YOR370C / MRS6

Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YOR370C / MRS6

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:-3.08|P-value:5.06E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.49|P-value:4.88E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:2.99|P-value:4.01E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.13|P-value:1.56E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:4.16|P-value:1.80E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:3.08|P-value:2.82E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.29|P-value:1.17E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.89|P-value:6.62E-18 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:2.91|P-value:5.62E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:2.97|P-value:4.47E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.66|P-value:1.80E-10 ID:SGTC_926|Compound:2268-1401|FD-Score:2.78|P-value:9.19E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.78|P-value:1.28E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.90|P-value:5.83E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.16|P-value:4.79E-12 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.80|P-value:1.16E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.03|P-value:3.65E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.41|P-value:1.30E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.79|P-value:8.82E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:2.84|P-value:7.33E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.91|P-value:5.63E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.53|P-value:7.80E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.65|P-value:2.35E-5 ID:SGTC_1727|Compound:st034309|FD-Score:2.81|P-value:8.00E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.93|P-value:9.08E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.19|P-value:4.42E-9 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.95|P-value:4.82E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.38|P-value:8.10E-5 ID:SGTC_2257|Compound:7960413|FD-Score:3.93|P-value:6.00E-6 ID:SGTC_2285|Compound:7945142|FD-Score:2.98|P-value:4.24E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.98|P-value:4.20E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.11|P-value:4.54E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.11|P-value:4.42E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.07|P-value:2.95E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-2.97|P-value:7.77E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.34|P-value:1.56E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.24|P-value:1.46E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.37|P-value:1.30E-9 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.69|P-value:1.98E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-9.89|P-value:3.78E-27 ID:SGTC_2701|Compound:st077767|FD-Score:3.97|P-value:4.85E-6 ID:SGTC_2702|Compound:st077768|FD-Score:-2.93|P-value:8.84E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.28|P-value:2.29E-4 ID:SGTC_2713|Compound:st079149|FD-Score:2.95|P-value:4.76E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-6.09|P-value:2.47E-11 ID:SGTC_2835|Compound:9006588|FD-Score:3.66|P-value:2.23E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.00|P-value:3.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.34|P-value:1.78E-4 ID:SGTC_2933|Compound:9026794|FD-Score:4.60|P-value:1.65E-7 ID:SGTC_2937|Compound:9044753|FD-Score:5.13|P-value:6.32E-9 ID:SGTC_2942|Compound:9052777|FD-Score:3.27|P-value:1.27E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.16|P-value:5.26E-9 ID:SGTC_2975|Compound:9084847|FD-Score:3.35|P-value:9.24E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.72|P-value:1.68E-5 ID:SGTC_3088|Compound:9117578|FD-Score:2.88|P-value:6.28E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-5.73|P-value:3.20E-10 ID:SGTC_3153|Compound:9100258|FD-Score:4.00|P-value:4.22E-6 ID:SGTC_3174|Compound:9107204|FD-Score:-2.92|P-value:9.18E-4 ID:SGTC_3204|Compound:9114183|FD-Score:2.78|P-value:9.15E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.01|P-value:3.98E-6 ID:SGTC_3223|Compound:9129970|FD-Score:3.02|P-value:3.59E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.12|P-value:4.35E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.25|P-value:1.17E-6 ID:SGTC_17|Compound:0960-0276|FD-Score:-3.08|P-value:5.06E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.49|P-value:4.88E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:2.99|P-value:4.01E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.13|P-value:1.56E-8 ID:SGTC_164|Compound:4100-3994|FD-Score:4.16|P-value:1.80E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:3.08|P-value:2.82E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.29|P-value:1.17E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.89|P-value:6.62E-18 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:2.91|P-value:5.62E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:2.97|P-value:4.47E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:5.66|P-value:1.80E-10 ID:SGTC_926|Compound:2268-1401|FD-Score:2.78|P-value:9.19E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.78|P-value:1.28E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.90|P-value:5.83E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:6.16|P-value:4.79E-12 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.80|P-value:1.16E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.03|P-value:3.65E-6 ID:SGTC_1242|Compound:0402-0103|FD-Score:-3.41|P-value:1.30E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.79|P-value:8.82E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:2.84|P-value:7.33E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:2.91|P-value:5.63E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.53|P-value:7.80E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.65|P-value:2.35E-5 ID:SGTC_1727|Compound:st034309|FD-Score:2.81|P-value:8.00E-4 ID:SGTC_1737|Compound:st035557|FD-Score:-2.93|P-value:9.08E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.19|P-value:4.42E-9 ID:SGTC_2131|Compound:toluylene red|FD-Score:2.95|P-value:4.82E-4 ID:SGTC_2138|Compound:5575593|FD-Score:3.38|P-value:8.10E-5 ID:SGTC_2257|Compound:7960413|FD-Score:3.93|P-value:6.00E-6 ID:SGTC_2285|Compound:7945142|FD-Score:2.98|P-value:4.24E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.98|P-value:4.20E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.11|P-value:4.54E-4 ID:SGTC_2367|Compound:9070478|FD-Score:-3.11|P-value:4.42E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.07|P-value:2.95E-4 ID:SGTC_2427|Compound:5545055|FD-Score:-2.97|P-value:7.77E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.34|P-value:1.56E-6 ID:SGTC_2452|Compound:5863136|FD-Score:3.24|P-value:1.46E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:5.37|P-value:1.30E-9 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.69|P-value:1.98E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-9.89|P-value:3.78E-27 ID:SGTC_2701|Compound:st077767|FD-Score:3.97|P-value:4.85E-6 ID:SGTC_2702|Compound:st077768|FD-Score:-2.93|P-value:8.84E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.28|P-value:2.29E-4 ID:SGTC_2713|Compound:st079149|FD-Score:2.95|P-value:4.76E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-6.09|P-value:2.47E-11 ID:SGTC_2835|Compound:9006588|FD-Score:3.66|P-value:2.23E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.00|P-value:3.92E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-3.34|P-value:1.78E-4 ID:SGTC_2933|Compound:9026794|FD-Score:4.60|P-value:1.65E-7 ID:SGTC_2937|Compound:9044753|FD-Score:5.13|P-value:6.32E-9 ID:SGTC_2942|Compound:9052777|FD-Score:3.27|P-value:1.27E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.16|P-value:5.26E-9 ID:SGTC_2975|Compound:9084847|FD-Score:3.35|P-value:9.24E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.72|P-value:1.68E-5 ID:SGTC_3088|Compound:9117578|FD-Score:2.88|P-value:6.28E-4 ID:SGTC_3151|Compound:9099821|FD-Score:-5.73|P-value:3.20E-10 ID:SGTC_3153|Compound:9100258|FD-Score:4.00|P-value:4.22E-6 ID:SGTC_3174|Compound:9107204|FD-Score:-2.92|P-value:9.18E-4 ID:SGTC_3204|Compound:9114183|FD-Score:2.78|P-value:9.15E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.01|P-value:3.98E-6 ID:SGTC_3223|Compound:9129970|FD-Score:3.02|P-value:3.59E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-3.12|P-value:4.35E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.25|P-value:1.17E-6

Top fitness defect scores for YOR370C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1161 k007-0610 6.16 110.0 µM 4.79E-12 ERAD & cell cycle 17 3.67E-10 0.34
2 SGTC_922 1866-0035 5.66 480.0 µM 1.80E-10 excess fatty acid 3 7.46E-9 0.36
3 SGTC_2533 agelasine 5.37 13.7 µM 1.30E-9 ERG2 6 3.84E-8 0.08
4 SGTC_2021 4019055 5.19 173.0 µM 4.42E-9 endomembrane recycling 24 1.06E-7 0.08
5 SGTC_2968 9090663 5.16 33.4 µM 5.26E-9 8 1.23E-7 0.95
6 SGTC_2937 9044753 5.13 11.3 µM 6.32E-9 60S ribosome export 5 1.43E-7 0.27
7 SGTC_2933 9026794 4.60 32.5 µM 1.65E-7 3 2.14E-6 0.60
8 SGTC_3325 9138760 4.25 55.2 µM 1.17E-6 Golgi 4 1.09E-5 0.70
9 SGTC_164 4100-3994 4.16 89.6 µM 1.80E-6 5 1.56E-5 0.23
10 SGTC_1203 3992-3522 4.03 103.0 µM 3.65E-6 12 2.80E-5 0.26
11 SGTC_3206 9114350 4.01 49.5 µM 3.98E-6 2 3.01E-5 0.30
12 SGTC_3153 9100258 4.00 49.5 µM 4.22E-6 5 3.16E-5 0.44
13 SGTC_2701 st077767 3.97 14.7 µM 4.85E-6 9 3.54E-5 0.36
14 SGTC_2257 7960413 3.93 200.0 µM 6.00E-6 NEO1-PIK1 18 4.23E-5 0.15
15 SGTC_1171 0368-0077 3.80 21.4 µM 1.16E-5 12 7.31E-5 0.02
16 SGTC_1002 4049-0206 3.78 172.0 µM 1.28E-5 7 7.94E-5 0.03
17 SGTC_3020 9089140 3.72 49.5 µM 1.68E-5 10 9.95E-5 0.00
18 SGTC_2640 pentamidine 3.69 10.4 µM 1.98E-5 mitochondrial processes 22 1.14E-4 0.10
19 SGTC_2835 9006588 3.66 71.4 µM 2.23E-5 12 1.26E-4 0.03
20 SGTC_1690 st023502 3.65 41.2 µM 2.35E-5 calcium & mitochondrial duress 3 1.31E-4 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 2.05E-41 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.169 8.18E-23 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.154 2.84E-19 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.146 2.07E-17 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.139 5.66E-16 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.133 8.89E-15 YIL063C YRB2 het Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
0.133 1.05E-14 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.132 1.91E-14 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.132 1.97E-14 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.127 1.97E-13 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.122 1.55E-12 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.117 1.29E-11 YMR170C ALD2 hom Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
0.116 1.49E-11 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.116 1.49E-11 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.113 5.18E-11 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha