YOR368W / RAD17

Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR368W / RAD17

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:-3.21|P-value:5.13E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.16|P-value:6.08E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-4.34|P-value:4.48E-6 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.37|P-value:2.84E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-4.04|P-value:1.77E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.16|P-value:6.93E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.17|P-value:5.85E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-3.24|P-value:4.57E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.98|P-value:2.21E-7 ID:SGTC_345|Compound:1362-0200|FD-Score:3.32|P-value:3.91E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.19|P-value:6.18E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.05|P-value:8.86E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.53|P-value:2.13E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.78|P-value:6.44E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:3.13|P-value:7.67E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.15|P-value:7.02E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.09|P-value:7.67E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.41|P-value:2.78E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.39|P-value:3.03E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.59|P-value:1.58E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.38|P-value:3.81E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:5.28|P-value:4.15E-8 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.11|P-value:7.20E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.43|P-value:2.60E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.13|P-value:1.40E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:6.59|P-value:1.12E-11 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.37|P-value:3.23E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.43|P-value:2.52E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.20|P-value:5.88E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.32|P-value:3.37E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.19|P-value:6.22E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.62|P-value:1.04E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.14|P-value:7.49E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.68|P-value:1.06E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.15|P-value:7.12E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.87|P-value:4.42E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.28|P-value:4.50E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.84|P-value:4.95E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.22|P-value:5.64E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.15|P-value:7.14E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.75|P-value:7.33E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.52|P-value:1.84E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.29|P-value:4.31E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.30|P-value:3.63E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.91|P-value:3.69E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.09|P-value:8.82E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.17|P-value:6.66E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.50|P-value:1.72E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.39|P-value:3.01E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.06|P-value:9.91E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.12|P-value:8.06E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.11|P-value:7.36E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.15|P-value:7.09E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.71|P-value:8.67E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-4.12|P-value:1.27E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.04|P-value:9.21E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.32|P-value:3.91E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.56|P-value:1.38E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:-3.21|P-value:5.13E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.16|P-value:6.08E-4 ID:SGTC_105|Compound:0111-0055|FD-Score:-4.34|P-value:4.48E-6 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.37|P-value:2.84E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:-4.04|P-value:1.77E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.16|P-value:6.93E-4 ID:SGTC_174|Compound:3553-0389|FD-Score:-3.17|P-value:5.85E-4 ID:SGTC_228|Compound:caffeine|FD-Score:-3.24|P-value:4.57E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:4.98|P-value:2.21E-7 ID:SGTC_345|Compound:1362-0200|FD-Score:3.32|P-value:3.91E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:3.19|P-value:6.18E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:-3.05|P-value:8.86E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:4.53|P-value:2.13E-6 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.78|P-value:6.44E-5 ID:SGTC_496|Compound:calpeptin|FD-Score:3.13|P-value:7.67E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.15|P-value:7.02E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:-3.09|P-value:7.67E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:3.41|P-value:2.78E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:3.39|P-value:3.03E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:4.59|P-value:1.58E-6 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.38|P-value:3.81E-6 ID:SGTC_967|Compound:1306-0166|FD-Score:5.28|P-value:4.15E-8 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:-3.11|P-value:7.20E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.43|P-value:2.60E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.13|P-value:1.40E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:6.59|P-value:1.12E-11 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.37|P-value:3.23E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:3.43|P-value:2.52E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:3.20|P-value:5.88E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:-3.32|P-value:3.37E-4 ID:SGTC_1608|Compound:st001473|FD-Score:3.19|P-value:6.22E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:-3.62|P-value:1.04E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.14|P-value:7.49E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.68|P-value:1.06E-6 ID:SGTC_1678|Compound:st019265|FD-Score:3.15|P-value:7.12E-4 ID:SGTC_1738|Compound:st035555|FD-Score:3.87|P-value:4.42E-5 ID:SGTC_1739|Compound:st037196|FD-Score:3.28|P-value:4.50E-4 ID:SGTC_1761|Compound:st044296|FD-Score:3.84|P-value:4.95E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.22|P-value:5.64E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.15|P-value:7.14E-4 ID:SGTC_2088|Compound:5278280|FD-Score:3.75|P-value:7.33E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.52|P-value:1.84E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.29|P-value:4.31E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.30|P-value:3.63E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.91|P-value:3.69E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.09|P-value:8.82E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.17|P-value:6.66E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.50|P-value:1.72E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.39|P-value:3.01E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.06|P-value:9.91E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.12|P-value:8.06E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.11|P-value:7.36E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.15|P-value:7.09E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.71|P-value:8.67E-5 ID:SGTC_3050|Compound:9093513|FD-Score:-4.12|P-value:1.27E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-3.04|P-value:9.21E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.32|P-value:3.91E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.56|P-value:1.38E-4

Top fitness defect scores for YOR368W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1126 isoteolin 6.59 1.0 µM 1.12E-11 5 2.23E-11
2 SGTC_967 1306-0166 5.28 352.0 µM 4.15E-8 9 6.35E-8
3 SGTC_301 4119-0100 4.98 24.5 µM 2.21E-7 NEO1 55 3.21E-7
4 SGTC_1670 st016595 4.68 4.0 µM 1.06E-6 4 1.47E-6
5 SGTC_950 1165-0508 4.59 94.1 µM 1.58E-6 15 2.17E-6
6 SGTC_405 ebelactone b 4.53 50.0 µM 2.13E-6 4 2.89E-6
7 SGTC_1124 fisetin 4.13 1.2 µM 1.40E-5 30 1.79E-5
8 SGTC_2508 celastrol 3.91 40.5 µM 3.69E-5 PDR1 19 4.60E-5
9 SGTC_1738 st035555 3.87 74.0 µM 4.42E-5 TSC3-RPN4 33 5.48E-5
10 SGTC_1761 st044296 3.84 37.0 µM 4.95E-5 17 6.11E-5
11 SGTC_473 2-arachidonoylglycerol 3.78 10.0 µM 6.44E-5 22 7.89E-5
12 SGTC_2088 5278280 3.75 127.4 µM 7.33E-5 29 8.94E-5
13 SGTC_3025 9087895 3.71 49.5 µM 8.67E-5 PDR1 46 1.05E-4
14 SGTC_2302 7771753 3.52 200.0 µM 1.84E-4 57 2.19E-4
15 SGTC_1424 4048-1941 3.43 275.0 µM 2.52E-4 39 2.97E-4
16 SGTC_1073 triclabendazole 3.43 3.1 µM 2.60E-4 49 3.06E-4
17 SGTC_845 0330-0138 3.41 4.5 µM 2.78E-4 34 3.27E-4
18 SGTC_2899 9053889 3.39 58.4 µM 3.01E-4 22 3.52E-4
19 SGTC_858 0438-0351 3.39 2.8 µM 3.03E-4 copper-dependent oxidative stress 38 3.55E-4
20 SGTC_1243 0416-0003 3.37 5.7 µM 3.23E-4 PDR1 59 3.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.46E-12 YFR041C ERJ5 hom Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
0.085 7.59E-7 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.085 7.82E-7 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication
0.084 1.25E-6 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.079 4.13E-6 YBR270C_p BIT2_p hom Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication
0.074 1.60E-5 YPL083C SEN54 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
0.072 2.68E-5 YER155C BEM2 hom Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
0.072 3.27E-5 YPL162C_p YPL162C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology
0.069 6.69E-5 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.068 7.45E-5 YER026C CHO1 hom Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
0.068 9.20E-5 YHR206W SKN7 hom Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication
0.067 1.10E-4 YPR015C_p YPR015C_p hom Putative protein of unknown function; overexpression causes a cell cycle delay or arrest
0.066 1.29E-4 YDL229W SSB1 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication
0.066 1.35E-4 YDL116W NUP84 hom Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107
0.065 1.49E-4 YJL047C-A_p YJL047C-A_p hom Putative protein of unknown function