YOR354C / MSC6

Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR354C / MSC6

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.63|P-value:2.50E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.28|P-value:8.28E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.45|P-value:4.65E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.79|P-value:1.40E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.11|P-value:4.10E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:4.93|P-value:1.18E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.31|P-value:7.53E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-3.35|P-value:6.62E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.80|P-value:2.17E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.24|P-value:9.36E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.46|P-value:9.52E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.46|P-value:4.55E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.07|P-value:4.91E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.62|P-value:2.67E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.62|P-value:2.62E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.47|P-value:4.41E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.24|P-value:2.45E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:5.28|P-value:2.11E-7 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.91|P-value:9.10E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.42|P-value:5.23E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.81|P-value:1.28E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.88|P-value:1.45E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-4.82|P-value:1.86E-6 ID:SGTC_1947|Compound:st076332|FD-Score:3.72|P-value:1.85E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.23|P-value:9.60E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.77|P-value:1.50E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.91|P-value:8.96E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.35|P-value:6.70E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.58|P-value:5.55E-6 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.53|P-value:3.55E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.49|P-value:4.13E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.46|P-value:9.61E-6 ID:SGTC_2706|Compound:st078239|FD-Score:3.28|P-value:8.53E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.77|P-value:1.47E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-5.27|P-value:2.19E-7 ID:SGTC_2810|Compound:7959871|FD-Score:4.74|P-value:2.75E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.62|P-value:2.62E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.33|P-value:7.10E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.68|P-value:2.12E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-4.89|P-value:1.38E-6 ID:SGTC_2936|Compound:9038235|FD-Score:5.96|P-value:5.78E-9 ID:SGTC_2940|Compound:9060638|FD-Score:3.37|P-value:6.19E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.87|P-value:1.06E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.63|P-value:2.50E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:3.28|P-value:8.28E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:-3.45|P-value:4.65E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.79|P-value:1.40E-4 ID:SGTC_276|Compound:colchicine|FD-Score:4.11|P-value:4.10E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:4.93|P-value:1.18E-6 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.31|P-value:7.53E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:-3.35|P-value:6.62E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:4.80|P-value:2.17E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.24|P-value:9.36E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:-4.46|P-value:9.52E-6 ID:SGTC_808|Compound:0711-0032|FD-Score:-3.46|P-value:4.55E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.07|P-value:4.91E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.62|P-value:2.67E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.62|P-value:2.62E-4 ID:SGTC_1146|Compound:3579-1023|FD-Score:3.47|P-value:4.41E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.24|P-value:2.45E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:5.28|P-value:2.11E-7 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.91|P-value:9.10E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.42|P-value:5.23E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.81|P-value:1.28E-4 ID:SGTC_1617|Compound:st002906|FD-Score:4.88|P-value:1.45E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-4.82|P-value:1.86E-6 ID:SGTC_1947|Compound:st076332|FD-Score:3.72|P-value:1.85E-4 ID:SGTC_1961|Compound:st076550|FD-Score:-3.23|P-value:9.60E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.77|P-value:1.50E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.91|P-value:8.96E-5 ID:SGTC_2332|Compound:7982454|FD-Score:3.35|P-value:6.70E-4 ID:SGTC_2390|Compound:9097792|FD-Score:-4.58|P-value:5.55E-6 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:3.53|P-value:3.55E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.49|P-value:4.13E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.46|P-value:9.61E-6 ID:SGTC_2706|Compound:st078239|FD-Score:3.28|P-value:8.53E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.77|P-value:1.47E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-5.27|P-value:2.19E-7 ID:SGTC_2810|Compound:7959871|FD-Score:4.74|P-value:2.75E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-3.62|P-value:2.62E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.33|P-value:7.10E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.68|P-value:2.12E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-4.89|P-value:1.38E-6 ID:SGTC_2936|Compound:9038235|FD-Score:5.96|P-value:5.78E-9 ID:SGTC_2940|Compound:9060638|FD-Score:3.37|P-value:6.19E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.87|P-value:1.06E-4

Top fitness defect scores for YOR354C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2936 9038235 5.96 15.6 µM 5.78E-9 3 1.29E-9
2 SGTC_1187 1391-0724 5.28 117.0 µM 2.11E-7 amide catabolism 6 6.44E-8
3 SGTC_361 000s-0510 4.93 1.4 µM 1.18E-6 16 4.18E-7
4 SGTC_1617 st002906 4.88 78.0 µM 1.45E-6 14 5.22E-7
5 SGTC_665 3914-0008 4.80 307.0 µM 2.17E-6 8 8.10E-7
6 SGTC_2810 7959871 4.74 45.5 µM 2.75E-6 copper-dependent oxidative stress 23 1.05E-6
7 SGTC_2703 st077852 4.46 53.4 µM 9.61E-6 11 4.07E-6
8 SGTC_1156 4092-0367 4.24 4.9 µM 2.45E-5 14 1.12E-5
9 SGTC_276 colchicine 4.11 750.0 µM 4.10E-5 13 1.97E-5
10 SGTC_1045 1348-1485 4.07 165.0 µM 4.91E-5 25 2.39E-5
11 SGTC_2113 5491891 3.91 107.0 µM 8.96E-5 TSC3-RPN4 22 4.59E-5
12 SGTC_1198 1612-1005 3.91 86.7 µM 9.10E-5 13 4.66E-5
13 SGTC_2947 9072639 3.87 7.7 µM 1.06E-4 tubulin folding & SWR complex 47 5.52E-5
14 SGTC_2069 5228469 3.77 200.0 µM 1.50E-4 17 8.03E-5
15 SGTC_1947 st076332 3.72 61.6 µM 1.85E-4 17 1.00E-4
16 SGTC_2930 9013230 3.68 14.9 µM 2.12E-4 heme biosynthesis & mitochondrial translocase 50 1.17E-4
17 SGTC_1123 mangostin 3.62 811.3 nM 2.62E-4 mitochondrial response to ROS 48 1.47E-4
18 SGTC_1065 prochlorperazine maleate 3.62 2.5 µM 2.67E-4 21 1.50E-4
19 SGTC_2498 4'-Methoxychalcone 3.53 54.6 µM 3.55E-4 RPP1 & pyrimidine depletion 47 2.04E-4
20 SGTC_1146 3579-1023 3.47 7.0 µM 4.41E-4 31 2.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.41E-10 YGL208W SIP2 hom One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane
0.105 9.00E-10 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.099 1.03E-8 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.098 1.15E-8 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme
0.087 4.82E-7 YER085C_p YER085C_p hom Putative protein of unknown function
0.085 8.21E-7 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.084 1.09E-6 YDR281C PHM6 hom Protein of unknown function, expression is regulated by phosphate levels
0.084 1.15E-6 YKL150W MCR1 hom Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
0.082 1.81E-6 YML005W TRM12 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
0.079 4.55E-6 YOL010W RCL1 het Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected
0.077 7.63E-6 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.073 2.47E-5 YIL025C_d YIL025C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 2.82E-5 YPR174C YPR174C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication
0.071 4.25E-5 YAL022C FUN26 hom Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis
0.070 4.86E-5 YDR465C RMT2 hom Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress