YOR369C / RPS12

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog

Zygosity: Homozygous strain
fixedexpanded
Profile for YOR369C / RPS12

Click on Significant Values for Screen Details ID:SGTC_98|Compound:0074-0023|FD-Score:-4.36|P-value:1.14E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:4.87|P-value:7.66E-7 ID:SGTC_251|Compound:melphalan|FD-Score:5.77|P-value:6.42E-9 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.60|P-value:2.40E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.57|P-value:2.69E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.12|P-value:2.28E-5 ID:SGTC_442|Compound:cape|FD-Score:-3.31|P-value:6.66E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.52|P-value:3.20E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.54|P-value:2.29E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.97|P-value:6.70E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.38|P-value:5.32E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-4.57|P-value:4.50E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:3.89|P-value:5.85E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.21|P-value:7.35E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.70|P-value:1.25E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.59|P-value:1.88E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.66|P-value:1.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.53|P-value:3.16E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:5.02|P-value:3.55E-7 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.49|P-value:2.70E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.20|P-value:1.66E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.32|P-value:7.66E-8 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.04|P-value:3.24E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.38|P-value:5.29E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.77|P-value:9.53E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.15|P-value:8.85E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.29|P-value:5.47E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.52|P-value:2.47E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.77|P-value:9.65E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.64|P-value:2.25E-6 ID:SGTC_2008|Compound:4012253|FD-Score:4.15|P-value:2.05E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.35|P-value:8.53E-6 ID:SGTC_2074|Compound:5212007|FD-Score:4.27|P-value:1.20E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.16|P-value:8.72E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.36|P-value:4.32E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.09|P-value:2.60E-5 ID:SGTC_2421|Compound:5690543|FD-Score:4.44|P-value:5.63E-6 ID:SGTC_2517|Compound:totarol|FD-Score:3.73|P-value:1.12E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.17|P-value:1.89E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.57|P-value:2.02E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.16|P-value:2.73E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.13|P-value:3.06E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.63|P-value:1.64E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.22|P-value:9.29E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.81|P-value:1.11E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.26|P-value:6.09E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.42|P-value:4.66E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.59|P-value:2.52E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.26|P-value:8.13E-4 ID:SGTC_2998|Compound:9066762|FD-Score:5.06|P-value:2.98E-7 ID:SGTC_2999|Compound:9069765|FD-Score:3.24|P-value:6.57E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.27|P-value:5.89E-4 ID:SGTC_3089|Compound:9117425|FD-Score:5.37|P-value:6.01E-8 ID:SGTC_3096|Compound:9117468|FD-Score:3.21|P-value:7.20E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.41|P-value:3.62E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.15|P-value:2.08E-5 ID:SGTC_3291|Compound:9121177|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-4.36|P-value:1.14E-5 ID:SGTC_99|Compound:0109-0120|FD-Score:4.87|P-value:7.66E-7 ID:SGTC_251|Compound:melphalan|FD-Score:5.77|P-value:6.42E-9 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.60|P-value:2.40E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.57|P-value:2.69E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.12|P-value:2.28E-5 ID:SGTC_442|Compound:cape|FD-Score:-3.31|P-value:6.66E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.52|P-value:3.20E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.54|P-value:2.29E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:-4.97|P-value:6.70E-7 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.38|P-value:5.32E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.23|P-value:6.93E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:-4.57|P-value:4.50E-6 ID:SGTC_933|Compound:2914-0560|FD-Score:3.89|P-value:5.85E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.21|P-value:7.35E-4 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.70|P-value:1.25E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.59|P-value:1.88E-4 ID:SGTC_1101|Compound:ebselen|FD-Score:3.66|P-value:1.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.53|P-value:3.16E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:5.02|P-value:3.55E-7 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.49|P-value:2.70E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:4.20|P-value:1.66E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.32|P-value:7.66E-8 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.04|P-value:3.24E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.38|P-value:5.29E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:3.53|P-value:2.35E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.77|P-value:9.53E-5 ID:SGTC_1590|Compound:st077108|FD-Score:3.15|P-value:8.85E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.46|P-value:3.04E-4 ID:SGTC_1893|Compound:st059353|FD-Score:3.29|P-value:5.47E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.52|P-value:2.47E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.77|P-value:9.65E-5 ID:SGTC_1953|Compound:st076800|FD-Score:4.64|P-value:2.25E-6 ID:SGTC_2008|Compound:4012253|FD-Score:4.15|P-value:2.05E-5 ID:SGTC_2064|Compound:5220758|FD-Score:4.35|P-value:8.53E-6 ID:SGTC_2074|Compound:5212007|FD-Score:4.27|P-value:1.20E-5 ID:SGTC_2089|Compound:5281248|FD-Score:3.16|P-value:8.72E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.36|P-value:4.32E-4 ID:SGTC_2329|Compound:6138490|FD-Score:4.09|P-value:2.60E-5 ID:SGTC_2421|Compound:5690543|FD-Score:4.44|P-value:5.63E-6 ID:SGTC_2517|Compound:totarol|FD-Score:3.73|P-value:1.12E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:4.17|P-value:1.89E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.57|P-value:2.02E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:-4.16|P-value:2.73E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.13|P-value:3.06E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.63|P-value:1.64E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.22|P-value:9.29E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.81|P-value:1.11E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.26|P-value:6.09E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.42|P-value:4.66E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.59|P-value:2.52E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.26|P-value:8.13E-4 ID:SGTC_2998|Compound:9066762|FD-Score:5.06|P-value:2.98E-7 ID:SGTC_2999|Compound:9069765|FD-Score:3.24|P-value:6.57E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.27|P-value:5.89E-4 ID:SGTC_3089|Compound:9117425|FD-Score:5.37|P-value:6.01E-8 ID:SGTC_3096|Compound:9117468|FD-Score:3.21|P-value:7.20E-4 ID:SGTC_3124|Compound:9127567|FD-Score:3.41|P-value:3.62E-4 ID:SGTC_3252|Compound:9135871|FD-Score:4.15|P-value:2.08E-5 ID:SGTC_3291|Compound:9121177|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.64|P-value:1.57E-4

Top fitness defect scores for YOR369C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_251 melphalan 5.77 456.5 µM 6.42E-9 DNA damage response 8 4.00E-9
2 SGTC_3089 9117425 5.37 49.5 µM 6.01E-8 4 4.04E-8
3 SGTC_1446 4239-0190 5.32 62.0 µM 7.66E-8 12 5.20E-8
4 SGTC_2998 9066762 5.06 71.4 µM 2.98E-7 RPP1 & pyrimidine depletion 8 2.11E-7
5 SGTC_1253 0550-0034 5.02 176.0 µM 3.55E-7 7 2.53E-7
6 SGTC_99 0109-0120 4.87 622.8 µM 7.66E-7 4 5.61E-7
7 SGTC_1953 st076800 4.64 12.1 µM 2.25E-6 33 1.71E-6
8 SGTC_2421 5690543 4.44 90.7 µM 5.63E-6 13 4.40E-6
9 SGTC_2064 5220758 4.35 200.0 µM 8.53E-6 23 6.76E-6
10 SGTC_2074 5212007 4.27 75.4 µM 1.20E-5 8 9.62E-6
11 SGTC_1402 3909-7673 4.20 35.9 µM 1.66E-5 19 1.34E-5
12 SGTC_2576 guaiol 4.17 23.1 µM 1.89E-5 15 1.53E-5
13 SGTC_2008 4012253 4.15 172.0 µM 2.05E-5 20 1.67E-5
14 SGTC_3252 9135871 4.15 49.5 µM 2.08E-5 8 1.70E-5
15 SGTC_379 3970-0972 4.12 5.9 µM 2.28E-5 tubulin folding & SWR complex 32 1.86E-5
16 SGTC_2329 6138490 4.09 200.0 µM 2.60E-5 28 2.14E-5
17 SGTC_1448 4255-0083 4.04 152.0 µM 3.24E-5 ERG2 18 2.68E-5
18 SGTC_933 2914-0560 3.89 114.0 µM 5.85E-5 26 4.93E-5
19 SGTC_1538 2',3',6-trimethoxyflavanone 3.77 63.6 µM 9.53E-5 20 8.15E-5
20 SGTC_1932 st074806 3.77 40.9 µM 9.65E-5 31 8.25E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.73E-9 YIL130W ASG1 hom Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
0.094 4.62E-8 YKL009W MRT4 hom Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
0.088 2.91E-7 YKL180W RPL17A het Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.083 1.32E-6 YJR010C-A SPC1 hom Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress
0.080 3.89E-6 YOL080C REX4 hom Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
0.078 6.59E-6 YPL097W MSY1 hom Mitochondrial tyrosyl-tRNA synthetase
0.071 4.40E-5 YGR023W MTL1 hom Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p
0.070 4.47E-5 YBR019C GAL10 hom UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
0.069 6.49E-5 YDR085C AFR1 hom Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication
0.066 1.22E-4 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.065 1.56E-4 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
0.065 1.76E-4 YOR106W VAM3 hom Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
0.064 2.02E-4 YOL077W-A ATP19 hom Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase
0.064 2.14E-4 YGR108W CLB1 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.064 2.30E-4 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication