YOR351C / MEK1

Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR351C / MEK1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:2.91|P-value:8.67E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-2.90|P-value:7.66E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.52|P-value:5.22E-7 ID:SGTC_260|Compound:nsc-65238|FD-Score:-4.17|P-value:2.77E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:4.08|P-value:5.31E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.03|P-value:5.47E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.06|P-value:4.88E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.49|P-value:8.56E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.21|P-value:2.67E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.12|P-value:3.90E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.52|P-value:5.26E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:3.10|P-value:4.26E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.21|P-value:2.70E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.98|P-value:8.69E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:3.40|P-value:1.22E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:6.38|P-value:2.67E-12 ID:SGTC_1068|Compound:loratadine|FD-Score:3.92|P-value:1.18E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.49|P-value:8.37E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.26|P-value:2.21E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:2.93|P-value:8.06E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.72|P-value:1.78E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.00|P-value:6.16E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:2.87|P-value:9.88E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.67|P-value:3.87E-5 ID:SGTC_1602|Compound:st001878|FD-Score:2.98|P-value:6.60E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.33|P-value:1.67E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-3.16|P-value:2.80E-4 ID:SGTC_1802|Compound:st050112|FD-Score:4.39|P-value:1.06E-6 ID:SGTC_1870|Compound:st057514|FD-Score:-3.16|P-value:2.82E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.18|P-value:2.56E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.22|P-value:2.61E-4 ID:SGTC_2047|Compound:4141938|FD-Score:2.97|P-value:6.90E-4 ID:SGTC_2378|Compound:9074213|FD-Score:2.94|P-value:7.82E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.45|P-value:1.00E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.33|P-value:1.69E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.90|P-value:1.30E-5 ID:SGTC_2585|Compound:alliin|FD-Score:3.16|P-value:3.27E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-6.82|P-value:5.72E-14 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.53|P-value:4.05E-7 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.84|P-value:1.72E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.92|P-value:5.26E-8 ID:SGTC_2982|Compound:9019404|FD-Score:3.35|P-value:1.50E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.26|P-value:2.26E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.33|P-value:1.67E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.91|P-value:1.21E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:2.91|P-value:8.67E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-2.90|P-value:7.66E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.52|P-value:5.22E-7 ID:SGTC_260|Compound:nsc-65238|FD-Score:-4.17|P-value:2.77E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:4.08|P-value:5.31E-6 ID:SGTC_493|Compound:zm226600|FD-Score:3.03|P-value:5.47E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.06|P-value:4.88E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:3.49|P-value:8.56E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:3.21|P-value:2.67E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:3.12|P-value:3.90E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:4.52|P-value:5.26E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:3.10|P-value:4.26E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.21|P-value:2.70E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.98|P-value:8.69E-6 ID:SGTC_952|Compound:1185-0122|FD-Score:3.40|P-value:1.22E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:6.38|P-value:2.67E-12 ID:SGTC_1068|Compound:loratadine|FD-Score:3.92|P-value:1.18E-5 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.49|P-value:8.37E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.26|P-value:2.21E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:2.93|P-value:8.06E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.72|P-value:1.78E-7 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.00|P-value:6.16E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:2.87|P-value:9.88E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:3.67|P-value:3.87E-5 ID:SGTC_1602|Compound:st001878|FD-Score:2.98|P-value:6.60E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.33|P-value:1.67E-4 ID:SGTC_1767|Compound:st044992|FD-Score:-3.16|P-value:2.80E-4 ID:SGTC_1802|Compound:st050112|FD-Score:4.39|P-value:1.06E-6 ID:SGTC_1870|Compound:st057514|FD-Score:-3.16|P-value:2.82E-4 ID:SGTC_1920|Compound:st075728|FD-Score:-3.18|P-value:2.56E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.22|P-value:2.61E-4 ID:SGTC_2047|Compound:4141938|FD-Score:2.97|P-value:6.90E-4 ID:SGTC_2378|Compound:9074213|FD-Score:2.94|P-value:7.82E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.45|P-value:1.00E-4 ID:SGTC_2466|Compound:5983409|FD-Score:3.33|P-value:1.69E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.90|P-value:1.30E-5 ID:SGTC_2585|Compound:alliin|FD-Score:3.16|P-value:3.27E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-6.82|P-value:5.72E-14 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:-4.53|P-value:4.05E-7 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.84|P-value:1.72E-5 ID:SGTC_2800|Compound:7887935|FD-Score:4.92|P-value:5.26E-8 ID:SGTC_2982|Compound:9019404|FD-Score:3.35|P-value:1.50E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.26|P-value:2.26E-4 ID:SGTC_3107|Compound:9121808|FD-Score:3.33|P-value:1.67E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.91|P-value:1.21E-5

Top fitness defect scores for YOR351C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_961 1252-1571 6.38 372.0 µM 2.67E-12 7 8.86E-11
2 SGTC_2800 7887935 4.92 81.8 µM 5.26E-8 RPP1 & pyrimidine depletion 8 4.23E-7
3 SGTC_1480 1070-0044 4.72 41.2 µM 1.78E-7 5 1.20E-6
4 SGTC_159 3970-0959 4.52 50.0 µM 5.22E-7 52 3.04E-6
5 SGTC_913 3487-1245 4.52 167.0 µM 5.26E-7 14 3.06E-6
6 SGTC_1802 st050112 4.39 57.9 µM 1.06E-6 6 5.59E-6
7 SGTC_307 1501-1223 4.08 22.3 µM 5.31E-6 12 2.23E-5
8 SGTC_947 3447-0010 3.98 211.0 µM 8.69E-6 12 3.41E-5
9 SGTC_1068 loratadine 3.92 26.9 µM 1.18E-5 22 4.43E-5
10 SGTC_3234 9132280 3.91 49.5 µM 1.21E-5 20 4.54E-5
11 SGTC_2573 2',4'-dihydroxychalcone 3.90 15.0 µM 1.30E-5 51 4.82E-5
12 SGTC_2755 lomerizine 3.84 42.7 µM 1.72E-5 28 6.13E-5
13 SGTC_1578 josamycin 3.67 24.2 µM 3.87E-5 18 1.23E-4
14 SGTC_1093 fluphenazine 3.49 8.0 µM 8.37E-5 24 2.40E-4
15 SGTC_594 1487-1584 3.49 10.8 µM 8.56E-5 36 2.45E-4
16 SGTC_2405 ticlatone 3.45 3.5 µM 1.00E-4 89 2.80E-4
17 SGTC_952 1185-0122 3.40 232.0 µM 1.22E-4 39 3.33E-4
18 SGTC_2982 9019404 3.35 26.0 µM 1.50E-4 39 3.97E-4
19 SGTC_3107 9121808 3.33 49.5 µM 1.67E-4 17 4.37E-4
20 SGTC_1636 st007707 3.33 68.9 µM 1.67E-4 72 4.37E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 3.01E-13 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.119 5.36E-12 YPL085W SEC16 het COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p
0.117 1.14E-11 YMR316C-B_d YMR316C-B_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.109 2.31E-10 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.097 1.71E-8 YIL062C ARC15 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity
0.087 5.02E-7 YPL133C RDS2 hom Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole
0.086 5.87E-7 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.086 7.01E-7 YNL216W RAP1 het Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
0.084 1.09E-6 YPL007C TFC8 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
0.082 1.95E-6 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.081 2.32E-6 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.080 3.52E-6 YGR117C_p YGR117C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.078 6.90E-6 YJL057C IKS1 hom Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
0.077 7.88E-6 YIL016W SNL1 hom Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
0.076 9.78E-6 YPR085C ASA1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1