HIPHOP chemogenomics database
YOR361C / PRT1 
eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YOR361C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.107 | 4.88E-10 | YCL048W | SPS22 | hom | Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall |
| 0.105 | 1.13E-9 | YPR054W | SMK1 | hom | Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p |
| 0.101 | 5.52E-9 | YDL073W_p | YDL073W_p | hom | Putative protein of unknown function; YDL073W is not an essential gene |
| 0.098 | 1.23E-8 | YFR043C | IRC6 | hom | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.095 | 3.93E-8 | YOR090C | PTC5 | hom | Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p |
| 0.093 | 6.84E-8 | YLR050C_p | YLR050C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene |
| 0.083 | 1.52E-6 | YDR464W | SPP41 | het | Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 |
| 0.081 | 2.52E-6 | YNL265C | IST1 | hom | Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p |
| 0.081 | 3.01E-6 | YPL098C | MGR2 | hom | Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) |
| 0.078 | 5.92E-6 | YLR427W | MAG2 | hom | Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 |
| 0.074 | 1.76E-5 | YER101C | AST2 | hom | Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication |
| 0.074 | 1.77E-5 | YLR342W-A_p | YLR342W-A_p | hom | Putative protein of unknown function |
| 0.072 | 3.20E-5 | YCR020C | PET18 | hom | Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin |
| 0.071 | 3.56E-5 | YHR086W-A_p | YHR086W-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.071 | 3.92E-5 | YGR045C_d | YGR045C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |