YOR353C / SOG2

Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR353C / SOG2

Click on Significant Values for Screen Details ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.39|P-value:4.75E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.70|P-value:1.54E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.50|P-value:3.17E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.64|P-value:1.90E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.26|P-value:7.44E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.73|P-value:7.77E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.74|P-value:1.72E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.18|P-value:6.07E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-4.72|P-value:9.48E-7 ID:SGTC_1632|Compound:st005650|FD-Score:3.37|P-value:5.13E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.59|P-value:2.31E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.60|P-value:1.30E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.19|P-value:5.77E-4 ID:SGTC_1925|Compound:st057770|FD-Score:4.02|P-value:4.20E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.50|P-value:3.26E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.93|P-value:6.10E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.30|P-value:4.00E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-5.64|P-value:6.52E-9 ID:SGTC_2602|Compound:kawain|FD-Score:-6.19|P-value:2.28E-10 ID:SGTC_2935|Compound:9038016|FD-Score:-3.12|P-value:7.39E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-5.09|P-value:1.38E-7 ID:SGTC_3302|Compound:9125395|FD-Score:3.45|P-value:3.89E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.38|P-value:2.96E-4 ID:SGTC_390|Compound:dec-rvkr-cmk|FD-Score:3.39|P-value:4.75E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.70|P-value:1.54E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.50|P-value:3.17E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.64|P-value:1.90E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:3.26|P-value:7.44E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.73|P-value:7.77E-5 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.74|P-value:1.72E-6 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.18|P-value:6.07E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:-4.72|P-value:9.48E-7 ID:SGTC_1632|Compound:st005650|FD-Score:3.37|P-value:5.13E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.59|P-value:2.31E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.60|P-value:1.30E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.19|P-value:5.77E-4 ID:SGTC_1925|Compound:st057770|FD-Score:4.02|P-value:4.20E-5 ID:SGTC_2280|Compound:7785178|FD-Score:3.50|P-value:3.26E-4 ID:SGTC_2434|Compound:5670830|FD-Score:3.93|P-value:6.10E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.30|P-value:4.00E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-5.64|P-value:6.52E-9 ID:SGTC_2602|Compound:kawain|FD-Score:-6.19|P-value:2.28E-10 ID:SGTC_2935|Compound:9038016|FD-Score:-3.12|P-value:7.39E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-5.09|P-value:1.38E-7 ID:SGTC_3302|Compound:9125395|FD-Score:3.45|P-value:3.89E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-3.38|P-value:2.96E-4

Top fitness defect scores for YOR353C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1182 1222-0449 4.74 220.0 µM 1.72E-6 1 1.09E-6 0.50
2 SGTC_1925 st057770 4.02 10.1 µM 4.20E-5 TSC3-RPN4 3 2.88E-5 0.05
3 SGTC_2434 5670830 3.93 169.9 µM 6.10E-5 7 4.22E-5 0.25
4 SGTC_429 1112-0049 3.70 25.5 µM 1.54E-4 DNA damage response 11 1.09E-4 0.18
5 SGTC_1046 2001-0062 3.64 216.0 µM 1.90E-4 3 1.35E-4 0.18
6 SGTC_1633 st005664 3.59 67.9 µM 2.31E-4 8 1.66E-4 0.20
7 SGTC_849 0386-0493 3.50 241.0 µM 3.17E-4 8 2.29E-4 0.09
8 SGTC_2280 7785178 3.50 200.0 µM 3.26E-4 3 2.36E-4 0.02
9 SGTC_3302 9125395 3.45 16.4 µM 3.89E-4 6 2.83E-4 0.02
10 SGTC_390 dec-rvkr-cmk 3.39 16.7 µM 4.75E-4 calcium & mitochondrial duress 16 3.47E-4 0.00
11 SGTC_1632 st005650 3.37 90.0 µM 5.13E-4 11 3.75E-4 0.03
12 SGTC_1070 indatraline 3.26 8.8 µM 7.44E-4 60S ribosome export 8 5.51E-4 9.36E-4
13 SGTC_2291 7917025 3.11 104.3 µM 0.00125 iron homeostasis 19 9.40E-4 0.00
14 SGTC_2287 7945887 3.08 168.8 µM 0.00139 6 0.00105 0.22
15 SGTC_2811 7967822 3.04 32.5 µM 0.00155 17 0.00117 0.03
16 SGTC_260 nsc-65238 2.96 4.0 µM 0.00203 endomembrane recycling 14 0.00155 0.11
17 SGTC_2281 7943571 2.94 200.0 µM 0.00213 16 0.00163 0.04
18 SGTC_300 r073-0011 2.94 5.0 µM 0.00213 10 0.00163 0.08
19 SGTC_662 k832-1615 2.90 104.0 µM 0.00246 13 0.00189 0.01
20 SGTC_555 4296-0685 2.89 37.0 µM 0.00251 ergosterol biosynthesis 12 0.00192 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.34E-15 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p
0.127 1.29E-13 YKL075C_p YKL075C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin
0.127 1.80E-13 YBR183W YPC1 hom Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication
0.124 5.08E-13 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.117 1.02E-11 YLR264W RPS28B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication
0.113 5.48E-11 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.110 1.85E-10 YGL028C SCW11 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
0.108 4.04E-10 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.100 7.52E-9 YLR122C_d YLR122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
0.096 2.44E-8 YLR454W_p FMP27_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.096 2.76E-8 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.096 2.92E-8 YPL103C FMP30 hom Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D
0.094 5.53E-8 YPL168W_p YPL168W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated
0.092 8.29E-8 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.088 3.80E-7 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein