YOR365C_p

Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR365C / YOR365C

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.01|P-value:6.34E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.19|P-value:3.24E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.00|P-value:6.66E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:6.23|P-value:1.53E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:5.33|P-value:6.54E-9 ID:SGTC_160|Compound:3453-0671|FD-Score:3.47|P-value:1.04E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.38|P-value:1.48E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:3.02|P-value:6.02E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.55|P-value:7.41E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.26|P-value:2.94E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-4.11|P-value:7.13E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.26|P-value:2.48E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.65|P-value:4.87E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.53|P-value:9.73E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.39|P-value:1.44E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:2.90|P-value:9.44E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.50|P-value:7.63E-7 ID:SGTC_863|Compound:0466-0191|FD-Score:3.15|P-value:3.78E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.27|P-value:2.36E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.40|P-value:1.36E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.68|P-value:4.16E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.47|P-value:1.26E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.97|P-value:5.80E-8 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.01|P-value:6.33E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.16|P-value:4.27E-4 ID:SGTC_1594|Compound:piperine|FD-Score:2.98|P-value:7.00E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.15|P-value:4.41E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.17|P-value:3.50E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-2.99|P-value:8.21E-4 ID:SGTC_1950|Compound:st077106|FD-Score:2.93|P-value:8.64E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.90|P-value:1.53E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.46|P-value:1.08E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.55|P-value:8.89E-5 ID:SGTC_2188|Compound:6126565|FD-Score:4.07|P-value:6.76E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.04|P-value:6.80E-4 ID:SGTC_2455|Compound:5377712|FD-Score:5.64|P-value:8.99E-10 ID:SGTC_2459|Compound:5811157|FD-Score:-3.93|P-value:1.63E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-3.66|P-value:5.61E-5 ID:SGTC_2474|Compound:5321570|FD-Score:4.40|P-value:1.31E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.77|P-value:2.81E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.68|P-value:2.90E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.02|P-value:6.15E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.32|P-value:2.28E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.93|P-value:1.33E-5 ID:SGTC_2873|Compound:9040596|FD-Score:-3.06|P-value:6.23E-4 ID:SGTC_2919|Compound:7978188|FD-Score:6.99|P-value:4.79E-14 ID:SGTC_2927|Compound:9011802|FD-Score:4.39|P-value:1.38E-6 ID:SGTC_2937|Compound:9044753|FD-Score:2.89|P-value:9.87E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.00|P-value:9.43E-6 ID:SGTC_3026|Compound:9090633|FD-Score:4.43|P-value:1.10E-6 ID:SGTC_3136|Compound:9095672|FD-Score:4.14|P-value:4.93E-6 ID:SGTC_3140|Compound:9094243|FD-Score:-3.75|P-value:3.79E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-2.99|P-value:8.05E-4 ID:SGTC_3328|Compound:9140624|FD-Score:2.92|P-value:8.97E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.01|P-value:6.34E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.19|P-value:3.24E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.00|P-value:6.66E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:6.23|P-value:1.53E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:5.33|P-value:6.54E-9 ID:SGTC_160|Compound:3453-0671|FD-Score:3.47|P-value:1.04E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.38|P-value:1.48E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:3.02|P-value:6.02E-4 ID:SGTC_198|Compound:3454-2873|FD-Score:3.55|P-value:7.41E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:-3.26|P-value:2.94E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-4.11|P-value:7.13E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:3.26|P-value:2.48E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.65|P-value:4.87E-5 ID:SGTC_577|Compound:r071-0003|FD-Score:-3.53|P-value:9.73E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:3.39|P-value:1.44E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:2.90|P-value:9.44E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:4.50|P-value:7.63E-7 ID:SGTC_863|Compound:0466-0191|FD-Score:3.15|P-value:3.78E-4 ID:SGTC_869|Compound:0564-0080|FD-Score:3.27|P-value:2.36E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.40|P-value:1.36E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:3.68|P-value:4.16E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.47|P-value:1.26E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.97|P-value:5.80E-8 ID:SGTC_1219|Compound:1469-0211|FD-Score:3.01|P-value:6.33E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:-3.16|P-value:4.27E-4 ID:SGTC_1594|Compound:piperine|FD-Score:2.98|P-value:7.00E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.15|P-value:4.41E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.17|P-value:3.50E-4 ID:SGTC_1922|Compound:5578187|FD-Score:-2.99|P-value:8.21E-4 ID:SGTC_1950|Compound:st077106|FD-Score:2.93|P-value:8.64E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.90|P-value:1.53E-5 ID:SGTC_2116|Compound:5511452|FD-Score:3.46|P-value:1.08E-4 ID:SGTC_2123|Compound:5259487|FD-Score:-3.55|P-value:8.89E-5 ID:SGTC_2188|Compound:6126565|FD-Score:4.07|P-value:6.76E-6 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.04|P-value:6.80E-4 ID:SGTC_2455|Compound:5377712|FD-Score:5.64|P-value:8.99E-10 ID:SGTC_2459|Compound:5811157|FD-Score:-3.93|P-value:1.63E-5 ID:SGTC_2460|Compound:5552655|FD-Score:-3.66|P-value:5.61E-5 ID:SGTC_2474|Compound:5321570|FD-Score:4.40|P-value:1.31E-6 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.77|P-value:2.81E-5 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.68|P-value:2.90E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.02|P-value:6.15E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.32|P-value:2.28E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.93|P-value:1.33E-5 ID:SGTC_2873|Compound:9040596|FD-Score:-3.06|P-value:6.23E-4 ID:SGTC_2919|Compound:7978188|FD-Score:6.99|P-value:4.79E-14 ID:SGTC_2927|Compound:9011802|FD-Score:4.39|P-value:1.38E-6 ID:SGTC_2937|Compound:9044753|FD-Score:2.89|P-value:9.87E-4 ID:SGTC_2991|Compound:9074669|FD-Score:4.00|P-value:9.43E-6 ID:SGTC_3026|Compound:9090633|FD-Score:4.43|P-value:1.10E-6 ID:SGTC_3136|Compound:9095672|FD-Score:4.14|P-value:4.93E-6 ID:SGTC_3140|Compound:9094243|FD-Score:-3.75|P-value:3.79E-5 ID:SGTC_3303|Compound:9125618|FD-Score:-2.99|P-value:8.05E-4 ID:SGTC_3328|Compound:9140624|FD-Score:2.92|P-value:8.97E-4

Top fitness defect scores for YOR365C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2919 7978188 6.99 46.4 µM 4.79E-14 1 1.42E-12
2 SGTC_130 0136-0219 6.23 337.7 µM 1.53E-11 3 2.34E-10
3 SGTC_2455 5377712 5.64 9.8 µM 8.99E-10 8 8.57E-9
4 SGTC_140 0062-0056 5.33 502.5 µM 6.54E-9 8 4.96E-8
5 SGTC_1068 loratadine 4.97 26.9 µM 5.80E-8 11 3.43E-7
6 SGTC_2638 epoxomicin 4.68 18.0 µM 2.90E-7 19 1.43E-6
7 SGTC_830 4076-0286 4.50 57.8 µM 7.63E-7 translation 41 3.36E-6
8 SGTC_3026 9090633 4.43 49.5 µM 1.10E-6 11 4.66E-6
9 SGTC_2474 5321570 4.40 43.3 µM 1.31E-6 7 5.42E-6
10 SGTC_2927 9011802 4.39 47.9 µM 1.38E-6 18 5.67E-6
11 SGTC_3136 9095672 4.14 49.5 µM 4.93E-6 22 1.75E-5
12 SGTC_2188 6126565 4.07 140.7 µM 6.76E-6 mitochondrial processes 12 2.32E-5
13 SGTC_2991 9074669 4.00 71.4 µM 9.43E-6 azole & statin 60 3.12E-5
14 SGTC_2837 9008476 3.93 45.5 µM 1.33E-5 34 4.23E-5
15 SGTC_2105 5350118 3.90 200.0 µM 1.53E-5 28 4.79E-5
16 SGTC_2541 muurolladie-3-one 3.77 83.1 µM 2.81E-5 excess fatty acid 36 8.21E-5
17 SGTC_914 3820-6779 3.68 408.0 µM 4.16E-5 33 1.16E-4
18 SGTC_572 0960-0087 3.65 17.7 µM 4.87E-5 36 1.34E-4
19 SGTC_198 3454-2873 3.55 16.2 µM 7.41E-5 60S ribosome export 25 1.94E-4
20 SGTC_160 3453-0671 3.47 289.7 µM 1.04E-4 54 2.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 5.49E-14 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.120 2.71E-12 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.102 3.34E-9 YKL067W YNK1 hom Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress
0.095 3.67E-8 YPL116W HOS3 hom Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
0.087 4.69E-7 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.084 1.19E-6 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.083 1.41E-6 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.082 2.08E-6 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.075 1.21E-5 YLR458W_d YLR458W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
0.074 1.59E-5 YGR160W_d YGR160W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.074 2.01E-5 YNL303W_d YNL303W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.073 2.35E-5 YER046W-A_d YER046W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.39E-5 YDR472W TRS31 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.073 2.50E-5 YNL092W_p YNL092W_p hom Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
0.072 3.04E-5 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p