YOR355W / GDS1

Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR355W / GDS1

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.21|P-value:3.49E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:5.17|P-value:5.36E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:3.40|P-value:6.70E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.67|P-value:2.64E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.32|P-value:8.55E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.10|P-value:5.32E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.32|P-value:8.47E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.94|P-value:1.01E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:9.39|P-value:3.94E-19 ID:SGTC_631|Compound:k072-0230|FD-Score:3.53|P-value:4.31E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.40|P-value:6.62E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.58|P-value:3.68E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.68|P-value:2.53E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.71|P-value:4.38E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.76|P-value:1.91E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.63|P-value:3.08E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.35|P-value:2.04E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.34|P-value:8.14E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.84|P-value:1.45E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.03|P-value:7.19E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.61|P-value:6.73E-6 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.62|P-value:3.20E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.70|P-value:2.40E-4 ID:SGTC_1633|Compound:st005664|FD-Score:5.52|P-value:9.47E-8 ID:SGTC_1710|Compound:st031758|FD-Score:3.48|P-value:5.01E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.86|P-value:2.28E-6 ID:SGTC_1807|Compound:st050092|FD-Score:3.34|P-value:8.19E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.88|P-value:1.26E-4 ID:SGTC_1832|Compound:st054113|FD-Score:3.48|P-value:5.06E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.35|P-value:7.82E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.94|P-value:9.99E-5 ID:SGTC_1913|Compound:st060213|FD-Score:4.46|P-value:1.30E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.66|P-value:2.74E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.33|P-value:2.47E-7 ID:SGTC_1941|Compound:st076221|FD-Score:-4.51|P-value:1.02E-5 ID:SGTC_1948|Compound:st076329|FD-Score:4.40|P-value:1.64E-5 ID:SGTC_1995|Compound:st072814|FD-Score:4.33|P-value:2.18E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.53|P-value:4.34E-4 ID:SGTC_2172|Compound:5754775|FD-Score:5.87|P-value:1.50E-8 ID:SGTC_2330|Compound:7979373|FD-Score:4.19|P-value:3.86E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.68|P-value:2.53E-4 ID:SGTC_2373|Compound:9071805|FD-Score:4.75|P-value:3.67E-6 ID:SGTC_2387|Compound:9077560|FD-Score:4.80|P-value:2.91E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-3.97|P-value:9.08E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.02|P-value:7.47E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.70|P-value:2.41E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.79|P-value:1.73E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.44|P-value:1.38E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.68|P-value:4.89E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.34|P-value:8.10E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:-3.36|P-value:7.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.39|P-value:6.96E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.34|P-value:8.02E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.79|P-value:1.76E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.88|P-value:2.08E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-4.73|P-value:3.97E-6 ID:SGTC_2875|Compound:9039966|FD-Score:5.10|P-value:7.40E-7 ID:SGTC_2970|Compound:9090938|FD-Score:5.03|P-value:1.03E-6 ID:SGTC_2974|Compound:9094440|FD-Score:3.40|P-value:6.64E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.48|P-value:5.14E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.21|P-value:3.49E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:5.17|P-value:5.36E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:3.40|P-value:6.70E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.67|P-value:2.64E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:3.32|P-value:8.55E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:4.10|P-value:5.32E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.32|P-value:8.47E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.94|P-value:1.01E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:9.39|P-value:3.94E-19 ID:SGTC_631|Compound:k072-0230|FD-Score:3.53|P-value:4.31E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.40|P-value:6.62E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.58|P-value:3.68E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.68|P-value:2.53E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.71|P-value:4.38E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:-3.76|P-value:1.91E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.63|P-value:3.08E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.35|P-value:2.04E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:-3.34|P-value:8.14E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.84|P-value:1.45E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.03|P-value:7.19E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.61|P-value:6.73E-6 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.62|P-value:3.20E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.70|P-value:2.40E-4 ID:SGTC_1633|Compound:st005664|FD-Score:5.52|P-value:9.47E-8 ID:SGTC_1710|Compound:st031758|FD-Score:3.48|P-value:5.01E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.86|P-value:2.28E-6 ID:SGTC_1807|Compound:st050092|FD-Score:3.34|P-value:8.19E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.88|P-value:1.26E-4 ID:SGTC_1832|Compound:st054113|FD-Score:3.48|P-value:5.06E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.35|P-value:7.82E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.94|P-value:9.99E-5 ID:SGTC_1913|Compound:st060213|FD-Score:4.46|P-value:1.30E-5 ID:SGTC_1934|Compound:st074720|FD-Score:3.66|P-value:2.74E-4 ID:SGTC_1935|Compound:st074532|FD-Score:5.33|P-value:2.47E-7 ID:SGTC_1941|Compound:st076221|FD-Score:-4.51|P-value:1.02E-5 ID:SGTC_1948|Compound:st076329|FD-Score:4.40|P-value:1.64E-5 ID:SGTC_1995|Compound:st072814|FD-Score:4.33|P-value:2.18E-5 ID:SGTC_2165|Compound:5727197|FD-Score:3.53|P-value:4.34E-4 ID:SGTC_2172|Compound:5754775|FD-Score:5.87|P-value:1.50E-8 ID:SGTC_2330|Compound:7979373|FD-Score:4.19|P-value:3.86E-5 ID:SGTC_2363|Compound:9053361|FD-Score:3.68|P-value:2.53E-4 ID:SGTC_2373|Compound:9071805|FD-Score:4.75|P-value:3.67E-6 ID:SGTC_2387|Compound:9077560|FD-Score:4.80|P-value:2.91E-6 ID:SGTC_2482|Compound:5981709|FD-Score:-3.97|P-value:9.08E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.02|P-value:7.47E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.70|P-value:2.41E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.79|P-value:1.73E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.44|P-value:1.38E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.68|P-value:4.89E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.34|P-value:8.10E-4 ID:SGTC_2669|Compound:eugenol|FD-Score:-3.36|P-value:7.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.39|P-value:6.96E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.34|P-value:8.02E-4 ID:SGTC_2865|Compound:9030313|FD-Score:3.79|P-value:1.76E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.88|P-value:2.08E-6 ID:SGTC_2874|Compound:9043904|FD-Score:-4.73|P-value:3.97E-6 ID:SGTC_2875|Compound:9039966|FD-Score:5.10|P-value:7.40E-7 ID:SGTC_2970|Compound:9090938|FD-Score:5.03|P-value:1.03E-6 ID:SGTC_2974|Compound:9094440|FD-Score:3.40|P-value:6.64E-4 ID:SGTC_2981|Compound:9013952|FD-Score:-3.48|P-value:5.14E-4

Top fitness defect scores for YOR355W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_517 1365-0151 9.39 113.0 µM 3.94E-19 1 3.10E-21
2 SGTC_2172 5754775 5.87 163.9 µM 1.50E-8 3 2.18E-9
3 SGTC_1633 st005664 5.52 67.9 µM 9.47E-8 8 1.72E-8
4 SGTC_1935 st074532 5.33 41.6 µM 2.47E-7 6 5.01E-8
5 SGTC_201 4262-0159 5.17 12.8 µM 5.36E-7 ergosterol depletion effects on membrane 22 1.19E-7
6 SGTC_2875 9039966 5.10 71.4 µM 7.40E-7 3 1.71E-7
7 SGTC_2970 9090938 5.03 41.9 µM 1.03E-6 RNA processing & uracil transport 11 2.48E-7
8 SGTC_2867 9039098 4.88 71.4 µM 2.08E-6 iron homeostasis 16 5.43E-7
9 SGTC_1717 st033143 4.86 58.0 µM 2.28E-6 24 6.02E-7
10 SGTC_2387 9077560 4.80 195.1 µM 2.91E-6 7 7.88E-7
11 SGTC_2373 9071805 4.75 200.0 µM 3.67E-6 5 1.02E-6
12 SGTC_928 2764-0428 4.71 58.7 µM 4.38E-6 cell wall 38 1.25E-6
13 SGTC_1304 1165-0502 4.61 251.0 µM 6.73E-6 49 2.01E-6
14 SGTC_1913 st060213 4.46 96.1 µM 1.30E-5 19 4.19E-6
15 SGTC_2594 a-mangostin 4.44 100.0 µM 1.38E-5 20 4.48E-6
16 SGTC_1948 st076329 4.40 66.6 µM 1.64E-5 17 5.44E-6
17 SGTC_1159 4092-0538 4.35 61.2 µM 2.04E-5 18 6.94E-6
18 SGTC_1995 st072814 4.33 61.1 µM 2.18E-5 10 7.49E-6
19 SGTC_118 0083-0097 4.21 135.3 µM 3.49E-5 translation 108 1.27E-5
20 SGTC_2330 7979373 4.19 200.0 µM 3.86E-5 60S ribosome export 30 1.41E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.31E-7 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.091 1.34E-7 YLR406C RPL31B hom Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication
0.090 2.00E-7 YGL121C GPG1 hom Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing
0.090 2.03E-7 YJR003C_p YJR003C_p hom Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
0.089 2.09E-7 YNL109W_d YNL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C
0.089 2.25E-7 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.089 2.57E-7 YFL011W HXT10 hom Putative hexose transporter, expressed at low levels and expression is repressed by glucose
0.082 2.08E-6 YDR245W MNN10 hom Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
0.082 2.30E-6 YJL134W LCB3 hom Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication
0.081 2.43E-6 YGL041C-B_p YGL041C-B_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.081 2.53E-6 YMR100W MUB1 hom MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene
0.081 2.50E-6 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.080 3.20E-6 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.080 3.78E-6 YJL135W_d YJL135W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
0.079 4.95E-6 YGR086C PIL1 hom Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress