YOR361C / PRT1

eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR361C / PRT1

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:3.13|P-value:4.23E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.51|P-value:7.77E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:3.15|P-value:4.00E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.28|P-value:2.38E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.09|P-value:5.07E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.74|P-value:3.47E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.09|P-value:4.92E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.98|P-value:5.84E-8 ID:SGTC_670|Compound:4204-0025|FD-Score:-5.60|P-value:1.31E-9 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.76|P-value:3.25E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.20|P-value:3.25E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.22|P-value:3.16E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.07|P-value:5.29E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.29|P-value:2.32E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:2.93|P-value:9.02E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.10|P-value:4.87E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.85|P-value:2.09E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-3.08|P-value:5.28E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.23|P-value:2.93E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.66|P-value:4.80E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.11|P-value:4.79E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.83|P-value:2.26E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.01|P-value:6.64E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.45|P-value:1.18E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.03|P-value:6.34E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.40|P-value:1.43E-6 ID:SGTC_1721|Compound:st082152|FD-Score:4.43|P-value:1.20E-6 ID:SGTC_1845|Compound:st056753|FD-Score:3.29|P-value:2.26E-4 ID:SGTC_1910|Compound:st062352|FD-Score:5.12|P-value:2.57E-8 ID:SGTC_1925|Compound:st057770|FD-Score:3.22|P-value:3.02E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.22|P-value:3.08E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.50|P-value:9.82E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.21|P-value:3.26E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-2.96|P-value:8.34E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:2.95|P-value:8.36E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-4.83|P-value:1.40E-7 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.44|P-value:1.26E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.30|P-value:2.27E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.52|P-value:7.62E-7 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.01|P-value:9.61E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.70|P-value:4.23E-5 ID:SGTC_2829|Compound:7992743|FD-Score:-3.62|P-value:5.96E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-4.71|P-value:2.69E-7 ID:SGTC_2837|Compound:9008476|FD-Score:-3.48|P-value:1.08E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.70|P-value:4.14E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-4.04|P-value:8.88E-6 ID:SGTC_2850|Compound:9015429|FD-Score:4.01|P-value:9.56E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-2.95|P-value:8.71E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.94|P-value:9.06E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.10|P-value:4.87E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.51|P-value:9.37E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-4.40|P-value:1.48E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.90|P-value:1.63E-5 ID:SGTC_3208|Compound:9114115|FD-Score:4.06|P-value:7.74E-6 ID:SGTC_89|Compound:0302-0250|FD-Score:3.13|P-value:4.23E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.51|P-value:7.77E-7 ID:SGTC_98|Compound:0074-0023|FD-Score:3.15|P-value:4.00E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:3.28|P-value:2.38E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.09|P-value:5.07E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.74|P-value:3.47E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.09|P-value:4.92E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.98|P-value:5.84E-8 ID:SGTC_670|Compound:4204-0025|FD-Score:-5.60|P-value:1.31E-9 ID:SGTC_682|Compound:0kpi-0099|FD-Score:-3.76|P-value:3.25E-5 ID:SGTC_711|Compound:k292-0785|FD-Score:3.20|P-value:3.25E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:-3.22|P-value:3.16E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.07|P-value:5.29E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.29|P-value:2.32E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:2.93|P-value:9.02E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.10|P-value:4.87E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.85|P-value:2.09E-5 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.39|P-value:1.53E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:-3.08|P-value:5.28E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:-3.23|P-value:2.93E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.66|P-value:4.80E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:-3.11|P-value:4.79E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.83|P-value:2.26E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.01|P-value:6.64E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.45|P-value:1.18E-4 ID:SGTC_1672|Compound:st016598|FD-Score:-3.03|P-value:6.34E-4 ID:SGTC_1677|Compound:st019204|FD-Score:4.40|P-value:1.43E-6 ID:SGTC_1721|Compound:st082152|FD-Score:4.43|P-value:1.20E-6 ID:SGTC_1845|Compound:st056753|FD-Score:3.29|P-value:2.26E-4 ID:SGTC_1910|Compound:st062352|FD-Score:5.12|P-value:2.57E-8 ID:SGTC_1925|Compound:st057770|FD-Score:3.22|P-value:3.02E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.22|P-value:3.08E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.50|P-value:9.82E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.21|P-value:3.26E-4 ID:SGTC_2415|Compound:st077333|FD-Score:-2.96|P-value:8.34E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:2.95|P-value:8.36E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-4.83|P-value:1.40E-7 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:-3.44|P-value:1.26E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.30|P-value:2.27E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:4.52|P-value:7.62E-7 ID:SGTC_2684|Compound:capsaicin|FD-Score:4.01|P-value:9.61E-6 ID:SGTC_2792|Compound:7535235|FD-Score:3.01|P-value:6.82E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.70|P-value:4.23E-5 ID:SGTC_2829|Compound:7992743|FD-Score:-3.62|P-value:5.96E-5 ID:SGTC_2833|Compound:9001315|FD-Score:-4.71|P-value:2.69E-7 ID:SGTC_2837|Compound:9008476|FD-Score:-3.48|P-value:1.08E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.70|P-value:4.14E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-4.04|P-value:8.88E-6 ID:SGTC_2850|Compound:9015429|FD-Score:4.01|P-value:9.56E-6 ID:SGTC_2951|Compound:9072950|FD-Score:-2.95|P-value:8.71E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-2.94|P-value:9.06E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.10|P-value:4.87E-4 ID:SGTC_3123|Compound:9126162|FD-Score:3.51|P-value:9.37E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-4.40|P-value:1.48E-6 ID:SGTC_3147|Compound:9097027|FD-Score:3.90|P-value:1.63E-5 ID:SGTC_3208|Compound:9114115|FD-Score:4.06|P-value:7.74E-6

Top fitness defect scores for YOR361C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1910 st062352 5.12 60.4 µM 2.57E-8 1 1.56E-7 1.13
2 SGTC_343 4130-2827 4.98 29.8 µM 5.84E-8 2 3.23E-7 0.92
3 SGTC_2592 piperlongumine 4.52 83.3 µM 7.62E-7 TSC3-RPN4 3 3.15E-6 0.39
4 SGTC_95 0471-0001 4.51 561.1 µM 7.77E-7 3 3.21E-6 0.39
5 SGTC_1721 st082152 4.43 9.3 µM 1.20E-6 60S ribosome export 6 4.72E-6 0.22
6 SGTC_1677 st019204 4.40 53.9 µM 1.43E-6 5 5.50E-6 0.10
7 SGTC_3208 9114115 4.06 49.5 µM 7.74E-6 9 2.47E-5 0.02
8 SGTC_2850 9015429 4.01 58.4 µM 9.56E-6 5 2.98E-5 0.37
9 SGTC_2684 capsaicin 4.01 100.0 µM 9.61E-6 4 2.99E-5 0.08
10 SGTC_3147 9097027 3.90 49.5 µM 1.63E-5 8 4.77E-5 0.04
11 SGTC_1159 4092-0538 3.85 61.2 µM 2.09E-5 5 5.97E-5 0.17
12 SGTC_1391 3442-0225 3.83 151.0 µM 2.26E-5 4 6.38E-5 0.33
13 SGTC_2841 9004761 3.70 39.0 µM 4.14E-5 amide catabolism 11 1.09E-4 0.08
14 SGTC_1376 2910-0861 3.66 41.3 µM 4.80E-5 6 1.25E-4 0.29
15 SGTC_3123 9126162 3.51 49.5 µM 9.37E-5 3 2.26E-4 0.23
16 SGTC_2404 5161160 3.50 200.0 µM 9.82E-5 12 2.36E-4 0.05
17 SGTC_1559 coumarin 343 3.45 70.1 µM 1.18E-4 4 2.78E-4 0.22
18 SGTC_2033 5192550 3.43 145.0 µM 1.30E-4 7 3.03E-4 0.06
19 SGTC_1198 1612-1005 3.39 86.7 µM 1.53E-4 5 3.49E-4 0.10
20 SGTC_1845 st056753 3.29 3.0 µM 2.26E-4 TSC3-RPN4 16 4.95E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 4.88E-10 YCL048W SPS22 hom Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
0.105 1.13E-9 YPR054W SMK1 hom Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
0.101 5.52E-9 YDL073W_p YDL073W_p hom Putative protein of unknown function; YDL073W is not an essential gene
0.098 1.23E-8 YFR043C IRC6 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
0.095 3.93E-8 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.093 6.84E-8 YLR050C_p YLR050C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
0.083 1.52E-6 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.081 2.52E-6 YNL265C IST1 hom Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
0.081 3.01E-6 YPL098C MGR2 hom Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)
0.078 5.92E-6 YLR427W MAG2 hom Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
0.074 1.76E-5 YER101C AST2 hom Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication
0.074 1.77E-5 YLR342W-A_p YLR342W-A_p hom Putative protein of unknown function
0.072 3.20E-5 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.071 3.56E-5 YHR086W-A_p YHR086W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.071 3.92E-5 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data