Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YOR353C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.136 | 2.34E-15 | YDL028C | MPS1 | het | Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p |
0.127 | 1.29E-13 | YKL075C_p | YKL075C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin |
0.127 | 1.80E-13 | YBR183W | YPC1 | hom | Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication |
0.124 | 5.08E-13 | YGR096W | TPC1 | hom | Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family |
0.117 | 1.02E-11 | YLR264W | RPS28B | hom | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication |
0.113 | 5.48E-11 | YMR041C | ARA2 | hom | NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase |
0.110 | 1.85E-10 | YGL028C | SCW11 | hom | Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p |
0.108 | 4.04E-10 | YMR058W | FET3 | hom | Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress |
0.100 | 7.52E-9 | YLR122C_d | YLR122C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C |
0.096 | 2.44E-8 | YLR454W_p | FMP27_p | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.096 | 2.76E-8 | YBR265W | TSC10 | het | 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family |
0.096 | 2.92E-8 | YPL103C | FMP30 | hom | Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D |
0.094 | 5.53E-8 | YPL168W_p | YPL168W_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated |
0.092 | 8.29E-8 | YGR030C | POP6 | het | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
0.088 | 3.80E-7 | YMR040W | YET2 | hom | Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein |