YOR358W / HAP5

Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR358W / HAP5

Click on Significant Values for Screen Details ID:SGTC_48|Compound:0382-0018|FD-Score:-3.11|P-value:4.87E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.79|P-value:1.95E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:2.96|P-value:8.81E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:5.53|P-value:2.56E-9 ID:SGTC_75|Compound:0159-0059|FD-Score:3.29|P-value:2.61E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.12|P-value:4.99E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.26|P-value:2.87E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.33|P-value:2.18E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.57|P-value:7.82E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.36|P-value:1.92E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.08|P-value:8.26E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.38|P-value:1.71E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:5.28|P-value:1.18E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:8.10|P-value:5.68E-18 ID:SGTC_251|Compound:melphalan|FD-Score:2.98|P-value:8.37E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.70|P-value:3.48E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.09|P-value:5.25E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-2.99|P-value:7.69E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.62|P-value:6.36E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.74|P-value:3.99E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.25|P-value:2.84E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.30|P-value:2.37E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-3.02|P-value:6.76E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.13|P-value:4.77E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.45|P-value:1.27E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.30|P-value:2.77E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:3.13|P-value:4.77E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.04|P-value:6.62E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.00|P-value:7.32E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.43|P-value:1.38E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.26|P-value:2.92E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.11|P-value:7.07E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.11|P-value:4.87E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.03|P-value:6.48E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.02|P-value:7.20E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.26|P-value:2.89E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.25|P-value:3.02E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.29|P-value:2.60E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:2.94|P-value:9.64E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.88|P-value:2.07E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:5.39|P-value:6.25E-9 ID:SGTC_1635|Compound:st007035|FD-Score:7.46|P-value:1.56E-15 ID:SGTC_1718|Compound:roemerine|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.32|P-value:2.16E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.06|P-value:5.92E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.86|P-value:2.25E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.12|P-value:4.88E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.03|P-value:6.52E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.20|P-value:3.48E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.36|P-value:1.92E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.39|P-value:1.66E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.22|P-value:3.35E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.01|P-value:7.35E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.07|P-value:8.50E-6 ID:SGTC_2126|Compound:5251174|FD-Score:4.80|P-value:2.04E-7 ID:SGTC_2194|Compound:5927483|FD-Score:3.07|P-value:6.03E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.30|P-value:2.43E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.07|P-value:8.66E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.59|P-value:6.32E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.85|P-value:2.40E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.65|P-value:5.87E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.51|P-value:1.01E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.58|P-value:1.89E-9 ID:SGTC_2794|Compound:7785382|FD-Score:3.74|P-value:3.87E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.03|P-value:6.94E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-3.76|P-value:3.43E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-3.11|P-value:4.83E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.91|P-value:1.82E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.36|P-value:1.94E-4 ID:SGTC_3162|Compound:9099653|FD-Score:4.07|P-value:8.79E-6 ID:SGTC_3186|Compound:9110464|FD-Score:3.44|P-value:1.40E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.95|P-value:1.55E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.05|P-value:6.38E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.41|P-value:1.61E-4 ID:SGTC_3320|Compound:9137005|FD-Score:4.35|P-value:2.14E-6 ID:SGTC_48|Compound:0382-0018|FD-Score:-3.11|P-value:4.87E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.79|P-value:1.95E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:2.96|P-value:8.81E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:5.53|P-value:2.56E-9 ID:SGTC_75|Compound:0159-0059|FD-Score:3.29|P-value:2.61E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.12|P-value:4.99E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.26|P-value:2.87E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.33|P-value:2.18E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.57|P-value:7.82E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.36|P-value:1.92E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.08|P-value:8.26E-6 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.38|P-value:1.71E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:5.28|P-value:1.18E-8 ID:SGTC_236|Compound:1509-0011|FD-Score:8.10|P-value:5.68E-18 ID:SGTC_251|Compound:melphalan|FD-Score:2.98|P-value:8.37E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:4.70|P-value:3.48E-7 ID:SGTC_369|Compound:0957-0393|FD-Score:-3.09|P-value:5.25E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:-2.99|P-value:7.69E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.62|P-value:6.36E-5 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.74|P-value:3.99E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.25|P-value:2.84E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-3.30|P-value:2.37E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:-3.02|P-value:6.76E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.13|P-value:4.77E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-3.45|P-value:1.27E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.30|P-value:2.77E-6 ID:SGTC_708|Compound:3448-5400|FD-Score:3.13|P-value:4.77E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.04|P-value:6.62E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-3.00|P-value:7.32E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.43|P-value:1.38E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.26|P-value:2.92E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.11|P-value:7.07E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-3.11|P-value:4.87E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.03|P-value:6.48E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.02|P-value:7.20E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:3.26|P-value:2.89E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.25|P-value:3.02E-4 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.29|P-value:2.60E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:2.94|P-value:9.64E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.88|P-value:2.07E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:5.39|P-value:6.25E-9 ID:SGTC_1635|Compound:st007035|FD-Score:7.46|P-value:1.56E-15 ID:SGTC_1718|Compound:roemerine|FD-Score:3.33|P-value:2.19E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-3.32|P-value:2.16E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.06|P-value:5.92E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.86|P-value:2.25E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.12|P-value:4.88E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.03|P-value:6.52E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.20|P-value:3.48E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.32|P-value:2.32E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.36|P-value:1.92E-4 ID:SGTC_2011|Compound:4012611|FD-Score:-3.39|P-value:1.66E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.22|P-value:3.35E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.01|P-value:7.35E-4 ID:SGTC_2125|Compound:5246583|FD-Score:4.07|P-value:8.50E-6 ID:SGTC_2126|Compound:5251174|FD-Score:4.80|P-value:2.04E-7 ID:SGTC_2194|Compound:5927483|FD-Score:3.07|P-value:6.03E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.30|P-value:2.43E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.07|P-value:8.66E-6 ID:SGTC_2472|Compound:5377652|FD-Score:4.59|P-value:6.32E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.85|P-value:2.40E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.65|P-value:5.87E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.51|P-value:1.01E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:5.58|P-value:1.89E-9 ID:SGTC_2794|Compound:7785382|FD-Score:3.74|P-value:3.87E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.03|P-value:6.94E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-3.76|P-value:3.43E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-3.11|P-value:4.83E-4 ID:SGTC_3054|Compound:9094397|FD-Score:3.91|P-value:1.82E-5 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.36|P-value:1.94E-4 ID:SGTC_3162|Compound:9099653|FD-Score:4.07|P-value:8.79E-6 ID:SGTC_3186|Compound:9110464|FD-Score:3.44|P-value:1.40E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.95|P-value:1.55E-5 ID:SGTC_3201|Compound:9113999|FD-Score:3.05|P-value:6.38E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.41|P-value:1.61E-4 ID:SGTC_3320|Compound:9137005|FD-Score:4.35|P-value:2.14E-6

Top fitness defect scores for YOR358W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 8.10 5.3 µM 5.68E-18 247 2.79E-16
2 SGTC_1635 st007035 7.46 42.4 µM 1.56E-15 105 4.27E-14
3 SGTC_2686 alizarin 5.58 95.4 µM 1.89E-9 RPP1 & pyrimidine depletion 11 1.22E-8
4 SGTC_73 0327-0325 5.53 16.2 µM 2.56E-9 DNA damage response 19 1.60E-8
5 SGTC_1583 clindamycin 5.39 39.6 µM 6.25E-9 mitochondrial processes 2 3.56E-8
6 SGTC_169 k015-0017 5.28 16.0 µM 1.18E-8 5 6.31E-8
7 SGTC_2126 5251174 4.80 33.9 µM 2.04E-7 11 8.13E-7
8 SGTC_310 1273-0058 4.70 1.1 µM 3.48E-7 mitochondrial stress 196 1.31E-6
9 SGTC_2472 5377652 4.59 49.4 µM 6.32E-7 TRP & mitochondrial translation 39 2.25E-6
10 SGTC_3320 9137005 4.35 35.1 µM 2.14E-6 endomembrane recycling 9 6.72E-6
11 SGTC_632 0781-2353 4.30 4.7 µM 2.77E-6 Golgi 31 8.47E-6
12 SGTC_1133 3473-0247 4.11 50.0 µM 7.07E-6 RSC complex & mRNA processing 41 1.97E-5
13 SGTC_159 3970-0959 4.08 50.0 µM 8.26E-6 71 2.26E-5
14 SGTC_2125 5246583 4.07 200.0 µM 8.50E-6 tubulin folding & SWR complex 40 2.32E-5
15 SGTC_2310 7668677 4.07 200.0 µM 8.66E-6 28 2.36E-5
16 SGTC_3162 9099653 4.07 49.5 µM 8.79E-6 4 2.39E-5
17 SGTC_3188 9110789 3.95 49.5 µM 1.55E-5 iron homeostasis 21 3.98E-5
18 SGTC_3054 9094397 3.91 49.5 µM 1.82E-5 fatty acid desaturase (OLE1) 33 4.61E-5
19 SGTC_1575 cyproterone acetate 3.88 48.0 µM 2.07E-5 22 5.18E-5
20 SGTC_1780 st038448 3.86 24.5 µM 2.25E-5 iron homeostasis 21 5.57E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.297 2.37E-69 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.290 6.29E-66 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.287 1.38E-64 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.285 1.52E-63 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.284 2.82E-63 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.283 5.88E-63 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.282 2.99E-62 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.278 1.46E-60 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.277 3.21E-60 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.276 8.54E-60 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.275 4.58E-59 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.271 1.07E-57 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.271 1.63E-57 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.267 5.17E-56 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.267 1.17E-55 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV