YOR349W / CIN1

Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR349W / CIN1

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:4.53|P-value:2.60E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:3.91|P-value:4.17E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:6.18|P-value:2.39E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:5.25|P-value:6.25E-8 ID:SGTC_90|Compound:0870-0863|FD-Score:3.80|P-value:6.53E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:3.58|P-value:1.57E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.30|P-value:7.58E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:15.60|P-value:9.96E-56 ID:SGTC_150|Compound:3970-0969|FD-Score:3.75|P-value:7.99E-5 ID:SGTC_190|Compound:3970-0790|FD-Score:3.95|P-value:3.50E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:17.90|P-value:6.47E-73 ID:SGTC_212|Compound:3807-4682|FD-Score:13.80|P-value:4.11E-44 ID:SGTC_214|Compound:4373-3496|FD-Score:4.43|P-value:4.15E-6 ID:SGTC_229|Compound:benomyl|FD-Score:18.60|P-value:2.04E-78 ID:SGTC_286|Compound:k060-0067|FD-Score:10.20|P-value:3.65E-25 ID:SGTC_315|Compound:k915-0449|FD-Score:3.45|P-value:2.58E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.11|P-value:1.82E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.60|P-value:1.49E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.64|P-value:1.29E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.46|P-value:2.52E-4 ID:SGTC_480|Compound:am 92016|FD-Score:4.87|P-value:4.81E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:4.07|P-value:2.13E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:8.34|P-value:2.27E-17 ID:SGTC_565|Compound:1418-0001|FD-Score:4.17|P-value:1.38E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:10.20|P-value:7.22E-25 ID:SGTC_611|Compound:3453-1652|FD-Score:3.78|P-value:7.28E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:7.08|P-value:4.86E-13 ID:SGTC_697|Compound:0508-1955|FD-Score:3.53|P-value:1.92E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:5.37|P-value:3.17E-8 ID:SGTC_731|Compound:3966-0296|FD-Score:3.59|P-value:1.55E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.19|P-value:6.85E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.94|P-value:3.37E-7 ID:SGTC_806|Compound:3966-4455|FD-Score:3.57|P-value:1.67E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.88|P-value:4.86E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.26|P-value:5.27E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:6.06|P-value:5.09E-10 ID:SGTC_881|Compound:0833-0569|FD-Score:3.49|P-value:2.22E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:12.30|P-value:1.48E-35 ID:SGTC_897|Compound:1000-0139|FD-Score:10.30|P-value:1.10E-25 ID:SGTC_926|Compound:2268-1401|FD-Score:3.31|P-value:4.39E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.71|P-value:1.06E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.47|P-value:2.16E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.33|P-value:3.69E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.72|P-value:9.21E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.77|P-value:3.23E-9 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.51|P-value:1.43E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.31|P-value:4.36E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.80|P-value:6.01E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.42|P-value:4.30E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.55|P-value:1.14E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.41|P-value:3.00E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:6.73|P-value:6.20E-12 ID:SGTC_1433|Compound:4060-0023|FD-Score:6.65|P-value:1.09E-11 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.79|P-value:7.11E-7 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.20|P-value:6.47E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.10|P-value:9.31E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.62|P-value:1.24E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-6.01|P-value:5.92E-10 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.69|P-value:9.17E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.17|P-value:1.39E-5 ID:SGTC_1643|Compound:st009866|FD-Score:10.00|P-value:2.35E-24 ID:SGTC_1661|Compound:st013063|FD-Score:12.50|P-value:1.16E-36 ID:SGTC_1690|Compound:st023502|FD-Score:3.30|P-value:4.60E-4 ID:SGTC_1773|Compound:st048542|FD-Score:10.10|P-value:1.81E-24 ID:SGTC_1836|Compound:st055642|FD-Score:3.31|P-value:4.37E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:21.00|P-value:3.90E-100 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.72|P-value:9.27E-5 ID:SGTC_1958|Compound:st076513|FD-Score:9.27|P-value:4.92E-21 ID:SGTC_2004|Compound:4023728|FD-Score:6.09|P-value:4.43E-10 ID:SGTC_2011|Compound:4012611|FD-Score:5.61|P-value:8.14E-9 ID:SGTC_2040|Compound:5100729|FD-Score:4.22|P-value:1.07E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.26|P-value:5.26E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.59|P-value:1.52E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.06|P-value:2.24E-5 ID:SGTC_2090|Compound:5301565|FD-Score:7.81|P-value:1.78E-15 ID:SGTC_2092|Compound:5303694|FD-Score:4.89|P-value:4.37E-7 ID:SGTC_2125|Compound:5246583|FD-Score:10.80|P-value:6.98E-28 ID:SGTC_2141|Compound:5621638|FD-Score:7.15|P-value:3.03E-13 ID:SGTC_2158|Compound:5657123|FD-Score:3.24|P-value:5.62E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.46|P-value:2.57E-4 ID:SGTC_2173|Compound:5763948|FD-Score:5.67|P-value:5.60E-9 ID:SGTC_2174|Compound:5790901|FD-Score:10.20|P-value:7.29E-25 ID:SGTC_2200|Compound:6600604|FD-Score:11.90|P-value:1.26E-33 ID:SGTC_2214|Compound:7179297|FD-Score:3.56|P-value:1.72E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.43|P-value:3.64E-14 ID:SGTC_2246|Compound:7293507|FD-Score:3.97|P-value:3.20E-5 ID:SGTC_2255|Compound:7941087|FD-Score:5.39|P-value:2.83E-8 ID:SGTC_2319|Compound:6033012|FD-Score:11.90|P-value:1.07E-33 ID:SGTC_2323|Compound:6148992|FD-Score:3.88|P-value:4.68E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:7.57|P-value:1.17E-14 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-4.34|P-value:5.70E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-3.38|P-value:3.14E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.47|P-value:3.44E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-3.92|P-value:3.55E-5 ID:SGTC_2430|Compound:5571206|FD-Score:14.00|P-value:2.12E-45 ID:SGTC_2433|Compound:5607874|FD-Score:3.32|P-value:4.24E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.35|P-value:6.08E-6 ID:SGTC_2461|Compound:5755302|FD-Score:4.01|P-value:2.81E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.08|P-value:2.02E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.02|P-value:2.63E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:3.33|P-value:4.02E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:7.38|P-value:5.36E-14 ID:SGTC_2619|Compound:obliquin|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.30|P-value:9.51E-14 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.58|P-value:1.61E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.23|P-value:5.94E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-5.74|P-value:3.26E-9 ID:SGTC_2882|Compound:9058044|FD-Score:-4.41|P-value:3.94E-6 ID:SGTC_2897|Compound:9048598|FD-Score:5.50|P-value:1.56E-8 ID:SGTC_2912|Compound:7964298|FD-Score:3.52|P-value:2.01E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.22|P-value:6.06E-4 ID:SGTC_2947|Compound:9072639|FD-Score:12.00|P-value:8.00E-34 ID:SGTC_2949|Compound:9072542|FD-Score:5.82|P-value:2.26E-9 ID:SGTC_2952|Compound:9073731|FD-Score:7.94|P-value:6.41E-16 ID:SGTC_3013|Compound:9080133|FD-Score:-3.22|P-value:5.55E-4 ID:SGTC_3024|Compound:9090631|FD-Score:4.65|P-value:1.42E-6 ID:SGTC_3069|Compound:9117009|FD-Score:3.44|P-value:2.72E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.56|P-value:2.25E-6 ID:SGTC_3078|Compound:9116413|FD-Score:-3.83|P-value:5.18E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.13|P-value:1.61E-5 ID:SGTC_3242|Compound:9133940|FD-Score:3.65|P-value:1.19E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.23|P-value:5.89E-4 ID:SGTC_3282|Compound:9108498|FD-Score:7.92|P-value:7.48E-16 ID:SGTC_3294|Compound:9122953|FD-Score:8.63|P-value:1.71E-18 ID:SGTC_3317|Compound:9138495|FD-Score:7.29|P-value:1.05E-13 ID:SGTC_3321|Compound:9137793|FD-Score:3.17|P-value:7.16E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:4.53|P-value:2.60E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:3.91|P-value:4.17E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:6.18|P-value:2.39E-10 ID:SGTC_87|Compound:0100-0052|FD-Score:5.25|P-value:6.25E-8 ID:SGTC_90|Compound:0870-0863|FD-Score:3.80|P-value:6.53E-5 ID:SGTC_111|Compound:0083-0039|FD-Score:3.58|P-value:1.57E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.30|P-value:7.58E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:15.60|P-value:9.96E-56 ID:SGTC_150|Compound:3970-0969|FD-Score:3.75|P-value:7.99E-5 ID:SGTC_190|Compound:3970-0790|FD-Score:3.95|P-value:3.50E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:17.90|P-value:6.47E-73 ID:SGTC_212|Compound:3807-4682|FD-Score:13.80|P-value:4.11E-44 ID:SGTC_214|Compound:4373-3496|FD-Score:4.43|P-value:4.15E-6 ID:SGTC_229|Compound:benomyl|FD-Score:18.60|P-value:2.04E-78 ID:SGTC_286|Compound:k060-0067|FD-Score:10.20|P-value:3.65E-25 ID:SGTC_315|Compound:k915-0449|FD-Score:3.45|P-value:2.58E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.11|P-value:1.82E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.60|P-value:1.49E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:3.64|P-value:1.29E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.46|P-value:2.52E-4 ID:SGTC_480|Compound:am 92016|FD-Score:4.87|P-value:4.81E-7 ID:SGTC_514|Compound:4466-0038|FD-Score:4.07|P-value:2.13E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:8.34|P-value:2.27E-17 ID:SGTC_565|Compound:1418-0001|FD-Score:4.17|P-value:1.38E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:10.20|P-value:7.22E-25 ID:SGTC_611|Compound:3453-1652|FD-Score:3.78|P-value:7.28E-5 ID:SGTC_638|Compound:3970-0837|FD-Score:7.08|P-value:4.86E-13 ID:SGTC_697|Compound:0508-1955|FD-Score:3.53|P-value:1.92E-4 ID:SGTC_713|Compound:1488-1073|FD-Score:5.37|P-value:3.17E-8 ID:SGTC_731|Compound:3966-0296|FD-Score:3.59|P-value:1.55E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.19|P-value:6.85E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.94|P-value:3.37E-7 ID:SGTC_806|Compound:3966-4455|FD-Score:3.57|P-value:1.67E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:3.88|P-value:4.86E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:3.26|P-value:5.27E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:6.06|P-value:5.09E-10 ID:SGTC_881|Compound:0833-0569|FD-Score:3.49|P-value:2.22E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:12.30|P-value:1.48E-35 ID:SGTC_897|Compound:1000-0139|FD-Score:10.30|P-value:1.10E-25 ID:SGTC_926|Compound:2268-1401|FD-Score:3.31|P-value:4.39E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:4.71|P-value:1.06E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.47|P-value:2.16E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.33|P-value:3.69E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.72|P-value:9.21E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:5.77|P-value:3.23E-9 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.51|P-value:1.43E-8 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.31|P-value:4.36E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.80|P-value:6.01E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.42|P-value:4.30E-6 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.55|P-value:1.14E-8 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.41|P-value:3.00E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:6.73|P-value:6.20E-12 ID:SGTC_1433|Compound:4060-0023|FD-Score:6.65|P-value:1.09E-11 ID:SGTC_1436|Compound:4092-1007|FD-Score:4.79|P-value:7.11E-7 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.61|P-value:1.41E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.20|P-value:6.47E-4 ID:SGTC_1558|Compound:st069300|FD-Score:3.10|P-value:9.31E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.62|P-value:1.24E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-6.01|P-value:5.92E-10 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:-3.69|P-value:9.17E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:4.17|P-value:1.39E-5 ID:SGTC_1643|Compound:st009866|FD-Score:10.00|P-value:2.35E-24 ID:SGTC_1661|Compound:st013063|FD-Score:12.50|P-value:1.16E-36 ID:SGTC_1690|Compound:st023502|FD-Score:3.30|P-value:4.60E-4 ID:SGTC_1773|Compound:st048542|FD-Score:10.10|P-value:1.81E-24 ID:SGTC_1836|Compound:st055642|FD-Score:3.31|P-value:4.37E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:21.00|P-value:3.90E-100 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.72|P-value:9.27E-5 ID:SGTC_1958|Compound:st076513|FD-Score:9.27|P-value:4.92E-21 ID:SGTC_2004|Compound:4023728|FD-Score:6.09|P-value:4.43E-10 ID:SGTC_2011|Compound:4012611|FD-Score:5.61|P-value:8.14E-9 ID:SGTC_2040|Compound:5100729|FD-Score:4.22|P-value:1.07E-5 ID:SGTC_2061|Compound:5245884|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.26|P-value:5.26E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.59|P-value:1.52E-4 ID:SGTC_2089|Compound:5281248|FD-Score:4.06|P-value:2.24E-5 ID:SGTC_2090|Compound:5301565|FD-Score:7.81|P-value:1.78E-15 ID:SGTC_2092|Compound:5303694|FD-Score:4.89|P-value:4.37E-7 ID:SGTC_2125|Compound:5246583|FD-Score:10.80|P-value:6.98E-28 ID:SGTC_2141|Compound:5621638|FD-Score:7.15|P-value:3.03E-13 ID:SGTC_2158|Compound:5657123|FD-Score:3.24|P-value:5.62E-4 ID:SGTC_2161|Compound:5662504|FD-Score:3.46|P-value:2.57E-4 ID:SGTC_2173|Compound:5763948|FD-Score:5.67|P-value:5.60E-9 ID:SGTC_2174|Compound:5790901|FD-Score:10.20|P-value:7.29E-25 ID:SGTC_2200|Compound:6600604|FD-Score:11.90|P-value:1.26E-33 ID:SGTC_2214|Compound:7179297|FD-Score:3.56|P-value:1.72E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.43|P-value:3.64E-14 ID:SGTC_2246|Compound:7293507|FD-Score:3.97|P-value:3.20E-5 ID:SGTC_2255|Compound:7941087|FD-Score:5.39|P-value:2.83E-8 ID:SGTC_2319|Compound:6033012|FD-Score:11.90|P-value:1.07E-33 ID:SGTC_2323|Compound:6148992|FD-Score:3.88|P-value:4.68E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:7.57|P-value:1.17E-14 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-4.34|P-value:5.70E-6 ID:SGTC_2415|Compound:st077333|FD-Score:-3.38|P-value:3.14E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.47|P-value:3.44E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-3.92|P-value:3.55E-5 ID:SGTC_2430|Compound:5571206|FD-Score:14.00|P-value:2.12E-45 ID:SGTC_2433|Compound:5607874|FD-Score:3.32|P-value:4.24E-4 ID:SGTC_2434|Compound:5670830|FD-Score:4.35|P-value:6.08E-6 ID:SGTC_2461|Compound:5755302|FD-Score:4.01|P-value:2.81E-5 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.08|P-value:2.02E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.02|P-value:2.63E-5 ID:SGTC_2508|Compound:celastrol|FD-Score:3.33|P-value:4.02E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:7.38|P-value:5.36E-14 ID:SGTC_2619|Compound:obliquin|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.30|P-value:9.51E-14 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.58|P-value:1.61E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:3.23|P-value:5.94E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-5.74|P-value:3.26E-9 ID:SGTC_2882|Compound:9058044|FD-Score:-4.41|P-value:3.94E-6 ID:SGTC_2897|Compound:9048598|FD-Score:5.50|P-value:1.56E-8 ID:SGTC_2912|Compound:7964298|FD-Score:3.52|P-value:2.01E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.22|P-value:6.06E-4 ID:SGTC_2947|Compound:9072639|FD-Score:12.00|P-value:8.00E-34 ID:SGTC_2949|Compound:9072542|FD-Score:5.82|P-value:2.26E-9 ID:SGTC_2952|Compound:9073731|FD-Score:7.94|P-value:6.41E-16 ID:SGTC_3013|Compound:9080133|FD-Score:-3.22|P-value:5.55E-4 ID:SGTC_3024|Compound:9090631|FD-Score:4.65|P-value:1.42E-6 ID:SGTC_3069|Compound:9117009|FD-Score:3.44|P-value:2.72E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.56|P-value:2.25E-6 ID:SGTC_3078|Compound:9116413|FD-Score:-3.83|P-value:5.18E-5 ID:SGTC_3236|Compound:9132701|FD-Score:4.13|P-value:1.61E-5 ID:SGTC_3242|Compound:9133940|FD-Score:3.65|P-value:1.19E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.23|P-value:5.89E-4 ID:SGTC_3282|Compound:9108498|FD-Score:7.92|P-value:7.48E-16 ID:SGTC_3294|Compound:9122953|FD-Score:8.63|P-value:1.71E-18 ID:SGTC_3317|Compound:9138495|FD-Score:7.29|P-value:1.05E-13 ID:SGTC_3321|Compound:9137793|FD-Score:3.17|P-value:7.16E-4

Top fitness defect scores for YOR349W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1875 nocodazole 21.00 6.0 µM 3.90E-100 tubulin folding & SWR complex 4 1.69E-98
2 SGTC_229 benomyl 18.60 22.9 µM 2.04E-78 tubulin folding & SWR complex 4 3.73E-77
3 SGTC_210 3551-0445 17.90 56.8 µM 6.47E-73 4 9.53E-72
4 SGTC_149 3970-0822 15.60 46.1 µM 9.96E-56 tubulin folding & SWR complex 3 7.45E-55
5 SGTC_2430 5571206 14.00 200.0 µM 2.12E-45 1 1.06E-44
6 SGTC_212 3807-4682 13.80 38.8 µM 4.11E-44 tubulin folding & SWR complex 4 1.95E-43
7 SGTC_1661 st013063 12.50 9.7 µM 1.16E-36 2 4.11E-36
8 SGTC_885 0865-0106 12.30 16.8 µM 1.48E-35 TSC3-RPN4 2 5.03E-35
9 SGTC_2947 9072639 12.00 7.7 µM 8.00E-34 tubulin folding & SWR complex 2 2.55E-33
10 SGTC_2319 6033012 11.90 152.6 µM 1.07E-33 tubulin folding & SWR complex 6 3.37E-33
11 SGTC_2200 6600604 11.90 21.9 µM 1.26E-33 tubulin folding & SWR complex 9 3.97E-33
12 SGTC_2125 5246583 10.80 200.0 µM 6.98E-28 tubulin folding & SWR complex 3 1.77E-27
13 SGTC_897 1000-0139 10.30 31.4 µM 1.10E-25 5 2.55E-25
14 SGTC_286 k060-0067 10.20 22.9 µM 3.65E-25 tubulin folding & SWR complex 5 8.33E-25
15 SGTC_589 1227-0070 10.20 34.1 µM 7.22E-25 6 1.63E-24
16 SGTC_2174 5790901 10.20 200.0 µM 7.29E-25 tubulin folding & SWR complex 10 1.65E-24
17 SGTC_1773 st048542 10.10 73.6 µM 1.81E-24 6 4.03E-24
18 SGTC_1643 st009866 10.00 20.2 µM 2.35E-24 8 5.20E-24
19 SGTC_1958 st076513 9.27 41.9 µM 4.92E-21 60S ribosome export 2 9.60E-21
20 SGTC_3294 9122953 8.63 26.3 µM 1.71E-18 tubulin folding & SWR complex 3 3.04E-18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.764 0 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.664 0 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.608 0 YML124C TUB3 hom Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.437 1.89E-156 YML041C VPS71 hom Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.428 2.23E-149 YDR485C VPS72 hom Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.421 1.59E-144 YLR085C ARP6 hom Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.421 2.99E-144 YDR334W SWR1 hom Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.418 3.10E-142 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.342 1.96E-92 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.340 2.56E-91 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.339 5.85E-91 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.321 2.63E-81 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.297 3.14E-69 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.293 1.17E-67 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.288 5.39E-65 YOL012C HTZ1 hom Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin