YOR367W / SCP1

Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR367W / SCP1

Click on Significant Values for Screen Details ID:SGTC_588|Compound:3970-1144|FD-Score:4.16|P-value:5.65E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:4.18|P-value:5.13E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.21|P-value:4.67E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:-8.00|P-value:4.60E-14 ID:SGTC_870|Compound:0573-2213|FD-Score:3.56|P-value:4.80E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.69|P-value:6.51E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.86|P-value:1.69E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.79|P-value:2.18E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:5.42|P-value:2.41E-7 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.95|P-value:2.18E-6 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.66|P-value:3.35E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.84|P-value:1.80E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.40|P-value:7.68E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.51|P-value:5.54E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.74|P-value:2.61E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.33|P-value:2.00E-9 ID:SGTC_1554|Compound:st069299|FD-Score:3.75|P-value:2.47E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-4.57|P-value:1.04E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-4.49|P-value:1.45E-5 ID:SGTC_1969|Compound:st069479|FD-Score:4.43|P-value:1.95E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.53|P-value:5.30E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.28|P-value:3.60E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.50|P-value:5.90E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.52|P-value:5.40E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.33|P-value:2.92E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.49|P-value:5.91E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:8.32|P-value:5.24E-15 ID:SGTC_2795|Compound:7780010|FD-Score:-4.00|P-value:9.74E-5 ID:SGTC_2937|Compound:9044753|FD-Score:3.90|P-value:1.46E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.33|P-value:9.67E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.49|P-value:5.65E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.31|P-value:3.10E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.34|P-value:9.79E-4 ID:SGTC_3272|Compound:9137413|FD-Score:7.45|P-value:2.22E-12 ID:SGTC_3281|Compound:9140613|FD-Score:5.57|P-value:1.14E-7 ID:SGTC_588|Compound:3970-1144|FD-Score:4.16|P-value:5.65E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:4.18|P-value:5.13E-5 ID:SGTC_717|Compound:1532-0246|FD-Score:4.21|P-value:4.67E-5 ID:SGTC_726|Compound:3448-4391|FD-Score:-8.00|P-value:4.60E-14 ID:SGTC_870|Compound:0573-2213|FD-Score:3.56|P-value:4.80E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.69|P-value:6.51E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.86|P-value:1.69E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.79|P-value:2.18E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:5.42|P-value:2.41E-7 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.95|P-value:2.18E-6 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.66|P-value:3.35E-4 ID:SGTC_1418|Compound:3966-3099|FD-Score:3.84|P-value:1.80E-4 ID:SGTC_1429|Compound:4049-0205|FD-Score:-3.40|P-value:7.68E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.51|P-value:5.54E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:3.74|P-value:2.61E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:6.33|P-value:2.00E-9 ID:SGTC_1554|Compound:st069299|FD-Score:3.75|P-value:2.47E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-4.57|P-value:1.04E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-4.49|P-value:1.45E-5 ID:SGTC_1969|Compound:st069479|FD-Score:4.43|P-value:1.95E-5 ID:SGTC_2020|Compound:4017018|FD-Score:3.53|P-value:5.30E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.28|P-value:3.60E-5 ID:SGTC_2067|Compound:5224629|FD-Score:3.50|P-value:5.90E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.52|P-value:5.40E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.33|P-value:2.92E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.49|P-value:5.91E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:8.32|P-value:5.24E-15 ID:SGTC_2795|Compound:7780010|FD-Score:-4.00|P-value:9.74E-5 ID:SGTC_2937|Compound:9044753|FD-Score:3.90|P-value:1.46E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.33|P-value:9.67E-4 ID:SGTC_3013|Compound:9080133|FD-Score:-3.49|P-value:5.65E-4 ID:SGTC_3056|Compound:9094900|FD-Score:4.31|P-value:3.10E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.34|P-value:9.79E-4 ID:SGTC_3272|Compound:9137413|FD-Score:7.45|P-value:2.22E-12 ID:SGTC_3281|Compound:9140613|FD-Score:5.57|P-value:1.14E-7

Top fitness defect scores for YOR367W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2628 lathosterol 8.32 100.0 µM 5.24E-15 1 4.34E-17
2 SGTC_3272 9137413 7.45 49.5 µM 2.22E-12 1 4.67E-14
3 SGTC_1510 1123-0200 6.33 71.5 µM 2.00E-9 13 1.20E-10
4 SGTC_3281 9140613 5.57 49.5 µM 1.14E-7 RPP1 & pyrimidine depletion 4 1.27E-8
5 SGTC_1280 0880-0253 5.42 10.1 µM 2.41E-7 1 3.00E-8
6 SGTC_1410 3909-8106 4.95 77.9 µM 2.18E-6 5 3.79E-7
7 SGTC_1077 5-fluorocytosine 4.69 377.0 nM 6.51E-6 exosome 8 1.34E-6
8 SGTC_1969 st069479 4.43 40.1 µM 1.95E-5 7 4.72E-6
9 SGTC_2620 irigenin 4.33 100.0 µM 2.92E-5 26 7.49E-6
10 SGTC_3056 9094900 4.31 49.5 µM 3.10E-5 15 8.04E-6
11 SGTC_2050 5263056 4.28 171.0 µM 3.60E-5 fatty acid desaturase (OLE1) 34 9.55E-6
12 SGTC_717 1532-0246 4.21 73.2 µM 4.67E-5 Golgi 27 1.29E-5
13 SGTC_684 1140-0066 4.18 328.0 µM 5.13E-5 Golgi 18 1.43E-5
14 SGTC_588 3970-1144 4.16 52.9 µM 5.65E-5 24 1.60E-5
15 SGTC_2937 9044753 3.90 11.3 µM 1.46E-4 60S ribosome export 35 4.78E-5
16 SGTC_1127 asiatic acid 3.86 681.4 nM 1.69E-4 24 5.66E-5
17 SGTC_1418 3966-3099 3.84 2.4 µM 1.80E-4 24 6.06E-5
18 SGTC_1252 0493-0875 3.79 34.8 µM 2.18E-4 35 7.57E-5
19 SGTC_1554 st069299 3.75 38.7 µM 2.47E-4 29 8.73E-5
20 SGTC_1494 4358-1428 3.74 177.0 µM 2.61E-4 28 9.31E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 9.10E-9 YBR233W PBP2 hom RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress
0.088 3.46E-7 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.085 8.44E-7 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data
0.085 9.37E-7 YDR021W FAL1 het Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
0.082 1.81E-6 YJR069C HAM1 hom Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress
0.081 2.53E-6 YPL083C SEN54 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.081 2.75E-6 YLR247C IRC20 hom Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
0.078 6.71E-6 YGR053C_p YGR053C_p hom Putative protein of unknown function
0.077 7.22E-6 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.077 7.46E-6 YDR241W_d BUD26_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.074 1.93E-5 YOL032W OPI10 hom Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress
0.073 2.54E-5 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.072 2.71E-5 YBR253W SRB6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.072 3.12E-5 YOR193W PEX27 hom Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
0.071 4.20E-5 YEL056W HAT2 hom Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing