YOR356W / CIR2

Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR356W / CIR2

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.22|P-value:5.38E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.33|P-value:3.76E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.22|P-value:5.47E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.28|P-value:4.36E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.68|P-value:9.15E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.13|P-value:7.47E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.35|P-value:3.36E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.19|P-value:5.97E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.35|P-value:3.41E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.95|P-value:2.96E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.16|P-value:6.72E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.50|P-value:2.39E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.08|P-value:8.67E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.53|P-value:2.09E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.36|P-value:3.28E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.11|P-value:7.76E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.89|P-value:3.90E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.24|P-value:4.98E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.64|P-value:1.14E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.62|P-value:1.32E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.31|P-value:6.00E-6 ID:SGTC_1714|Compound:st033236|FD-Score:-3.31|P-value:4.00E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.45|P-value:2.37E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.14|P-value:7.29E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-3.07|P-value:9.38E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.07|P-value:9.37E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.68|P-value:9.43E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.75|P-value:6.95E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.49|P-value:2.04E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-5.74|P-value:2.94E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.29|P-value:4.30E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.59|P-value:1.35E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.22|P-value:9.18E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.48|P-value:2.08E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.48|P-value:1.28E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:7.82|P-value:1.02E-15 ID:SGTC_2944|Compound:9067346|FD-Score:-4.50|P-value:2.52E-6 ID:SGTC_2947|Compound:9072639|FD-Score:3.26|P-value:4.71E-4 ID:SGTC_2963|Compound:9082507|FD-Score:7.34|P-value:4.63E-14 ID:SGTC_2998|Compound:9066762|FD-Score:3.61|P-value:1.24E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.11|P-value:7.98E-4 ID:SGTC_3203|Compound:9113543|FD-Score:5.37|P-value:2.48E-8 ID:SGTC_3258|Compound:9138477|FD-Score:3.07|P-value:9.11E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-6.51|P-value:1.98E-11 ID:SGTC_3270|Compound:9137563|FD-Score:3.79|P-value:5.80E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:3.59|P-value:1.31E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.22|P-value:5.38E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.33|P-value:3.76E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:-3.22|P-value:5.47E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.28|P-value:4.36E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.68|P-value:9.15E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:3.13|P-value:7.47E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:3.35|P-value:3.36E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:3.19|P-value:5.97E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:-3.35|P-value:3.41E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.95|P-value:2.96E-5 ID:SGTC_889|Compound:0919-1524|FD-Score:3.16|P-value:6.72E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:4.50|P-value:2.39E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.08|P-value:8.67E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.53|P-value:2.09E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.36|P-value:3.28E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.11|P-value:7.76E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.89|P-value:3.90E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.24|P-value:4.98E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-3.64|P-value:1.14E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.62|P-value:1.32E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.31|P-value:6.00E-6 ID:SGTC_1714|Compound:st033236|FD-Score:-3.31|P-value:4.00E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.45|P-value:2.37E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-3.14|P-value:7.29E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-3.07|P-value:9.38E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.07|P-value:9.37E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.68|P-value:9.43E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.75|P-value:6.95E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-3.49|P-value:2.04E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-5.74|P-value:2.94E-9 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.29|P-value:4.30E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.59|P-value:1.35E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:4.22|P-value:9.18E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.48|P-value:2.08E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:5.48|P-value:1.28E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:7.82|P-value:1.02E-15 ID:SGTC_2944|Compound:9067346|FD-Score:-4.50|P-value:2.52E-6 ID:SGTC_2947|Compound:9072639|FD-Score:3.26|P-value:4.71E-4 ID:SGTC_2963|Compound:9082507|FD-Score:7.34|P-value:4.63E-14 ID:SGTC_2998|Compound:9066762|FD-Score:3.61|P-value:1.24E-4 ID:SGTC_3093|Compound:9117344|FD-Score:3.11|P-value:7.98E-4 ID:SGTC_3203|Compound:9113543|FD-Score:5.37|P-value:2.48E-8 ID:SGTC_3258|Compound:9138477|FD-Score:3.07|P-value:9.11E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-6.51|P-value:1.98E-11 ID:SGTC_3270|Compound:9137563|FD-Score:3.79|P-value:5.80E-5

Top fitness defect scores for YOR356W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2758 dehydroepiandrosterone 7.82 69.3 µM 1.02E-15 14 2.65E-15
2 SGTC_2963 9082507 7.34 9.0 µM 4.63E-14 3 1.08E-13
3 SGTC_2751 anetholtrithion 5.48 17.2 µM 1.28E-8 8 2.08E-8
4 SGTC_3203 9113543 5.37 49.5 µM 2.48E-8 9 3.95E-8
5 SGTC_1675 st018485 4.62 24.5 µM 1.32E-6 60S ribosome export 14 1.88E-6
6 SGTC_1160 4092-0570 4.53 10.5 µM 2.09E-6 plasma membrane duress 27 2.94E-6
7 SGTC_981 1488-1094 4.50 54.9 µM 2.39E-6 12 3.34E-6
8 SGTC_1679 4130-1276 4.31 6.7 µM 6.00E-6 Golgi 50 8.18E-6
9 SGTC_2610 ononetin 4.22 44.2 µM 9.18E-6 34 1.23E-5
10 SGTC_778 3456-2434 3.95 196.0 µM 2.96E-5 mitochondrial response to ROS 75 3.85E-5
11 SGTC_1467 k284-1082 3.89 293.0 µM 3.90E-5 18 5.04E-5
12 SGTC_3270 9137563 3.79 49.5 µM 5.80E-5 RPP1 & pyrimidine depletion 7 7.40E-5
13 SGTC_2349 9023730 3.75 187.1 µM 6.95E-5 28 8.82E-5
14 SGTC_253 dyclonine 3.68 31.2 µM 9.15E-5 amide catabolism 34 1.15E-4
15 SGTC_2998 9066762 3.61 71.4 µM 1.24E-4 RPP1 & pyrimidine depletion 33 1.56E-4
16 SGTC_68 0986-0284 3.59 82.8 µM 1.31E-4 88 1.63E-4
17 SGTC_588 3970-1144 3.35 52.9 µM 3.36E-4 42 4.08E-4
18 SGTC_213 1246-0773 3.28 967.0 nM 4.36E-4 49 5.26E-4
19 SGTC_2947 9072639 3.26 7.7 µM 4.71E-4 tubulin folding & SWR complex 79 5.66E-4
20 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.24 66.5 µM 4.98E-4 32 5.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.32E-15 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.103 2.19E-9 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.097 1.80E-8 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.094 4.63E-8 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.093 6.16E-8 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.092 1.10E-7 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.091 1.28E-7 YDR423C CAD1 hom AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication
0.084 1.07E-6 YMR065W KAR5 hom Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone
0.084 1.26E-6 YNL162W-A_p YNL162W-A_p hom Putative protein of unknown function; identified by homology
0.083 1.34E-6 YDR412W RRP17 het Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA
0.081 3.03E-6 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.080 3.89E-6 YBR176W ECM31 hom Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
0.076 9.74E-6 YNL201C PSY2 hom Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3
0.076 1.14E-5 YLR377C FBP1 hom Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p
0.074 1.77E-5 YPL086C ELP3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin