2.21E-7
7 SGTC_368 fentichlor 4.82 4.6 µM 3.33E-7 13 7.18E-7
8 SGTC_2157 5649910 4.39 96.4 µM 3.02E-6 14 5.74E-6
9 SGTC_362 0310-0100 4.35 9.0 µM 3.56E-6 RPP1 & pyrimidine depletion 23 6.71E-6
10 SGTC_3010 9080089 4.29 71.4 µM 4.81E-6 10 8.91E-6
11 SGTC_3336 9143619 4.12 71.4 µM 1.06E-5 17 1.87E-5
12 SGTC_2046 4110841 4.09 106.0 µM 1.24E-5 iron homeostasis 26 2.18E-5
13 SGTC_2797 7859098 3.74 81.8 µM 5.70E-5 30 9.17E-5
14 SGTC_2167 5876490 3.54 200.0 µM 1.31E-4 46 2.01E-4
15 SGTC_720 r052-1644 3.51 49.9 µM 1.45E-4 TSC3-RPN4 41 2.21E-4
16 SGTC_38 0929-0051 3.42 58.3 µM 2.10E-4 38 3.14E-4
17 SGTC_3 0833-0587 3.37 95.6 µM 2.50E-4 redox potentiating 38 3.70E-4
18 SGTC_998 3996-0085 3.36 177.0 µM 2.66E-4 42 3.92E-4
19 SGTC_3300 9124615 3.35 50.5 µM 2.72E-4 37 4.02E-4
20 SGTC_1528 arabinosylhypoxanthine 3.26 74.6 µM 3.92E-4 45 5.66E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.48E-11 YJL064W_d YJL064W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1
0.113 6.17E-11 YDR496C PUF6 hom Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis
0.095 3.60E-8 YPR115W RGC1 hom Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication
0.092 9.08E-8 YBR196C-B_p YBR196C-B_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.092 1.03E-7 YJL026W RNR2 het Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
0.090 1.64E-7 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.088 3.54E-7 YKL046C DCW1 hom Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
0.085 9.16E-7 YMR284W YKU70 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.084 1.18E-6 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.64E-6 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.082 2.22E-6 YBL091C-A SCS22 hom Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication
0.080 3.13E-6 YMR193C-A_d YMR193C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.39E-6 YFL015C_d YFL015C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
0.079 4.20E-6 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.078 6.88E-6 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP