HIPHOP chemogenomics database
YOR366W_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YOR366W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.127 | 1.44E-13 | YHR063C | PAN5 | hom | 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE |
| 0.119 | 3.98E-12 | YOL044W | PEX15 | hom | Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly |
| 0.113 | 5.76E-11 | YDR042C_p | YDR042C_p | hom | Putative protein of unknown function; expression is increased in ssu72-ts69 mutant |
| 0.112 | 9.50E-11 | YML101C-A_d | YML101C-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.111 | 9.60E-11 | YOR047C | STD1 | hom | Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] |
| 0.100 | 6.22E-9 | YHR001W | OSH7 | hom | Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability |
| 0.099 | 8.02E-9 | YDR271C_d | YDR271C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W |
| 0.094 | 5.44E-8 | YKR045C_p | YKR045C_p | hom | Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm |
| 0.093 | 6.24E-8 | YBR270C_p | BIT2_p | hom | Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication |
| 0.090 | 2.11E-7 | YDR247W | VHS1 | hom | Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p |
| 0.088 | 3.33E-7 | YBR062C_p | YBR062C_p | hom | Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. |
| 0.087 | 4.69E-7 | YJR064W | CCT5 | het | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
| 0.085 | 9.49E-7 | YPL067C_p | YPL067C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene |
| 0.083 | 1.30E-6 | YOR244W | ESA1 | het | Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy |
| 0.083 | 1.45E-6 | YPL123C | RNY1 | hom | Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity |