HIPHOP chemogenomics database

YOR349W / CIN1

Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl

Zygosity: Homozygous strain

fixedexpanded
Profile for YOR349W / CIN1

Click on Significant Values for Screen Details

Top fitness defect scores for YOR349W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1875	nocodazole	21.00	6.0 µM	3.90E-100	tubulin folding & SWR complex	4	1.69E-98
2	SGTC_229	benomyl	18.60	22.9 µM	2.04E-78	tubulin folding & SWR complex	4	3.73E-77
3	SGTC_210	3551-0445	17.90	56.8 µM	6.47E-73		4	9.53E-72
4	SGTC_149	3970-0822	15.60	46.1 µM	9.96E-56	tubulin folding & SWR complex	3	7.45E-55
5	SGTC_2430	5571206	14.00	200.0 µM	2.12E-45		1	1.06E-44
6	SGTC_212	3807-4682	13.80	38.8 µM	4.11E-44	tubulin folding & SWR complex	4	1.95E-43
7	SGTC_1661	st013063	12.50	9.7 µM	1.16E-36		2	4.11E-36
8	SGTC_885	0865-0106	12.30	16.8 µM	1.48E-35	TSC3-RPN4	2	5.03E-35
9	SGTC_2947	9072639	12.00	7.7 µM	8.00E-34	tubulin folding & SWR complex	2	2.55E-33
10	SGTC_2319	6033012	11.90	152.6 µM	1.07E-33	tubulin folding & SWR complex	6	3.37E-33
11	SGTC_2200	6600604	11.90	21.9 µM	1.26E-33	tubulin folding & SWR complex	9	3.97E-33
12	SGTC_2125	5246583	10.80	200.0 µM	6.98E-28	tubulin folding & SWR complex	3	1.77E-27
13	SGTC_897	1000-0139	10.30	31.4 µM	1.10E-25		5	2.55E-25
14	SGTC_286	k060-0067	10.20	22.9 µM	3.65E-25	tubulin folding & SWR complex	5	8.33E-25
15	SGTC_589	1227-0070	10.20	34.1 µM	7.22E-25		6	1.63E-24
16	SGTC_2174	5790901	10.20	200.0 µM	7.29E-25	tubulin folding & SWR complex	10	1.65E-24
17	SGTC_1773	st048542	10.10	73.6 µM	1.81E-24		6	4.03E-24
18	SGTC_1643	st009866	10.00	20.2 µM	2.35E-24		8	5.20E-24
19	SGTC_1958	st076513	9.27	41.9 µM	4.92E-21	60S ribosome export	2	9.60E-21
20	SGTC_3294	9122953	8.63	26.3 µM	1.71E-18	tubulin folding & SWR complex	3	3.04E-18

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.764	0	YER007W	PAC2	hom	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.664	0	YPL241C	CIN2	hom	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.608	0	YML124C	TUB3	hom	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
0.437	1.89E-156	YML041C	VPS71	hom	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.428	2.23E-149	YDR485C	VPS72	hom	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
0.421	1.59E-144	YLR085C	ARP6	hom	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.421	2.99E-144	YDR334W	SWR1	hom	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
0.418	3.10E-142	YAL011W	SWC3	hom	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.342	1.96E-92	YBR231C	SWC5	hom	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress
0.340	2.56E-91	YAL024C	LTE1	hom	Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.339	5.85E-91	YNL298W	CLA4	hom	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.321	2.63E-81	YGL094C	PAN2	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.297	3.14E-69	YLR243W	GPN3	het	Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.293	1.17E-67	YKL025C	PAN3	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.288	5.39E-65	YOL012C	HTZ1	hom	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin