YOR366W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR366W / YOR366W

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.19|P-value:9.14E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.17|P-value:9.70E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.48|P-value:3.31E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.96|P-value:5.34E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:3.97|P-value:5.14E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.73|P-value:1.33E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.27|P-value:6.19E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.94|P-value:3.05E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.00|P-value:2.11E-9 ID:SGTC_543|Compound:3844-1095|FD-Score:3.30|P-value:6.41E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.20|P-value:8.03E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.40|P-value:8.37E-6 ID:SGTC_600|Compound:1495-0418|FD-Score:3.17|P-value:9.81E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.54|P-value:2.70E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.51|P-value:2.63E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.20|P-value:9.00E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.05|P-value:3.76E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.67|P-value:1.65E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.51|P-value:3.06E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.50|P-value:2.72E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.19|P-value:2.12E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.76|P-value:1.58E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.40|P-value:6.21E-8 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.34|P-value:5.53E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.49|P-value:3.22E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.38|P-value:9.06E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.27|P-value:6.98E-4 ID:SGTC_1804|Compound:st050076|FD-Score:4.27|P-value:1.45E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.41|P-value:4.30E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.11|P-value:2.78E-7 ID:SGTC_1911|Compound:st060208|FD-Score:6.73|P-value:2.16E-11 ID:SGTC_2080|Compound:5212524|FD-Score:4.21|P-value:1.90E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-3.44|P-value:3.40E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.41|P-value:3.87E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_2274|Compound:7947094|FD-Score:5.00|P-value:4.86E-7 ID:SGTC_2295|Compound:7971645|FD-Score:-3.62|P-value:1.78E-4 ID:SGTC_2352|Compound:9027995|FD-Score:8.08|P-value:1.17E-15 ID:SGTC_2464|Compound:5717415|FD-Score:5.28|P-value:1.19E-7 ID:SGTC_2482|Compound:5981709|FD-Score:3.39|P-value:4.66E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.89|P-value:3.32E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.33|P-value:5.65E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.37|P-value:5.01E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.73|P-value:1.81E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.70|P-value:1.50E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.34|P-value:4.81E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-3.24|P-value:6.98E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.79|P-value:9.07E-5 ID:SGTC_3|Compound:0833-0587|FD-Score:3.19|P-value:9.14E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.17|P-value:9.70E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.48|P-value:3.31E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.96|P-value:5.34E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:3.97|P-value:5.14E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.73|P-value:1.33E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.27|P-value:6.19E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.94|P-value:3.05E-9 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.00|P-value:2.11E-9 ID:SGTC_543|Compound:3844-1095|FD-Score:3.30|P-value:6.41E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.20|P-value:8.03E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.40|P-value:8.37E-6 ID:SGTC_600|Compound:1495-0418|FD-Score:3.17|P-value:9.81E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:3.54|P-value:2.70E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.51|P-value:2.63E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.20|P-value:9.00E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.05|P-value:3.76E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.67|P-value:1.65E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.51|P-value:3.06E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:-3.50|P-value:2.72E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.19|P-value:2.12E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.76|P-value:1.58E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.40|P-value:6.21E-8 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.34|P-value:5.53E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.49|P-value:3.22E-4 ID:SGTC_1773|Compound:st048542|FD-Score:4.38|P-value:9.06E-6 ID:SGTC_1776|Compound:st049249|FD-Score:3.27|P-value:6.98E-4 ID:SGTC_1804|Compound:st050076|FD-Score:4.27|P-value:1.45E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.41|P-value:4.30E-4 ID:SGTC_1908|Compound:st060353|FD-Score:5.11|P-value:2.78E-7 ID:SGTC_1911|Compound:st060208|FD-Score:6.73|P-value:2.16E-11 ID:SGTC_2080|Compound:5212524|FD-Score:4.21|P-value:1.90E-5 ID:SGTC_2081|Compound:5214970|FD-Score:-3.44|P-value:3.40E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.71|P-value:1.42E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.41|P-value:3.87E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.75|P-value:1.23E-4 ID:SGTC_2274|Compound:7947094|FD-Score:5.00|P-value:4.86E-7 ID:SGTC_2295|Compound:7971645|FD-Score:-3.62|P-value:1.78E-4 ID:SGTC_2352|Compound:9027995|FD-Score:8.08|P-value:1.17E-15 ID:SGTC_2464|Compound:5717415|FD-Score:5.28|P-value:1.19E-7 ID:SGTC_2482|Compound:5981709|FD-Score:3.39|P-value:4.66E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-5.89|P-value:3.32E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.33|P-value:5.65E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.37|P-value:5.01E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.73|P-value:1.81E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.70|P-value:1.50E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-3.34|P-value:4.81E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-3.24|P-value:6.98E-4 ID:SGTC_3187|Compound:9109394|FD-Score:-3.79|P-value:9.07E-5

Top fitness defect scores for YOR366W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2352 9027995 8.08 87.8 µM 1.17E-15 tubulin folding & SWR complex 4 3.13E-16
2 SGTC_1911 st060208 6.73 74.3 µM 2.16E-11 2 8.48E-12
3 SGTC_457 grayanotoxin iii 6.00 135.0 µM 2.11E-9 22 9.89E-10
4 SGTC_453 enantio-paf c16 5.94 10.0 µM 3.05E-9 53 1.45E-9
5 SGTC_1122 capsaicin 5.40 818.6 nM 6.21E-8 7 3.32E-8
6 SGTC_2464 5717415 5.28 7.7 µM 1.19E-7 2 6.51E-8
7 SGTC_1908 st060353 5.11 56.5 µM 2.78E-7 RPP1 & pyrimidine depletion 19 1.57E-7
8 SGTC_2274 7947094 5.00 46.1 µM 4.86E-7 8 2.81E-7
9 SGTC_1120 ficusin 4.76 1.8 µM 1.58E-6 11 9.58E-7
10 SGTC_2578 7,8-dihydroxyflavone 4.73 64.4 µM 1.81E-6 20 1.10E-6
11 SGTC_585 0kpi-0023 4.40 191.0 µM 8.37E-6 12 5.40E-6
12 SGTC_1773 st048542 4.38 73.6 µM 9.06E-6 32 5.87E-6
13 SGTC_1804 st050076 4.27 49.1 µM 1.45E-5 9 9.56E-6
14 SGTC_2080 5212524 4.21 12.4 µM 1.90E-5 copper-dependent oxidative stress 10 1.27E-5
15 SGTC_1021 4476-0760 4.19 85.3 µM 2.12E-5 17 1.42E-5
16 SGTC_723 4182-0001 4.05 115.0 µM 3.76E-5 25 2.57E-5
17 SGTC_284 0988-0104 3.97 32.6 µM 5.14E-5 heme requiring 11 3.56E-5
18 SGTC_212 3807-4682 3.96 38.8 µM 5.34E-5 tubulin folding & SWR complex 69 3.70E-5
19 SGTC_2188 6126565 3.75 140.7 µM 1.23E-4 mitochondrial processes 16 8.79E-5
20 SGTC_370 0180-0345 3.73 38.7 µM 1.33E-4 DNA intercalators 14 9.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.44E-13 YHR063C PAN5 hom 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
0.119 3.98E-12 YOL044W PEX15 hom Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly
0.113 5.76E-11 YDR042C_p YDR042C_p hom Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
0.112 9.50E-11 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 9.60E-11 YOR047C STD1 hom Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]
0.100 6.22E-9 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.099 8.02E-9 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.094 5.44E-8 YKR045C_p YKR045C_p hom Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
0.093 6.24E-8 YBR270C_p BIT2_p hom Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication
0.090 2.11E-7 YDR247W VHS1 hom Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
0.088 3.33E-7 YBR062C_p YBR062C_p hom Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.
0.087 4.69E-7 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.085 9.49E-7 YPL067C_p YPL067C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
0.083 1.30E-6 YOR244W ESA1 het Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy
0.083 1.45E-6 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity