YOR345C_d

Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR345C / YOR345C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.08|P-value:9.92E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.69|P-value:1.32E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.39|P-value:4.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.66|P-value:1.55E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.75|P-value:1.04E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.44|P-value:4.31E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.84|P-value:7.15E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.23|P-value:1.38E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:4.37|P-value:5.98E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:4.88|P-value:5.22E-7 ID:SGTC_750|Compound:4073-0104|FD-Score:-7.63|P-value:1.69E-14 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.82|P-value:7.89E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.20|P-value:7.87E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.79|P-value:8.69E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.83|P-value:7.35E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.77|P-value:9.50E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.44|P-value:2.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.90|P-value:6.01E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.55|P-value:1.83E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.33|P-value:4.22E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.69|P-value:1.32E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.09|P-value:9.63E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.52|P-value:2.51E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.50|P-value:2.64E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.34|P-value:4.69E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.88|P-value:5.02E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:-3.38|P-value:4.17E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.20|P-value:6.51E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.81|P-value:8.02E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.63|P-value:1.38E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-5.36|P-value:5.25E-8 ID:SGTC_1810|Compound:st050138|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.73|P-value:1.10E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.71|P-value:7.39E-9 ID:SGTC_2133|Compound:5320837|FD-Score:5.23|P-value:8.30E-8 ID:SGTC_2160|Compound:5660466|FD-Score:4.17|P-value:1.51E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.63|P-value:1.37E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.46|P-value:2.61E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.98|P-value:4.01E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.79|P-value:7.34E-5 ID:SGTC_2551|Compound:apiole|FD-Score:5.09|P-value:1.75E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-7.94|P-value:1.58E-15 ID:SGTC_2593|Compound:nobiletin|FD-Score:-8.78|P-value:1.36E-18 ID:SGTC_2600|Compound:tangeritin|FD-Score:-10.40|P-value:1.95E-25 ID:SGTC_2601|Compound:securinine|FD-Score:-3.63|P-value:1.63E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.64|P-value:1.65E-6 ID:SGTC_2816|Compound:7982706|FD-Score:3.79|P-value:7.21E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-4.10|P-value:2.43E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.53|P-value:1.98E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.37|P-value:3.55E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.37|P-value:4.34E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.13|P-value:8.34E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.01|P-value:3.49E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.08|P-value:9.92E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.69|P-value:1.32E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.39|P-value:4.02E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.66|P-value:1.55E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:-3.75|P-value:1.04E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.44|P-value:4.31E-6 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.84|P-value:7.15E-5 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.23|P-value:1.38E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:4.37|P-value:5.98E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:4.88|P-value:5.22E-7 ID:SGTC_750|Compound:4073-0104|FD-Score:-7.63|P-value:1.69E-14 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.82|P-value:7.89E-5 ID:SGTC_816|Compound:0325-0417|FD-Score:-3.20|P-value:7.87E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.79|P-value:8.69E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.83|P-value:7.35E-5 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.77|P-value:9.50E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.44|P-value:2.85E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.90|P-value:6.01E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.55|P-value:1.83E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.33|P-value:4.22E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.69|P-value:1.32E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.09|P-value:9.63E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.52|P-value:2.51E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.50|P-value:2.64E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.34|P-value:4.69E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.88|P-value:5.02E-5 ID:SGTC_1693|Compound:xanthone|FD-Score:-3.38|P-value:4.17E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.20|P-value:6.51E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.81|P-value:8.02E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:3.63|P-value:1.38E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-5.36|P-value:5.25E-8 ID:SGTC_1810|Compound:st050138|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.73|P-value:1.10E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.71|P-value:7.39E-9 ID:SGTC_2133|Compound:5320837|FD-Score:5.23|P-value:8.30E-8 ID:SGTC_2160|Compound:5660466|FD-Score:4.17|P-value:1.51E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.63|P-value:1.37E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.46|P-value:2.61E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.98|P-value:4.01E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.71|P-value:1.02E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.79|P-value:7.34E-5 ID:SGTC_2551|Compound:apiole|FD-Score:5.09|P-value:1.75E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-7.94|P-value:1.58E-15 ID:SGTC_2593|Compound:nobiletin|FD-Score:-8.78|P-value:1.36E-18 ID:SGTC_2600|Compound:tangeritin|FD-Score:-10.40|P-value:1.95E-25 ID:SGTC_2601|Compound:securinine|FD-Score:-3.63|P-value:1.63E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.64|P-value:1.65E-6 ID:SGTC_2816|Compound:7982706|FD-Score:3.79|P-value:7.21E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-4.10|P-value:2.43E-5 ID:SGTC_2842|Compound:9000675|FD-Score:3.53|P-value:1.98E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.37|P-value:3.55E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.37|P-value:4.34E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.13|P-value:8.34E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-4.01|P-value:3.49E-5

Top fitness defect scores for YOR345C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2133 5320837 5.23 200.0 µM 8.30E-8 ERG2 8 8.46E-8
2 SGTC_2551 apiole 5.09 73.9 µM 1.75E-7 3 1.79E-7
3 SGTC_735 3076-0345 4.88 636.0 µM 5.22E-7 14 5.35E-7
4 SGTC_453 enantio-paf c16 4.66 10.0 µM 1.55E-6 102 1.60E-6
5 SGTC_2765 myclobutanil 4.64 7.7 µM 1.65E-6 azole & statin 32 1.70E-6
6 SGTC_545 4218-0007 4.44 221.0 µM 4.31E-6 15 4.44E-6
7 SGTC_634 1611-4317 4.37 11.2 µM 5.98E-6 ERG2 10 6.16E-6
8 SGTC_2160 5660466 4.17 132.9 µM 1.51E-5 60S ribosome export 11 1.56E-5
9 SGTC_1690 st023502 3.88 41.2 µM 5.02E-5 calcium & mitochondrial duress 9 5.20E-5
10 SGTC_2816 7982706 3.79 58.4 µM 7.21E-5 azole & statin 56 7.48E-5
11 SGTC_2528 xanthyletin 3.79 44.8 µM 7.34E-5 26 7.60E-5
12 SGTC_2414 st077232 3.71 92.9 µM 1.02E-4 27 1.05E-4
13 SGTC_1810 st050138 3.70 53.0 µM 1.03E-4 PDR1 17 1.06E-4
14 SGTC_2164 5685496 3.63 200.0 µM 1.37E-4 29 1.42E-4
15 SGTC_1718 roemerine 3.63 11.9 µM 1.38E-4 redox potentiating 69 1.43E-4
16 SGTC_1110 3-hydroxy-3'-methoxyflavone 3.55 1.2 µM 1.83E-4 iron homeostasis 57 1.90E-4
17 SGTC_2842 9000675 3.53 19.5 µM 1.98E-4 35 2.05E-4
18 SGTC_2349 9023730 3.46 187.1 µM 2.61E-4 51 2.71E-4
19 SGTC_1098 clofazimine 3.44 15.1 µM 2.85E-4 heme biosynthesis & mitochondrial translocase 47 2.96E-4
20 SGTC_2944 9067346 3.37 25.6 µM 3.55E-4 52 3.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 1.48E-43 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.227 2.70E-40 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.216 1.36E-36 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.195 3.45E-30 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.194 1.18E-29 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.179 2.06E-25 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.169 8.25E-23 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.168 1.57E-22 YKL127W PGM1 hom Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
0.166 3.71E-22 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.161 8.27E-21 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.159 1.94E-20 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.154 2.37E-19 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.154 2.72E-19 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.152 6.66E-19 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.148 5.81E-18 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D