Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YOR362C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.485 | 1.65E-197 | YMR314W | PRE5 | het | Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress |
0.478 | 2.68E-191 | YER094C | PUP3 | het | Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 |
0.455 | 5.00E-171 | YOL038W | PRE6 | het | Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress |
0.446 | 7.00E-164 | YER012W | PRE1 | het | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
0.426 | 7.80E-148 | YFR050C | PRE4 | het | Beta 7 subunit of the 20S proteasome |
0.415 | 1.79E-139 | YML092C | PRE8 | het | Alpha 2 subunit of the 20S proteasome |
0.403 | 4.58E-131 | YGR253C | PUP2 | het | Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta |
0.392 | 1.85E-123 | YGL011C | SCL1 | het | Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria |
0.318 | 1.81E-79 | YBL041W | PRE7 | het | Beta 6 subunit of the 20S proteasome |
0.285 | 8.59E-64 | YJL001W | PRE3 | het | Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides |
0.284 | 4.50E-63 | YJL165C | HAL5 | hom | Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication |
0.266 | 2.45E-55 | YLR021W | IRC25 | hom | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |
0.265 | 7.18E-55 | YPR103W | PRE2 | het | Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome |
0.251 | 1.79E-49 | YDR086C | SSS1 | het | Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p |
0.249 | 8.29E-49 | YML034C-A_d | YML034C-A_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |